当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF RADIATION BIOLOGY期刊下所有文献 > Bronchoalveolar lavage and interstitial cells have different roles in radiation-induced lung injury.

Bronchoalveolar lavage and interstitial cells have different roles in radiation-induced lung injury.

Abstract：

PURPOSE:To determine the contribution of intra-alveolar cells as opposed to cells fixed in the interstitium in the development of radiation-induced lung injury. MATERIALS AND METHODS:C3H/HeN mice were irradiated to the thorax with various doses of radiation. The cellular composition and cytokine production were assessed in the two sites by histological staining and RNase protection assay. RESULTS:Following thoracic irradiation, there was an initial decrease in the number of bronchial alveolar lavage (BAL) cells that was followed after 2 months by a dose-dependent increase up to 4 months. Foamy Mac-1 positive macrophages were present early in the BAL populations, which also expressed the pro-inflammatory cytokines TNF-alpha, IL-1alpha and IL-1beta, but this response subsided by the time of onset of pneumonitis (3 months). In contrast, in whole lung tissue there was a steady increase in Mac-1 positive cells and increased expression of TNF-alpha, IL-1alpha and IL-1beta mRNAs to maximum levels at 3-4 months. CONCLUSIONS:These data indicate distinct temporal and spatial changes in pro-inflammatory cytokine gene expression in different cellular compartments of the irradiated lung. BAL cells became inflammatory early on, but interstitial cells became involved later and were probably more involved in contributing to the pneumonitis.

journal_name

Int J Radiat Biol

journal_title

International journal of radiation biology

authors

Hong JH,Jung SM,Tsao TC,Wu CJ,Lee CY,Chen FH,Hsu CH,McBride WH,Chiang CS

doi

10.1080/0955300031000076894

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

159-67

issue

3

eissn

0955-3002

issn

1362-3095

pii

5EUKT9PHKMLTAM7B

journal_volume

79

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY文献大全
  • Can radiation research impact the estimation of risk?

    abstract：PURPOSE:This review is a contribution to the memory of Dr William (Bill) Morgan and highlights an area of research and deliberation that he considered extremely important in support of the setting of protective radiation dose limits. Biological research has generally played a minor role in the estimation of adverse hea...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/09553002.2017.1290848

    authors： Preston RJ

    更新日期：2017-10-01 00:00:00

  • Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans - joint RENEB and EURADOS inter-laboratory comparisons.

    abstract：PURPOSE:RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2016.1206233

    authors： Ainsbury E,Badie C,Barnard S,Manning G,Moquet J,Abend M,Antunes AC,Barrios L,Bassinet C,Beinke C,Bortolin E,Bossin L,Bricknell C,Brzoska K,Buraczewska I,Castaño CH,Čemusová Z,Christiansson M,Cordero SM,Cosler G,Mo

    更新日期：2017-01-01 00:00:00

  • Whole mouse blood microRNA as biomarkers for exposure to γ-rays and (56)Fe ion.

    abstract：PURPOSE:Biomarkers of ionising radiation exposure are useful in a variety of scenarios, such as medical diagnostic imaging, occupational exposures, and spaceflight. This study investigates to what extent microRNA (miRNA) expression signatures in mouse peripheral blood can be used as biomarkers for exposures to radiatio...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2010.549537

    authors： Templin T,Amundson SA,Brenner DJ,Smilenov LB

    更新日期：2011-07-01 00:00:00

  • Neutrons do not produce a bystander effect in zebrafish irradiated in vivo.

    abstract：PURPOSE:Neutron irradiations at the McMaster Tandetron Accelerator were performed to study direct and bystander effects of neutrons in a live organism. METHODS:The neutrons were produced through (7)Li(p,n)(7)Be reaction. Although the gamma contamination of the neutron beam cannot be completely eliminated, it was desig...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2011.584939

    authors： Wang C,Smith RW,Duhig J,Prestwich WV,Byun SH,McNeill FE,Seymour CB,Mothersill CE

    更新日期：2011-09-01 00:00:00

  • Low dose radiation-induced endothelial cell retraction.

    abstract：:We characterized in vitro the effects of gamma-radiation (12.5-100 cGy) on pulmonary microvascular endothelial cell (PMEC) morphology and F-actin organization. Cellular retraction was documented by phase-contrast microscopy and the organization of actin microfilaments was determined by immunofluorescence. Characteriza...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009314551471

    authors： Kantak SS,Diglio CA,Onoda JM

    更新日期：1993-09-01 00:00:00

  • Concomitant low dose-rate irradiation and cisplatin treatment in ovarian carcinoma cell lines sensitive and resistant to cisplatin treatment.

    abstract：:Human ovarian carcinoma parental and cisplatin-resistant cells were evaluated for their radiation sensitivity to high and low dose-rate irradiation and for the effectiveness of cisplatin in radiosensitization. The cisplatin resistant variant A2780cp showed increased radiation resistance for both low dose-rate (LDRI) a...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530096145634

    authors： Raaphorst GP,Wang G,Stewart D,Ng CE

    更新日期：1996-05-01 00:00:00

  • Biophysical model of the radiation-induced bystander effect.

    abstract：PURPOSE:To construct a quantitative model of the radiation-induced bystander effect based on diffusion-type spreading of bystander signal communication between the hit and non-hit cells. Cell inactivation and induced oncogenic transformation by broad- and microbeam irradiation systems are considered. MATERIALS AND MET...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：

    authors： Nikjoo H,Khvostunov IK

    更新日期：2003-01-01 00:00:00

  • Lung cancer response following inhaled radon in the A/J and C57BL/6J mouse.

    abstract：:A/J and C57BL/6J mice, strains which differ in susceptibility to chemical-induced lung tumours, were examined for differential sensitivity to radon-induced lung cancer. Sixty weeks after exposure to 952 WLM radon (3.34 J h1 m-3), no lung tumours were found in the control, sham- (one dust-) exposed, or radon-exposed C5...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530097144184

    authors： Groch KM,Khan MA,Brooks AL,Saffer JD

    更新日期：1997-03-01 00:00:00

  • Ca2+ mobilization is related to the lethal effect of X-irradiation in L5178Y cells.

    abstract：:Radiation-resistant L5178Y-R (LY-R) and radiation-sensitive L5178Y-S (LY-S) murine lymphoma cells were X-irradiated and their free Ca2+ concentration was examined with Fura-2 in Ca2(+)-free salt solution. The release of free Ca2+ from intracellular stores was linear between 10 and 60 min after irradiation (1-5 Gy X-ra...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009014551481

    authors： Szumiel I,Sochanowicz B,Buraczewska I

    更新日期：1990-07-01 00:00:00

  • Calculation of the biological effects of ion beams based on the microscopic spatial damage distribution pattern.

    abstract：PURPOSE:To present details of the recent version of the 'Local Effect Model' (LEM), that has been developed and implemented in treatment planning for the ion beam therapy pilot project performed at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. MATERIALS AND METHODS:The new version of the model i...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2011.611213

    authors： Friedrich T,Scholz U,Elsässer T,Durante M,Scholz M

    更新日期：2012-01-01 00:00:00

  • Analysis of structural and numerical chromosomal anomalies at the first, second, and third mitosis after irradiation of one-cell mouse embryos with X-rays or neutrons.

    abstract：:One-cell mouse embryos were irradiated with X-rays or neutrons. Analysis of the first, second, and third postradiation mitoses revealed that the yields of structural aberrations increased linearly after exposure to both radiation qualities. For X-rays the aberration frequency decreased from the first to the third mito...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553008814551771

    authors： Weissenborn U,Streffer C

    更新日期：1988-09-01 00:00:00

  • Treatment with 3,4,3-LIHOPO of simulated wounds contaminated with plutonium and americium in rat.

    abstract：:The effect of a siderophore analogue 3,4,3-LIHOPO has been investigated in rat after intramuscular injection of 238Pu, 239Pu and 241Am simulating puncture wounds. Various treatment regimens were used to remove the radioactivity from its injection site and to reduce its retention in body tissues. The local deposits cou...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530096145382

    authors： Volf V,Burgada R,Raymond KN,Durbin PW

    更新日期：1996-07-01 00:00:00

  • Increased chromatid-type chromosomal aberrations in mouse m5S cells exposed to power-line frequency magnetic fields.

    abstract：PURPOSE:To investigate the induction of chromosomal aberrations in mouse m5S cells after exposure to power-line frequency magnetic fields (extremely low frequency magnetic fields; ELFMF) at high-flux densities. MATERIAL AND METHOD:m5S cells were either untreated or pretreated during the G1 phase with mitomycin C (MMC,...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000050201172

    authors： Yaguchi H,Yoshida M,Ding GR,Shingu K,Miyakoshi J

    更新日期：2000-12-01 00:00:00

  • Evidence for a physical component to the radiation-induced bystander effect?

    abstract：PURPOSE:The nature of the transferrable factor which goes from irradiated objects to bystander objects remains undefined. Most agree that a chemical entity is the likely 'factor' although some authors have produced in vitro evidence for the involvement of a physical component or a very potent volatile capable of travel...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2012.698366

    authors： Mothersill C,Smith RW,Fazzari J,McNeill F,Prestwich W,Seymour CB

    更新日期：2012-08-01 00:00:00

  • Human cancer predisposition and the implications for radiological protection.

    abstract：:It is well established from clinical, epidemiological and laboratory studies that specific human germ line mutation can predispose to spontaneously arising cancer. Some of the responsible genes have been characterized at the molecular level and evidence is rapidly accumulating on mechanistic aspects of the problem. A ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/09553009414551761

    authors： Cox R

    更新日期：1994-11-01 00:00:00

  • Minor contribution of direct ionization to DNA base damage inducedby heavy ions.

    abstract：PURPOSE:The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases. Emphasis was placed on the estimation of the respective contribution of direct ionization and indirect effects, mostly by comparison with low linear energy transfer (LET) g...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000600573788

    authors： Douki T,Ravanat JL,Pouget JP,Testard I,Cadet J

    更新日期：2006-02-01 00:00:00

  • The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight.

    abstract：PURPOSE:The space environment contains two major biologically significant influences; space radiations and microgravity. The 53 kDa tumour suppressor protein (p53) plays a role as a guardian of the genome through the activity of p53-centered signal transduction pathways. The aim of this study was to clarify the biologi...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553001003789596

    authors： Takahashi A,Suzuki H,Omori K,Seki M,Hashizume T,Shimazu T,Ishioka N,Ohnishi T

    更新日期：2010-08-01 00:00:00

  • Relative biological effectiveness of radon: An in vitro study using chromosome aberrations as a biomarker.

    abstract：PURPOSE:The need to determine a reliable relative biological effectiveness (RBE) value for alpha exposures has become important as reports remain controversial. Although a radiation-weighting factor of 20 has been designated for alpha particles, uncertainty exists on realistic value of the RBE of alpha radiation. The a...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.3109/09553002.2015.1047986

    authors： Meenakshi C,Mohankumar MN

    更新日期：2015-08-01 00:00:00

  • The long-term effects of γ-radiation on the growth of Allium cepa plants.

    abstract：PURPOSE:The purpose of this study was to assess the long-term effects of gamma-radiation, including low-dose radiation, on growth parameters of onion (Allium cepa) seedling roots 6-10 days after irradiation. MATERIALS AND METHODS:Onion seedlings were exposed to a 137Cs gamma source at doses ranging from 0.1 to 10 gray...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2021.1844337

    authors： Bolsunovsky A,Trofimova E,Dementyev D,Petrichenkov M

    更新日期：2020-11-16 00:00:00

  • Combination of agents modifying effects in hadrontherapy: modelization of the role of HO° free radicals.

    abstract：:Purpose: A study is presented of the irradiation of cancerous cervical cell line HeLa loaded with a platinum salt, betamethasone and deoxyglucose. The presence of the platinum increases the free-radical concentration and augments the cell death rate, whereas betamethasone or deoxyglucose induces radiosensitization by ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2020.1721594

    authors： Usami N,Hirayama R,Kobayashi K,Furusawa Y,Le Sech C

    更新日期：2020-05-01 00:00:00

  • Migration patterns in pulsed-field electrophoresis of DNA restriction fragments from log-phase mammalian cells after irradiation and incubation for repair.

    abstract：:An assay system was developed to detect changes of restriction fragment profiles obtained after pulsed-field gel electrophoresis (PFGE) for DNA from mammalian cells that were irradiated and incubated for repair. DNA was prepared from irradiated log-phase human melanoma cells (MRI 221) after incubation for repair (6 h)...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530096144518

    authors： Latz D,Dewey WC,Flentje M,Lohr F,Wenz F,Weber KJ

    更新日期：1996-12-01 00:00:00

  • Characterization of the specific response to serotonin of mouse tumour-feeding arterioles.

    abstract：PURPOSE:To investigate the role of tumour versus non-tumour factors in the specific response to serotonin (5-HT) of tumour-feeding arterioles (TFA). MATERIALS AND METHODS:Using mouse models of intra-vital microscopy, the response to topical administration of 5-HT was studied in arterioles feeding tumours: fibrosarcoma...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530098141519

    authors： Laemmel E,Stücker O,Darmon PL,Vicaut E

    更新日期：1998-09-01 00:00:00

  • Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation.

    abstract：PURPOSE:Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L., has demonstrated a promising impact on chemotherapy in a variety of malignancies. The effects of the drug on cell survival, alteration of the cell cycle and induction of apoptosis were examined without and in combination with ionizing r...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553000110089991

    authors： Cordes N,Plasswilm L,Bamberg M,Rodemann HP

    更新日期：2002-01-01 00:00:00

  • Proliferation saturation index in an adaptive Bayesian approach to predict patient-specific radiotherapy responses.

    abstract：:Purpose: Radiotherapy prescription dose and dose fractionation protocols vary little between individual patients having the same tumor grade and stage. To personalize radiotherapy a predictive model is needed to simulate radiation response. Previous modeling attempts with multiple variables and parameters have been sh...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2019.1589013

    authors： Sunassee ED,Tan D,Ji N,Brady R,Moros EG,Caudell JJ,Yartsev S,Enderling H

    更新日期：2019-10-01 00:00:00

  • Heavy ion-induced DNA double-strand breaks in yeast.

    abstract：:DNA double-strand break (dsb) induction in diploid yeast was measured by neutral sucrose sedimentation after exposure to very heavy ions with values of linear energy transfer (LET) ranging from about 300 to 11500 ke V/microns. Linear fluence dependencies were found in all cases from which dsb production cross-sections...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553009214552121

    authors： Akpa TC,Weber KJ,Schneider E,Kiefer J,Frankenberg-Schwager M,Harbich R,Frankenberg D

    更新日期：1992-09-01 00:00:00

  • Lack of correlation between ATM protein expression and tumour cell radiosensitivity.

    abstract：PURPOSE:Cells derived from individuals in which the ataxia telangiectasia (ATM) gene is mutated are hypersensitive to ionizing radiation. Whether differences in ATM protein levels exist among human malignant glioma cell lines and whether such differences are correlated with cellular radiosensitivity were determined. M...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530098141591

    authors： Chan DW,Gately DP,Urban S,Galloway AM,Lees-Miller SP,Yen T,Allalunis-Turner J

    更新日期：1998-08-01 00:00:00

  • Stable chromosomal aberrations in haemopoietic stem cells in the blood of radiation accident victims.

    abstract：PURPOSE:The detection of long-term persistent chromosome aberrations in circulating haemopoietic stem cells after accidental radiation exposure. MATERIAL AND METHODS:Peripheral blood samples from highly exposed persons were collected 7-25 years after the radiation accidents in Moscow (1971), Kazan (1975) and Chernobyl...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530099139395

    authors： Kreja L,Greulich KM,Fliedner TM,Heinze B

    更新日期：1999-10-01 00:00:00

  • The molecular biology of radiation-induced carcinogenesis: thymic lymphoma, myeloid leukaemia and osteosarcoma.

    abstract：:In mice, external X- or gamma-irradiation may induce thymic lymphomas or myeloid leukaemias, while bone-seeking alpha-emitters may induce osteosarcomas and, to a lesser extent, acute myeloid leukaemia. The present paper aims to review briefly some of the experimental data with respect to the molecular mechanisms under...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章,评审

    doi：10.1080/09553009014550851

    authors： Janowski M,Cox R,Strauss PG

    更新日期：1990-04-01 00:00:00

  • A novel vertebrate system for the examination and direct comparison of the relative biological effectiveness for different radiation qualities and sources.

    abstract：PURPOSE:The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation. AIM:The aim of this paper was to test the relative biological effectiveness ...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/09553002.2018.1511928

    authors： Szabó ER,Reisz Z,Polanek R,Tőkés T,Czifrus S,Pesznyák C,Biró B,Fenyvesi A,Király B,Molnár J,Brunner S,Daroczi B,Varga Z,Hideghéty K

    更新日期：2018-11-01 00:00:00

  • Modification of survival by DNA repair modifiers: a probable explanation for the phenomenon of increased radioresistance.

    abstract：PURPOSE:The low dose (<1 Gy) survival curve of mammalian cells is characterized by a region of hypersensitivity (HRS) followed by increased resistance (IRR). Above 1 Gy, the survival response can be described with a smooth downward-bending curve. Indirect evidence has indicated that the IRR response might reflect an in...

    journal_title：International journal of radiation biology

    pub_type： 杂志文章

    doi：10.1080/095530000138646

    authors： Marples B,Joiner MC

    更新日期：2000-03-01 00:00:00