Non-fluorescent chromosome painting using the peroxidase/diaminobenzidine (DAB) reaction.

abstract：:Purpose To investigate the effect of increasing the overall treatment time as well as delivering the compensating doses on the Balb/c breast adenocarcinoma (4T1) tumor. Materials and methods A total of 72 mice were divided into two aliquots (classes A and B) based on the initial size of their induced tumor. Each class...

journal_title：International journal of radiation biology

authors： Nikzad S,Hashemi B,Hasan ZS,Mozdarani H,Baradaran-Ghahfarokhi M,Amini P

更新日期：2016-01-01 00:00:00

abstract：:Calibration of the non-denaturing (pH 9.6) filter elution technique by 125I decays has been used to examine the relationship between X-ray-induced DNA double-strand breaks (dsb) and cellular survival of CHO cells and human fibroblasts. DNA dsb induction varies markedly between the two cell lines, reflecting the differ...

journal_title：International journal of radiation biology

authors： Baumstark-Khan C

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:Exposition of best practice in management and experimental use of human stem cell lines in radiobiological research. This paper outlines the key challenges to be addressed by radiobiologists wishing to use human pluripotent stem cell (hPSC) lines in their research including human embryonic stem cell (hESC) line...

journal_title：International journal of radiation biology

authors： Stacey G

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To assess health, growth and reproductive success of mammals exposed for multiple generations to levels of radium-226 known to occur in environments surrounding uranium mines and mills in Canada. METHODS:The study consisted of a control group and four treatment groups each containing 40 mice (20 males and 20 f...

journal_title：International journal of radiation biology

authors： Walsh S,Satkunam M,Su B,Festarini A,Bugden M,Peery H,Mothersill C,Stuart M

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Many strategies have been investigated to exclude the several side-effects of pharmacological or invasive treatments. Non-invasive pulsed magnetic field (PMF) treatment with no toxicity or side-effects can be an alternative to pharmacologic treatments. The purpose of this study was, therefore, to investigate th...

journal_title：International journal of radiation biology

authors： Mert T,Ocal I,Cinar E,Yalcin MS,Gunay I

更新日期：2014-01-01 00:00:00

abstract：:The relationship between cellular radiosensitivity and normal-tissue response to radiotherapy in individual cancer patients has attracted increasing attention over the last few years. Recent work has suggested that a correlation exists between fibroblast sensitivity and normal-tissue reactions. We have examined the ra...

journal_title：International journal of radiation biology

authors： Burnet NG,Wurm R,Peacock JH

更新日期：1996-09-01 00:00:00

abstract：:Most estimates of the radiation dose lethal to 50 per cent of a human population are based on historical data taken from well-known experiences reflecting inadequately known physical and biological conditions, or from medical procedures where individual patients received advantages of modern clinical care. It has been...

journal_title：International journal of radiation biology

authors： Morris MD,Jones TD

更新日期：1989-03-01 00:00:00

abstract：:The role of protein kinase C in radiation-induced death of thymocytes was studied. For this purpose murine thymocytes were irradiated and incubated for 6 h at 37 degrees C and afterwards the fraction of fragmented DNA was measured. Results indicate that radiation-induced DNA fragmentation can be prevented by adding th...

journal_title：International journal of radiation biology

authors： Ojeda F,Guarda MI,Maldonado C,Folch H,Diehl H

更新日期：1992-05-01 00:00:00

abstract：:In this report, in situ hybridization with whole chromosome painting probes was used to paint radiation-induced micronuclei (MN) in three lymphoblastoid cells lines to investigate the frequency of radiation-induced MN. The results obtained for four different chromosomes showed that there was a significant deviation of...

journal_title：International journal of radiation biology

authors： Slavotinek A,Sauer-Nehls S,Braselmann H,Taylor GM,Nüsse M

更新日期：1996-10-01 00:00:00

abstract：PURPOSE:The aim is to assess the change with age and disease of the oxygen concentration within the coronary artery walls. MATERIALS AND METHODS:In an accompanying paper, Part A, the age-dependent morphology and composition for the wall layers of normal and diseased coronary arteries were developed from published data...

journal_title：International journal of radiation biology

authors： Richardson RB

更新日期：2008-10-01 00:00:00

abstract：:Induction of mutations to 6-thioguanine resistance (TGr) by gamma-rays at three different dose-rates and molecular changes in the HPRT gene were studied in human lymphoblastoid WIL2-NS cells. Mutant induction showed a curvilinear dose-response for acute irradiation (30 Gy/h). The total mutant frequency was lower after...

journal_title：International journal of radiation biology

authors： Furuno-Fukushi I,Tatsumi K,Takahagi M,Tachibana A

更新日期：1996-08-01 00:00:00

abstract：:We studied the extent of split-dose recovery in seven non-transformed human fibroblast cell lines of different intrinsic radiosensitivity (HF19, 1BR3, 149BR, 84BR, GM739, 180BR and AT2EM). Experiments were performed on both growing and plateau-phase cells. The seven cell lines displayed a wide range of intrinsic radio...

journal_title：International journal of radiation biology

authors： Alsbeih MG,Fertil B,Arlett CF,Malaise EP

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...

journal_title：International journal of radiation biology

authors： Park HR,Jo SK,Eom HS

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:The purpose of this work was to determine whether the cellular components of Hairless-rat skin are affected by a chronic local exposure to non-ionizing radiations of Global Mobile Phone System: GSM-900 or -1800 radiations at specific absorption rate (SAR) 2.5 and 5 W/kg. MATERIALS AND METHODS:A selected part o...

journal_title：International journal of radiation biology

authors： Sanchez S,Masuda H,Billaudel B,Haro E,Anane R,Lévêque P,Ruffie G,Lagroye I,Veyret B

更新日期：2006-09-01 00:00:00

abstract：:A study has been made of the intrinsic radiosensitivity of peripheral blood lymphocytes from normal individuals. Cell survival following in vitro high (1.55 Gy min-1) and low (0.0098 Gy min-1) dose-rate irradiation was obtained for single lymphocyte samples from three individuals in six experiments. Despite wide inter...

journal_title：International journal of radiation biology

authors： Elyan SA,West CM,Roberts SA,Hunter RD

更新日期：1993-10-01 00:00:00

abstract：:The recently released data on cancer incidence in the Japanese atomic bomb survivors are analysed using a variety of relative risk models which take account of errors in estimates of dose to assess the dose-response at low doses. For all solid cancers analysed together there is a significant positive dose-response (at...

journal_title：International journal of radiation biology

authors： Little MP,Muirhead CR

更新日期：1996-07-01 00:00:00

abstract：:Resolving the molecular mechanisms of radiation oncogenesis represents an important but daunting challenge in radiation research. This brief review outlines the principal oncogenic mechanisms that need to be considered in the context of radiation effects on the genome, how these might relate to specific gene and chrom...

journal_title：International journal of radiation biology

authors： Cox R

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:In radiation biology, rats are often irradiated, but the precise dose distributions are often lacking, particularly in areas that receive scatter radiation. We used a non-dedicated set of resources to calculate detailed dose distributions, including doses to peripheral organs well outside of the primary field, ...

journal_title：International journal of radiation biology

authors： Kirkby C,Ghasroddashti E,Kovalchuk A,Kolb B,Kovalchuk O

更新日期：2013-09-01 00:00:00

abstract：:The mitogen phytohemagglutinin (PHA) works well in both human and cynomolgus monkey (Macaca fascicularis) lymphocyte cultures to stimulate T cell proliferation. T cells from rhesus monkeys (Macaca mulatta) are less responsive than human cells, producing few metaphases when thousands are required, e.g. in biological do...

journal_title：International journal of radiation biology

authors： Hill FS,Cox AB,Salmon YL,Cantu AO,Lucas JN

更新日期：1994-10-01 00:00:00

abstract：:During previous studies on the relationship between thermosensitivity and intracellular pH (pHi) regulation in mammalian cells, we observed that the thermoresistant TR-4 cells appeared to be resistant to manipulations of the Na+/H+ antiport, one of the two primary membrane regulators of pHi. We hypothesized that this ...

journal_title：International journal of radiation biology

authors： Liu FF,Lee C,Li JH

更新日期：1996-10-01 00:00:00

abstract：PURPOSE:To illustrate the progress in normal tissue radiation biology over the last five decades and its impact on radiotherapy. MATERIALS AND METHODS:Major milestones over the last 50 years and their consequences for radiation oncology are described: The identification of clonogenic cell survival and the (target) ste...

journal_title：International journal of radiation biology

authors： Stewart FA,Dörr W

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To evaluate the characteristic features of mechanical responses and the membrane potential changes induced by repetitive pulsed electromagnetic field (PEMF, 50 Hz, 5 mT) in thoracic aorta rings obtained from streptozotocin-induced diabetic and healthy control rats to determine if PEMF could ameliorate problems ...

journal_title：International journal of radiation biology

authors： Kavak S,Emre M,Meral I,Unlugenc H,Pelit A,Demirkazik A

更新日期：2009-08-01 00:00:00

abstract：:This study evaluated the cell-mediated (CMI) and humoral immune responses in four Beagle dogs five to six years after single inhalation exposures to different monodisperse 239PuO2 aerosols (0.72-1.4 microns activity median aerodynamic diameter). These exposures resulted in initial lung burdens ranging from 19 to 35 kB...

journal_title：International journal of radiation biology

authors： Galvin JB,Bice DE,Guilmette RA,Muggenburg BA,Haley PJ

更新日期：1989-02-01 00:00:00

abstract：:Base damages, sugar damages, and single-strand breaks produced by free radicals are the preponderant lesions produced in DNA by ionizing radiation. These lesions have been individually introduced into substrate, template, and biologically active DNA molecules and enzymatic processing and biological consequences determ...

journal_title：International journal of radiation biology

authors： Wallace SS

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:To investigate possible variations in topoisomerase (topo) I and II activities and levels after X-ray treatment in the radiation repair proficient AA8 Chinese hamster cell line for comparison with the radiation sensitive mutant EM9. MATERIALS AND METHODS:AA8 and EM9 cells were irradiated with 5 Gy of X-rays an...

journal_title：International journal of radiation biology

authors： Pastor N,Piñero J,Ortiz T,Mateos JC,De Miguel M,Cortés F

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:High dose ionizing radiation exposure is associated with myelo-depression leading to pancytopenia and the expected clinical manifestations of acute radiation syndrome (ARS). Herein, we evaluated the efficacy of sargramostim (Leukine®, yeast-derived rhu GM-CSF), with regimens delivered at 48, 72, 96, or 120 h...

journal_title：International journal of radiation biology

authors： Zhong Y,Pouliot M,Downey AM,Mockbee C,Roychowdhury D,Wierzbicki W,Authier S

更新日期：2020-09-22 00:00:00

abstract：:The rate of recovery from radiation damage, as a function of dose per fraction, was investigated in mouse skin. Two different experimental designs were used, both incorporating the neutron top-up technique which enables the X-ray dose per fraction to be kept constant whilst changing the interfraction interval. Either ...

journal_title：International journal of radiation biology

authors： Rojas A,Joiner MC,Johns H

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:Radioresistance is highly correlated with radiotherapy failure in clinical cancer treatment. In the current study, we sought to examine the efficacy of Celecoxib and Afatinib co-treatment as radiosensitizers in the management of non-small cell lung cancer (NSCLC) A549 cells. MATERIALS AND METHODS:Generally, A5...

journal_title：International journal of radiation biology

authors： Zhang P,Song E,Jiang M,Song Y

更新日期：2020-11-12 00:00:00

abstract：:The past recommendations of the ICRP about dose limits to the skin are reviewed. Recently, an ICRP Task Group has been revisiting the old arguments and setting them against new data. With the exception of the function of cells in the skin associated with immunocompetence, non-stochastic effects have been well characte...

journal_title：International journal of radiation biology

authors： Fry RJ

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:Previous systematic structure-activity studies of the desferrithiocin (DFT) platform have allowed the design and synthesis of analogues and derivatives of DFT that retain the exceptional iron-clearing activity of the parent, while eliminating its adverse effects. We hypothesized that a similar approach could be...

journal_title：International journal of radiation biology

authors： Bergeron RJ,Wiegand J,Singh S

更新日期：2009-04-01 00:00:00