Abstract:
:DNA double-strand break (dsb) induction in diploid yeast was measured by neutral sucrose sedimentation after exposure to very heavy ions with values of linear energy transfer (LET) ranging from about 300 to 11500 ke V/microns. Linear fluence dependencies were found in all cases from which dsb production cross-sections (sigma dsb) could be calculated. Corresponding cross-sections for cell killing (sigma i) were derived from final slopes of survival curves measured in parallel and for the same fluence range. A close correlation was found between sigma i and sigma dsb. It is calculated that over the entire LET range, including 30 MeV electron irradiation, about 22 dsb are induced per lethal event when high exposures are considered.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Akpa TC,Weber KJ,Schneider E,Kiefer J,Frankenberg-Schwager M,Harbich R,Frankenberg Ddoi
10.1080/09553009214552121subject
Has Abstractpub_date
1992-09-01 00:00:00pages
279-87issue
3eissn
0955-3002issn
1362-3095pii
C80K9H3YCT10XC2Wjournal_volume
62pub_type
杂志文章abstract:PURPOSE:To investigate within the framework of a multilaboratory study the suitability of FISH chromosome painting to measure so-called stable translocations in peripheral lymphocytes of Mayak nuclear-industrial workers (from the Southern Urals) and their use for retrospective biodosimetry. MATERIALS AND METHODS:Chrom...
journal_title:International journal of radiation biology
pub_type: 杂志文章,多中心研究
doi:10.1080/09553000010018693
更新日期:2001-03-01 00:00:00
abstract:PURPOSE:The effect of boronophenylalanine (BPA)-mediated boron neutron capture therapy (BNCT) on human oral squamous cell carcinoma (SCC) xenografts in nude mice was examined. MATERIALS AND METHODS:Tumor-bearing mice were given BPA at a dose of 250 mg/kg body weight. The tumor (10)B concentration 2 h after an injectio...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000600570453
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To investigate the p53 ionizing radiation-induced response, G1/S cell-cycle block and cytogenetic damage in Nijmegen breakage syndrome (NBS) cells characterized by different haplotypes. MATERIAL AND METHODS:Lymphoblastoid cell lines derived from three normals, five NBS and two ataxia telangiectasia (AT) indivi...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530099140221
更新日期:1999-05-01 00:00:00
abstract:PURPOSE:To compare experimental yields of single strand breaks (SSB) and double strand breaks (DSB) induced in plasmid DNA in aqueous solution by alpha-particles and Al(K) ultrasoft X-rays (USX) with the corresponding yields, generated via computer simulations, for a range of mean diffusion distances of the hydroxyl ra...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000110069308
更新日期:2001-10-01 00:00:00
abstract::Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530096146246
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To examine whether the levels of micronuclei induction, as a marker for genomic instability in the progeny of X-irradiated cells, correlates with DNA repair function. MATERIALS AND METHODS:Two repair deficient cell lines (X-ray repair cross-complementing 1 [XRCC1] deficient cell line [EM9] and X-ray repair cro...
journal_title:International journal of radiation biology
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更新日期:2013-04-01 00:00:00
abstract:PURPOSE:Recently, it was found that MK615 possessed an anti-proliferative ability on treated cancer cells as a consequence of triterpenoid compounds. It is well known that radiation affects cellular-mediated immunity in cancer patients who are treated with radiotherapy. Similarly, the ability of triterpenoid compounds ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2010.518202
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Ionizing radiation causes various types of DNA damage e.g. single strand breaks (SSB) and double strand breaks (DSB), whereby the SSB/DSB ratio is shifted toward the DSB with increasing LET. For the DNA-incorporated Auger electron emitter Iodine-125 a SSB/DSB ratio of 5.4:1 is calculated based on computer simul...
journal_title:International journal of radiation biology
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更新日期:2020-12-03 00:00:00
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journal_title:International journal of radiation biology
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更新日期:2000-05-01 00:00:00
abstract:PURPOSE:Caveolin-1 is a membrane protein highly expressed in many tumors and plays an important role in tumor progression and metastasis. This review describes the structure of the Caveolin-1 protein and its pre-clinical and clinical significance, demonstrating that Caveolin-1 is a novel biomarker for radioresistance w...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
abstract::Chinese hamster ovary cells were exposed to various heat treatments followed by X-irradiation, and the induction and repair of DNA strand breaks was studied using the alkaline unwinding technique. Heat treatments alone were found to cause DNA strand breakage only for temperatures greater than or equal to 43 degrees C,...
journal_title:International journal of radiation biology
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doi:10.1080/09553009214550851
更新日期:1992-02-01 00:00:00
abstract:PURPOSE:Despite proven antitumor activity of gemcitabine in chemoradiotherapy of advanced head and neck cancer, many authors refer to severe acute and late local and haematological toxicity. Fludarabine does imply nearly the same mechanisms of action as gemcitabine, inhibiting various enzymes involved in DNA replicatio...
journal_title:International journal of radiation biology
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doi:10.1080/09553000802241754
更新日期:2008-08-01 00:00:00
abstract::Induction of mutations to 6-thioguanine resistance (TGr) by gamma-rays at three different dose-rates and molecular changes in the HPRT gene were studied in human lymphoblastoid WIL2-NS cells. Mutant induction showed a curvilinear dose-response for acute irradiation (30 Gy/h). The total mutant frequency was lower after...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530096145201
更新日期:1996-08-01 00:00:00
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doi:10.1080/095530098141195
更新日期:1998-11-01 00:00:00
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doi:10.3109/09553002.2013.825057
更新日期:2013-11-01 00:00:00
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journal_title:International journal of radiation biology
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doi:10.1080/09553008914550961
更新日期:1989-06-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530098141771
更新日期:1998-07-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:2005-02-01 00:00:00
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更新日期:1989-02-01 00:00:00
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更新日期:2011-02-01 00:00:00
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pub_type: 历史文章
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更新日期:2010-11-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章
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更新日期:1995-12-01 00:00:00
abstract::Most estimates of the radiation dose lethal to 50 per cent of a human population are based on historical data taken from well-known experiences reflecting inadequately known physical and biological conditions, or from medical procedures where individual patients received advantages of modern clinical care. It has been...
journal_title:International journal of radiation biology
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更新日期:1989-03-01 00:00:00
abstract:PURPOSE:To seek the delayed appearance of chromosomal abnormalities in human fibroblasts exposed to the Auger electron emitter 125I. MATERIALS AND METHODS:Normal untransformed human fibroblasts, HF19, were exposed to a concentration of [I125]IUdR, which allowed the survival of 37% of clonogens. Chromosomal analysis us...
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更新日期:2000-07-01 00:00:00
abstract:PURPOSE:Solar energy has a number of short- and long-term detrimental effects on skin that can result in several skin disorders. The aim of this review is to summarise current knowledge on endogenous systems within the skin for protection from solar radiation and present research findings to date, on the exogenous opti...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
doi:10.3109/09553002.2010.501842
更新日期:2010-12-01 00:00:00
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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更新日期:1990-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-05-01 00:00:00