Abstract:
:Cell killing and the production of DNA double-strand breaks (dsbs) were measured in parallel for V79 cells and a human tumour cell line (Caski) following exposure to radiations of differing linear energy transfer (LET) including accelerated heavy ions. Dsb induction was assessed by neutral filter elution (pH 7.4) and elution from agarose plugs in pulsed-field electrophoresis. The elution data were consistent with linear lesion induction and allowed to derive dsb yields or production cross-sections (sigma dsb), respectively. Both cell lines as well as the two elution approaches gave comparable results. sigma dsb was found to rise up to the heaviest ions used (LET = 11,500 keV/microns) but relative biological effectiveness was always smaller than unity. Slopes of the exponential survival curves (final slope with 60Co-radiation) were normalized to the respective dsb yields and allowed to calculate the relative lethality per induced dsb. This parameter increased with LET up to about 300 keV/microns followed by a steep decline for the very heavy ions. The extent of dsb rejoining was concomitantly reduced with ionization density.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Weber KJ,Flentje Mdoi
10.1080/09553009314551261subject
Has Abstractpub_date
1993-08-01 00:00:00pages
169-78issue
2eissn
0955-3002issn
1362-3095pii
8KK9W951N53QWXUXjournal_volume
64pub_type
杂志文章abstract::It is well established from clinical, epidemiological and laboratory studies that specific human germ line mutation can predispose to spontaneously arising cancer. Some of the responsible genes have been characterized at the molecular level and evidence is rapidly accumulating on mechanistic aspects of the problem. A ...
journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
doi:10.1080/09553009414551761
更新日期:1994-11-01 00:00:00
abstract:PURPOSE:The assessment of biological effects caused by radiation exposure has been currently carried out with the linear-quadratic (LQ) model as an extension of the linear non-threshold (LNT) model. In this study, we suggest a new mathematical model named as SeaSaw (SS) model, which describes proliferation and cell dea...
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
pub_type: 杂志文章,收录出版
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journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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更新日期:1994-11-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:2008-02-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:2011-05-01 00:00:00
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更新日期:1999-09-01 00:00:00
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更新日期:1990-08-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章,随机对照试验
doi:10.3109/09553002.2012.661916
更新日期:2012-05-01 00:00:00
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更新日期:2000-05-01 00:00:00