Sonolysis of ubiquinone in aqueous solutions. An EPR spin-trapping study.

Abstract:

:Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition of.OH or.H to the double bonds of the ubiquinone ring and methyl radicals were observed as the major spin adducts. The methyl radicals were formed by pyrolysis of ubiquinone. These radicals led to the degradation of ubiquinone. The reduced from of ubiquinone, ubiquinol, was formed by sonication in the presence of argon, and its formation was prevented by addition of native but not of denatured superoxide dismutase. Sodium formate, which scavenges .OH to form CO2-., enhanced ubiquinol formation but partially inhibited the degradation of the ubiquinone ring. No ubiquinol was formed in nitrogen- or oxygen-saturated solutions under our conditions. These results indicate that ubiquinol was formed by reduction of ubiquinone by O2-., which was generated by the sonolysis of argon-saturated water.

journal_name

Int J Radiat Biol

authors

Kondo T,Riesz P

doi

10.1080/095530096146246

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

113-21

issue

1

eissn

0955-3002

issn

1362-3095

journal_volume

69

pub_type

杂志文章
  • Technical report. The application of probability-generating functions to linear-quadratic radiation survival curves.

    abstract:PURPOSE:To illustrate how probability-generating functions (PGFs) can be employed to derive a simple probabilistic model for clonogenic survival after exposure to ionizing irradiation. METHODS:Both repairable and irreparable radiation damage to DNA were assumed to occur by independent (Poisson) processes, at intensiti...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530000138600

    authors: Kendal WS

    更新日期:2000-04-01 00:00:00

  • DNA double-strand break repair and radiation response in human tumour primary cultures.

    abstract::The accumulation and repair of radiation-induced DNA double-strand breaks (dsbs) were determined by neutral filter elution on 20 primary cultures obtained from ovarian cancer and malignant melanoma clinical specimens. The initial frequency of DNA dsbs after exposure to 50 Gy gamma-irradiation varied greatly for the in...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009414551211

    authors: Zaffaroni N,Orlandi L,Villa R,Bearzatto A,Rofstad EK,Silvestrini R

    更新日期:1994-09-01 00:00:00

  • Use of an internal standard in comparative measurements of the intrinsic radiosensitivities of human T-lymphocytes.

    abstract::A study has been made of the intrinsic radiosensitivity of peripheral blood lymphocytes from normal individuals. Cell survival following in vitro high (1.55 Gy min-1) and low (0.0098 Gy min-1) dose-rate irradiation was obtained for single lymphocyte samples from three individuals in six experiments. Despite wide inter...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009314551571

    authors: Elyan SA,West CM,Roberts SA,Hunter RD

    更新日期:1993-10-01 00:00:00

  • Rearrangement of human cell homologous chromosome domains in response to ionizing radiation.

    abstract::Chromosomes are located within the interphase nucleus in regions called domains. Using fluorescence in situ hybridization with whole chromosome paints, a pain of homologous chromosomes can be visualized as two discrete domains and their relative spatial location determined. This study examines the effects of an ionizi...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097143293

    authors: Dolling JA,Boreham DR,Brown DL,Raaphorst GP,Mitchel RE

    更新日期:1997-09-01 00:00:00

  • Enhancement of SR 2508 (etanidazole) radiosensitization by buthionine sulphoximine at low-dose-rate irradiation.

    abstract::SR 2508 (etanidazole) (1 mM) or buthionine sulphoximine (BSO, 50 microM) or both drugs together did not radiosensitize oxic V79 Chinese hamster cells irradiated at either an acute dose rate (2.35 Gy/min) or at a low dose rate (0.117 Gy/min). BSO pretreatment (15 h at 37 degrees C) depleted cellular glutathione (GSH) t...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114550121

    authors: Wong RS,Basas RA,Ling CC

    更新日期:1991-01-01 00:00:00

  • Marrow stromal cell recovery after radiation-induced aplasia in mice.

    abstract:PURPOSE:The identification of fibroblast-like cells of the marrow stroma by means of alkaline phosphatase (ALP) cytochemistry reveals delicate ALP-positive structures interspersed among haematopoietic cells and arranged in a loosely meshed network. These cells are often referred to as 'reticular' cells and the network ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/0955300031000085740

    authors: Almohamad K,Thiry A,Hubin F,Belaid Z,Humblet C,Boniver J,Defresne MP

    更新日期:2003-04-01 00:00:00

  • Lung cancer response following inhaled radon in the A/J and C57BL/6J mouse.

    abstract::A/J and C57BL/6J mice, strains which differ in susceptibility to chemical-induced lung tumours, were examined for differential sensitivity to radon-induced lung cancer. Sixty weeks after exposure to 952 WLM radon (3.34 J h1 m-3), no lung tumours were found in the control, sham- (one dust-) exposed, or radon-exposed C5...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097144184

    authors: Groch KM,Khan MA,Brooks AL,Saffer JD

    更新日期:1997-03-01 00:00:00

  • Adaptive response in mouse embryos?

    abstract::Pre-implantation embryos of the mouse were studied for the occurrence of an adaptive response, i.e. induction of radio-resistance by a previous low dose. Various experimental designs were checked (initial doses between 3 and 10 cGy; second dose 2-6 Gy at 6-24 h after the first dose). Some of the experiments were carri...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551981

    authors: Müller WU,Streffer C,Niedereichholz F

    更新日期:1992-08-01 00:00:00

  • Influence of low doses of gamma-irradiation on mouse skin collagen fibrils.

    abstract::The structure of mouse skin collagen fibrils after treatment with 0.5, 1 and 2.5 Gy gamma-irradiation was studied by electron microscopy. Animals were sacrificed 1, 4 and 8 weeks after irradiation. Although there were areas where the normal parallel packing of fibrils was retained in some regions packing was interrupt...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097144481

    authors: Tzaphlidou M,Kounadi E,Leontiou I,Matthopoulos DP,Glaros D

    更新日期:1997-01-01 00:00:00

  • Stable chromosomal aberrations in haemopoietic stem cells in the blood of radiation accident victims.

    abstract:PURPOSE:The detection of long-term persistent chromosome aberrations in circulating haemopoietic stem cells after accidental radiation exposure. MATERIAL AND METHODS:Peripheral blood samples from highly exposed persons were collected 7-25 years after the radiation accidents in Moscow (1971), Kazan (1975) and Chernobyl...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530099139395

    authors: Kreja L,Greulich KM,Fliedner TM,Heinze B

    更新日期:1999-10-01 00:00:00

  • Analgetic effects of non-thermal GSM-1900 radiofrequency electromagnetic fields in the land snail Helix pomatia.

    abstract:PURPOSE:To investigate whether mobile phone radiation might affect snail nociception, employing radiofrequency (RF) electromagnetic fields (EMF) which, to our knowledge, have hitherto not been studied in a snail model. Exposure to extremely low frequency (ELF) magnetic fields has however been shown to significantly aff...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2012.644257

    authors: Nittby H,Moghadam MK,Sun W,Malmgren L,Eberhardt J,Persson BR,Salford LG

    更新日期:2012-03-01 00:00:00

  • The molecular biology of radiation-induced carcinogenesis: thymic lymphoma, myeloid leukaemia and osteosarcoma.

    abstract::In mice, external X- or gamma-irradiation may induce thymic lymphomas or myeloid leukaemias, while bone-seeking alpha-emitters may induce osteosarcomas and, to a lesser extent, acute myeloid leukaemia. The present paper aims to review briefly some of the experimental data with respect to the molecular mechanisms under...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553009014550851

    authors: Janowski M,Cox R,Strauss PG

    更新日期:1990-04-01 00:00:00

  • Short-term magnetic field exposures (60 Hz) induce protection against ultraviolet radiation damage.

    abstract:PURPOSE:To investigate the ability of electromagnetic (EM) field pre-exposures to induce protection in chick embryos against subsequent ultraviolet (UV) light exposure. MATERIALS AND METHOD:Chick embryos in the 4th day of gestation were exposed for 20 minutes (short term) or 96 hours (long term) to 60 Hz, 8 microT mag...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530099139142

    authors: Dicarlo AL,Hargis MT,Penafiel LM,Litovitz TA

    更新日期:1999-12-01 00:00:00

  • Inhibition of UV-induced G1 arrest by exposure to 50 Hz magnetic fields in repair-proficient and -deficient yeast strains.

    abstract:PURPOSE:To assess the possibility that extremely low frequency (ELF) magnetic fields obstruct the damage repair process, the gene conversion frequency and cell cycle kinetics in a DNA repair-proficient and nucleotide excision repair (NER)-deficient strain of diploid yeast Saccharomyces cerevisiae. MATERIALS AND METHOD...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000310001621437

    authors: Takashima Y,Ikehata M,Miyakoshi J,Koana T

    更新日期:2003-11-01 00:00:00

  • Fat cells in red bone marrow of human rib: their size and spatial distribution with respect to the radon-derived dose to the haemopoietic tissue.

    abstract::Samples of human rib were collected at autopsy and 20 were selected for marrow fat cell measurement, representing an age range of 16-96 years. The mean diameter of fat cells in red bone marrow of human rib was found to increase from around 48 microns at ages 16-29 years to around 65 microns at ages 82-96 years. There ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009514551681

    authors: Allen JE,Henshaw DL,Keitch PA,Fews AP,Eatough JP

    更新日期:1995-12-01 00:00:00

  • Putative determinants of the cellular response to hyperthermia.

    abstract::Recently, it has been demonstrated that two different thermal resistant states found in Chinese hamster cells, one transient, associated with thermotolerance, and the other permanent, associated with the increased expression of the cognate member of the hsp 70 family, are characterized by faster recovery from heat-ind...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009314450751

    authors: Laszlo A,Davidson T,Hu A,Landry J,Bedford J

    更新日期:1993-05-01 00:00:00

  • The linear nonthreshold (LNT) model as used in radiation protection: an NCRP update.

    abstract:PURPOSE:The linear nonthreshold (LNT) model has been used in radiation protection for over 40 years and has been hotly debated. It relies heavily on human epidemiology, with support from radiobiology. The scientific underpinnings include NCRP Report No. 136 ('Evaluation of the Linear-Nonthreshold Dose-Response Model fo...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2017.1328750

    authors: Boice JD Jr

    更新日期:2017-10-01 00:00:00

  • Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli.

    abstract:PURPOSE:5-Formyluracil (5-foU) is a major derivative of thymine produced in DNA by ionizing radiation and various chemical oxidants. It has been previously shown that 5-foU in template DNA directs misincorporation of nucleotides by DNA polymerases during in vitro DNA synthesis. The present experiments were designed to ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530001453113

    authors: Miyabe I,Zhang QM,Sugiyama H,Kino K,Yonei S

    更新日期:2001-01-01 00:00:00

  • Comparative effects of UV A and UV B on clonogenic survival and delayed cell death in skin cell lines from humans and fish.

    abstract::The effects of UV radiation on humans and animals are receiving increasing attention and much interest has recently been focused on the environmental effects of UV A and UV B. This study compares the in vitro effects of UV A and UV B on the clonogenic survival of two human skin keratinocyte cell lines, HaCaT which are...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097143590

    authors: O'Reilly JP,Mothersill C

    更新日期:1997-07-01 00:00:00

  • Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model.

    abstract:PURPOSE:The aim was to evaluate the utility of multiple blood-protein biomarkers for early-response assessment of radiation exposure using a murine radiation model system. MATERIAL AND METHODS:BALB/c male mice (8-10 weeks old) were exposed to whole-body 60Co gamma-rays (10 cGy min(-1)) over a broad dose range (0-7 Gy)...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:

    authors: Ossetrova NI,Blakely WF

    更新日期:2009-01-01 00:00:00

  • Cell survival characteristics of a human colon adenocarcinoma cell line after photodynamic treatment: a comparison of Photofrin II and TPPS.

    abstract::A comparison has been made of the in vitro light-activated drug cytotoxicities of two different porphyrin compounds, Photofrin II and TPPS4. An early passage human colon adenocarcinoma cell line, WiDr, has been exposed to either drug for 24 h, the excess drug washed from the cells and the cells irradiated with light u...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008814552061

    authors: West CM,Moore JV

    更新日期:1988-10-01 00:00:00

  • An interspecies comparison of the phagocytosis and dissolution of 241AmO2 particles by rat, dog and monkey alveolar macrophages in vitro.

    abstract::Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551861

    authors: Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

    更新日期:1992-07-01 00:00:00

  • The effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles.

    abstract:PURPOSE:The purpose of this study was to determine whether the effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles. MATERIALS AND METHODS:The whole bodies of C57BL/10JHir mice in the 1st telogen phase were irradiated with (60)Co γ-rays. Mice were examined for the effects o...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2015.1101647

    authors: Sugaya K,Ishihara Y,Inoue S,Hirobe T

    更新日期:2015-01-01 00:00:00

  • Relative toxicity of (45)Ca beta-particles and (242)Cm alpha-particles following their intravenous injection into mice as radiolabelled FAP.

    abstract:PURPOSE:To determine the relative toxicity of alpha- and beta-radiations under conditions of controlled temporal and spatial dose distribution. METHODS:Fused aluminosilicate particles were radiolabelled with either (45)Ca (a beta-emitter) or (242)Cm (an alpha-emitter). These were injected into CBA/Ca mice to give life...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553000903564075

    authors: Priest ND,Hoel DG,Brooks PN

    更新日期:2010-04-01 00:00:00

  • Effect of 5-hydroxytryptamine (serotonin) receptor inhibitors on the radiation-induced bystander effect.

    abstract:PURPOSE:To test the importance of serotonin as a signaling molecule involved in the production and response of radiation-induced bystander effects. MATERIALS AND METHODS:HPV-G human keratinocyte cultures were spiked with various concentrations of Granisetron or Ketanserin and subject to either 0 Gy or 0.5 Gy X-irradia...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2012.714519

    authors: Fazzari J,Mersov A,Smith R,Seymour C,Mothersill C

    更新日期:2012-10-01 00:00:00

  • An in vitro 125IUdR-release assay for measuring the kinetics of cell death.

    abstract::A radionuclide release assay for measuring the in vitro kinetics of cell death has been developed. CHO cells were labelled for 24 h with 3.0 hBq/ml of [125I] iododeoxyuridine (125IUdR) and the fate of the labelled cells and their progeny was monitored at daily intervals by measuring the rate of 125I release. Prelabell...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114550361

    authors: Schneiderman MH,Hofer KG,Schneiderman GS

    更新日期:1991-02-01 00:00:00

  • DNA double-strand break repair defects in syndromes associated with acute radiation response: at least two different assays to predict intrinsic radiosensitivity?

    abstract:PURPOSE:Human diseases associated with acute radiation responses are rare genetic disorders with common clinical and biological features including radiosensitivity, genomic instability, chromosomal aberrations, and frequently immunodeficiency. To determine what molecular assays are predictive of cellular radiosensitivi...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000701797039

    authors: Joubert A,Zimmerman KM,Bencokova Z,Gastaldo J,Chavaudra N,Favaudon V,Arlett CF,Foray N

    更新日期:2008-02-01 00:00:00

  • Inhibitory effects of Rhenium-188-labeled Herceptin on prostate cancer cell growth: a possible radioimmunotherapy to prostate carcinoma.

    abstract:PURPOSE:Herceptin is widely used in treating Her2-overexpressing breast cancer. However, the application of Herceptin in prostate cancer is still controversial. Our previous results have indicated the relevance of Her2 in the transition of the androgen requirement in prostate cancer cells. In this study, the effects of...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2013.762136

    authors: Wang HY,Lin WY,Chen MC,Lin T,Chao CH,Hsu FN,Lin E,Huang CY,Luo TY,Lin H

    更新日期:2013-05-01 00:00:00

  • Molecular mechanisms of radiation oncogenesis.

    abstract::Resolving the molecular mechanisms of radiation oncogenesis represents an important but daunting challenge in radiation research. This brief review outlines the principal oncogenic mechanisms that need to be considered in the context of radiation effects on the genome, how these might relate to specific gene and chrom...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553009414550081

    authors: Cox R

    更新日期:1994-01-01 00:00:00

  • Evaluation of the cytogenotoxic damage in immature and mature rats exposed to 900 MHz radiofrequency electromagnetic fields.

    abstract:PURPOSE:One of the most important issues regarding radiofrequency electromagnetic fields (RF-EMF) is their effect on genetic material. Therefore, we investigated the cytogenotoxic effects of 900 MHz radiofrequency electromagnetic fields (RF-EMF) and the effect of a recovery period after exposure to RF-EMF on bone marro...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2013.809170

    authors: Atlı Şekeroğlu Z,Akar A,Şekeroğlu V

    更新日期:2013-11-01 00:00:00