Applying a multiscale systems biology approach to study the effect of chronic low-dose exposure to uranium in rat kidneys.

abstract：PURPOSE:To evaluate the radioprotective activity of C3, a regioisomer of water-soluble carboxyfullerene and a potent free radical scavenger, on both normal and tumour cells. MATERIALS AND METHODS:The murine committed bone-marrow stem cells for both granulocytes and monocytes (GM-CFC) were used to represent normal cell...

journal_title：International journal of radiation biology

authors： Lin HS,Lin TS,Lai RS,D'Rosario T,Luh TY

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:To determine the relative toxicity of alpha- and beta-radiations under conditions of controlled temporal and spatial dose distribution. METHODS:Fused aluminosilicate particles were radiolabelled with either (45)Ca (a beta-emitter) or (242)Cm (an alpha-emitter). These were injected into CBA/Ca mice to give life...

journal_title：International journal of radiation biology

authors： Priest ND,Hoel DG,Brooks PN

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:The aim of this research was to demonstrate the effects of 50 Hz sinusoidal extremely low frequency of magnetic fields (ELF-MF) on preincubated chicken embryo hearts at histopathological, biochemical, and ultrastructural levels. MATERIALS AND METHODS:Ninety healthy fertilized eggs were divided into six groups ...

journal_title：International journal of radiation biology

authors： Shams Lahijani M,Tehrani DM,Fereydouni N

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns. MATERIALS AND METHODS:The analysis of patterns of RIF (radiation-induced foci) produced by high-LET Fe and Ti ions were conducted by using a Monte Carlo model that combines the heavy ion trac...

journal_title：International journal of radiation biology

authors： Ponomarev AL,Huff J,Cucinotta FA

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To investigate the induction and persistence of chromosome aberrations in mouse bone marrow cells after X-ray exposure and to detect differential involvement of individual chromosomes in translocations. MATERIALS AND METHODS:Male and female Swiss mice were exposed to 1 and 3 Gy of X-rays. Chromosome aberration...

journal_title：International journal of radiation biology

authors： Xiao Y,Darroudi F,Grigorova M,Natarajan AT

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:Effects of radiation on the differentiation of C2C12 myoblasts were studied using cell cultures in which the cells differentiated into either muscle cells or osteoblasts. MATERIALS AND METHODS:A mouse skeletal myoblast cell line, C2C12, was cultured and irradiated at confluence. Muscle differentiation was esti...

journal_title：International journal of radiation biology

authors： Ikeda S,Hachisu R,Yamaguchi A,Gao YH,Okano T

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:Solar energy has a number of short- and long-term detrimental effects on skin that can result in several skin disorders. The aim of this review is to summarise current knowledge on endogenous systems within the skin for protection from solar radiation and present research findings to date, on the exogenous opti...

journal_title：International journal of radiation biology

authors： Svobodová A,Vostálová J

更新日期：2010-12-01 00:00:00

abstract：:The recently released data on cancer incidence in the Japanese atomic bomb survivors are analysed using a variety of relative risk models which take account of errors in estimates of dose to assess the dose-response at low doses. For all solid cancers analysed together there is a significant positive dose-response (at...

journal_title：International journal of radiation biology

authors： Little MP,Muirhead CR

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:The assessment of biological effects caused by radiation exposure has been currently carried out with the linear-quadratic (LQ) model as an extension of the linear non-threshold (LNT) model. In this study, we suggest a new mathematical model named as SeaSaw (SS) model, which describes proliferation and cell dea...

journal_title：International journal of radiation biology

authors： Bando M,Tsunoyama Y,Suzuki K,Toki H

更新日期：2020-12-15 00:00:00

abstract：PURPOSE:To study by fluorescence in situ hybridization (FISH) the involvement of Chinese hamster chromosomes 3, 4, 8, and 9, and their separate chromosome arms in X-ray-induced aberrations. MATERIALS AND METHODS:Male embryonic primary cells of Chinese hamster were used and metaphases were collected and scored at 20 h ...

journal_title：International journal of radiation biology

authors： Xiao Y,Natarajan AT

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:To examine how folate status influences chromosomal damage following X-ray irradiation. MATERIAL AND METHODS:In an animal study, mice were fed either a low, basal, or high folic acid diet (0, 2, or 40 mg/kg diet, respectively) for 4 weeks, and then given total body irradiation (TBI) at 0.5 Gy. In a human study...

journal_title：International journal of radiation biology

authors： Endoh K,Murakami M,Araki R,Maruyama C,Umegaki K

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:To determine whether murine lymphoid cell lines can discriminate between high- and low-LET (linear energy transfer) radiation-induced DNA lesions. MATERIALS AND METHODS:Sensitivity to killing by DNA-incorporated 3H and 125I decays, accumulated during storage in the gas phase of a liquid nitrogen tank, was dete...

journal_title：International journal of radiation biology

authors： Radford IR

更新日期：2002-06-01 00:00:00

abstract：:Cells use substrates such as glucose and glutamine to provide energy for repair of radiation damage. Glutaminolysis and glycolysis were inhibited by aminooxyacetic acid (AOAA) and 2-deoxyglucose (2DG), respectively, to inhibit metabolism of these substrates in order to determine the effect on radiation response of CHO...

journal_title：International journal of radiation biology

authors： Hunter AJ,Blekkenhorst GH

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:The behavioral responses of planaria to the exposures of a range of concentrations of morphine (μM to attoM) or the μ-opiate antagonist naloxone or to either of these compounds and a burst-firing magnetic field (5 μT) were studied. MATERIAL AND METHODS:The locomotor velocity (LMV) of planaria was measured afte...

journal_title：International journal of radiation biology

authors： Murugan NJ,Persinger MA

更新日期：2014-10-01 00:00:00

abstract：:The radioprotective agent WR-2721 is dephosphorylated to the free thiol form WR-1065 in vivo. The effects of WR-2721, WR-1065 and reduced glutathione on a mitochondrial lipid peroxidation system were compared. WR-2721 had no effect on mitochondrial lipid peroxidation in vitro, and could not prevent the inactivation of...

journal_title：International journal of radiation biology

authors： Tretter L,Rónai E,Szabados G,Hermann R,Andó A,Horváth I

更新日期：1990-03-01 00:00:00

abstract：:Radiation-induced myocardial degeneration in the rat is preceded by changes in capillary structure and function, which may be a major factor in the pathogenesis of radiation-induced heart disease. In order to investigate the mechanism of capillary damage we studied endothelial cell proliferation in untreated control r...

journal_title：International journal of radiation biology

authors： Lauk S,Trott KR

更新日期：1990-05-01 00:00:00

abstract：:Four of the most radiosensitive xrs variants of CHO-K1 cells, obtained after mutagenizing treatment with EMS, have been studied in detail over three to five decades of cell survival. Although these lines were initially reported to have very steep exponential survival curves, and to vary in sensitivity between themselv...

journal_title：International journal of radiation biology

authors： Denekamp J,Whitmore GF,Jeggo P

更新日期：1989-04-01 00:00:00

abstract：PURPOSE:The impact of the damage distribution to cellular survival and chromosomal aberrations following high Linear Energy Transfer (LET) radiation was investigated. MATERIALS AND METHODS:High LET iron-ions (500 MeV/n, LET 200 keV/μm) were delivered to G1-phase synchronized Chinese Hamster Ovary (CHO) cells located a...

journal_title：International journal of radiation biology

authors： Fujii Y,Yurkon CR,Maeda J,Genet SC,Okayasu R,Kitamura H,Fujimori A,Kato TA

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:To investigate the mechanisms inducing and maintaining the permanent elimination of low dose hyper-radiosensitivity (HRS) in cells given a dose of 0.3 Gy at low dose-rate (LDR) (0.3 Gy/h). MATERIALS AND METHODS:Two human HRS-positive cell lines (T-47D, T98G) were used. The effects of pretreatments with transfo...

journal_title：International journal of radiation biology

authors： Edin NJ,Sandvik JA,Cheng C,Bergersen L,Pettersen EO

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:To determine whether cigarette smoke condensate (CSC) without metabolic activation induces direct DNA double strand breaks (DSB) in the G1 phase of various radiosensitive mutants of CHO cells and whether these breaks display collateral hypersensitivity to CSC with respect to cell killing. MATERIALS & METHODS:W...

journal_title：International journal of radiation biology

authors： Kato T,Nagasawa H,Warner C,Okayasu R,Bedford JS

更新日期：2007-09-01 00:00:00

abstract：:A comparison has been made of the in vitro light-activated drug cytotoxicities of two different porphyrin compounds, Photofrin II and TPPS4. An early passage human colon adenocarcinoma cell line, WiDr, has been exposed to either drug for 24 h, the excess drug washed from the cells and the cells irradiated with light u...

journal_title：International journal of radiation biology

authors： West CM,Moore JV

更新日期：1988-10-01 00:00:00

abstract：:DNA double-strand break (dsb) induction in diploid yeast was measured by neutral sucrose sedimentation after exposure to very heavy ions with values of linear energy transfer (LET) ranging from about 300 to 11500 ke V/microns. Linear fluence dependencies were found in all cases from which dsb production cross-sections...

journal_title：International journal of radiation biology

authors： Akpa TC,Weber KJ,Schneider E,Kiefer J,Frankenberg-Schwager M,Harbich R,Frankenberg D

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:To investigate the consequence of continuous low dose-rate exposure to gamma-rays on ornithine decarboxylase (ODC EC 4.1.1.17) activity in organs of rat. MATERIALS AND METHODS:Young male Wistar rats were irradiated at 1.1, 2.1 and 12.9 cGy/day in the dose ranges of 9-165, 17-315 and 100-2000 cGy, respectively,...

journal_title：International journal of radiation biology

authors： Slozhenikina LV,Fialkovskaya LA,Kolomiytseva IK

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the long-term effects of gamma-radiation, including low-dose radiation, on growth parameters of onion (Allium cepa) seedling roots 6-10 days after irradiation. MATERIALS AND METHODS:Onion seedlings were exposed to a 137Cs gamma source at doses ranging from 0.1 to 10 gray...

journal_title：International journal of radiation biology

authors： Bolsunovsky A,Trofimova E,Dementyev D,Petrichenkov M

更新日期：2020-11-16 00:00:00

abstract：:The induction of chromosome aberrations by X-rays was investigated in synchronized quiescent and proliferating CHO-K1 cells. Kinetics of chromosome lesion repair was studied using the method of fractionated irradiation. In both cell types the time-course of repair during fractionation intervals followed first-order ki...

journal_title：International journal of radiation biology

authors： Volkmer B,Virsik-Peuckert RP

更新日期：1990-12-01 00:00:00

abstract：:PACE (programmable, autonomously controlled electrodes) pulsed field gel electrophoresis technology was used to develop a DNA double-strand break assay that simultaneously combined (1) resolution across a broad range of DNA sizes, (2) high sensitivity (in terms of detecting dsb at low doses) and (3) speed. A 48 h PACE...

journal_title：International journal of radiation biology

authors： Elia MC,Nichols WW

更新日期：1993-01-01 00:00:00

abstract：:Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...

journal_title：International journal of radiation biology

authors： Gramatyka M,Sokół M

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:To investigate whether an adaptive response can be induced in mice which were pre-exposed to 900 MHz radiofrequency fields. MATERIALS AND METHODS:Adult male Kunming mice were exposed to 900 MHz radiofrequency fields (RF) at power intensities of 12, 120 and 1200 μW/cm(2) for 1 h/day for 14 days and then subject...

journal_title：International journal of radiation biology

authors： Cao Y,Xu Q,Jin ZD,Zhou Z,Nie JH,Tong J

更新日期：2011-07-01 00:00:00

abstract：:Purpose: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protecti...

journal_title：International journal of radiation biology

authors： Laskowski L,Williams D,Seymour C,Mothersill C

更新日期：2020-05-26 00:00:00

abstract：PURPOSE:Radiation-induced bystander effects have important implications in radiotherapy. Their persistence in normal cells may contribute to risk of health hazards, including cancer. This study investigates the role of radiation quality and gap junction intercellular communication (GJIC) in the propagation of harmful e...

journal_title：International journal of radiation biology

authors： Autsavapromporn N,Plante I,Liu C,Konishi T,Usami N,Funayama T,Azzam EI,Murakami T,Suzuki M

更新日期：2015-01-01 00:00:00