Radioprotection of C3H mice by recombinant human interleukin-1 alpha.

Abstract:

:High doses of rHIL-1 protected C3H/HeN mice against lethal radiation damage. The optimum time of radioprotection was found when this cytokine was administered at 4 h and at 20 h before irradiation. The dose reduction factors when the IL-1 was administered at those times were about 1.30. The radioprotection at the optimum times was also observed in the cell kinetic behaviour of GM-CFC in the bone marrow. In previous studies it was reported that less radioprotection was found in C3H/HeN mice pretreated with IL-1. This may not be the case with a higher dose of IL-1.

journal_name

Int J Radiat Biol

authors

Wu SG,Tuboi A,Miyamoto T

doi

10.1080/09553008914551621

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

485-92

issue

4

eissn

0955-3002

issn

1362-3095

pii

JCRA2EF2K8Q7LWUY

journal_volume

56

pub_type

杂志文章
  • The roles of TGF-β3 and peroxynitrite in removal of hyper-radiosensitivity by priming irradiation.

    abstract:PURPOSE:To investigate the mechanisms inducing and maintaining the permanent elimination of low dose hyper-radiosensitivity (HRS) in cells given a dose of 0.3 Gy at low dose-rate (LDR) (0.3 Gy/h). MATERIALS AND METHODS:Two human HRS-positive cell lines (T-47D, T98G) were used. The effects of pretreatments with transfo...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2014.906767

    authors: Edin NJ,Sandvik JA,Cheng C,Bergersen L,Pettersen EO

    更新日期:2014-07-01 00:00:00

  • Endothelial cell proliferation in the rat heart following local heart irradiation.

    abstract::Radiation-induced myocardial degeneration in the rat is preceded by changes in capillary structure and function, which may be a major factor in the pathogenesis of radiation-induced heart disease. In order to investigate the mechanism of capillary damage we studied endothelial cell proliferation in untreated control r...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009014551131

    authors: Lauk S,Trott KR

    更新日期:1990-05-01 00:00:00

  • Incorporation and distribution of tritium in rats after chronic exposure to various tritiated compounds.

    abstract::Rats were chronically exposed to tritiated water (3HHO) and several tritiated organic compounds [( 3H]leucine, [3H]lysine, [3H]glucose, [3H]glucosamine, [3H]thymidine and [3H]uridine) dissolved in their drinking water. An analysis of tritium in wet and dry tissues of rats at the end of 22 days' chronic exposure showed...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114550731

    authors: Takeda H

    更新日期:1991-03-01 00:00:00

  • Biphasic survival curves for XRS radiosensitive cells: subpopulations or transient expression of repair competence?

    abstract::Four of the most radiosensitive xrs variants of CHO-K1 cells, obtained after mutagenizing treatment with EMS, have been studied in detail over three to five decades of cell survival. Although these lines were initially reported to have very steep exponential survival curves, and to vary in sensitivity between themselv...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008914550651

    authors: Denekamp J,Whitmore GF,Jeggo P

    更新日期:1989-04-01 00:00:00

  • The different doses of radiation therapy-induced damage to the ovarian environment in rats.

    abstract:PURPOSE:The sequelae of premature loss of ovarian function can undoubtedly have undesirable effects for a woman although radiotherapy is one of the most relevant treatment modalities for various types of malignancies. The aim of this study was to determine the effect of different doses of radiation on ovarian folliculo...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2021.1864497

    authors: Onder GO,Balcioglu E,Baran M,Ceyhan A,Cengiz O,Suna PA,Yıldız OG,Yay A

    更新日期:2021-01-06 00:00:00

  • Adaptive response in mouse embryos?

    abstract::Pre-implantation embryos of the mouse were studied for the occurrence of an adaptive response, i.e. induction of radio-resistance by a previous low dose. Various experimental designs were checked (initial doses between 3 and 10 cGy; second dose 2-6 Gy at 6-24 h after the first dose). Some of the experiments were carri...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551981

    authors: Müller WU,Streffer C,Niedereichholz F

    更新日期:1992-08-01 00:00:00

  • Relative toxicity of (45)Ca beta-particles and (242)Cm alpha-particles following their intravenous injection into mice as radiolabelled FAP.

    abstract:PURPOSE:To determine the relative toxicity of alpha- and beta-radiations under conditions of controlled temporal and spatial dose distribution. METHODS:Fused aluminosilicate particles were radiolabelled with either (45)Ca (a beta-emitter) or (242)Cm (an alpha-emitter). These were injected into CBA/Ca mice to give life...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553000903564075

    authors: Priest ND,Hoel DG,Brooks PN

    更新日期:2010-04-01 00:00:00

  • Repair of radiation-induced chromatid aberrations: relationship to G2 arrest in CHO cells.

    abstract::The literature suggests that the function of radiation-induced G2 arrest is to allow repair of potentially lethal damage before cell-entry into, and damage expression in, mitosis. The nature of the damage repaired is not known, but chromosome aberrations have been considered. To examine this possibility in G2 cells, t...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009014551831

    authors: Rowley R

    更新日期:1990-09-01 00:00:00

  • Radiation metabolomics in the quest of cardiotoxicity biomarkers: the review.

    abstract::Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2020.1704299

    authors: Gramatyka M,Sokół M

    更新日期:2020-03-01 00:00:00

  • Sourcing and using stem cell lines for radiation research: Potential, challenges and good stem cell culture practice.

    abstract:PURPOSE:Exposition of best practice in management and experimental use of human stem cell lines in radiobiological research. This paper outlines the key challenges to be addressed by radiobiologists wishing to use human pluripotent stem cell (hPSC) lines in their research including human embryonic stem cell (hESC) line...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2012.714518

    authors: Stacey G

    更新日期:2012-10-01 00:00:00

  • A 1.8-GHz radiofrequency radiation induces EGF receptor clustering and phosphorylation in cultured human amniotic (FL) cells.

    abstract:PURPOSE:Many studies have shown that exposure to radiofrequency radiation (RFR) could activate cellular signal transduction pathways. In the present research, we investigated the effects of exposure to a 1.8-GHz RFR at different intensities on epidermal growth factor (EGF) receptor clustering and phosphorylation in hum...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2011.634882

    authors: Sun W,Shen X,Lu D,Fu Y,Lu D,Chiang H

    更新日期:2012-03-01 00:00:00

  • Relationship between radiation response and p53 status in human bladder cancer cells.

    abstract::Mutations in the p53 tumour suppressor gene are found at high frequency in bladder cancer. There is strong evidence that p53 plays an important role in controlling the cell cycle after DNA damage by ionizing radiation. However, the effect of loss of p53 function on radiosensitivity is not yet clear. Radiotherapy combi...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530097143491

    authors: Ribeiro JC,Barnetson AR,Fisher RJ,Mameghan H,Russell PJ

    更新日期:1997-07-01 00:00:00

  • Biochemical effects of heat shock and caffeine on post-irradiation oxic and anoxic damage in barley seeds of low and high water content.

    abstract::Wet heat shock (60 degrees C, 90 s) and caffeine (3.8 X 10(-4) M) afford significant radioprotection against post-irradiation O2-dependent damage which develops in seeds of approximately 3.5% moisture content. The damage was assessed in terms of seedling injury on the eighth day of growth. An increase in seedling inju...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114551101

    authors: Singh SP,Kesavan PC

    更新日期:1991-05-01 00:00:00

  • Polyamines in the small intestine of rats after whole-body irradiation.

    abstract::The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels re...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008914551191

    authors: Becciolini A,Porciani S,Lanini A,Attanasio M

    更新日期:1989-07-01 00:00:00

  • Natural radionuclides in fish species from surface water of Bagjata and Banduhurang uranium mining areas, East Singhbhum, Jharkhand, India.

    abstract:PURPOSE:To study the natural radionuclides in the freshwater fish samples around the uranium mining areas of Bagjata and Banduhurang, East Singhbhum, Jharkhand, India. MATERIALS AND METHODS:The naturally occurring radioisotopes of uranium, U(nat), consisting of (234)U, (235)U and (238)U; (226)Ra, (230)Th and (210)Po w...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2010.492490

    authors: Giri S,Singh G,Jha VN,Tripathi RM

    更新日期:2010-11-01 00:00:00

  • Quantitative and qualitative effect of gamma-ray dose-rate on mutagenesis in human lymphoblastoid cells.

    abstract::Induction of mutations to 6-thioguanine resistance (TGr) by gamma-rays at three different dose-rates and molecular changes in the HPRT gene were studied in human lymphoblastoid WIL2-NS cells. Mutant induction showed a curvilinear dose-response for acute irradiation (30 Gy/h). The total mutant frequency was lower after...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530096145201

    authors: Furuno-Fukushi I,Tatsumi K,Takahagi M,Tachibana A

    更新日期:1996-08-01 00:00:00

  • Microdistribution of 237Np in the skeleton of female rats.

    abstract::237Np nitrate was injected intravenously into 4-week-old (young) and 10-12-week-old (adult) female albino Sprague-Dawley rats. The amounts given were 52 (young), 5.2 (adult) and 26 kBq kg-1 body weight (adult). The microscopic distribution in the femur and the lumbar vertebrae was studied. Initially, neptunium was dis...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009314550511

    authors: Sontag W

    更新日期:1993-03-01 00:00:00

  • Calculation of the biological effects of ion beams based on the microscopic spatial damage distribution pattern.

    abstract:PURPOSE:To present details of the recent version of the 'Local Effect Model' (LEM), that has been developed and implemented in treatment planning for the ion beam therapy pilot project performed at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. MATERIALS AND METHODS:The new version of the model i...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2011.611213

    authors: Friedrich T,Scholz U,Elsässer T,Durante M,Scholz M

    更新日期:2012-01-01 00:00:00

  • Lethal mutations attributable to misrepair of Q-lesions.

    abstract::Lethal mutations are induced in mammalian cells mainly, perhaps wholly, within the dose range encompassing the 'shoulder,' and may well be attributable to error-prone Q-repair. ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553008814551961

    authors: Alper T,Mothersill C,Seymour CB

    更新日期:1988-10-01 00:00:00

  • Modification of murine adult haemopoiesis and response to methyl nitrosourea following exposure to radiation at different developmental stages.

    abstract:PURPOSE:To investigate the hypothesis that the developmental phase at which an individual encounters radiation damage affects its long-term sensitivity to a subsequent tumourigenic insult. MATERIALS AND METHODS:Either the pregnant C57B16 mouse was exposed to 137Cs gamma-rays at 4 or 15 days post-conception (embryonic ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530000139032

    authors: Hoyes KP,Hendry JH,Lord BI

    更新日期:2000-01-01 00:00:00

  • Alterations in transcriptome and proteome on metallothioneins following oxidative stress induced by sublethal doses of cadmium and gamma rays in Plantago ovata.

    abstract:PURPOSE:To study the oxidative stress-induced changes by sublethal doses of cadmium chloride (CdCl2) and gamma irradiation, two redox-inducing agents, on metallothionein (MT) gene and protein expression in Plantago ovata Forsk (P. ovata). MATERIALS AND METHODS:Chlorophyll content was estimated to study the stress resp...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.3109/09553002.2013.782109

    authors: Ghoshal N,Talapatra S,Moulick A,Chakraborty A,Raychaudhuri SS

    更新日期:2013-07-01 00:00:00

  • Low-dose hyper-radiosensitivity of progressive and regressive cells isolated from a rat colon tumour: impact of DNA repair.

    abstract:PURPOSE:To ask whether highly metastatic sublines show more marked low-dose hyper-radiosensitivity (HRS) response than poorly metastatic ones. MATERIALS AND METHODS:The progressive (PRO) subline showing tumourigenicity and metastatic potential and the regressive (REG) subline showing neither tumourigenicity nor metast...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000802195331

    authors: Thomas C,Charrier J,Massart C,Cherel M,Fertil B,Barbet J,Foray N

    更新日期:2008-07-01 00:00:00

  • The long-term effects of γ-radiation on the growth of Allium cepa plants.

    abstract:PURPOSE:The purpose of this study was to assess the long-term effects of gamma-radiation, including low-dose radiation, on growth parameters of onion (Allium cepa) seedling roots 6-10 days after irradiation. MATERIALS AND METHODS:Onion seedlings were exposed to a 137Cs gamma source at doses ranging from 0.1 to 10 gray...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2021.1844337

    authors: Bolsunovsky A,Trofimova E,Dementyev D,Petrichenkov M

    更新日期:2020-11-16 00:00:00

  • Raman spectroscopy of tissue samples irradiated by protons.

    abstract:PURPOSE:Since the number of cancer patients treated by proton irradiation has increased in the last few years, it seems appropriate to study dose-dependent effects of proton irradiation on mammalian tissues in more detail. MATERIALS AND METHODS:Tissue samples of normal skin of mouse and swine, of a human tumour model ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000412331283515

    authors: Synytsya A,Alexa P,Besserer J,De Boer J,Froschauer S,Gerlach R,Loewe M,Moosburger M,Obstová I,Quicken P,Sosna B,Volka K,Würkner M

    更新日期:2004-08-01 00:00:00

  • Repetitive 50 Hz pulsed electromagnetic field ameliorates the diabetes-induced impairments in the relaxation response of rat thoracic aorta rings.

    abstract:PURPOSE:To evaluate the characteristic features of mechanical responses and the membrane potential changes induced by repetitive pulsed electromagnetic field (PEMF, 50 Hz, 5 mT) in thoracic aorta rings obtained from streptozotocin-induced diabetic and healthy control rats to determine if PEMF could ameliorate problems ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553000903009522

    authors: Kavak S,Emre M,Meral I,Unlugenc H,Pelit A,Demirkazik A

    更新日期:2009-08-01 00:00:00

  • Repair of potentially lethal damage by introduction of T4 DNA ligase in eucaryotic cells.

    abstract::The bacterial enzyme PvuII, which generates blunt-ended DNA double-strand breaks, and T4 DNA ligase, which seals adjacent DNA fragments in coupling to ATP cleavage, were introduced in mouse C3H10T1/2 fibroblasts using osmolytic shock of pinocytic vesicles. Cells were then assayed for their clonogenic ability. In agree...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009114550851

    authors: Durante M,Grossi GF,Napolitano M,Gialanella G

    更新日期:1991-04-01 00:00:00

  • Environmental and industrial developments in radiation cataractogenesis.

    abstract::Purpose: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protecti...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553002.2020.1767820

    authors: Laskowski L,Williams D,Seymour C,Mothersill C

    更新日期:2020-05-26 00:00:00

  • Education and training to support radiation protection research in Europe: the DoReMi experience.

    abstract::A review is presented to the program of education and training setup within the DoReMi Network of Excellence. DoReMi was funded by Euratom under the EU 7th Framework Programme to coordinate the EU research into risks from low-dose ionizing radiation. It was seen to be necessary to form a network of expert institutions...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审

    doi:10.1080/09553002.2018.1454616

    authors: Ottolenghi A,Trott KR,Smyth V

    更新日期:2019-01-01 00:00:00

  • Survival of synchronized human NHIK 3025 cells irradiated aerobically following a prolonged treatment with extremely hypoxic conditions.

    abstract:PURPOSE:To investigate whether radiation survival of cells irradiated aerobically in the oxygen-sensitive restriction point in late G1 is dependent on where in the cell cycle the cells first were rendered hypoxic. MATERIALS AND METHODS:Human cervix carcinoma, NHIK 3025 cells, were synchronized and rendered hypoxic whi...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/095530098141366

    authors: Koritzinsky M,Furre T,Amellem O,Pettersen EO

    更新日期:1998-10-01 00:00:00

  • Hypoxia-specific inhibition of recovery from radiation damage by a novel 2-nitroimidazole with a theophylline side chain.

    abstract::A novel 2-nitroimidazole with a theophylline side-chain, 7-(4'-(2-nitroimidazol-1-yl)-butyl)-theophylline, (NITP) was as efficient a hypoxic-cell radiosensitizer as misonidazole. However, if cells were irradiated with NITP under hypoxic conditions and then exposed to the drug under aerobic conditions, a much larger ra...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章

    doi:10.1080/09553009214551671

    authors: Hodgkiss RJ,Kelleher E,Parrick J

    更新日期:1992-06-01 00:00:00