Recovery kinetics of X-ray damage in mouse skin: the influence of dose per fraction.

Abstract:

:The rate of recovery from radiation damage, as a function of dose per fraction, was investigated in mouse skin. Two different experimental designs were used, both incorporating the neutron top-up technique which enables the X-ray dose per fraction to be kept constant whilst changing the interfraction interval. Either equally spaced X-ray fractions (concertina design) or single or multiple pairs of X-ray doses (single and multiple split-dose designs) were given at varying intervals, followed by graded doses of neutrons. A wide range of X-ray doses per fraction were investigated (from 1 to 10.5 Gy) and the data were analysed using the Thames Incomplete Repair (IR) model modified for use with neutron top-up doses. Analyses of the data, obtained from five different experiments, indicate that the rate of recovery from radiation damage is significantly faster at doses per fraction between 1 and 4.4 Gy than at 10.5 Gy. These data appear not to support the assumption, made by most recovery models, that the rate of recovery is independent of dose.

journal_name

Int J Radiat Biol

authors

Rojas A,Joiner MC,Johns H

doi

10.1080/09553009114550461

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

517-36

issue

2

eissn

0955-3002

issn

1362-3095

pii

9TJUVRXYJDD0R4K3

journal_volume

59

pub_type

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