Metaphase yields from staphylococcal enterotoxin A stimulated peripheral blood lymphocytes of unirradiated and irradiated aged rhesus monkeys.

abstract：:Purpose: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protecti...

journal_title：International journal of radiation biology

authors： Laskowski L,Williams D,Seymour C,Mothersill C

更新日期：2020-05-26 00:00:00

abstract：:Purpose To investigate the effect of increasing the overall treatment time as well as delivering the compensating doses on the Balb/c breast adenocarcinoma (4T1) tumor. Materials and methods A total of 72 mice were divided into two aliquots (classes A and B) based on the initial size of their induced tumor. Each class...

journal_title：International journal of radiation biology

authors： Nikzad S,Hashemi B,Hasan ZS,Mozdarani H,Baradaran-Ghahfarokhi M,Amini P

更新日期：2016-01-01 00:00:00

abstract：:Experimental data for acute radiation-induced skin reactions are reviewed. These show that for dose fractionation schedules with gaps, repopulation is initiated after a lag period. After this lag period, the isoeffective dose for a given level of skin reaction first increases rapidly, but then slows. The timing of the...

journal_title：International journal of radiation biology

authors： Hopewell JW,Nyman J,Turesson I

更新日期：2003-07-01 00:00:00

abstract：:Mutations in the p53 tumour suppressor gene are found at high frequency in bladder cancer. There is strong evidence that p53 plays an important role in controlling the cell cycle after DNA damage by ionizing radiation. However, the effect of loss of p53 function on radiosensitivity is not yet clear. Radiotherapy combi...

journal_title：International journal of radiation biology

authors： Ribeiro JC,Barnetson AR,Fisher RJ,Mameghan H,Russell PJ

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:In order to understand the molecular mechanism of nucleobase damage caused by ultrasoft X-ray irradiation, guanine radicals have been studied using an X-band EPR (electron paramagnetic resonance) spectrometer installed in a synchrotron soft X-ray beamline. MATERIALS AND METHODS:Guanine pellets were irradiated ...

journal_title：International journal of radiation biology

authors： Yokoya A,Akamatsu K,Fujii K,Ukai M

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To identify and assess, among the participants in the RENEB (Realizing the European Network of Biodosimetry) project, the emergency preparedness, response capabilities and resources that can be deployed in the event of a radiological or nuclear accident/incident affecting a large number of individuals. These ca...

journal_title：International journal of radiation biology

authors： Monteiro Gil O,Vaz P,Romm H,De Angelis C,Antunes AC,Barquinero JF,Beinke C,Bortolin E,Burbidge CI,Cucu A,Della Monaca S,Domene MM,Fattibene P,Gregoire E,Hadjidekova V,Kulka U,Lindholm C,Meschini R,M'Kacher R,Moquet

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To determine the radiosensitivity difference of human Cluster of Differentiation (CD)4(+)CD25(+) regulatory T cells (Treg) and effector T cells to low dose gamma ray and elucidate the underlying mechanisms in vitro. MATERIALS AND METHODS:Blood samples were collected from five health subjects and five patients ...

journal_title：International journal of radiation biology

authors： Cao M,Cabrera R,Xu Y,Liu C,Nelson D

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Many studies have shown that exposure to radiofrequency radiation (RFR) could activate cellular signal transduction pathways. In the present research, we investigated the effects of exposure to a 1.8-GHz RFR at different intensities on epidermal growth factor (EGF) receptor clustering and phosphorylation in hum...

journal_title：International journal of radiation biology

authors： Sun W,Shen X,Lu D,Fu Y,Lu D,Chiang H

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Angiotensin-converting enzyme (ACE) inhibitors are effective in the prophylaxis of radiation-induced renal and lung injury. Studies were designed to determine whether blocking the angiotensin II (AII) receptor, rather than blocking AII synthesis with ACE inhibitors, would also be effective. MATERIALS AND METHO...

journal_title：International journal of radiation biology

authors： Moulder JE,Fish BL,Cohen EP

更新日期：1998-04-01 00:00:00

abstract：:We have examined the timing of gamma-irradiation-induced death in relation to cell cycle progression using a panel of mouse lymphoid or myeloid cell lines. Death was found to occur immediately after irradiation ('rapid interphase' death), or after arrest in G2 phase ('delayed interphase' death). In part II of this ser...

journal_title：International journal of radiation biology

authors： Radford IR,Murphy TK

更新日期：1994-02-01 00:00:00

abstract：:PACE (programmable, autonomously controlled electrodes) pulsed field gel electrophoresis technology was used to develop a DNA double-strand break assay that simultaneously combined (1) resolution across a broad range of DNA sizes, (2) high sensitivity (in terms of detecting dsb at low doses) and (3) speed. A 48 h PACE...

journal_title：International journal of radiation biology

authors： Elia MC,Nichols WW

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:High dose ionizing radiation exposure is associated with myelo-depression leading to pancytopenia and the expected clinical manifestations of acute radiation syndrome (ARS). Herein, we evaluated the efficacy of sargramostim (Leukine®, yeast-derived rhu GM-CSF), with regimens delivered at 48, 72, 96, or 120 h...

journal_title：International journal of radiation biology

authors： Zhong Y,Pouliot M,Downey AM,Mockbee C,Roychowdhury D,Wierzbicki W,Authier S

更新日期：2020-09-22 00:00:00

abstract：PURPOSE:The increased bioactivity 'windows' of GSM 900 and 1800 MHz radiations, (Global System for Mobile telecommunications) revealed recently by us and published in this issue, manifesting themselves as a maximum decrease in the reproductive capacity of the insect Drosophila melanogaster, were examined to discover wh...

journal_title：International journal of radiation biology

authors： Panagopoulos DJ,Margaritis LH

更新日期：2010-05-01 00:00:00

abstract：:Primary chick embryo myoblasts can be a useful tool for studying the developmental events which accompany myoblast differentiation, particularly myoblast membrane fusion. To determine whether the electrical properties and/or fusion in these systems are affected by 50 Hz magnetic fields, chick embryo myoblast cultures ...

journal_title：International journal of radiation biology

authors： Grandolfo M,Santini MT,Vecchia P,Bonincontro A,Cametti C,Indovina PL

更新日期：1991-12-01 00:00:00

abstract：:Base damages, sugar damages, and single-strand breaks produced by free radicals are the preponderant lesions produced in DNA by ionizing radiation. These lesions have been individually introduced into substrate, template, and biologically active DNA molecules and enzymatic processing and biological consequences determ...

journal_title：International journal of radiation biology

authors： Wallace SS

更新日期：1994-11-01 00:00:00

abstract：:The relative efficiencies of two types of densely ionizing particles were compared for the induction of mutations at two distinct genetic loci in human cells. Mutations to 6-thioguanine resistance (hgprt locus) or to trifluorothymidine resistance (tk) locus were scored in TK6 human lymphoblastoid cells exposed to grad...

journal_title：International journal of radiation biology

authors： Kronenberg A,Little JB

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:To investigate whether radiation survival of cells irradiated aerobically in the oxygen-sensitive restriction point in late G1 is dependent on where in the cell cycle the cells first were rendered hypoxic. MATERIALS AND METHODS:Human cervix carcinoma, NHIK 3025 cells, were synchronized and rendered hypoxic whi...

journal_title：International journal of radiation biology

authors： Koritzinsky M,Furre T,Amellem O,Pettersen EO

更新日期：1998-10-01 00:00:00

abstract：:We have compared the repair kinetics of X-ray-induced sublethal damage (SLD) and potentially lethal damage (PLD) in V79 cells during postirradiation incubation in growth medium at 37 degrees C. Kinetics of SLD repair were studied by dose fractionation (D1 + D2 = 2 + 2, 4 + 2, 4 + 4, 10 + 4 and 10 + 7 Gy). Kinetics of ...

journal_title：International journal of radiation biology

authors： Reddy NM,Lange CS

更新日期：1989-09-01 00:00:00

abstract：:Resolving the molecular mechanisms of radiation oncogenesis represents an important but daunting challenge in radiation research. This brief review outlines the principal oncogenic mechanisms that need to be considered in the context of radiation effects on the genome, how these might relate to specific gene and chrom...

journal_title：International journal of radiation biology

authors： Cox R

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To examine the protective effects of histamine on intestinal damage produced by gamma-radiation. MATERIALS AND METHODS:56 mice were divided into 4 groups. Histamine and Histamine-10 Gy groups received a daily subcutaneous histamine injection (0.1 mg/kg) starting 20 hours before irradiation and continued until ...

journal_title：International journal of radiation biology

authors： Medina VA,Croci M,Mohamad NA,Massari N,Garbarino G,Cricco GP,Núñez MA,Martín GA,Crescenti EJ,Bergoc RM,Rivera ES

更新日期：2007-10-01 00:00:00

abstract：:We studied the extent of split-dose recovery in seven non-transformed human fibroblast cell lines of different intrinsic radiosensitivity (HF19, 1BR3, 149BR, 84BR, GM739, 180BR and AT2EM). Experiments were performed on both growing and plateau-phase cells. The seven cell lines displayed a wide range of intrinsic radio...

journal_title：International journal of radiation biology

authors： Alsbeih MG,Fertil B,Arlett CF,Malaise EP

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrimental effects of radiation, in part due to the compromised repair of c...

journal_title：International journal of radiation biology

authors： Cunniffe S,Walker A,Stabler R,O'Neill P,Lomax ME

更新日期：2014-06-01 00:00:00

abstract：:Intact Chinese hamster ovary cells were exposed to the restriction endonucleases (REs) AluI or BamHI. In metaphase spreads from these cells, 300 breakpoints per RE were localized in G-banded chromosome type aberrations (dicentrics, translocations, rings, terminal and interstitial deletions). The majority of breakpoint...

journal_title：International journal of radiation biology

authors： Folle GA,Obe G

更新日期：1995-10-01 00:00:00

abstract：:Reasonable expectations, based on the normal physiology of the human fetus, cast new light on the possibilities of extrapolation from the finding of severe mental retardation (SMR) in Japanese bomb survivors after maternal exposure to 1.8-5.5 Gy T65DR Gy. After such large exposures the fetal haematopoietic tissues (DS...

journal_title：International journal of radiation biology

authors： Mole RH

更新日期：1990-10-01 00:00:00

abstract：:In the last decade the 'comet assay' or 'single cell gel electrophoresis assay' has been established as a sensitive method for the detection of DNA damage and the measurement of its recovery. The results published in the literature have often been obtained with different methods for comet structure measurement. In mos...

journal_title：International journal of radiation biology

authors： Böcker W,Bauch T,Müller WU,Streffer C

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:To study by fluorescence in situ hybridization (FISH) the involvement of Chinese hamster chromosomes 3, 4, 8, and 9, and their separate chromosome arms in X-ray-induced aberrations. MATERIALS AND METHODS:Male embryonic primary cells of Chinese hamster were used and metaphases were collected and scored at 20 h ...

journal_title：International journal of radiation biology

authors： Xiao Y,Natarajan AT

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There ...

journal_title：International journal of radiation biology

authors： Ainsbury E,Badie C,Barnard S,Manning G,Moquet J,Abend M,Antunes AC,Barrios L,Bassinet C,Beinke C,Bortolin E,Bossin L,Bricknell C,Brzoska K,Buraczewska I,Castaño CH,Čemusová Z,Christiansson M,Cordero SM,Cosler G,Mo

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To determine whether chromosomal instability is induced in human diploid fibroblasts by ionizing radiation and to investigate the effects of radiation quality by comparing X-rays, neutrons and alpha-particles. MATERIALS AND METHODS:Cells from two human diploid fibroblast lines, HF12 and HF19, were irradiated a...

journal_title：International journal of radiation biology

authors： Kadhim MA,Marsden SJ,Wright EG

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:The chromosomal radiosensitivity of a selected group of familial breast cancer patients carrying a mutation in BRCA1 (n=11) or BRCA2 (n=9) and a group of healthy mutation carriers (n=12) was investigated and compared to a reference group of breast cancer patients without a BRCA1/2 mutation (n=78) and a group of...

journal_title：International journal of radiation biology

authors： Baeyens A,Thierens H,Claes K,Poppe B,de Ridder L,Vral A

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:In a previous study, we found that exposure to a 50 Hz magnetic field (MF) could activate stress-activated protein kinase (SAPK) and P38 mitogen-activated protein (MAP) kinase (P38 MAPK) in Chinese hamster lung (CHL) fibroblast cells, and simultaneous exposure to a 'noise' MF of the same intensity inhibited the...

journal_title：International journal of radiation biology

authors： Ke XQ,Sun WJ,Lu DQ,Fu YT,Chiang H

更新日期：2008-05-01 00:00:00