Age-dependent changes in oxygen tension, radiation dose and sensitivity within normal and diseased coronary arteries-Part B: modeling oxygen diffusion into vessel walls.


PURPOSE:The aim is to assess the change with age and disease of the oxygen concentration within the coronary artery walls. MATERIALS AND METHODS:In an accompanying paper, Part A, the age-dependent morphology and composition for the wall layers of normal and diseased coronary arteries were developed from published data. In this paper, Part B, the oxygen concentration in the coronary artery walls was evaluated taking account the diffusion of oxygen from blood and the solubility of oxygen in tissues. Part C evaluates the oxygen effect and its biological implications for different radiations. RESULTS:Diseased arteries exhibited a relatively moderate increase in the solubility of oxygen (or=38% stenosis had anoxic areas. CONCLUSION:Based on simulation results from the one-dimensional diffusion model, extensive hypoxic areas were determined for atherosclerotic arteries in this analysis of oxygen levels in coronary arteries modelling for the first time the effects of age and disease and associated changes in oxygen solubility due to the presence of lipids and calcium.


Int J Radiat Biol


Richardson RB




Has Abstract


2008-10-01 00:00:00














  • Role of cell cycle control in radiosensitization of mouse spermatogonial stem cells.

    abstract:PURPOSE:To investigate the possible role of cell cycle arrest in the radiosensitization of mouse spermatogonial stem cells due to small conditioning X-ray exposures. MATERIALS AND METHODS:A 24 h fractionation interval between conditioning (1 Gy) and challenging (8 or 9 Gy) exposures was used. Two approaches were follo...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Van Buul PP,Van Duyn-Goedhart A,Beumer T,Bootsma AL

    更新日期:2001-03-01 00:00:00

  • Critical energies for ssb and dsb induction in plasmid DNA by vacuum-UV photons: an arrangement for irradiating dry or hydrated DNA with monochromatic photons.

    abstract:PURPOSE:Theoretical modelling techniques are often used to simulate the action of ionizing radiations on cells at the nanometre level. Using monoenergetic vacuum-UV (VUV) radiation to irradiate DNA either dry or humidified, the action spectra for the induction of DNA damage by low energy photons and the role of water a...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Folkard M,Prise KM,Vojnovic B,Brocklehurst B,Michael BD

    更新日期:2000-06-01 00:00:00

  • Alpha particle-induced bystander effect is mediated by ROS via a p53-dependent SCO2 pathway in hepatoma cells.

    abstract:PURPOSE:The radiation-induced bystander effect (RIBE) has important implications for the efficiency of radiotherapy but the underlying role of cellular metabolism is widely unknown. The roles of synthesis of cytochrome c oxidase 2 (SCO2), a key effector for respiratory chain, and related signaling factors in α-particle...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Li J,He M,Shen B,Yuan D,Shao C

    更新日期:2013-12-01 00:00:00

  • Concomitant low dose-rate irradiation and cisplatin treatment in ovarian carcinoma cell lines sensitive and resistant to cisplatin treatment.

    abstract::Human ovarian carcinoma parental and cisplatin-resistant cells were evaluated for their radiation sensitivity to high and low dose-rate irradiation and for the effectiveness of cisplatin in radiosensitization. The cisplatin resistant variant A2780cp showed increased radiation resistance for both low dose-rate (LDRI) a...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Raaphorst GP,Wang G,Stewart D,Ng CE

    更新日期:1996-05-01 00:00:00

  • Expression of genes and pathways associated with the B7-CD28 superfamily in response to irradiation of blood cells using 137Cs.

    abstract:PURPOSE:DNA damage is one of the main consequences of exposure to ionizing irradiation (IR). Recent studies indicate that IR can modulate the expression of immune system-related genes. However, the effects of IR on the expression of genes and pathways of the B7-CD28 superfamily remain poorly defined. The aim of this st...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Silveira DA,Ribeiro FM,Simão ÉM,Mattos VLD,Góes EG

    更新日期:2020-12-17 00:00:00

  • V-79 Chinese hamster cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation.

    abstract:PURPOSE:Radiotherapy of cancer carries a perceived risk of inducing secondary cancer and other damage due to dose delivered to normal tissue. While expectedly small, this risk must be carefully analysed for all modalities. Especially in the use of exotic particles like pions and antiprotons, which annihilate and produc...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Kovacevic S,Bassler N,Hartley O,Knudsen H,Vranjes S,Garaj-Vrhovac V,Holzscheiter M

    更新日期:2009-12-01 00:00:00

  • Radioprotection of the rat intestinal mucosa by tirilazad.

    abstract:PURPOSE:To assess intestinal radioprotection by systemic or lumenal tirilazad mesylate and to test potential tumour radioprotection. MATERIALS AND METHODS:Segments of the mid small bowel were surgically exteriorized. Tirilazad was given either intravenously or intralumenally 30 min prior to 11 Gy of X-irradiation to t...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Felemovicius I,Bonsack ME,Griffin RJ,Delaney JP

    更新日期:1998-02-01 00:00:00

  • Mitophagy and mitochondrial morphology in human melanoma-derived cells post exposure to simulated sunlight.

    abstract:PURPOSE:To assess changes in mitochondrial morphology and mitophagy induced by simulated sunlight irradiation (SSI) and how these changes are modulated by mitochondrial activity and energy source. MATERIALS AND METHODS:Human malignant amelanotic melanoma A375 cells were pre-treated with either a mitochondrial activity...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Zanchetta LM,Garcia A,Lyng F,Walsh J,Murphy JE

    更新日期:2011-05-01 00:00:00

  • The effect of ATM kinase inhibition on the initial response of human dental pulp and periodontal ligament mesenchymal stem cells to ionizing radiation.

    abstract:PURPOSE:This study evaluates early changes in human mesenchymal stem cells (MSC) isolated from dental pulp and periodontal ligament after γ-irradiation and the effect of ataxia-telangiectasia mutated (ATM) inhibition. METHODS:MSC were irradiated with 2 and 20 Gy by (60)Co. For ATM inhibition, specific inhibitor KU5593...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Cmielova J,Havelek R,Kohlerova R,Soukup T,Bruckova L,Suchanek J,Vavrova J,Mokry J,Rezacova M

    更新日期:2013-07-01 00:00:00

  • Low dose-rate fibroblast radiosensitivity and the prediction of patient response to radiotherapy.

    abstract::The relationship between cellular radiosensitivity and normal-tissue response to radiotherapy in individual cancer patients has attracted increasing attention over the last few years. Recent work has suggested that a correlation exists between fibroblast sensitivity and normal-tissue reactions. We have examined the ra...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Burnet NG,Wurm R,Peacock JH

    更新日期:1996-09-01 00:00:00

  • An image analysis technique for detection of radiation-induced DNA fragmentation after CHEF electrophoresis.

    abstract::CHEF-electrophoresis was used as a technique to detect radiation-induced DNA breakage with special emphasis to biological relevant X-ray doses (0-10 Gy). Fluorescence detection of DNA-fragments using a sensitive image analysis system was directly compared with conventional scintillation counting of 3H-thymidine prelab...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Rosemann M,Kanon B,Konings AW,Kampinga HH

    更新日期:1993-08-01 00:00:00

  • DNA radiolysis in DNA-protein complexes: a stochastic simulation of attack by hydroxyl radicals.

    abstract:PURPOSE:To propose an improved version of RADACK, a stochastic simulation of radiolytic attack on DNA, that takes into account the reactivity of each amino acid of a specifically bound protein with hydroxyl radicals. To apply it to the natural lactose operator-repressor complex taking advantage of recently reported str...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Begusova M,Giliberto S,Gras J,Sy D,Charlier M,Spotheim-Maurizot M

    更新日期:2003-06-01 00:00:00

  • An interspecies comparison of the phagocytosis and dissolution of 241AmO2 particles by rat, dog and monkey alveolar macrophages in vitro.

    abstract::Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

    更新日期:1992-07-01 00:00:00

  • The molecular regulation of apoptosis and implications for radiation oncology.

    abstract::One of the major goals of cancer research is to identify and understand the causes of cellular proliferation. The role of cell death, or lack thereof, in carcinogenesis, tumour growth, metastatic spread and response to treatment has been largely overlooked even though the morphology of apoptosis (programmed cell death...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审


    authors: Blank KR,Rudoltz MS,Kao GD,Muschel RJ,McKenna WG

    更新日期:1997-05-01 00:00:00

  • Radiosynthesis, molecular modeling studies and biological evaluation of 99mTc-Ifosfamide complex as a novel probe for solid tumor imaging.

    abstract:PURPOSE:Ifosfamide as a chemotherapeutic drug is used for the treatment of different cancer types. The purpose of this study is the preparation of 99mTc-ifosfamide complex to be evaluated as a potential candidate for tumor imaging. MATERIALS AND METHODS:The radiolabeling of ifosfamide with technetium-99m was carried o...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Motaleb MA,El-Safoury DM,Abd-Alla WH,Awad GAS,Sakr TM

    更新日期:2018-12-01 00:00:00

  • Alterations in transcriptome and proteome on metallothioneins following oxidative stress induced by sublethal doses of cadmium and gamma rays in Plantago ovata.

    abstract:PURPOSE:To study the oxidative stress-induced changes by sublethal doses of cadmium chloride (CdCl2) and gamma irradiation, two redox-inducing agents, on metallothionein (MT) gene and protein expression in Plantago ovata Forsk (P. ovata). MATERIALS AND METHODS:Chlorophyll content was estimated to study the stress resp...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Ghoshal N,Talapatra S,Moulick A,Chakraborty A,Raychaudhuri SS

    更新日期:2013-07-01 00:00:00

  • Relative toxicity of (45)Ca beta-particles and (242)Cm alpha-particles following their intravenous injection into mice as radiolabelled FAP.

    abstract:PURPOSE:To determine the relative toxicity of alpha- and beta-radiations under conditions of controlled temporal and spatial dose distribution. METHODS:Fused aluminosilicate particles were radiolabelled with either (45)Ca (a beta-emitter) or (242)Cm (an alpha-emitter). These were injected into CBA/Ca mice to give life...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Priest ND,Hoel DG,Brooks PN

    更新日期:2010-04-01 00:00:00

  • Ultrastructural morphometric analysis of peripheral nerves after intraoperative irradiation.

    abstract::Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

    更新日期:1995-07-01 00:00:00

  • Sonolysis of ubiquinone in aqueous solutions. An EPR spin-trapping study.

    abstract::Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Kondo T,Riesz P

    更新日期:1996-01-01 00:00:00

  • Aneuploidy studies in human cells exposed in vitro to GSM-900 MHz radiofrequency radiation using FISH.

    abstract:PURPOSE:Since previous research found an increase in the rate of aneuploidies in human lymphocytes exposed to radiofrequencies, it seems important to perform further studies. The objective of this study was then to investigate whether the exposure to RF (radiofrequency) radiation similar to that emitted by mobile phone...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Bourthoumieu S,Terro F,Leveque P,Collin A,Joubert V,Yardin C

    更新日期:2011-04-01 00:00:00

  • Treatment with 3,4,3-LIHOPO of simulated wounds contaminated with plutonium and americium in rat.

    abstract::The effect of a siderophore analogue 3,4,3-LIHOPO has been investigated in rat after intramuscular injection of 238Pu, 239Pu and 241Am simulating puncture wounds. Various treatment regimens were used to remove the radioactivity from its injection site and to reduce its retention in body tissues. The local deposits cou...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Volf V,Burgada R,Raymond KN,Durbin PW

    更新日期:1996-07-01 00:00:00

  • Lambda-prophage induction in repair-deficient and wild type E. coli strains by gamma-rays and heavy ions.

    abstract::Lambda-prophage induction in repair-deficient and wild-type E. coli strains by heavy ions and gamma-rays has been investigated. The dose dependence of the fraction of induced cells has been measured and its initial slope (lambda-induction potency) determined. The induction by gamma-rays was found to be more efficient ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Bonev MN,Kozubek S,Krasavin EA,Amirtajev KG

    更新日期:1990-05-01 00:00:00

  • Putative determinants of the cellular response to hyperthermia.

    abstract::Recently, it has been demonstrated that two different thermal resistant states found in Chinese hamster cells, one transient, associated with thermotolerance, and the other permanent, associated with the increased expression of the cognate member of the hsp 70 family, are characterized by faster recovery from heat-ind...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Laszlo A,Davidson T,Hu A,Landry J,Bedford J

    更新日期:1993-05-01 00:00:00

  • Hematopoietic death of unprotected man from photon irradiations: statistical modeling from animal experiments.

    abstract::Most estimates of the radiation dose lethal to 50 per cent of a human population are based on historical data taken from well-known experiences reflecting inadequately known physical and biological conditions, or from medical procedures where individual patients received advantages of modern clinical care. It has been...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Morris MD,Jones TD

    更新日期:1989-03-01 00:00:00

  • A 1.8-GHz radiofrequency radiation induces EGF receptor clustering and phosphorylation in cultured human amniotic (FL) cells.

    abstract:PURPOSE:Many studies have shown that exposure to radiofrequency radiation (RFR) could activate cellular signal transduction pathways. In the present research, we investigated the effects of exposure to a 1.8-GHz RFR at different intensities on epidermal growth factor (EGF) receptor clustering and phosphorylation in hum...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Sun W,Shen X,Lu D,Fu Y,Lu D,Chiang H

    更新日期:2012-03-01 00:00:00

  • Radiation-induced DNA double-strand break frequencies in human squamous cell carcinoma cell lines of different radiation sensitivities.

    abstract::DNA neutral (pH 9.6) filter elution was used to measure radiation-induced DNA double-strand break (dsb) frequencies in eight human squamous cell carcinoma cell lines with radiosensitivities (D0) ranging from 1.07 to 2.66 Gy and D values ranging from 1.46 to 4.08 Gy. The elution profiles of unirradiated samples from mo...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Schwartz JL,Mustafi R,Beckett MA,Czyzewski EA,Farhangi E,Grdina DJ,Rotmensch J,Weichselbaum RR

    更新日期:1991-06-01 00:00:00

  • On the genetic background of the adaptive response to X-rays in Drosophila melanogaster.

    abstract::The effects of a low dose (0.1-20 mGy) preirradiation with X-rays followed by a higher dose (2 Gy) of the same radiation on the recovery of the genetic damage induced as dominant lethals in mature oocytes (stage 14) of different strains of Drosophila melanogaster were investigated. The response was shown to be depende...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Schäppi-Büchi C

    更新日期:1994-04-01 00:00:00

  • Chromatin- and temperature-dependent modulation of radiation-induced double-strand breaks.

    abstract:PURPOSE:To investigate the influence of chromatin organization and scavenging capacity in relation to irradiation temperature on the induction of double-strand breaks (DSB) in structures derived from human diploid fibroblasts. MATERIALS AND METHODS:Agarose plugs with different chromatin structures (intact cells+/-wort...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Elmroth K,Nygren J,Stenerlöw B,Hultborn R

    更新日期:2003-10-01 00:00:00

  • Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines.

    abstract:PURPOSE:Genotoxic effects have been considered the gold standard to determine if an environmental factor is a carcinogen, but the currently available data for extremely low frequency time-varying magnetic fields (ELF-MF) remain controversial. As an environmental stimulus, the effect of ELF-MF on cellular DNA may be sub...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Yoon HE,Lee JS,Myung SH,Lee YS

    更新日期:2014-04-01 00:00:00

  • Monte Carlo-based dose reconstruction in a rat model for scattered ionizing radiation investigations.

    abstract:PURPOSE:In radiation biology, rats are often irradiated, but the precise dose distributions are often lacking, particularly in areas that receive scatter radiation. We used a non-dedicated set of resources to calculate detailed dose distributions, including doses to peripheral organs well outside of the primary field, ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Kirkby C,Ghasroddashti E,Kovalchuk A,Kolb B,Kovalchuk O

    更新日期:2013-09-01 00:00:00