The relationship between the anoxic sensitivity and the extent of sensitization by nitrous oxide.

Abstract:

:Nitrous oxide reacts during irradiation to increase the yield of .OH, a radical many believe to be a major cause of lethality. Logically, one would expect N2O to be a radiation sensitizer. In some instances it is, while in others it is not. In some cases we can explain why N2O fails to sensitize; factors such as dose rate, cell concentration, buffer composition and ionic strength all influence when N2O will sensitize and, if it sensitizes, by what magnitude. Based on the results presented here with multiple strains of procaryotic and eucaryotic cells, we believe the anoxic sensitivity is another critical factor that governs whether N2O will sensitize. Our data, with data from the literature, show a relationship between the anoxic sensitivity and the N2O enhancement ratio. N2O does not sensitize in vitro unless the anoxic sensitivity (inactivation constant, k) is less than approximately 0.2 daGy-1.

journal_name

Int J Radiat Biol

authors

Ewing D,Walton HL,Guilfoil DS,Ohm MB

doi

10.1080/09553009114550631

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

717-27

issue

3

eissn

0955-3002

issn

1362-3095

pii

790QMGT0PB05N7C9

journal_volume

59

pub_type

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