Abstract：
:The effect of local stimulation on mitotic activity and radiation tolerance was studied in mouse tongue mucosa. Silver nitrate solution (0.5-20%) was used for local conditioning. The most effective protocol comprised three daily treatments (days 0-2), yielding a delayed increase in 24 h mitotic counts by about 30% on days 5-7. The stimulating effect was independent of silver nitrate concentration. Sham treatment with saline or anaesthesia alone clearly depressed mitotic activity on days 2-4 without any subsequent overshoot. Radiation treatment was initiated on day 5 after three daily treatments with 3% silver nitrate solution. A top-up technique was employed, consisting of fractionated irradiation (300 kV X-rays) of the whole snout, followed by graded local test doses (25 kV X-rays) to induce denudation in a confined area of the inferior tongue surface. Silver nitrate conditioning did not alter the radiosensitivity of the epithelium to single local doses, but shortened the latency to denudation from 11 to 8 days. In contrast, a clear increase in tolerance to fractionated irradiation, delivering 5 x 2.5, 5 x 3.5, 5 x 4.5 Gy or 3 x 5.2 Gy in 7 days, was observed, equivalent to about four, two, one and two extra dose fractions. This approach may be a suitable way to increase radiation tolerance of oral mucosa in clinical radiotherapy.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Dörr W,Kummermehr Jdoi
10.1080/09553009214551061subject
Has Abstractpub_date
1992-03-01 00:00:00pages
369-79issue
3eissn
0955-3002issn
1362-3095pii
KUXF7YP97X8VBEJ8journal_volume
61pub_type
杂志文章abstract：PURPOSE:A model that identifies radiation-induced genetic instability as the earliest cellular event in the multi-step sequence leading to radiation-induced cancer was previously proposed. In this paper ongoing experiments are discussed which are designed to test this model and its predictions in mouse mammary epitheli...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/095530098141023
更新日期：1998-12-01 00:00:00
abstract：PURPOSE:The LET position of the RBE maximum and its dependence on the cellular repair capacity was determined for carbon ions. Hamster cell lines of differing repair capacity were irradiated with monoenergetic carbon ions. RBE values for cell inactivation at different survival levels were determined and the differences...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530099139232
更新日期：1999-11-01 00:00:00
abstract：PURPOSE:To determine the relative toxicity of alpha- and beta-radiations under conditions of controlled temporal and spatial dose distribution. METHODS:Fused aluminosilicate particles were radiolabelled with either (45)Ca (a beta-emitter) or (242)Cm (an alpha-emitter). These were injected into CBA/Ca mice to give life...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553000903564075
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:In this study we addressed the question whether radiation-induced adverse effects on T cell activation are associated with alterations of T cell checkpoint receptors. MATERIALS AND METHODS:Expression levels of checkpoint receptors on T cell subpopulations were analyzed at multiple post-radiation time points ra...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2017.1400192
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:To seek the delayed appearance of chromosomal abnormalities in human fibroblasts exposed to the Auger electron emitter 125I. MATERIALS AND METHODS:Normal untransformed human fibroblasts, HF19, were exposed to a concentration of [I125]IUdR, which allowed the survival of 37% of clonogens. Chromosomal analysis us...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000050050972
更新日期：2000-07-01 00:00:00
abstract：:Studies of early physical interactions of ionizing radiation in biological medium have evolved from water cylinders or spheres to structured volumes representing nucleosomal DNA, based on spatial co-ordinates for each individual atom. Regarding the physico-chemical and chemical stages, the models of DNA have evolved f...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009414551441
更新日期：1994-11-01 00:00:00
abstract：PURPOSE:Estimating the absorbed dose to tumour relative to normal tissues has often been used in the assessment of the therapeutic efficacy of radiolabelled antibodies for radioimmunotherapy. Typically, the calculations assume a uniform dose deposition and response throughout the tumour. However, the heterogeneity of t...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000110117818
更新日期：2002-05-01 00:00:00
abstract：PURPOSE:To examine the protective effects of histamine on intestinal damage produced by gamma-radiation. MATERIALS AND METHODS:56 mice were divided into 4 groups. Histamine and Histamine-10 Gy groups received a daily subcutaneous histamine injection (0.1 mg/kg) starting 20 hours before irradiation and continued until ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000701570238
更新日期：2007-10-01 00:00:00
abstract：:Cell cultures derived from skin biopsies of mouse fetuses X-irradiated at the zygote stage (2 Gy) were studied for the presence of chromosomal aberrations and micronuclei. In comparison with cells from control, unirradiated fetuses significantly higher spontaneous frequencies of aberrations per 100 metaphases and aber...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553008914550091
更新日期：1989-01-01 00:00:00
abstract：:Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530096146246
更新日期：1996-01-01 00:00:00
abstract：:DNA double-strand break (dsb) induction in diploid yeast was measured by neutral sucrose sedimentation after exposure to very heavy ions with values of linear energy transfer (LET) ranging from about 300 to 11500 ke V/microns. Linear fluence dependencies were found in all cases from which dsb production cross-sections...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009214552121
更新日期：1992-09-01 00:00:00
abstract：PURPOSE:The nature of the transferrable factor which goes from irradiated objects to bystander objects remains undefined. Most agree that a chemical entity is the likely 'factor' although some authors have produced in vitro evidence for the involvement of a physical component or a very potent volatile capable of travel...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2012.698366
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:The effects of radiation +/- hypogravity on immunologic function were investigated using the Partial Weight Suspension (PWS) model ( Wagner et al. 2010 ). MATERIALS AND METHODS:Mice were exposed to 0.5, 1, or 2 Gray (Gy) dose of gamma radiation and then placed in the PWS system for 4, 24, 48 hours, or 4 days. ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2011.595875
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:To evaluate the characteristic features of mechanical responses and the membrane potential changes induced by repetitive pulsed electromagnetic field (PEMF, 50 Hz, 5 mT) in thoracic aorta rings obtained from streptozotocin-induced diabetic and healthy control rats to determine if PEMF could ameliorate problems ...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000903009522
更新日期：2009-08-01 00:00:00
abstract：PURPOSE:Conditionally Replicative Adenovirus (CRAd) has been previously demonstrated to augment the activity of radiation, resulting in synergy of cell kill. However, previous models combining radiation with CRAd have not focused on the methods of radiation delivery. MATERIALS AND METHODS:We model the combination of a...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553000903419338
更新日期：2010-03-01 00:00:00
abstract：:The chemical instability of DNA under physiological conditions requires that cells have highly developed processes for repairing stochastic single-strand damage. It is proposed here that provided ionizing-radiation-induced single-strand damage does not occur at a rate sufficient to perturb the dynamic steady state bet...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009114552421
更新日期：1991-10-01 00:00:00
abstract：PURPOSE:To study the formation and subsequent reactions of the 5-methyl-2'-deoxycytidine cation radical (5-Me-2'-dC•(+)) in nucleosides and DNA-oligomers and compare to one-electron oxidized thymidine. MATERIALS AND METHODS:Employing electron spin resonance (ESR), cation radical formation and its reactions were invest...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2014.884293
更新日期：2014-06-01 00:00:00
abstract：:Radiation-induced myocardial degeneration in the rat is preceded by changes in capillary structure and function, which may be a major factor in the pathogenesis of radiation-induced heart disease. In order to investigate the mechanism of capillary damage we studied endothelial cell proliferation in untreated control r...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009014551131
更新日期：1990-05-01 00:00:00
abstract：PURPOSE:Angiotensin-converting enzyme (ACE) inhibitors are effective in the prophylaxis of radiation-induced renal and lung injury. Studies were designed to determine whether blocking the angiotensin II (AII) receptor, rather than blocking AII synthesis with ACE inhibitors, would also be effective. MATERIALS AND METHO...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530098142257
更新日期：1998-04-01 00:00:00
abstract：PURPOSE:To investigate the influence of chromatin organization and scavenging capacity in relation to irradiation temperature on the induction of double-strand breaks (DSB) in structures derived from human diploid fibroblasts. MATERIALS AND METHODS:Agarose plugs with different chromatin structures (intact cells+/-wort...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000310001610204
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:To estimate gamma-ray doses received by Hiroshima atomic bomb survivors using electron spin resonance (ESR) of tooth enamel and to compare the results with cytogenetic data. MATERIALS AND METHODS:Tooth enamel ESR was performed for 100 teeth donated from 69 Hiroshima survivors, and conventional cytogenetic exam...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530098141870
更新日期：1998-06-01 00:00:00
abstract：PURPOSE:Static magnetic field (SMF) exposure was shown experimentally to beneficially affect the healing process. The aim of this randomized, controlled trial was to evaluate the pain-inhibitory effect of local exposure to SMF on temporomandibular disorders, on alveolitis and on aphta in the oral mucosa. MATERIALS AND...
journal_title：International journal of radiation biology
pub_type： 杂志文章,随机对照试验
doi：10.3109/09553002.2012.661916
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:A minority of patients exhibits severe late normal tissue toxicity after radiotherapy (RT), possibly related to their inherent individual radiation sensitivity. This study aimed to evaluate four different candidate in vitro cellular radiosensitivity assays for prediction of late normal tissue reactions, in a re...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553002.2016.1230238
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To investigate the possible role of vitamin E, coenzyme Q10 and rutin in ameliorating the biochemical changes in brain and serum induced by cerebral ischemia/reperfusion (I/R) in whole body γ-irradiated rats. MATERIALS AND METHODS:Cerebral ischemia was induced in male Wistar rats (either irradiated or non-irra...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2010.501844
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:This review will examine the role of phosphatases in cancer cell signalling and also outline emerging findings regarding the influence of phosphatases on tumor cell survival after ionising radiation. CONCLUSION:The exposure of tumour cells to clinically relevant doses of ionising radiation causes DNA damage an...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.3109/09553000903232827
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:Exposition of best practice in management and experimental use of human stem cell lines in radiobiological research. This paper outlines the key challenges to be addressed by radiobiologists wishing to use human pluripotent stem cell (hPSC) lines in their research including human embryonic stem cell (hESC) line...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.3109/09553002.2012.714518
更新日期：2012-10-01 00:00:00
abstract：:The effects of UV radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UV A and UV B. This study compares the in vitro effects of UV A and UV B on the clonogenic survival of two human skin keratinocyte cell lines, HaCaT which are...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/095530097143590
更新日期：1997-07-01 00:00:00
abstract：PURPOSE:Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted populations, are an ever-growing worldwide concern in government and public sectors as they become more frequent, violent, and sensational. If given the chance, it is lik...
journal_title：International journal of radiation biology
pub_type： 杂志文章,评审
doi：10.1080/09553002.2017.1332440
更新日期：2017-09-01 00:00:00
abstract：:The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus and apoptosis assays was determined in three established cell lines (L929, HL-60, and Chang). Irradiation experiments revealed a dose-dependent increase of micronucleated cells until a certain dose was reached....
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553009514550371
更新日期：1995-03-01 00:00:00
abstract：PURPOSE:The tumour suppressor protein p53 is considered to have an impact on the radiosensitivity of tumour cells. However, this concept does not easily translate to the tumour sensitivity in the clinics. The aim of the present study was to determine whether a functional or dysfunctional p53 is associated with a sensit...
journal_title：International journal of radiation biology
pub_type： 杂志文章
doi：10.1080/09553000310001642902
更新日期：2004-01-01 00:00:00
