Age-dependent changes in oxygen tension, radiation dose and sensitivity within normal and diseased coronary arteries-Part B: modeling oxygen diffusion into vessel walls.

Abstract:

PURPOSE:The aim is to assess the change with age and disease of the oxygen concentration within the coronary artery walls. MATERIALS AND METHODS:In an accompanying paper, Part A, the age-dependent morphology and composition for the wall layers of normal and diseased coronary arteries were developed from published data. In this paper, Part B, the oxygen concentration in the coronary artery walls was evaluated taking account the diffusion of oxygen from blood and the solubility of oxygen in tissues. Part C evaluates the oxygen effect and its biological implications for different radiations. RESULTS:Diseased arteries exhibited a relatively moderate increase in the solubility of oxygen (or=38% stenosis had anoxic areas. CONCLUSION:Based on simulation results from the one-dimensional diffusion model, extensive hypoxic areas were determined for atherosclerotic arteries in this analysis of oxygen levels in coronary arteries modelling for the first time the effects of age and disease and associated changes in oxygen solubility due to the presence of lipids and calcium.

journal_name

Int J Radiat Biol

authors

Richardson RB

doi

10.1080/09553000802389645

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

849-57

issue

10

eissn

0955-3002

issn

1362-3095

pii

904997317

journal_volume

84

pub_type

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