Radiation-induced bystander phenomenon: insight and implications in radiotherapy.

Abstract:

:Despite the extensive utilization of radiotherapy in cancer treatments, clinicians often face challenges in achieving desired outcomes. This is because of the existence of secondary radiation effects like bystander phenomenon that influence radiation nontargeted cells and tissues. The concept of bystander effects of radiation was first proposed in the latter half of the last century which led to a paradigm shift in classical dogma of radiation biology. This review primarily focuses on the diverse mechanisms of bystander signal production and response under the influence of different sources of radiation like α-, β-, γ rays as well as protons and ions. The dependency of bystander effects on cell type and linear energies are also reviewed. Furthermore, the reciprocal effects exerted by bystander cells on radiation-targeted cells have been discussed. Radiation-induced signaling in targeted cells stimulates the release of different mediators that induce a plethora of molecular effects on adjacent unirradiated cells, leading to cell death or proliferation. These responses are regulated by the cell type and linear energies of radiation. Different radiation sources have diverse damaging impacts on bystander cells wherein the complex interplay of signaling molecules, inflammation, apoptosis, necrosis, and autophagy determine the fate of the cells. Further, the feedback mechanism of bystander cells controls the severity of effects in radiation-targeted cells. From the existing literature, it is difficult to speculate how far the fundamental mechanisms of induction of bystander effects by irradiated cancer cells differ from that of normal cells, although cell-specific responses are observed in bystander cells. To have an accurate idea about the actual scenario, consideration of all possible variations of experimental conditions is necessary. This is crucial for optimal utilization of radiotherapy protocols to serve twofold purposes, increase radiotherapy efficiency while causing minimal health risks.

journal_name

Int J Radiat Biol

authors

Mukherjee S,Chakraborty A

doi

10.1080/09553002.2019.1547440

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

243-263

issue

3

eissn

0955-3002

issn

1362-3095

journal_volume

95

pub_type

杂志文章,评审
  • Radiation-induced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification.

    abstract::Cell death induced by various radiation doses in Molt-4 and L5178Y cells was studied. Molt-4 cells have a low threshold for induction of interphase death while L5178Y cells have a high threshold. Interphase death in Molt-4 cells at doses > 100 Gy and in L5178Y cells at doses > 300 Gy showed typical necrosis. In contra...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009314551101

    authors: Akagi Y,Ito K,Sawada S

    更新日期:1993-07-01 00:00:00

  • DNA radiolysis in DNA-protein complexes: a stochastic simulation of attack by hydroxyl radicals.

    abstract:PURPOSE:To propose an improved version of RADACK, a stochastic simulation of radiolytic attack on DNA, that takes into account the reactivity of each amino acid of a specifically bound protein with hydroxyl radicals. To apply it to the natural lactose operator-repressor complex taking advantage of recently reported str...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/0955300031000137788

    authors: Begusova M,Giliberto S,Gras J,Sy D,Charlier M,Spotheim-Maurizot M

    更新日期:2003-06-01 00:00:00

  • Repair of DNA strand breaks at hyperthermic temperatures in Chinese hamster ovary cells.

    abstract::The repair of DNA double-strand breaks was measured by pH 7.2 filter elution in cells incubated at 25-45 degrees C either before or after X-irradiation. Exposure to 45 degrees C for 15 minutes immediately prior to X-irradiation significantly increased both the half-time for DNA double-strand break closure and the numb...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214550601

    authors: Warters RL,Axtell J

    更新日期:1992-01-01 00:00:00

  • Genetic changes in progeny of bystander human fibroblasts after microbeam irradiation with X-rays, protons or carbon ions: the relevance to cancer risk.

    abstract:PURPOSE:Radiation-induced bystander effects have important implications in radiotherapy. Their persistence in normal cells may contribute to risk of health hazards, including cancer. This study investigates the role of radiation quality and gap junction intercellular communication (GJIC) in the propagation of harmful e...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2014.950715

    authors: Autsavapromporn N,Plante I,Liu C,Konishi T,Usami N,Funayama T,Azzam EI,Murakami T,Suzuki M

    更新日期:2015-01-01 00:00:00

  • A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part III. Countermeasures under early stages of development along with 'standard of care' medicinal and procedures not requiring regulatory approv

    abstract:PURPOSE:Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted populations, are an ever-growing worldwide concern in government and public sectors as they become more frequent, violent, and sensational. If given the chance, it is lik...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2017.1332440

    authors: Singh VK,Hanlon BK,Santiago PT,Seed TM

    更新日期:2017-09-01 00:00:00

  • Increased radiation tolerance of mouse tongue epithelium after local conditioning.

    abstract::The effect of local stimulation on mitotic activity and radiation tolerance was studied in mouse tongue mucosa. Silver nitrate solution (0.5-20%) was used for local conditioning. The most effective protocol comprised three daily treatments (days 0-2), yielding a delayed increase in 24 h mitotic counts by about 30% on ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551061

    authors: Dörr W,Kummermehr J

    更新日期:1992-03-01 00:00:00

  • Sonolysis of ubiquinone in aqueous solutions. An EPR spin-trapping study.

    abstract::Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530096146246

    authors: Kondo T,Riesz P

    更新日期:1996-01-01 00:00:00

  • Possible role of vitamin E, coenzyme Q10 and rutin in protection against cerebral ischemia/reperfusion injury in irradiated rats.

    abstract:PURPOSE:To investigate the possible role of vitamin E, coenzyme Q10 and rutin in ameliorating the biochemical changes in brain and serum induced by cerebral ischemia/reperfusion (I/R) in whole body γ-irradiated rats. MATERIALS AND METHODS:Cerebral ischemia was induced in male Wistar rats (either irradiated or non-irra...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2010.501844

    authors: Abd-El-Fattah AA,El-Sawalhi MM,Rashed ER,El-Ghazaly MA

    更新日期:2010-12-01 00:00:00

  • Critical role of RecA and RecF proteins in strand break rejoining and maintenance of fidelity of rejoining following gamma-radiation-induced damage to pMTa4 DNA in E. coli.

    abstract:PURPOSE:This study was undertaken to understand the roles of RecA and RecF proteins in strand break rejoining and maintenance of fidelity of the process following exposure of E. coli to gamma-radiation in vivo. MATERIALS AND METHODS:A plasmid DNA construct, pMTa4, was transformed into isogenic repair proficient (wild)...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000601121140

    authors: Sharan RN,Ryo H,Nomura T

    更新日期:2007-02-01 00:00:00

  • Investigation of new cytogenetic biomarkers specific to high-LET radiation using in vivo and in vitro exposed human lymphocytes.

    abstract:PURPOSE:To find detectable cytogenetic biomarkers that can offer information about the radiation quality of in vivo exposure retrospectively. MATERIALS AND METHODS:Chromosome-type aberrations of peripheral lymphocytes of uterine cancer patients that received internal gamma- and external X-ray therapy or carbon beam th...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000600863064

    authors: Kanda R,Minamihisamatsu M,Tsuji S,Ohmachi Y,Hiraoka T,Shimada Y,Ogiu T,Ohno T,Hayata I

    更新日期:2006-07-01 00:00:00

  • Cell-cycle sensitivity, recovery from radiation damage and a new paradigm for risk assessment.

    abstract::Tikvah Alper's interest in science was broad, from scrapie to mammalian cells and cancer. Much of her own work focused on cell lethality, like that of many other radiobiologists, but this was natural because of the simplicity of the endpoint cell survival and its relevance to cancer therapy. Tikvah had broader interes...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097143662

    authors: Elkind MM

    更新日期:1997-06-01 00:00:00

  • Level of Flt3-ligand in plasma: a possible new bio-indicator for radiation-induced aplasia.

    abstract:PURPOSE:To follow plasma Flt3-ligand (FL) concentrations in irradiated animals in order to evaluate it as an indicator of bone marrow damage for the management of accidental radiation-induced aplasia. MATERIALS AND METHODS:Non-human primates were irradiated at doses ranging from 2 to 8 Gy, using whole- or partial-body...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000110043711

    authors: Bertho JM,Demarquay C,Frick J,Joubert C,Arenales S,Jacquet N,Sorokine-Durm I,Chau Q,Lopez M,Aigueperse J,Gorin NC,Gourmelon P

    更新日期:2001-06-01 00:00:00

  • Critical energies for ssb and dsb induction in plasmid DNA by vacuum-UV photons: an arrangement for irradiating dry or hydrated DNA with monochromatic photons.

    abstract:PURPOSE:Theoretical modelling techniques are often used to simulate the action of ionizing radiations on cells at the nanometre level. Using monoenergetic vacuum-UV (VUV) radiation to irradiate DNA either dry or humidified, the action spectra for the induction of DNA damage by low energy photons and the role of water a...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000050028913

    authors: Folkard M,Prise KM,Vojnovic B,Brocklehurst B,Michael BD

    更新日期:2000-06-01 00:00:00

  • Celecoxib and Afatinib synergistic enhance radiotherapy sensitivity on human non-small cell lung cancer A549 cells.

    abstract:PURPOSE:Radioresistance is highly correlated with radiotherapy failure in clinical cancer treatment. In the current study, we sought to examine the efficacy of Celecoxib and Afatinib co-treatment as radiosensitizers in the management of non-small cell lung cancer (NSCLC) A549 cells. MATERIALS AND METHODS:Generally, A5...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2021.1846817

    authors: Zhang P,Song E,Jiang M,Song Y

    更新日期:2020-11-12 00:00:00

  • Neutrons do not produce a bystander effect in zebrafish irradiated in vivo.

    abstract:PURPOSE:Neutron irradiations at the McMaster Tandetron Accelerator were performed to study direct and bystander effects of neutrons in a live organism. METHODS:The neutrons were produced through (7)Li(p,n)(7)Be reaction. Although the gamma contamination of the neutron beam cannot be completely eliminated, it was desig...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2011.584939

    authors: Wang C,Smith RW,Duhig J,Prestwich WV,Byun SH,McNeill FE,Seymour CB,Mothersill CE

    更新日期:2011-09-01 00:00:00

  • Chromosome painting of radiation-induced micronuclei.

    abstract::In this report, in situ hybridization with whole chromosome painting probes was used to paint radiation-induced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530096144860

    authors: Slavotinek A,Sauer-Nehls S,Braselmann H,Taylor GM,Nüsse M

    更新日期:1996-10-01 00:00:00

  • DNA double-strand break repair determines the RBE of alpha-particles.

    abstract::Radiation-induced DNA double-strand breaks (dsb) were studied in Ehrlich ascites tumour cells (EATC) by sedimentation in neutral sucrose gradients at low centrifuge speed. Dsb induction was found to be linear with dose with a frequency of: ndsbmr-1D-1 = (11.7 +/- 2) x 10(-12)Gy-1 for 140 kV X-rays and ndsbmr-1D-1 = (1...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008814552201

    authors: Blöcher D

    更新日期:1988-11-01 00:00:00

  • Responses of the bacterial community to chronic gamma radiation in a rice paddy ecosystem.

    abstract:PURPOSE:Public concern about radiation protection of the environment and non-human species is increasing. The potential impact of chronic gamma radiation on the bacterial community in a rice paddy ecosystem was investigated. MATERIALS AND METHODS:Paddy field microcosm samples were continuously exposed at a dose rate o...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2010.549534

    authors: Ishii N,Fuma S,Tagami K,Honma-Takeda S,Shikano S

    更新日期:2011-07-01 00:00:00

  • Ultrastructural morphometric analysis of peripheral nerves after intraoperative irradiation.

    abstract::Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009514550941

    authors: Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

    更新日期:1995-07-01 00:00:00

  • Possible role of inner-shell ionization phenomena in cell inactivation by heavy ions.

    abstract::The existence of a correlation between experimental probabilities of cell inactivation by charged particles and calculated probabilities for K-vacancy production in heavy atoms (C, N, O, P) of the DNA of cell nuclei is established. Both phenomena display a similar dependence upon the linear energy transfer (LET) of in...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009414550601

    authors: Chetioui A,Despiney I,Guiraud L,Adoui L,Sabatier L,Dutrillaux B

    更新日期:1994-05-01 00:00:00

  • Polyamines in the small intestine of rats after whole-body irradiation.

    abstract::The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels re...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008914551191

    authors: Becciolini A,Porciani S,Lanini A,Attanasio M

    更新日期:1989-07-01 00:00:00

  • The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review.

    abstract::The mechanisms of radiation damage production are used to examine the following premises: (1) the number of DNA double-strand breaks per unit dose increases with dose; (2) cell type to cell type variations in yield of DNA dsb per dose occur. Two stages of damage production are identified as possible sources of damage ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553009014551251

    authors: Ward JF

    更新日期:1990-06-01 00:00:00

  • Chronic exposure to bryostatin-1 increases the radiosensitivity of U937 leukaemia cells ectopically expressing Bcl-2 through a non-apoptotic mechanism.

    abstract:PURPOSE:Ionizing radiation (IR) produced a dose-dependent increase in apoptosis in U937/pCEP4 cells which was attenuated by the stable over expression of Bcl-2 (U937/Bcl-2). A dose of 2 Gy IR was selected for further analyses to determine if subsequent exposure to 10nM bryostatin- would overcome the resistance to IR-in...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000050151592

    authors: Cartee L,Davis C,Lin PS,Grant S

    更新日期:2000-10-01 00:00:00

  • Does incomplete repair explain the apparent failure of the basic LQ model to predict spinal cord and kidney responses to low doses per fraction?

    abstract::Recent evidence indicates that isoeffect doses for spinal cord and kidney may be overestimated for fraction sizes as small as 1 or 2 Gy when calculated from a linear-quadratic (LQ) model fitted to data obtained for fraction sizes larger than 2 Gy. Reasons for this are unknown, but possible interpretations include exha...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008814551461

    authors: Thames HD,Ang KK,Stewart FA,van der Schueren E

    更新日期:1988-07-01 00:00:00

  • Experimental and theoretical analysis of cytokine release for the study of radiation-induced bystander effect.

    abstract:PURPOSE:To clarify the experimental conditions that might influence the release of cytokines in the culture medium and give some basic input for building a model for cytokine (e.g., Interleukin-6, IL-6) regulation in the case of 'sham irradiation' and after ionising radiation exposure. MATERIALS AND METHODS:The influe...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000903020016

    authors: Facoetti A,Mariotti L,Ballarini F,Bertolotti A,Nano R,Pasi F,Ranza E,Ottolenghi A

    更新日期:2009-08-01 00:00:00

  • The intrinsic alpha/beta ratio for human tumour cells: is it a constant?

    abstract::The radiation response of 15 mammalian cell lines comprising 11 human tumour, two human fibroblast and two murine lymphoma cell lines, has been analysed using the linear-quadratic equation. As well as using conventional analysis of acute dose-survival curves to derive values for alpha and beta (termed alpha ac and bet...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551241

    authors: Peacock JH,Eady JJ,Edwards SM,McMillan TJ,Steel GG

    更新日期:1992-04-01 00:00:00

  • Correlation between cell reproductive death and chromosome aberrations assessed by FISH for low and high doses of radiation and sensitization by iodo-deoxyuridine in human SW-1573 cells.

    abstract:PURPOSE:To study the relationship between cell reproductive death and exchange frequency in SW-1573 human lung tumour cells with and without incorporated iodo-deoxyuridine (IdUrd) following irradiation of plateau-phase cultures with y-rays. METHOD:Linear-quadratic (LQ) analysis was performed for the data on clonogenic...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530099140474

    authors: Franken NA,Ruurs P,Ludwików G,van Bree C,Kipp JB,Darroudi F,Barendsen GW

    更新日期:1999-03-01 00:00:00

  • Enhanced transplantability of a cell line from a murine ovary granulosa cell tumour in syngeneic B6C3F(1) mice continuously irradiated with low dose-rate gamma-rays.

    abstract:PURPOSE:To understand the mechanisms of life-shortening due to early neoplastic death caused by chronic low dose-rate (LDR; 20 mGy/22 h/day) radiation which accumulates to a high dose (HD; 8 Gy) (LDR/HD) as reported previously. MATERIALS AND METHODS:Female B6C3F(1) mice were continuously exposed to LDR/HD gamma-rays u...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2010.545861

    authors: Takai D,Todate A,Yanai T,Ichinohe K,Oghiso Y

    更新日期:2011-07-01 00:00:00

  • Biphasic survival curves for XRS radiosensitive cells: subpopulations or transient expression of repair competence?

    abstract::Four of the most radiosensitive xrs variants of CHO-K1 cells, obtained after mutagenizing treatment with EMS, have been studied in detail over three to five decades of cell survival. Although these lines were initially reported to have very steep exponential survival curves, and to vary in sensitivity between themselv...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008914550651

    authors: Denekamp J,Whitmore GF,Jeggo P

    更新日期:1989-04-01 00:00:00

  • Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions.

    abstract:PURPOSE:Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrimental effects of radiation, in part due to the compromised repair of c...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2014.899449

    authors: Cunniffe S,Walker A,Stabler R,O'Neill P,Lomax ME

    更新日期:2014-06-01 00:00:00