Radiation protection guidelines for the skin.

Abstract:

:The past recommendations of the ICRP about dose limits to the skin are reviewed. Recently, an ICRP Task Group has been revisiting the old arguments and setting them against new data. With the exception of the function of cells in the skin associated with immunocompetence, non-stochastic effects have been well characterized and threshold doses are known with a precision appropriate for setting radiation protection standards. The current dose limitations of 0.5 Sv per year and a working lifetime dose limit of 20 Sv should protect the worker population against deterministic effects. When the ICRP made its recommendations in 1977 for dose limits there was no appreciation of the importance of the interaction of ultraviolet radiation (UVR) and X-rays. Both clinical and experimental data show that the risk of ionizing-radiation-induced cancer is significantly increased by subsequent exposures to UVR. Therefore, risks for sun-exposed areas of skin differ from those that are shielded. The risk estimate for skin cancer is very dependent on the selection of the projection model and on the mortality rate assumed. Based on the relative risk model a mortality rate of 0.2 per cent and summing risks for both UVR exposed and shielded skin the risk is about twice (1.94 x 10(-4) Sv-1) that which ICRP derived in 1977. With the absolute model the risk is considerably less, about 0.5 x 10(-4) Sv-1. There is still insufficient understanding of the effects of multiple or protracted exposures on the risk of skin cancer induction. Experimental results suggest that exposures, at least to relatively high total doses, that are protracted over a long period are more carcinogenic than a small number of exposures over a short period.

journal_name

Int J Radiat Biol

authors

Fry RJ

doi

10.1080/09553009014550961

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

829-39

issue

4

eissn

0955-3002

issn

1362-3095

pii

UT7X9R4DFT8DXE7L

journal_volume

57

pub_type

杂志文章,评审
  • Low dose radiation-induced endothelial cell retraction.

    abstract::We characterized in vitro the effects of gamma-radiation (12.5-100 cGy) on pulmonary microvascular endothelial cell (PMEC) morphology and F-actin organization. Cellular retraction was documented by phase-contrast microscopy and the organization of actin microfilaments was determined by immunofluorescence. Characteriza...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009314551471

    authors: Kantak SS,Diglio CA,Onoda JM

    更新日期:1993-09-01 00:00:00

  • Radiation-induced instability and its relation to radiation carcinogenesis.

    abstract:PURPOSE:A model that identifies radiation-induced genetic instability as the earliest cellular event in the multi-step sequence leading to radiation-induced cancer was previously proposed. In this paper ongoing experiments are discussed which are designed to test this model and its predictions in mouse mammary epitheli...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/095530098141023

    authors: Ullrich RL,Ponnaiya B

    更新日期:1998-12-01 00:00:00

  • Radiation-induced bystander phenomenon: insight and implications in radiotherapy.

    abstract::Despite the extensive utilization of radiotherapy in cancer treatments, clinicians often face challenges in achieving desired outcomes. This is because of the existence of secondary radiation effects like bystander phenomenon that influence radiation nontargeted cells and tissues. The concept of bystander effects of r...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2019.1547440

    authors: Mukherjee S,Chakraborty A

    更新日期:2019-03-01 00:00:00

  • Radioprotection of C3H mice by recombinant human interleukin-1 alpha.

    abstract::High doses of rHIL-1 protected C3H/HeN mice against lethal radiation damage. The optimum time of radioprotection was found when this cytokine was administered at 4 h and at 20 h before irradiation. The dose reduction factors when the IL-1 was administered at those times were about 1.30. The radioprotection at the opti...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008914551621

    authors: Wu SG,Tuboi A,Miyamoto T

    更新日期:1989-10-01 00:00:00

  • Heat effects on the repair of DNA double-strand breaks in CHO cells.

    abstract::The effect of heat (43-45 degrees C) on the induction and the repair of DNA double-strand breaks (dsb) was studied in CHO cells after 60 Gy of X-rays using constant-field gel electrophoresis. Heat given prior to irradiation was found not to alter the number of dsb when measured immediately after irradiation. In non-he...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097143392

    authors: Dahm-Daphi J,Brammer I,Dikomey E

    更新日期:1997-08-01 00:00:00

  • Aneuploidy studies in human cells exposed in vitro to GSM-900 MHz radiofrequency radiation using FISH.

    abstract:PURPOSE:Since previous research found an increase in the rate of aneuploidies in human lymphocytes exposed to radiofrequencies, it seems important to perform further studies. The objective of this study was then to investigate whether the exposure to RF (radiofrequency) radiation similar to that emitted by mobile phone...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2011.542543

    authors: Bourthoumieu S,Terro F,Leveque P,Collin A,Joubert V,Yardin C

    更新日期:2011-04-01 00:00:00

  • Milestones in normal tissue radiation biology over the past 50 years: from clonogenic cell survival to cytokine networks and back to stem cell recovery.

    abstract:PURPOSE:To illustrate the progress in normal tissue radiation biology over the last five decades and its impact on radiotherapy. MATERIALS AND METHODS:Major milestones over the last 50 years and their consequences for radiation oncology are described: The identification of clonogenic cell survival and the (target) ste...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553000902985136

    authors: Stewart FA,Dörr W

    更新日期:2009-07-01 00:00:00

  • Placental transfer of ruthenium in rat and guinea-pig.

    abstract::Ruthenium-106 in citrate solution was administered intravenously to rat at different stages of pregnancy and to guinea-pig either before conception or in late pregnancy. The results for rat showed that retention in the embryo/foetus measured at 3-5 days after administration increased from about 0.0002% of injected act...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:

    authors: Levack VM,Pottinger H,Harrison JD

    更新日期:1994-12-01 00:00:00

  • Short-term magnetic field exposures (60 Hz) induce protection against ultraviolet radiation damage.

    abstract:PURPOSE:To investigate the ability of electromagnetic (EM) field pre-exposures to induce protection in chick embryos against subsequent ultraviolet (UV) light exposure. MATERIALS AND METHOD:Chick embryos in the 4th day of gestation were exposed for 20 minutes (short term) or 96 hours (long term) to 60 Hz, 8 microT mag...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530099139142

    authors: Dicarlo AL,Hargis MT,Penafiel LM,Litovitz TA

    更新日期:1999-12-01 00:00:00

  • Gamma and pulse radiolysis investigation of the reaction of desferrioxamine with superoxide anions.

    abstract::The kinetic scheme of the reaction of desferrioxamine (DFO) with O2-. was studied using pulse and gamma-radiolysis. The rate constant k(O2-. + DFO) is equal to 1.3 +/- 0.1 x 10(6) dm3 mol-1s-1 at pH 7.4. Studying the competition between DFO and ferricytochrome-c for O2-. generated by gamma-radiolysis, we observed that...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008914552381

    authors: Sabourault D,Ribiere C,Nordmann R,Houee-Levin C,Ferradini C

    更新日期:1989-12-01 00:00:00

  • Stable chromosomal aberrations in haemopoietic stem cells in the blood of radiation accident victims.

    abstract:PURPOSE:The detection of long-term persistent chromosome aberrations in circulating haemopoietic stem cells after accidental radiation exposure. MATERIAL AND METHODS:Peripheral blood samples from highly exposed persons were collected 7-25 years after the radiation accidents in Moscow (1971), Kazan (1975) and Chernobyl...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530099139395

    authors: Kreja L,Greulich KM,Fliedner TM,Heinze B

    更新日期:1999-10-01 00:00:00

  • Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation.

    abstract:PURPOSE:Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. METHODS:The biological mechanisms associated with age-related cataracts (primarily nuclear cataracts, cortical cataracts and PSCs) were reviewed ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2020.1812759

    authors: Richardson RB,Ainsbury EA,Prescott CR,Lovicu FJ

    更新日期:2020-11-01 00:00:00

  • Chronic effects of single and fractionated γ-irradiation on an impairment of Th1-related immune response.

    abstract:PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2011.542540

    authors: Park HR,Jo SK,Eom HS

    更新日期:2011-05-01 00:00:00

  • Simulation of the relative damaging effects of Auger cascades with gel scintillators.

    abstract:PURPOSE:The aim of this work is to study the relative damaging effects of DNA-incorporated radionuclides by analyzing the behavior of the liquid-scintillation counting efficiency in volumes of nanometer size. METHODS:A liquid scintillation counter can detect changes in the micelle size when different percentages of an...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000802460156

    authors: Grau Carles A

    更新日期:2008-12-01 00:00:00

  • Non-proportional involvement of Chinese hamster chromosomes 3, 4, 8 and 9 in X-ray-induced chromosomal aberrations.

    abstract:PURPOSE:To study by fluorescence in situ hybridization (FISH) the involvement of Chinese hamster chromosomes 3, 4, 8, and 9, and their separate chromosome arms in X-ray-induced aberrations. MATERIALS AND METHODS:Male embryonic primary cells of Chinese hamster were used and metaphases were collected and scored at 20 h ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530099139700

    authors: Xiao Y,Natarajan AT

    更新日期:1999-08-01 00:00:00

  • Minisatellite and Hprt mutations in V79 cells irradiated with helium ions and gamma rays.

    abstract:PURPOSE:To evaluate and compare cytotoxic and mutational effects of graded doses of gamma-rays and 4He++ ions at different LET values (nominally 80 and 123 keV/microm) in V79 cells. MATERIALS AND METHODS:4He++ ion beams at 80 and 123 keV/microm were supplied by the 7 MV Van de Graaff CN accelerator of the INFN-LNL in ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000210146572

    authors: Cherubinit R,Canova S,Favaretto S,Bruna V,Battivelli P,Celotti L

    更新日期:2002-09-01 00:00:00

  • Monte Carlo-based dose reconstruction in a rat model for scattered ionizing radiation investigations.

    abstract:PURPOSE:In radiation biology, rats are often irradiated, but the precise dose distributions are often lacking, particularly in areas that receive scatter radiation. We used a non-dedicated set of resources to calculate detailed dose distributions, including doses to peripheral organs well outside of the primary field, ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2013.791407

    authors: Kirkby C,Ghasroddashti E,Kovalchuk A,Kolb B,Kovalchuk O

    更新日期:2013-09-01 00:00:00

  • Effects of 36.6 GHz and static magnetic field on degree of endoreduplication in Drosophila melanogaster polytene chromosomes.

    abstract::Purpose To study the effect of microwave (MW) irradiation and consistent action of microwaves and static magnetic field (MF) on the giant chromosomes endoreduplication in Drosophila melanogaster Meig. Materials and methods Experiments were carried out on inbred wild type Canton-S strain. Exposure to microwaves (freque...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2016.1137105

    authors: Dyka LD,Shakina LA,Strashnyuk VY,Shckorbatov YG

    更新日期:2016-01-01 00:00:00

  • Involvement of c-Jun NH2-terminal kinase-1 in heat-induced apoptotic cell death of human monoblastic leukaemia U937 cells.

    abstract:PURPOSE:To determine the involvement of c-Jun NH(2)-terminal kinase-1 (JNK1) and possibly of HSP27 in heat-induced apoptosis of human monoblastic leukaemia U937 cells. MATERIALS AND METHODS:Dominant negative JNK1 (APF), in which the phosphorylation sites Thr-Pro-Tyr were changed to Ala-Pro-Phe, was overexpressed in U9...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000110062512

    authors: Enomoto A,Suzuki N,Liu C,Kang Y,Zhu J,Serizawa S,Matsumoto Y,Morita A,Ito M,Hosoi Y

    更新日期:2001-08-01 00:00:00

  • Genome damage in testicular seminoma patients seven years after radiotherapy.

    abstract:PURPOSE:Testicular seminoma cancer incidence has significantly increased over the last few decades, and although it is successfully treated by radiotherapy, long-term health risks are still unclear. The aim of the study was to show long-term genome damage in patients with seminoma after radiotherapy. MATERIALS AND MET...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2013.825057

    authors: Fucic A,Gamulin M,Katic J,Milic M,Druzhinin V,Grgić M

    更新日期:2013-11-01 00:00:00

  • A 1.8-GHz radiofrequency radiation induces EGF receptor clustering and phosphorylation in cultured human amniotic (FL) cells.

    abstract:PURPOSE:Many studies have shown that exposure to radiofrequency radiation (RFR) could activate cellular signal transduction pathways. In the present research, we investigated the effects of exposure to a 1.8-GHz RFR at different intensities on epidermal growth factor (EGF) receptor clustering and phosphorylation in hum...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2011.634882

    authors: Sun W,Shen X,Lu D,Fu Y,Lu D,Chiang H

    更新日期:2012-03-01 00:00:00

  • Nuclear structure and the microdistribution of radiation damage in DNA.

    abstract::Evidence for the roles of proteins and metal ions in the microheterogeneity of DNA damage is reviewed. Decondensation of chromatin in hypotonic buffers markedly sensitizes the DNA to radiation, while treatment of nuclei with hypertonic buffers strips the DNA of histones and other nuclear proteins and enhances the radi...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553009414551561

    authors: Oleinick NL,Balasubramaniam U,Xue L,Chiu S

    更新日期:1994-11-01 00:00:00

  • An in vitro 125IUdR-release assay for measuring the kinetics of cell death.

    abstract::A radionuclide release assay for measuring the in vitro kinetics of cell death has been developed. CHO cells were labelled for 24 h with 3.0 hBq/ml of [125I] iododeoxyuridine (125IUdR) and the fate of the labelled cells and their progeny was monitored at daily intervals by measuring the rate of 125I release. Prelabell...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114550361

    authors: Schneiderman MH,Hofer KG,Schneiderman GS

    更新日期:1991-02-01 00:00:00

  • Comparison of DNA damage and repair following radiation challenge in buccal cells and lymphocytes using single-cell gel electrophoresis.

    abstract:PURPOSE:To develop a reproducible single-cell gel electrophoresis assay for DNA damage and repair in buccal mucosa and sublingual exfoliated cells. MATERIALS AND METHODS:Buccal mucosa and sublingual cells and lymphocytes from six individuals (three males, three females, aged 34-45 years) were challenged with increasin...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000410001723866

    authors: Dhillon VS,Thomas P,Fenech M

    更新日期:2004-07-01 00:00:00

  • Increase in DNA single-strand break rejoining by continuous exposure of human mononuclear blood cells to radioiodine ((131)I) in vitro.

    abstract::Radioiodine ((131)I) induced a dose- and time-dependent increase in DNA single-strand breaks (DNA-ssb) in human (G0) mononuclear blood cells (MNC) in vitro. Incubation of MNC with 22MBq (131)I/ml at 4 degrees C caused a linear, time-dependent induction of DNA-ssb (increase in elution rate: 24.7 x 10(-3) h(-1) per 100 ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097143103

    authors: Hengstler JG,Bockisch A,Fuchs J,Grimm W,Zapf AO,Lade K,Meinert R,Oesch-Bartlomowicz B,Tanner B,Oesch F

    更新日期:1997-11-01 00:00:00

  • Effects on micronuclei formation of 60-Hz electromagnetic field exposure with ionizing radiation, hydrogen peroxide, or c-Myc overexpression.

    abstract:PURPOSE:Epidemiological studies have demonstrated a possible correlation between exposure to extremely low-frequency magnetic fields (ELF-MF) and cancer. However, this correlation has yet to be definitively confirmed by epidemiological studies. The principal objective of this study was to assess the effects of 60 Hz ma...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2012.652724

    authors: Jin YB,Kang GY,Lee JS,Choi JI,Lee JW,Hong SC,Myung SH,Lee YS

    更新日期:2012-04-01 00:00:00

  • Radiation metabolomics in the quest of cardiotoxicity biomarkers: the review.

    abstract::Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2020.1704299

    authors: Gramatyka M,Sokół M

    更新日期:2020-03-01 00:00:00

  • Pain-relieving effects of pulsed magnetic fields in a rat model of carrageenan-induced hindpaw inflammation.

    abstract:PURPOSE:Many strategies have been investigated to exclude the several side-effects of pharmacological or invasive treatments. Non-invasive pulsed magnetic field (PMF) treatment with no toxicity or side-effects can be an alternative to pharmacologic treatments. The purpose of this study was, therefore, to investigate th...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2013.835501

    authors: Mert T,Ocal I,Cinar E,Yalcin MS,Gunay I

    更新日期:2014-01-01 00:00:00

  • Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous solutions.

    abstract:PURPOSE:The main aim of the present study is to gain mechanistic insights into the modulating effect of molecular hydrogen on the γ-radiation-induced alteration pathways of DNA nucleobases. MATERIALS AND METHODS:Aerated aqueous solutions of calf thymus DNA were exposed to a (60)Co source at doses ranging from 0 to 55 ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2016.1206234

    authors: Abou-Hamdan M,Gardette B,Cadet J,Gharib B,De Reggi M,Douki T,Triantaphylides C

    更新日期:2016-09-01 00:00:00

  • Monte Carlo/numerical treatment of alpha-particle spectra from sources buried in bone and resultant doses to surface cells.

    abstract:PURPOSE:To calculate the depth distribution of radioactive decays in bone by fitting a calculated alpha-particle energy spectrum to a measured spectrum. The dose to bone surface cells is then calculated from the depth distribution. MATERIALS AND METHODS:The spectra are calculated using Monte Carlo methods and a numeri...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530098142734

    authors: Charlton DE,Salmon PL,Utteridge TD

    更新日期:1998-01-01 00:00:00