Investigation of new cytogenetic biomarkers specific to high-LET radiation using in vivo and in vitro exposed human lymphocytes.

abstract：PURPOSE:To examine whether a simulated mobile telephone transmission at 915 MHz has an effect on cognitive function in man. MATERIALS AND METHODS:Thirty-six subjects in two groups were each given two training sessions and then three test sessions in a randomized three-way cross-over design. About 1 W mean power at 915...

journal_title：International journal of radiation biology

authors： Preece AW,Iwi G,Davies-Smith A,Wesnes K,Butler S,Lim E,Varey A

更新日期：1999-04-01 00:00:00

abstract：:Pre-implantation embryos of the mouse were studied for the occurrence of an adaptive response, i.e. induction of radio-resistance by a previous low dose. Various experimental designs were checked (initial doses between 3 and 10 cGy; second dose 2-6 Gy at 6-24 h after the first dose). Some of the experiments were carri...

journal_title：International journal of radiation biology

authors： Müller WU,Streffer C,Niedereichholz F

更新日期：1992-08-01 00:00:00

abstract：:Radiation-resistant L5178Y-R (LY-R) and radiation-sensitive L5178Y-S (LY-S) murine lymphoma cells were X-irradiated and their free Ca2+ concentration was examined with Fura-2 in Ca2(+)-free salt solution. The release of free Ca2+ from intracellular stores was linear between 10 and 60 min after irradiation (1-5 Gy X-ra...

journal_title：International journal of radiation biology

authors： Szumiel I,Sochanowicz B,Buraczewska I

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:To examine how folate status influences chromosomal damage following X-ray irradiation. MATERIAL AND METHODS:In an animal study, mice were fed either a low, basal, or high folic acid diet (0, 2, or 40 mg/kg diet, respectively) for 4 weeks, and then given total body irradiation (TBI) at 0.5 Gy. In a human study...

journal_title：International journal of radiation biology

authors： Endoh K,Murakami M,Araki R,Maruyama C,Umegaki K

更新日期：2006-04-01 00:00:00

abstract：:This study simulates the exposure of V79 Chinese hamster fibroblasts to low-energy protons, deuterons and alpha-particles in the LET range 10-200 keV/microm. The starting assumption is that the induction of clustered lesions in DNA is a fundamental step for cell inactivation. A non-homogeneous cell population was simu...

journal_title：International journal of radiation biology

authors： Ottolenghi A,Monforti F,Merzagora M

更新日期：1997-11-01 00:00:00

abstract：:Dose responses for the effects of four calcium antagonists on SCCVII/St back and leg tumour sensitivity to 20 Gy X-rays, and on tumour perfusion indicated by relative uptake of 86rubidium, were determined. The effects of these agents on 86rubidium uptake in some normal tissues were also investigated. Flunarizine sensi...

journal_title：International journal of radiation biology

authors： Wood PJ,Hirst DG

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:Epidemiological studies have demonstrated a possible correlation between exposure to extremely low-frequency magnetic fields (ELF-MF) and cancer. However, this correlation has yet to be definitively confirmed by epidemiological studies. The principal objective of this study was to assess the effects of 60 Hz ma...

journal_title：International journal of radiation biology

authors： Jin YB,Kang GY,Lee JS,Choi JI,Lee JW,Hong SC,Myung SH,Lee YS

更新日期：2012-04-01 00:00:00

abstract：:The studies of the late effects of atomic-bomb (A-bomb) radiation on the immune system were started about 20 years after the bombings in 1945. The most remarkable late effects of radiation are the functional and quantitative abnormalities of T and B cells in survivors exposed to high doses (> or = 1.0 Gy). Abnormaliti...

journal_title：International journal of radiation biology

authors： Akiyama M

更新日期：1995-11-01 00:00:00

abstract：PURPOSES:To estimate the ratio of risks for exposure to radon progeny relative to low-LET radiation based on human lung cancer data, taking account of possible time and age variations in radiation-induced lung cancer risk. MATERIALS AND METHODS:Fitting two sorts of time- and age-adjusted relative risk models to a case...

journal_title：International journal of radiation biology

authors： Little MP

更新日期：2002-03-01 00:00:00

abstract：:The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels re...

journal_title：International journal of radiation biology

authors： Becciolini A,Porciani S,Lanini A,Attanasio M

更新日期：1989-07-01 00:00:00

abstract：:Diploid elongated spermatids of mice were enriched by flow cytometry and cell sorting using a new type of sorter (Partec). The sorted abnormal spermatids were identified morphologically and by nuclear area integration. The radiation-induced increase in the frequency of diploid elongated spermatids was monitored with t...

journal_title：International journal of radiation biology

authors： Hacker-Klom U,Heiden T,Otto FJ,Mauro F,Göhde W

更新日期：1989-05-01 00:00:00

abstract：PURPOSE:To evaluate thiol-disulphide homeostasis - a novel, easily calculated, readily available, and relatively cheap oxidative stress marker - in radiation workers and compare the results with healthy controls. MATERIALS AND METHODS:A total of 108 participants were enrolled in the study including 63 hospital workers...

journal_title：International journal of radiation biology

authors： Koc U,Tan S,Ertem AG,Gumus M,Ozbek B,Erel O

更新日期：2017-07-01 00:00:00

abstract：:Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

journal_title：International journal of radiation biology

authors： Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

更新日期：1995-07-01 00:00:00

abstract：:Reasonable expectations, based on the normal physiology of the human fetus, cast new light on the possibilities of extrapolation from the finding of severe mental retardation (SMR) in Japanese bomb survivors after maternal exposure to 1.8-5.5 Gy T65DR Gy. After such large exposures the fetal haematopoietic tissues (DS...

journal_title：International journal of radiation biology

authors： Mole RH

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:Human embryonic stem cells (hESC) hold a great potential for regenerative medicine because, in principle, they can differentiate into any cell type found in the human body. In addition, studying the effect of ionizing radiation (IR) on hESC may provide valuable information about the response of human cells to I...

journal_title：International journal of radiation biology

authors： Panyutin IV,Eniafe R,Panyutin IG,Neumann RD

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:Chronic occupational exposure to ionizing radiation (IR) induces a wide spectrum of DNA damages. The aim of this study was to assess the frequencies of micronucleus (MN), sister chromatid exchanges (SCE) and to evaluate their association with XRCC1 399 Arg/Gln and XRCC3 241 Thr/Met polymorphisms in Hospital sta...

journal_title：International journal of radiation biology

authors： Doukali H,Ben Salah G,Ben Rhouma B,Hajjaji M,Jaouadi A,Belguith-Mahfouth N,Masmoudi ML,Ammar-Keskes L,Kamoun H

更新日期：2017-11-01 00:00:00

abstract：:The past recommendations of the ICRP about dose limits to the skin are reviewed. Recently, an ICRP Task Group has been revisiting the old arguments and setting them against new data. With the exception of the function of cells in the skin associated with immunocompetence, non-stochastic effects have been well characte...

journal_title：International journal of radiation biology

authors： Fry RJ

更新日期：1990-04-01 00:00:00

abstract：:The radiosensitization of two human tumour in vitro cell lines, HT-1080 and LoVo, has been compared with that of the Chinese hamster cell line V79-379A. Although the two human tumour cell lines were more radiosensitive than the V79 cell line sensitizer, enhancement ratios for misonidazole, pimonidazole and azomycin we...

journal_title：International journal of radiation biology

authors： Watts ME,Dennis MF,Roberts IJ

更新日期：1990-02-01 00:00:00

abstract：:Four of the most radiosensitive xrs variants of CHO-K1 cells, obtained after mutagenizing treatment with EMS, have been studied in detail over three to five decades of cell survival. Although these lines were initially reported to have very steep exponential survival curves, and to vary in sensitivity between themselv...

journal_title：International journal of radiation biology

authors： Denekamp J,Whitmore GF,Jeggo P

更新日期：1989-04-01 00:00:00

abstract：:The effect of a siderophore analogue 3,4,3-LIHOPO has been investigated in rat after intramuscular injection of 238Pu, 239Pu and 241Am simulating puncture wounds. Various treatment regimens were used to remove the radioactivity from its injection site and to reduce its retention in body tissues. The local deposits cou...

journal_title：International journal of radiation biology

authors： Volf V,Burgada R,Raymond KN,Durbin PW

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:To analyze the direct and transgenerational effects of exposure to low-dose 1 GHz (mobile phone/wireless telecommunication range) and 10 GHz (radar/satellite communication range) radiofrequency electromagnetic fields (RF-EMF) on the motility of ciliates Spirostomum ambiguum. MATERIALS AND METHODS:S. ambiguum w...

journal_title：International journal of radiation biology

authors： Sarapultseva EI,Igolkina JV,Tikhonov VN,Dubrova YE

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:To describe the design and dosimetric characterization of a simple and economical small animal irradiator. MATERIALS AND METHODS:A high dose rate (HDR) (192)Ir brachytherapy source from a commercially available afterloader was used with a 1.3 cm thick tungsten collimator to provide sharp beam penumbra suitable...

journal_title：International journal of radiation biology

authors： Grams MP,Wilson ZC,Sio TT,Beltran CJ,Tryggestad EJ,Gupta SK,Blackwell CR,McCollough KP,Sarkaria JN,Furutani KM

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:Radiotherapy of cancer carries a perceived risk of inducing secondary cancer and other damage due to dose delivered to normal tissue. While expectedly small, this risk must be carefully analysed for all modalities. Especially in the use of exotic particles like pions and antiprotons, which annihilate and produc...

journal_title：International journal of radiation biology

authors： Kovacevic S,Bassler N,Hartley O,Knudsen H,Vranjes S,Garaj-Vrhovac V,Holzscheiter M

更新日期：2009-12-01 00:00:00

abstract：:Mouse C3H 10T1/2 cells are most sensitive to radiation-induced neoplastic transformation in the G2/M-phase of the cell cycle. When synchronized 10T1/2 cells were exposed to phorbol 12-myristate 13-acetate (TPA) after irradiation, transformation of cells not in the transformation-sensitive window was enhanced, but tran...

journal_title：International journal of radiation biology

authors： Wells RL,Cao J,Xing Y,He L,Elkind MM

更新日期：1993-12-01 00:00:00

abstract：PURPOSE:To investigate the possible role of cell cycle arrest in the radiosensitization of mouse spermatogonial stem cells due to small conditioning X-ray exposures. MATERIALS AND METHODS:A 24 h fractionation interval between conditioning (1 Gy) and challenging (8 or 9 Gy) exposures was used. Two approaches were follo...

journal_title：International journal of radiation biology

authors： Van Buul PP,Van Duyn-Goedhart A,Beumer T,Bootsma AL

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:Testicular seminoma cancer incidence has significantly increased over the last few decades, and although it is successfully treated by radiotherapy, long-term health risks are still unclear. The aim of the study was to show long-term genome damage in patients with seminoma after radiotherapy. MATERIALS AND MET...

journal_title：International journal of radiation biology

authors： Fucic A,Gamulin M,Katic J,Milic M,Druzhinin V,Grgić M

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole) porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo and on tumour cell radiosensitivity in vitro. MATERIALS AND METHODS:MPA was administered directly into the right lateral ventricle of you...

journal_title：International journal of radiation biology

authors： Pearlstein RD,Higuchi Y,Moldovan M,Johnson K,Fukuda S,Gridley DS,Crapo JD,Warner DS,Slater JM

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:The fluorescent in situ hybridization (FISH) technique, which easily detects reciprocal translocations, is currently used to estimate doses in retrospective biological dosimetry, after suspected accidental overexposure to ionizing radiation (IR). This study of 42 cases aimed to verify the appropriateness of thi...

journal_title：International journal of radiation biology

authors： Grégoire E,Roy L,Buard V,Delbos M,Durand V,Martin-Bodiot C,Voisin P,Sorokine-Durm I,Vaurijoux A,Voisin P,Baldeyron C,Barquinero JF

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To evaluate a transcriptomic approach to identify healthy women at increased risk of breast cancer due to G2-radiosensitivity and look at transcripts that are differentially expressed between individuals. MATERIALS AND METHODS:We perform the first study to assess the association of G2 radiosensitivity with bas...

journal_title：International journal of radiation biology

authors： Sims AH,Finnon P,Miller CJ,Bouffler SD,Howell A,Scott D,Clarke RB

更新日期：2007-06-01 00:00:00

abstract：:SR 2508 (etanidazole) (1 mM) or buthionine sulphoximine (BSO, 50 microM) or both drugs together did not radiosensitize oxic V79 Chinese hamster cells irradiated at either an acute dose rate (2.35 Gy/min) or at a low dose rate (0.117 Gy/min). BSO pretreatment (15 h at 37 degrees C) depleted cellular glutathione (GSH) t...

journal_title：International journal of radiation biology

authors： Wong RS,Basas RA,Ling CC

更新日期：1991-01-01 00:00:00