Monte Carlo/numerical treatment of alpha-particle spectra from sources buried in bone and resultant doses to surface cells.

abstract：:The relative contributions of the OH-mediated and direct radiation effect on the induction of DNA double-strand breaks (dsbs) were evaluated in two haploid yeast cell lines (GSH+ and gsh-) irradiated under oxic or hypoxic conditions in the absence or presence of 6 M glycerol as an OH radical scavenger. Gsh- cells are ...

journal_title：International journal of radiation biology

authors： Frankenberg D,Frankenberg-Schwager M,Harbich R

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:Human diseases associated with acute radiation responses are rare genetic disorders with common clinical and biological features including radiosensitivity, genomic instability, chromosomal aberrations, and frequently immunodeficiency. To determine what molecular assays are predictive of cellular radiosensitivi...

journal_title：International journal of radiation biology

authors： Joubert A,Zimmerman KM,Bencokova Z,Gastaldo J,Chavaudra N,Favaudon V,Arlett CF,Foray N

更新日期：2008-02-01 00:00:00

abstract：:The relationship between cellular radiosensitivity and normal-tissue response to radiotherapy in individual cancer patients has attracted increasing attention over the last few years. Recent work has suggested that a correlation exists between fibroblast sensitivity and normal-tissue reactions. We have examined the ra...

journal_title：International journal of radiation biology

authors： Burnet NG,Wurm R,Peacock JH

更新日期：1996-09-01 00:00:00

abstract：:The induction of chromosome aberrations by X-rays was investigated in synchronized quiescent and proliferating CHO-K1 cells. Kinetics of chromosome lesion repair was studied using the method of fractionated irradiation. In both cell types the time-course of repair during fractionation intervals followed first-order ki...

journal_title：International journal of radiation biology

authors： Volkmer B,Virsik-Peuckert RP

更新日期：1990-12-01 00:00:00

abstract：:The mechanisms of radiation damage production are used to examine the following premises: (1) the number of DNA double-strand breaks per unit dose increases with dose; (2) cell type to cell type variations in yield of DNA dsb per dose occur. Two stages of damage production are identified as possible sources of damage ...

journal_title：International journal of radiation biology

authors： Ward JF

更新日期：1990-06-01 00:00:00

abstract：:The effect of local stimulation on mitotic activity and radiation tolerance was studied in mouse tongue mucosa. Silver nitrate solution (0.5-20%) was used for local conditioning. The most effective protocol comprised three daily treatments (days 0-2), yielding a delayed increase in 24 h mitotic counts by about 30% on ...

journal_title：International journal of radiation biology

authors： Dörr W,Kummermehr J

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:To ask whether highly metastatic sublines show more marked low-dose hyper-radiosensitivity (HRS) response than poorly metastatic ones. MATERIALS AND METHODS:The progressive (PRO) subline showing tumourigenicity and metastatic potential and the regressive (REG) subline showing neither tumourigenicity nor metast...

journal_title：International journal of radiation biology

authors： Thomas C,Charrier J,Massart C,Cherel M,Fertil B,Barbet J,Foray N

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To test whether radiolysis-induced fragmentation in frozen aqueous protein solution is dependent on solvent access to the surface of the protein or to the molecular mass of the polypeptide chain. MATERIALS AND METHODS:60Co gamma-irradiation of three proteins at -78 degrees C: lysozyme, citrate synthase and alp...

journal_title：International journal of radiation biology

authors： Audette M,Chen X,Houée-Levin C,Potier M,Le Maire M

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:The effect of boronophenylalanine (BPA)-mediated boron neutron capture therapy (BNCT) on human oral squamous cell carcinoma (SCC) xenografts in nude mice was examined. MATERIALS AND METHODS:Tumor-bearing mice were given BPA at a dose of 250 mg/kg body weight. The tumor (10)B concentration 2 h after an injectio...

journal_title：International journal of radiation biology

authors： Kamida A,Obayashi S,Kato I,Ono K,Suzuki M,Nagata K,Sakurai Y,Yura Y

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice. MATERIAL AND METHODS:MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitoneally (i.p.) at a dose o...

journal_title：International journal of radiation biology

authors： Canseven AG,Keskil ZA,Keskil S,Seyhan N

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns. MATERIALS AND METHODS:The analysis of patterns of RIF (radiation-induced foci) produced by high-LET Fe and Ti ions were conducted by using a Monte Carlo model that combines the heavy ion trac...

journal_title：International journal of radiation biology

authors： Ponomarev AL,Huff J,Cucinotta FA

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To develop and validate non-fluorescent chromosome painting for bright-field microscopy using the peroxidase/diaminobenzidine (DAB) reaction. MATERIALS AND METHODS:Peripheral blood lymphocytes were taken from patients with uterine cancer who had received heavy-ion radiation therapy. Chromosome slides were trea...

journal_title：International journal of radiation biology

authors： Kanda R,Suzuki M,Minamihisamatsu M,Furukawa A,Odaka T,Hayata I

更新日期：1998-05-01 00:00:00

abstract：:Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney. Methods: Male and female rats were contaminated for nine months through their drinking water with a nont...

journal_title：International journal of radiation biology

authors： Grison S,Kereselidze D,Cohen D,Gloaguen C,Elie C,Lestaevel P,Legendre A,Manens L,Habchi B,Benadjaoud MA,Tarlet G,Milliat F,Martin JC,Lobaccaro JM,Souidi M

更新日期：2019-06-01 00:00:00

abstract：:The form of the hazard function for radiation-induced pneumonitis death in mice was investigated. 'Hazard' refers to the instantaneous failure rate at a specified time, conditional upon non-failure to that time. Thus, the hazard function describes the time profile for the risk of pneumonitis death among still-survivin...

journal_title：International journal of radiation biology

authors： Tucker SL,Travis EL

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:The aim of this work is to study the relative damaging effects of DNA-incorporated radionuclides by analyzing the behavior of the liquid-scintillation counting efficiency in volumes of nanometer size. METHODS:A liquid scintillation counter can detect changes in the micelle size when different percentages of an...

journal_title：International journal of radiation biology

authors： Grau Carles A

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole) porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo and on tumour cell radiosensitivity in vitro. MATERIALS AND METHODS:MPA was administered directly into the right lateral ventricle of you...

journal_title：International journal of radiation biology

authors： Pearlstein RD,Higuchi Y,Moldovan M,Johnson K,Fukuda S,Gridley DS,Crapo JD,Warner DS,Slater JM

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To examine whether the levels of micronuclei induction, as a marker for genomic instability in the progeny of X-irradiated cells, correlates with DNA repair function. MATERIALS AND METHODS:Two repair deficient cell lines (X-ray repair cross-complementing 1 [XRCC1] deficient cell line [EM9] and X-ray repair cro...

journal_title：International journal of radiation biology

authors： Kashino G,Suzuki K,Kodama S,Watanabe M,Prise KM

更新日期：2013-04-01 00:00:00

abstract：:The radiation chemistry of the oligomer d(TpApCpG) X-irradiated in aqueous solution containing glutathione was studied. Four products were isolated by HPLC and characterized by NMR spectroscopy. Two of the major products are isomers of a 5-hydroxy-5,6-dihydrothymine modification of d(TpApCpG). A dihydrothymine modific...

journal_title：International journal of radiation biology

authors： Paul CR,Budzinski EE,Maccubbin A,Wallace JC,Box HC

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:A minority of patients exhibits severe late normal tissue toxicity after radiotherapy (RT), possibly related to their inherent individual radiation sensitivity. This study aimed to evaluate four different candidate in vitro cellular radiosensitivity assays for prediction of late normal tissue reactions, in a re...

journal_title：International journal of radiation biology

authors： Vandevoorde C,Depuydt J,Veldeman L,De Neve W,Sebastià N,Wieme G,Baert A,De Langhe S,Philippé J,Thierens H,Vral A

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To investigate the p53 ionizing radiation-induced response, G1/S cell-cycle block and cytogenetic damage in Nijmegen breakage syndrome (NBS) cells characterized by different haplotypes. MATERIAL AND METHODS:Lymphoblastoid cell lines derived from three normals, five NBS and two ataxia telangiectasia (AT) indivi...

journal_title：International journal of radiation biology

authors： Antoccia A,Stumm M,Saar K,Ricordy R,Maraschio P,Tanzarella C

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To test the importance of serotonin as a signaling molecule involved in the production and response of radiation-induced bystander effects. MATERIALS AND METHODS:HPV-G human keratinocyte cultures were spiked with various concentrations of Granisetron or Ketanserin and subject to either 0 Gy or 0.5 Gy X-irradia...

journal_title：International journal of radiation biology

authors： Fazzari J,Mersov A,Smith R,Seymour C,Mothersill C

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Chironomus ramosus is one of the recently reported radiotolerant insects. Salivary gland cells of fourth instar larvae respond to ionizing radiations with increases in the levels of antioxidant enzymes and chaperone proteins. Here we made an attempt to study the state of nuclear DNA after exposure of larvae to ...

journal_title：International journal of radiation biology

authors： Datkhile KD,Gaikwad PS,Ghaskadbi SS,Mukhopadhyaya R,Nath BB

更新日期：2015-01-01 00:00:00

abstract：:The literature suggests that the function of radiation-induced G2 arrest is to allow repair of potentially lethal damage before cell-entry into, and damage expression in, mitosis. The nature of the damage repaired is not known, but chromosome aberrations have been considered. To examine this possibility in G2 cells, t...

journal_title：International journal of radiation biology

authors： Rowley R

更新日期：1990-09-01 00:00:00

abstract：:The existence of a correlation between experimental probabilities of cell inactivation by charged particles and calculated probabilities for K-vacancy production in heavy atoms (C, N, O, P) of the DNA of cell nuclei is established. Both phenomena display a similar dependence upon the linear energy transfer (LET) of in...

journal_title：International journal of radiation biology

authors： Chetioui A,Despiney I,Guiraud L,Adoui L,Sabatier L,Dutrillaux B

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:The aim of this research was to demonstrate the effects of 50 Hz sinusoidal extremely low frequency of magnetic fields (ELF-MF) on preincubated chicken embryo hearts at histopathological, biochemical, and ultrastructural levels. MATERIALS AND METHODS:Ninety healthy fertilized eggs were divided into six groups ...

journal_title：International journal of radiation biology

authors： Shams Lahijani M,Tehrani DM,Fereydouni N

更新日期：2013-04-01 00:00:00

abstract：:The accumulation and repair of radiation-induced DNA double-strand breaks (dsbs) were determined by neutral filter elution on 20 primary cultures obtained from ovarian cancer and malignant melanoma clinical specimens. The initial frequency of DNA dsbs after exposure to 50 Gy gamma-irradiation varied greatly for the in...

journal_title：International journal of radiation biology

authors： Zaffaroni N,Orlandi L,Villa R,Bearzatto A,Rofstad EK,Silvestrini R

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:It has been proposed previously that the ratio of complete to incomplete translocations as seen by fluorescence in situ hybridization (FISH), the S value, can be a cytogenetic fingerprint of exposure to radiation of different qualities. Results from a previous study suggested that the S value is approximately 1...

journal_title：International journal of radiation biology

authors： Nakano M,Kodama Y,Ohtaki K,Itoh M,Nakamura N

更新日期：1999-01-01 00:00:00

abstract：:Induction of mutations to 6-thioguanine resistance (TGr) by gamma-rays at three different dose-rates and molecular changes in the HPRT gene were studied in human lymphoblastoid WIL2-NS cells. Mutant induction showed a curvilinear dose-response for acute irradiation (30 Gy/h). The total mutant frequency was lower after...

journal_title：International journal of radiation biology

authors： Furuno-Fukushi I,Tatsumi K,Takahagi M,Tachibana A

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:Ionizing radiation has been recognized to increase the risk of cardiovascular diseases (CVD). However, there is no consensus concerning the dose-risk relationship for low radiation doses and a mechanistic understanding of low dose effects is needed. MATERIAL AND METHODS:Previously, human umbilical vein endothe...

journal_title：International journal of radiation biology

authors： Rombouts C,Aerts A,Quintens R,Baselet B,El-Saghire H,Harms-Ringdahl M,Haghdoost S,Janssen A,Michaux A,Yentrapalli R,Benotmane MA,Van Oostveldt P,Baatout S

更新日期：2014-07-01 00:00:00

abstract：:237Np nitrate was injected intravenously into 4-week-old (young) and 10-12-week-old (adult) female albino Sprague-Dawley rats. The amounts given were 52 (young), 5.2 (adult) and 26 kBq kg-1 body weight (adult). The microscopic distribution in the femur and the lumbar vertebrae was studied. Initially, neptunium was dis...

journal_title：International journal of radiation biology

authors： Sontag W

更新日期：1993-03-01 00:00:00