Involvement of bystander effect in suppression of the cytokine production induced by heavy-ion broad beams.

Abstract:

PURPOSE:Immune cells accumulate in and around cancers and cooperate with each other using specific cytokines to attack the cancer cells. The heavy-ion beams for cancer therapy may stimulate immune cells and affect on the immune system. However, it is still poorly understood how the immune cells are stimulated by ion-beams. Here, we irradiated immune cells using heavy-ion beams and analyzed changes in production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) that are important cytokine for the cancer treatment. MATERIALS AND METHODS:The human THP-1 monocytes were differentiated into macrophages and then irradiated using carbon-ion broad-beams (108 keV μm(-1)). To examine the bystander response after heavy-ion irradiation, a very small fraction (approx. 0.45%) of the cell population was irradiated using heavy-ion microbeams. After irradiation, we examined the cytokine productions. RESULTS:When cells were irradiated with 5 Gy, cytokine levels were reduced after both microbeam irradiation and broad-beam irradiation. TNF-α production of macrophages with the nitric oxide (NO) inhibitor-treatment increased after carbon-ion broad-beam. NO was involved in the radiation-induced suppression of TNF-α production. CONCLUSIONS:The suppression of cytokine production arose after irradiation with heavy-ions, and may also be induced in the surrounding non-irradiated cells via the bystander effect.

journal_name

Int J Radiat Biol

authors

Mutou-Yoshihara Y,Funayama T,Yokota Y,Kobayashi Y

doi

10.3109/09553002.2012.636138

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

258-66

issue

3

eissn

0955-3002

issn

1362-3095

journal_volume

88

pub_type

杂志文章
  • The relevance of tumour and surrounding normal tissue vascular density in clinical hyperthermia of locally advanced breast carcinoma.

    abstract::It follows from the present work that the vascularization of the normal tissue present in the treatment volume limits the temperatures achieved during heat treatment of invasive ductal breast carcinoma. The temperatures can often be increased by giving fractionated heat treatment because heat treatment may reduce the ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114551821

    authors: Lyng H,Monge OR,Bøhler PJ,Rofstad EK

    更新日期:1991-07-01 00:00:00

  • Effect of heat on induction and repair of DNA strand breaks in X-irradiated CHO cells.

    abstract::Chinese hamster ovary cells were exposed to various heat treatments followed by X-irradiation, and the induction and repair of DNA strand breaks was studied using the alkaline unwinding technique. Heat treatments alone were found to cause DNA strand breakage only for temperatures greater than or equal to 43 degrees C,...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214550851

    authors: Dikomey E,Franzke J

    更新日期:1992-02-01 00:00:00

  • The linear nonthreshold (LNT) model as used in radiation protection: an NCRP update.

    abstract:PURPOSE:The linear nonthreshold (LNT) model has been used in radiation protection for over 40 years and has been hotly debated. It relies heavily on human epidemiology, with support from radiobiology. The scientific underpinnings include NCRP Report No. 136 ('Evaluation of the Linear-Nonthreshold Dose-Response Model fo...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2017.1328750

    authors: Boice JD Jr

    更新日期:2017-10-01 00:00:00

  • Lupeol enhances radiosensitivity of human hepatocellular carcinoma cell line SMMC-7721 in vitro and in vivo.

    abstract:PURPOSE:To investigate the effect of lupeol, a pentacyclictriterpene, on the radiosensitivity of a human hepatocellular carcinoma (HCC) in vitro and in vivo xenografts. METHODS:SMMC-7721 cells were exposed to γ-radiation with or without lupeol and assayed for proliferation, clonogenic survival, apoptosis and cell cycl...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2015.966209

    authors: Jin Y,Lyu Y,Tang X,Zhang Y,Chen J,Zheng D,Liang Y

    更新日期:2015-02-01 00:00:00

  • A novel vertebrate system for the examination and direct comparison of the relative biological effectiveness for different radiation qualities and sources.

    abstract:PURPOSE:The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation. AIM:The aim of this paper was to test the relative biological effectiveness ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2018.1511928

    authors: Szabó ER,Reisz Z,Polanek R,Tőkés T,Czifrus S,Pesznyák C,Biró B,Fenyvesi A,Király B,Molnár J,Brunner S,Daroczi B,Varga Z,Hideghéty K

    更新日期:2018-11-01 00:00:00

  • Repair of DNA strand breaks at hyperthermic temperatures in Chinese hamster ovary cells.

    abstract::The repair of DNA double-strand breaks was measured by pH 7.2 filter elution in cells incubated at 25-45 degrees C either before or after X-irradiation. Exposure to 45 degrees C for 15 minutes immediately prior to X-irradiation significantly increased both the half-time for DNA double-strand break closure and the numb...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214550601

    authors: Warters RL,Axtell J

    更新日期:1992-01-01 00:00:00

  • Track structure calculations on intracellular targets responsible for signal release in bystander experiments with transfer of irradiated cell-conditioned medium.

    abstract:PURPOSE:To investigate alternative scenarios for the dose-dependent emission of bystander signals by irradiated cells in medium transfer experiments. METHODS:Energy deposition patterns to hypothetical intracellular targets whose hit by radiation initiates the emission of bystander signals have been simulated by Monte ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2011.595874

    authors: Kundrát P,Friedland W

    更新日期:2012-01-01 00:00:00

  • Clinical interest in determinations of cellular radiation sensitivity.

    abstract::Determinations of cell sensitivity in terms of survival fraction after doses employed in clinical radiation therapy, say 1-3 Gy, are of increasing interest to clinicians as they provide direct experimental data which can be employed without reference to models of cell inactivation. SF2 values are expected ultimately t...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553008914551971

    authors: Suit HD,Baumann M,Skates S,Convery K

    更新日期:1989-11-01 00:00:00

  • Evidence for curvilinearity in the cancer incidence dose-response in the Japanese atomic bomb survivors.

    abstract::The recently released data on cancer incidence in the Japanese atomic bomb survivors are analysed using a variety of relative risk models which take account of errors in estimates of dose to assess the dose-response at low doses. For all solid cancers analysed together there is a significant positive dose-response (at...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530096145364

    authors: Little MP,Muirhead CR

    更新日期:1996-07-01 00:00:00

  • Nigella sativa oil and thymoquinone reduce oxidative stress in the brain tissue of rats exposed to total head irradiation.

    abstract::Purpose: To evaluate the antioxidant and radio-protective effects of Nigella sativa oil (NSO) and thymoquinone (TQ) on radiation-induced oxidative stress in brain tissue.Materials and methods: Fifty-four Sprague-Dawley rats were divided into six groups to test the radio-protective effectiveness of Nigella sativa oil a...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2020.1683636

    authors: Demir E,Taysi S,Ulusal H,Kaplan DS,Cinar K,Tarakcioglu M

    更新日期:2020-02-01 00:00:00

  • Migration patterns in pulsed-field electrophoresis of DNA restriction fragments from log-phase mammalian cells after irradiation and incubation for repair.

    abstract::An assay system was developed to detect changes of restriction fragment profiles obtained after pulsed-field gel electrophoresis (PFGE) for DNA from mammalian cells that were irradiated and incubated for repair. DNA was prepared from irradiated log-phase human melanoma cells (MRI 221) after incubation for repair (6 h)...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530096144518

    authors: Latz D,Dewey WC,Flentje M,Lohr F,Wenz F,Weber KJ

    更新日期:1996-12-01 00:00:00

  • Experimental and theoretical analysis of cytokine release for the study of radiation-induced bystander effect.

    abstract:PURPOSE:To clarify the experimental conditions that might influence the release of cytokines in the culture medium and give some basic input for building a model for cytokine (e.g., Interleukin-6, IL-6) regulation in the case of 'sham irradiation' and after ionising radiation exposure. MATERIALS AND METHODS:The influe...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000903020016

    authors: Facoetti A,Mariotti L,Ballarini F,Bertolotti A,Nano R,Pasi F,Ranza E,Ottolenghi A

    更新日期:2009-08-01 00:00:00

  • Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines.

    abstract:PURPOSE:Genotoxic effects have been considered the gold standard to determine if an environmental factor is a carcinogen, but the currently available data for extremely low frequency time-varying magnetic fields (ELF-MF) remain controversial. As an environmental stimulus, the effect of ELF-MF on cellular DNA may be sub...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2014.887866

    authors: Yoon HE,Lee JS,Myung SH,Lee YS

    更新日期:2014-04-01 00:00:00

  • Neuroprotective effects of melatonin and omega-3 on hippocampal cells prenatally exposed to 900 MHz electromagnetic fields.

    abstract:PURPOSE:Adverse effects on human health caused by electromagnetic fields (EMF) associated with the use of mobile phones, particularly among young people, are increasing all the time. The potential deleterious effects of EMF exposure resulting from mobile phones being used in close proximity to the brain require particu...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2016.1206223

    authors: Erdem Koç G,Kaplan S,Altun G,Gümüş H,Gülsüm Deniz Ö,Aydin I,Emin Onger M,Altunkaynak Z

    更新日期:2016-10-01 00:00:00

  • A close correlation between electron spin resonance (ESR) dosimetry from tooth enamel and cytogenetic dosimetry from lymphocytes of Hiroshima atomic-bomb survivors.

    abstract:PURPOSE:To estimate gamma-ray doses received by Hiroshima atomic bomb survivors using electron spin resonance (ESR) of tooth enamel and to compare the results with cytogenetic data. MATERIALS AND METHODS:Tooth enamel ESR was performed for 100 teeth donated from 69 Hiroshima survivors, and conventional cytogenetic exam...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530098141870

    authors: Nakamura N,Miyazawa C,Sawada S,Akiyama M,Awa AA

    更新日期:1998-06-01 00:00:00

  • Biophysical model of the radiation-induced bystander effect.

    abstract:PURPOSE:To construct a quantitative model of the radiation-induced bystander effect based on diffusion-type spreading of bystander signal communication between the hit and non-hit cells. Cell inactivation and induced oncogenic transformation by broad- and microbeam irradiation systems are considered. MATERIALS AND MET...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:

    authors: Nikjoo H,Khvostunov IK

    更新日期:2003-01-01 00:00:00

  • Alterations in water and electrolyte absorption in the rat colon following neutron irradiation: influence of neutron component and irradiation dose.

    abstract:PURPOSE:To study the absorptive function of rat colon following whole-body exposure to neutron irradiation, either to the same total dose with varying proportion of neutrons or to the same neutron proportion with an increasing irradiation dose. MATERIALS AND METHODS:Different proportions of neutron irradiation were pr...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/0955300021000019221

    authors: Dublineau I,Ksas B,Joubert C,Aigueperse J,Gourmelon P,Griffiths NM

    更新日期:2002-12-01 00:00:00

  • Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model.

    abstract:PURPOSE:The aim was to evaluate the utility of multiple blood-protein biomarkers for early-response assessment of radiation exposure using a murine radiation model system. MATERIAL AND METHODS:BALB/c male mice (8-10 weeks old) were exposed to whole-body 60Co gamma-rays (10 cGy min(-1)) over a broad dose range (0-7 Gy)...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:

    authors: Ossetrova NI,Blakely WF

    更新日期:2009-01-01 00:00:00

  • Severe mental retardation after large prenatal exposures to bomb radiation. Reduction in oxygen transport to fetal brain: a possible abscopal mechanism.

    abstract::Reasonable expectations, based on the normal physiology of the human fetus, cast new light on the possibilities of extrapolation from the finding of severe mental retardation (SMR) in Japanese bomb survivors after maternal exposure to 1.8-5.5 Gy T65DR Gy. After such large exposures the fetal haematopoietic tissues (DS...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009014552051

    authors: Mole RH

    更新日期:1990-10-01 00:00:00

  • Inhibition of UV-induced G1 arrest by exposure to 50 Hz magnetic fields in repair-proficient and -deficient yeast strains.

    abstract:PURPOSE:To assess the possibility that extremely low frequency (ELF) magnetic fields obstruct the damage repair process, the gene conversion frequency and cell cycle kinetics in a DNA repair-proficient and nucleotide excision repair (NER)-deficient strain of diploid yeast Saccharomyces cerevisiae. MATERIALS AND METHOD...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000310001621437

    authors: Takashima Y,Ikehata M,Miyakoshi J,Koana T

    更新日期:2003-11-01 00:00:00

  • DNA strand scission and base release photosensitized by metallo-phthalocyanines.

    abstract::Photoirradiation of aqueous solutions of DNA in the presence of Al- or Zn-tetrasulphonated phthalocyanines (AIPcS4 and ZnPcS4) causes formation of strand breaks and liberation of nucleobases. The effect of added D2O, which enhances singlet oxygen (1O2) lifetime, radical scavengers including alcohols and the spin-trap ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:

    authors: Gantchev TG,Gowans BJ,Hunting DJ,Wagner JR,van Lier JE

    更新日期:1994-12-01 00:00:00

  • The shape of DNA elution dose-response curves under non-denaturing conditions: the contribution of the degree of chromatin condensation.

    abstract::We have re-examined the effect of detergent type, pH and temperature of lysis on the shape of the DNA elution dose response under non-denaturing conditions using plateau-phase CHO cells. Results practically identical to those previously published (Okayasu and Iliakis, 1989) were obtained, with a 1 h incubation at 60 d...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551211

    authors: Okayasu R,Iliakis G

    更新日期:1992-04-01 00:00:00

  • Computer evaluation of direct and indirect damage induced by free and DNA-bound iodine-125 in the chromatin fibre.

    abstract:PURPOSE:When Iodine-125 decays within chromatin, several in vivo experiments have shown that the radiobiological effects are caused mainly by indirect mechanisms and that more than one DNA double strand break (DSB) is produced per decay. We present calculations to evaluate the contribution of direct and indirect effect...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000400017622

    authors: Terrissol M,Edel S,Pomplun E

    更新日期:2004-11-01 00:00:00

  • Effect of combined treatment of radiation and tissue-specific recombinant oncolytic adenovirus on bladder cancer cells.

    abstract:PURPOSE:Gene therapy combined with radiation has shown promising potential for the treatment of tumors. This paper aimed to clarify the synergistic effect of radiotherapy combined with the bladder cancer tissue-specific oncolytic adenovirus (Ad-PSCAE-UPII-E1A) on bladder cancer cells and to study the underlying synergy...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2017.1231942

    authors: Zhang H,Wang F,Mao C,Zhang Z,Fu S,Lu J,Zhai Z,Li R,Li S,Rodriguez R,Wang Z

    更新日期:2017-02-01 00:00:00

  • Efficacy of delayed administration of sargramostim up to 120 hours post exposure in a nonhuman primate total body radiation model.

    abstract:BACKGROUND:High dose ionizing radiation exposure is associated with myelo-depression leading to pancytopenia and the expected clinical manifestations of acute radiation syndrome (ARS). Herein, we evaluated the efficacy of sargramostim (Leukine®, yeast-derived rhu GM-CSF), with regimens delivered at 48, 72, 96, or 120 h...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2019.1673499

    authors: Zhong Y,Pouliot M,Downey AM,Mockbee C,Roychowdhury D,Wierzbicki W,Authier S

    更新日期:2020-09-22 00:00:00

  • RBE of α-particles from (211)At for complex DNA damage and cell survival in relation to cell cycle position.

    abstract:PURPOSE:To investigate cell cycle effects and relative biological effectiveness (RBE) of α-particles from the clinically relevant radionuclide Astatine-211 ((211)At), using X-rays as reference radiation. Double-strand breaks (DSB), non-DSB clusters containing oxidised purines and clonogenic survival were investigated. ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2011.538127

    authors: Claesson K,Magnander K,Kahu H,Lindegren S,Hultborn R,Elmroth K

    更新日期:2011-04-01 00:00:00

  • Possible role of vitamin E, coenzyme Q10 and rutin in protection against cerebral ischemia/reperfusion injury in irradiated rats.

    abstract:PURPOSE:To investigate the possible role of vitamin E, coenzyme Q10 and rutin in ameliorating the biochemical changes in brain and serum induced by cerebral ischemia/reperfusion (I/R) in whole body γ-irradiated rats. MATERIALS AND METHODS:Cerebral ischemia was induced in male Wistar rats (either irradiated or non-irra...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2010.501844

    authors: Abd-El-Fattah AA,El-Sawalhi MM,Rashed ER,El-Ghazaly MA

    更新日期:2010-12-01 00:00:00

  • Radiation retards muscle differentiation but does not affect osteoblastic differentiation induced by bone morphogenetic protein-2 in C2C12 myoblasts.

    abstract:PURPOSE:Effects of radiation on the differentiation of C2C12 myoblasts were studied using cell cultures in which the cells differentiated into either muscle cells or osteoblasts. MATERIALS AND METHODS:A mouse skeletal myoblast cell line, C2C12, was cultured and irradiated at confluence. Muscle differentiation was esti...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530000138745

    authors: Ikeda S,Hachisu R,Yamaguchi A,Gao YH,Okano T

    更新日期:2000-03-01 00:00:00

  • Low folate status increases chromosomal damage by X-ray irradiation.

    abstract:PURPOSE:To examine how folate status influences chromosomal damage following X-ray irradiation. MATERIAL AND METHODS:In an animal study, mice were fed either a low, basal, or high folic acid diet (0, 2, or 40 mg/kg diet, respectively) for 4 weeks, and then given total body irradiation (TBI) at 0.5 Gy. In a human study...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/09553000600721817

    authors: Endoh K,Murakami M,Araki R,Maruyama C,Umegaki K

    更新日期:2006-04-01 00:00:00

  • Stable chromosomal aberrations in haemopoietic stem cells in the blood of radiation accident victims.

    abstract:PURPOSE:The detection of long-term persistent chromosome aberrations in circulating haemopoietic stem cells after accidental radiation exposure. MATERIAL AND METHODS:Peripheral blood samples from highly exposed persons were collected 7-25 years after the radiation accidents in Moscow (1971), Kazan (1975) and Chernobyl...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530099139395

    authors: Kreja L,Greulich KM,Fliedner TM,Heinze B

    更新日期:1999-10-01 00:00:00