The relationship between the anoxic sensitivity and the extent of sensitization by nitrous oxide.


:Nitrous oxide reacts during irradiation to increase the yield of .OH, a radical many believe to be a major cause of lethality. Logically, one would expect N2O to be a radiation sensitizer. In some instances it is, while in others it is not. In some cases we can explain why N2O fails to sensitize; factors such as dose rate, cell concentration, buffer composition and ionic strength all influence when N2O will sensitize and, if it sensitizes, by what magnitude. Based on the results presented here with multiple strains of procaryotic and eucaryotic cells, we believe the anoxic sensitivity is another critical factor that governs whether N2O will sensitize. Our data, with data from the literature, show a relationship between the anoxic sensitivity and the N2O enhancement ratio. N2O does not sensitize in vitro unless the anoxic sensitivity (inactivation constant, k) is less than approximately 0.2 daGy-1.


Int J Radiat Biol


Ewing D,Walton HL,Guilfoil DS,Ohm MB




Has Abstract


1991-03-01 00:00:00














  • Effects of 50 Hz magnetic fields on cancer induced by ionizing radiation in mice.

    abstract:PURPOSE:To evaluate the effects of 50 Hz magnetic fields (MF) on the development of cancer induced by ionizing radiation. MATERIALS AND METHODS:A total of 150 female CBA/S mice were randomized into three equal groups at the age of 3-5 weeks. One of the groups served as a 'cage-control group'. The two other groups were...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Heikkinen P,Kosma VM,Huuskonen H,Komulainen H,Kumlin T,Penttilä I,Väänänen A,Juutilainen J

    更新日期:2001-04-01 00:00:00

  • An interspecies comparison of the phagocytosis and dissolution of 241AmO2 particles by rat, dog and monkey alveolar macrophages in vitro.

    abstract::Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

    更新日期:1992-07-01 00:00:00

  • Ultrastructural morphometric analysis of peripheral nerves after intraoperative irradiation.

    abstract::Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

    更新日期:1995-07-01 00:00:00

  • Rapid communication: effect of irradiation on lymphocyte proliferation and differentiation: potential of IL-6 in augmenting antibody responses in cultures of murine spleen cells.

    abstract::Ionizing radiation induces both quantitative and qualitative changes in the lymphoid cells of both man and experimental animals, including inhibition of antibody responses. However, the cellular basis of this immunological lesion is not clear. In the present study, groups of mice were exposed to 2.0 Gy gamma-rays or s...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Goud SN

    更新日期:1995-04-01 00:00:00

  • Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining.

    abstract:PURPOSE:To assess the potential of using the residual phosphorylation of histone H2AX (gammaH2AX) after irradiation as a marker of radiosensitivity in vitro. MATERIAL AND METHODS:Confluent cell cultures of FaDu and SKX human squamous cell carcinoma lines were irradiated with graded single doses. Twenty-four hours afte...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Menegakis A,Yaromina A,Eicheler W,Dörfler A,Beuthien-Baumann B,Thames HD,Baumann M,Krause M

    更新日期:2009-11-01 00:00:00

  • Accumulation of spermidine/spermine N1-acetyltransferase and alternatively spliced mRNAs as a delayed response of HeLa S3 cells following X-ray irradiation.

    abstract:PURPOSE:A key enzyme of polyamine catabolism, spermidine/spermine N(1)-acetyltransferase (SSAT), is responsive to antiproliferative agents. The role of SSAT in cellular responses to X-ray irradiation was examined. MATERIALS AND METHODS:Exponentially growing HeLa S3 cells were irradiated by X-rays, and mRNA levels for ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Mita K,Fukuchi K,Hamana K,Ichimura S,Nenoi M

    更新日期:2004-05-01 00:00:00

  • The influence of glutathione on single-strand breakage in single-stranded DNA irradiated in aqueous solution in the absence and presence of oxygen.

    abstract::The yields of strand break formation (Gssb) in single-stranded DNA (ssDNA) initiated by radiation-generated OH radicals have been determined using the method of low-angle laser light scattering (LALLS). The irradiations were carried out in aqueous, N2O-saturated solutions in the absence and presence of oxygen and at d...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Liphard M,Bothe E,Schulte-Frohlinde D

    更新日期:1990-10-01 00:00:00

  • Computer evaluation of direct and indirect damage induced by free and DNA-bound iodine-125 in the chromatin fibre.

    abstract:PURPOSE:When Iodine-125 decays within chromatin, several in vivo experiments have shown that the radiobiological effects are caused mainly by indirect mechanisms and that more than one DNA double strand break (DSB) is produced per decay. We present calculations to evaluate the contribution of direct and indirect effect...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Terrissol M,Edel S,Pomplun E

    更新日期:2004-11-01 00:00:00

  • The intrinsic alpha/beta ratio for human tumour cells: is it a constant?

    abstract::The radiation response of 15 mammalian cell lines comprising 11 human tumour, two human fibroblast and two murine lymphoma cell lines, has been analysed using the linear-quadratic equation. As well as using conventional analysis of acute dose-survival curves to derive values for alpha and beta (termed alpha ac and bet...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Peacock JH,Eady JJ,Edwards SM,McMillan TJ,Steel GG

    更新日期:1992-04-01 00:00:00

  • The combined effect of fludarabine monophosphate and radiation as well as gemcitabine and radiation on squamous carcinoma tumor cell lines in vitro.

    abstract:PURPOSE:Despite proven antitumor activity of gemcitabine in chemoradiotherapy of advanced head and neck cancer, many authors refer to severe acute and late local and haematological toxicity. Fludarabine does imply nearly the same mechanisms of action as gemcitabine, inhibiting various enzymes involved in DNA replicatio...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Nitsche M,Christiansen H,Hermann RM,Lucke EM,Peters K,Rave-Frank M,Schmidberger H,Pradier O

    更新日期:2008-08-01 00:00:00

  • TGF-beta1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype.

    abstract:PURPOSE:To study the influence of TGF-beta1 and TGF-beta-neutralizing antibodies on the clonogenic activity and terminal differentiation of rat lung fibroblasts following radiation exposure. MATERIAL AND METHODS:Early passage rat lung fibroblasts were used in this study. Colony formation assays were applied to determi...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Hakenjos L,Bamberg M,Rodemann HP

    更新日期:2000-04-01 00:00:00

  • Hypoxic cell sensitization: low-dose intrinsic radiosensitivity is predictive for etanidazole efficacy in a panel of human tumour cell lines.

    abstract::We used a cell sorter assay to evaluate the efficacy of the hypoxic cell sensitizer etanidazole over 3-4 logs of cell inactivation, with particular attention to the clinically relevant low-dose survival region. Analysis of the radiation responses in a panel of six human tumour cell lines under conditions of hypoxia an...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Wouters BG,Sy AM,Skarsgard LD

    更新日期:1996-12-01 00:00:00

  • Minisatellite and Hprt mutations in V79 cells irradiated with helium ions and gamma rays.

    abstract:PURPOSE:To evaluate and compare cytotoxic and mutational effects of graded doses of gamma-rays and 4He++ ions at different LET values (nominally 80 and 123 keV/microm) in V79 cells. MATERIALS AND METHODS:4He++ ion beams at 80 and 123 keV/microm were supplied by the 7 MV Van de Graaff CN accelerator of the INFN-LNL in ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Cherubinit R,Canova S,Favaretto S,Bruna V,Battivelli P,Celotti L

    更新日期:2002-09-01 00:00:00

  • 50-Hz magnetic field induces EGF-receptor clustering and activates RAS.

    abstract:PURPOSE:In a previous study, we found that exposure to a 50 Hz magnetic field (MF) could activate stress-activated protein kinase (SAPK) and P38 mitogen-activated protein (MAP) kinase (P38 MAPK) in Chinese hamster lung (CHL) fibroblast cells, and simultaneous exposure to a 'noise' MF of the same intensity inhibited the...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Ke XQ,Sun WJ,Lu DQ,Fu YT,Chiang H

    更新日期:2008-05-01 00:00:00

  • Theoretical predictions on the equality of radiation-produced dicentrics and translocations detected by chromosome painting.

    abstract::Existing models of chromosome aberrations produced by ionizing-radiation predict equal numbers of dicentrics and translocations if the dose is so low that complex aberrations can be ignored. We show that, for a specific subset of aberrations detected by FISH, dicentric/translocation equality is predicted even at highe...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Lucas JN,Chen AM,Sachs RK

    更新日期:1996-02-01 00:00:00

  • Biodosimetry using chromosomal translocations measured by FISH in a population chronically exposed to low dose-rate 60Co gamma-irradiation.

    abstract:PURPOSE:To evaluate the cumulative gamma-radiation personal exposure by analysing lymphocyte chromosome translocations using FISH painting and to compare FISH-derived biodoses with those derived from retrospective physical dose reconstruction in residents receiving chronic low dose-rate gamma-irradiation while living i...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Hsieh WA,Lucas JN,Hwang JJ,Chan CC,Chang WP

    更新日期:2001-07-01 00:00:00

  • Agarose overlay selectively improves macrocolony formation and radiosensitivity assessment in primary fibroblasts.

    abstract:PURPOSE:Primary fibroblasts are not suitable for in vitro macrocolony assay due to their inability to form distinct colonies. Here we present a modification of agarose overlay that yielded extensive improvement in their colony formation and assessment of radiosensitivity. MATERIALS AND METHODS:Macrocolony formation wa...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Chandna S,Dagur RS,Mathur A,Natarajan AT,Harms-Ringdahl M,Haghdoost S

    更新日期:2014-05-01 00:00:00

  • Therapy for prevention and treatment of skin ionizing radiation damage: a review.

    abstract::Radiologic accidents or terrorist acts involving radioactive material, as well as radiation exposure in medical or industrial procedures are potential sources of risk for human health. All these risks share a common element, exposure to ionizing radiation. The extent of ionizing radiation injury will depend on a numbe...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,评审


    authors: Soriano JL,Calpena AC,Souto EB,Clares B

    更新日期:2019-05-01 00:00:00

  • Radiation sensitization by an iodine-labelled DNA ligand.

    abstract::An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand. ...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Martin RF,Murray V,D'Cunha G,Pardee M,Kampouris E,Haigh A,Kelly DP,Hodgson GS

    更新日期:1990-05-01 00:00:00

  • Impaired p53-mediated DNA damage response, cell-cycle disturbance and chromosome aberrations in Nijmegen breakage syndrome lymphoblastoid cell lines.

    abstract:PURPOSE:To investigate the p53 ionizing radiation-induced response, G1/S cell-cycle block and cytogenetic damage in Nijmegen breakage syndrome (NBS) cells characterized by different haplotypes. MATERIAL AND METHODS:Lymphoblastoid cell lines derived from three normals, five NBS and two ataxia telangiectasia (AT) indivi...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Antoccia A,Stumm M,Saar K,Ricordy R,Maraschio P,Tanzarella C

    更新日期:1999-05-01 00:00:00

  • Induction and persistence of chromosomal exchanges in mouse bone marrow cells following whole-body exposure to X-rays.

    abstract:PURPOSE:To investigate the induction and persistence of chromosome aberrations in mouse bone marrow cells after X-ray exposure and to detect differential involvement of individual chromosomes in translocations. MATERIALS AND METHODS:Male and female Swiss mice were exposed to 1 and 3 Gy of X-rays. Chromosome aberration...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Xiao Y,Darroudi F,Grigorova M,Natarajan AT

    更新日期:1999-09-01 00:00:00

  • Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity.

    abstract:PURPOSE:The molecular basis of gene regulation in cells exposed to ionising radiation is not fully understood. Gene regulation occurs at the transcriptional and post-transcriptional levels. Recent studies have suggested that micro-RNA (miRNA) plays a significant role at the post-transcriptional gene regulation. miRNA a...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Chaudhry MA,Kreger B,Omaruddin RA

    更新日期:2010-07-01 00:00:00

  • Transformation-sensitive cells in G2/M-phase are not promoted by TPA following 137Cs gamma-rays.

    abstract::Mouse C3H 10T1/2 cells are most sensitive to radiation-induced neoplastic transformation in the G2/M-phase of the cell cycle. When synchronized 10T1/2 cells were exposed to phorbol 12-myristate 13-acetate (TPA) after irradiation, transformation of cells not in the transformation-sensitive window was enhanced, but tran...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Wells RL,Cao J,Xing Y,He L,Elkind MM

    更新日期:1993-12-01 00:00:00

  • Detrimental effect of UV-B radiation on growth, photosynthetic pigments, metabolites and ultrastructure of some cyanobacteria and freshwater chlorophyta.

    abstract:BACKGROUND:Global warming directly influencing ozone layer depletion, which eventually is increasing ultraviolet radiation penetration having far-reaching impacts on living biota. This particularly influences the primary producer microalgae which are the basic unit of food webs in the aquatic habitats. Therefore, it is...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: El-Sheekh MM,Alwaleed EA,Ibrahim A,Saber H

    更新日期:2020-12-03 00:00:00

  • Genetic damage in mammalian somatic cells exposed to extremely low frequency electro-magnetic fields: a meta-analysis of data from 87 publications (1990-2007).

    abstract:PURPOSE:A meta-analysis was conducted to obtain a 'quantitative' estimate of the extent of genetic damage in mammalian somatic cells exposed to non-ionizing radiation emitted from extremely low frequency electro-magnetic fields (ELF-EMF) and to compare with that in unexposed control cells. METHODS:The methods used for...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章,meta分析


    authors: Vijayalaxmi,Prihoda TJ

    更新日期:2009-03-01 00:00:00

  • Analysis of structural and numerical chromosomal anomalies at the first, second, and third mitosis after irradiation of one-cell mouse embryos with X-rays or neutrons.

    abstract::One-cell mouse embryos were irradiated with X-rays or neutrons. Analysis of the first, second, and third postradiation mitoses revealed that the yields of structural aberrations increased linearly after exposure to both radiation qualities. For X-rays the aberration frequency decreased from the first to the third mito...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Weissenborn U,Streffer C

    更新日期:1988-09-01 00:00:00

  • Health, growth and reproductive success of mice exposed to environmentally relevant levels of Ra-226 via drinking water over multiple generations.

    abstract:PURPOSE:To assess health, growth and reproductive success of mammals exposed for multiple generations to levels of radium-226 known to occur in environments surrounding uranium mines and mills in Canada. METHODS:The study consisted of a control group and four treatment groups each containing 40 mice (20 males and 20 f...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Walsh S,Satkunam M,Su B,Festarini A,Bugden M,Peery H,Mothersill C,Stuart M

    更新日期:2015-07-01 00:00:00

  • A 700 MHz 1H-NMR study reveals apoptosis-like behavior in human K562 erythroleukemic cells exposed to a 50 Hz sinusoidal magnetic field.

    abstract:PURPOSE:To study cell damage and possible apoptosis in K562 human erythroleukemic cells exposed for 2 h to an extremely low frequency (ELF) 50 Hz sinusoidal magnetic field with a magnetic induction of either 1 or 5 mT using high resolution proton nuclear magnetic resonance (1H-NMR) spectroscopy. MATERIALS AND METHODS:...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Santini MT,Ferrante A,Romano R,Rainaldi G,Motta A,Donelli G,Vecchia P,Indovina PL

    更新日期:2005-02-01 00:00:00

  • Fullerenes as a new class of radioprotectors.

    abstract:PURPOSE:To evaluate the radioprotective activity of C3, a regioisomer of water-soluble carboxyfullerene and a potent free radical scavenger, on both normal and tumour cells. MATERIALS AND METHODS:The murine committed bone-marrow stem cells for both granulocytes and monocytes (GM-CFC) were used to represent normal cell...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Lin HS,Lin TS,Lai RS,D'Rosario T,Luh TY

    更新日期:2001-02-01 00:00:00

  • Does tirapazamine (SR-4233) have any cytotoxic or sensitizing effect on three human tumour cell lines at clinically relevant partial oxygen pressure?

    abstract::Solid human tumours contain areas with low oxygen tension (pO2). For bioreductive drugs it is important to define the cytotoxic effect according to drug concentration and to clinically relevant pO2. In this study, the pO2 dependence of the survival of three human cell lines (HRT 18, Na11 +, and MEWO), exposed to tirap...

    journal_title:International journal of radiation biology

    pub_type: 杂志文章


    authors: Lartigau E,Guichard M

    更新日期:1995-02-01 00:00:00