Abstract:
PURPOSE:The aim is to assess the change with age and disease of the oxygen concentration within the coronary artery walls.
MATERIALS AND METHODS:In an accompanying paper, Part A, the age-dependent morphology and composition for the wall layers of normal and diseased coronary arteries were developed from published data. In this paper, Part B, the oxygen concentration in the coronary artery walls was evaluated taking account the diffusion of oxygen from blood and the solubility of oxygen in tissues. Part C evaluates the oxygen effect and its biological implications for different radiations.
RESULTS:Diseased arteries exhibited a relatively moderate increase in the solubility of oxygen (
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Richardson RBdoi
10.1080/09553000802389645subject
Has Abstractpub_date
2008-10-01 00:00:00pages
849-57issue
10eissn
0955-3002issn
1362-3095pii
904997317journal_volume
84pub_type
杂志文章abstract:PURPOSE:To investigate the mechanism of NFkappaB activation by X-rays in normal primary rat astrocytes. MATERIALS AND METHODS:Primary cultures of type I astrocytes generated from the cortex of neonatal rats were exposed to X-rays with and without various kinase inhibitors and a protease inhibitor. The nuclear or cytop...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530098141195
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:We aimed for a quantitative evaluation that justifies guidelines for evacuation which take into consideration both the human and economic costs. To the best of our knowledge, such an evaluation has not been performed yet. The present guidelines published by the International Atomic Energy Agency (IAEA) are prob...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553002.2020.1779962
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:Biomarkers of ionising radiation exposure are useful in a variety of scenarios, such as medical diagnostic imaging, occupational exposures, and spaceflight. This study investigates to what extent microRNA (miRNA) expression signatures in mouse peripheral blood can be used as biomarkers for exposures to radiatio...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2010.549537
更新日期:2011-07-01 00:00:00
abstract::Cultures of JU-56 cells were irradiated in either G1 or G2 and examined either in their first post-irradiation metaphase (in diploids) or in their second post-irradiation metaphase (in colcemid-induced tetraploids). The timing of fixation, together with tritiated thymidine pulse labelling, allowed selection for scorin...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009314552131
更新日期:1993-06-01 00:00:00
abstract:PURPOSE:To examine whether a simulated mobile telephone transmission at 915 MHz has an effect on cognitive function in man. MATERIALS AND METHODS:Thirty-six subjects in two groups were each given two training sessions and then three test sessions in a randomized three-way cross-over design. About 1 W mean power at 915...
journal_title:International journal of radiation biology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/095530099140375
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:To describe the design and dosimetric characterization of a simple and economical small animal irradiator. MATERIALS AND METHODS:A high dose rate (HDR) (192)Ir brachytherapy source from a commercially available afterloader was used with a 1.3 cm thick tungsten collimator to provide sharp beam penumbra suitable...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2014.922719
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:Solar energy has a number of short- and long-term detrimental effects on skin that can result in several skin disorders. The aim of this review is to summarise current knowledge on endogenous systems within the skin for protection from solar radiation and present research findings to date, on the exogenous opti...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
doi:10.3109/09553002.2010.501842
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:In order to understand the molecular mechanism of nucleobase damage caused by ultrasoft X-ray irradiation, guanine radicals have been studied using an X-band EPR (electron paramagnetic resonance) spectrometer installed in a synchrotron soft X-ray beamline. MATERIALS AND METHODS:Guanine pellets were irradiated ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000400017689
更新日期:2004-11-01 00:00:00
abstract:PURPOSE:To ask whether highly metastatic sublines show more marked low-dose hyper-radiosensitivity (HRS) response than poorly metastatic ones. MATERIALS AND METHODS:The progressive (PRO) subline showing tumourigenicity and metastatic potential and the regressive (REG) subline showing neither tumourigenicity nor metast...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000802195331
更新日期:2008-07-01 00:00:00
abstract:PURPOSE:To evaluate the radioprotective activity of C3, a regioisomer of water-soluble carboxyfullerene and a potent free radical scavenger, on both normal and tumour cells. MATERIALS AND METHODS:The murine committed bone-marrow stem cells for both granulocytes and monocytes (GM-CFC) were used to represent normal cell...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530001750068966
更新日期:2001-02-01 00:00:00
abstract:PURPOSE:To determine the contribution of intra-alveolar cells as opposed to cells fixed in the interstitium in the development of radiation-induced lung injury. MATERIALS AND METHODS:C3H/HeN mice were irradiated to the thorax with various doses of radiation. The cellular composition and cytokine production were assess...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/0955300031000076894
更新日期:2003-03-01 00:00:00
abstract::Radiation-induced DNA double-strand breaks (dsb) were studied in Ehrlich ascites tumour cells (EATC) by sedimentation in neutral sucrose gradients at low centrifuge speed. Dsb induction was found to be linear with dose with a frequency of: ndsbmr-1D-1 = (11.7 +/- 2) x 10(-12)Gy-1 for 140 kV X-rays and ndsbmr-1D-1 = (1...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553008814552201
更新日期:1988-11-01 00:00:00
abstract::The response to radiation of seven osteosarcoma cell lines was analysed by in vitro colony-forming assay and compared with that of eight human fibroblast strains. The values of D0, the surviving fraction after 2 Gy (S2Gy), and the mean inactivation dose (D) of osteosarcoma cells in log-phase culture were significantly...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009214552351
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:Hypoxic cells in tumours are resistant to 5-fluorouracil (5-FU). This in vivo study investigated the ability of hypoxia to regulate the gene expression of thymidylate synthase (TS), the target enzyme of 5-FU. MATERIALS AND METHODS:C3H mammary carcinomas, grown in the feet of female CDF1 mice, were used for all...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530099139944
更新日期:1999-07-01 00:00:00
abstract:PURPOSE:Conditionally Replicative Adenovirus (CRAd) has been previously demonstrated to augment the activity of radiation, resulting in synergy of cell kill. However, previous models combining radiation with CRAd have not focused on the methods of radiation delivery. MATERIALS AND METHODS:We model the combination of a...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553000903419338
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To study the relationship between cell reproductive death and exchange frequency in SW-1573 human lung tumour cells with and without incorporated iodo-deoxyuridine (IdUrd) following irradiation of plateau-phase cultures with y-rays. METHOD:Linear-quadratic (LQ) analysis was performed for the data on clonogenic...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530099140474
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:Cartilage degradation usually results as a consequence of inflammatory processes in the joints. To study this phenomenon experimentally, adjuvant-induced arthritis (AIA) was used as a model of chronic inflammation under the influence of irradiation. The potential chondroprotective effect of 13% aqueous extract ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2011.530337
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:Exposure to ionizing radiation induces plant defenses by regulating the expression of response genes. The systemic acquired resistance deficient 1 (SARD1) is a key gene in plant defense response. In this study, the function of Oryza sativa SARD1 (OsSARD1) was investigated after exposure of seeds/plants to ioniz...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553002.2017.1297901
更新日期:2017-07-01 00:00:00
abstract::Lambda-prophage induction in repair-deficient and wild-type E. coli strains by heavy ions and gamma-rays has been investigated. The dose dependence of the fraction of induced cells has been measured and its initial slope (lambda-induction potency) determined. The induction by gamma-rays was found to be more efficient ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009014551111
更新日期:1990-05-01 00:00:00
abstract::The effect of local stimulation on mitotic activity and radiation tolerance was studied in mouse tongue mucosa. Silver nitrate solution (0.5-20%) was used for local conditioning. The most effective protocol comprised three daily treatments (days 0-2), yielding a delayed increase in 24 h mitotic counts by about 30% on ...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009214551061
更新日期:1992-03-01 00:00:00
abstract::The relationship between cellular radiosensitivity and normal-tissue response to radiotherapy in individual cancer patients has attracted increasing attention over the last few years. Recent work has suggested that a correlation exists between fibroblast sensitivity and normal-tissue reactions. We have examined the ra...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530096145021
更新日期:1996-09-01 00:00:00
abstract::The effects of a low dose (0.1-20 mGy) preirradiation with X-rays followed by a higher dose (2 Gy) of the same radiation on the recovery of the genetic damage induced as dominant lethals in mature oocytes (stage 14) of different strains of Drosophila melanogaster were investigated. The response was shown to be depende...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009414550501
更新日期:1994-04-01 00:00:00
abstract:PURPOSE:This study is part of a general search for the anatomical bases of the severe mental retardation syndrome caused by prenatal irradiation. More specifically, it seeks reasons for the high radiosensitivity of a white matter area, the cingulum of the corpus callosum. MATERIALS AND METHODS:Pregnant primiparous Wis...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530099139494
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice. MATERIAL AND METHODS:MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitoneally (i.p.) at a dose o...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553000701206676
更新日期:2007-04-01 00:00:00
abstract::Reasonable expectations, based on the normal physiology of the human fetus, cast new light on the possibilities of extrapolation from the finding of severe mental retardation (SMR) in Japanese bomb survivors after maternal exposure to 1.8-5.5 Gy T65DR Gy. After such large exposures the fetal haematopoietic tissues (DS...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009014552051
更新日期:1990-10-01 00:00:00
abstract::Purpose To study the effect of microwave (MW) irradiation and consistent action of microwaves and static magnetic field (MF) on the giant chromosomes endoreduplication in Drosophila melanogaster Meig. Materials and methods Experiments were carried out on inbred wild type Canton-S strain. Exposure to microwaves (freque...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.3109/09553002.2016.1137105
更新日期:2016-01-01 00:00:00
abstract::Recent evidence indicates that isoeffect doses for spinal cord and kidney may be overestimated for fraction sizes as small as 1 or 2 Gy when calculated from a linear-quadratic (LQ) model fitted to data obtained for fraction sizes larger than 2 Gy. Reasons for this are unknown, but possible interpretations include exha...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553008814551461
更新日期:1988-07-01 00:00:00
abstract:PURPOSE:To investigate the ability of electromagnetic (EM) field pre-exposures to induce protection in chick embryos against subsequent ultraviolet (UV) light exposure. MATERIALS AND METHOD:Chick embryos in the 4th day of gestation were exposed for 20 minutes (short term) or 96 hours (long term) to 60 Hz, 8 microT mag...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530099139142
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:To investigate the consequence of continuous low dose-rate exposure to gamma-rays on ornithine decarboxylase (ODC EC 4.1.1.17) activity in organs of rat. MATERIALS AND METHODS:Young male Wistar rats were irradiated at 1.1, 2.1 and 12.9 cGy/day in the dose ranges of 9-165, 17-315 and 100-2000 cGy, respectively,...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530099140645
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:To develop and validate non-fluorescent chromosome painting for bright-field microscopy using the peroxidase/diaminobenzidine (DAB) reaction. MATERIALS AND METHODS:Peripheral blood lymphocytes were taken from patients with uterine cancer who had received heavy-ion radiation therapy. Chromosome slides were trea...
journal_title:International journal of radiation biology
pub_type:
doi:10.1080/095530098142077
更新日期:1998-05-01 00:00:00