Abstract:
PURPOSE:To study the absorptive function of rat colon following whole-body exposure to neutron irradiation, either to the same total dose with varying proportion of neutrons or to the same neutron proportion with an increasing irradiation dose. MATERIALS AND METHODS:Different proportions of neutron irradiation were produced from the reactor SILENE using a fissile solution of uranium nitrate (8, 47 and 87% neutron). Water and electrolyte fluxes were measured in the rat in vivo under anaesthesia by insertion into the descending colon of an agarose gel cylinder simulating the faeces. Functional studies were completed by histological analyses. In the first set of experiments, rats received 3.8 Gy with various neutron percentages and were studied from 1 to 14 days after exposure. In the second set of experiments, rats were exposed to increasing doses of irradiation (1-4Gy) with a high neutron percentage (87%n) and were studied at 4 days after exposure. RESULTS AND CONCLUSIONS:The absorptive capacity of rat colon was diminished by irradiation at 3-5 days, with a nadir at 4 days. The results demonstrate that an increase in the neutron proportion is associated with an amplification of the effects. Furthermore, a delay in the re-establishment of normal absorption was observed with the high neutron proportion (87%n). A dose-dependent reduction of water absorption by rat colon was also observed following neutron irradiation (87%n), with a 50% reduction at 3 Gy. Comparison of this dose-effect curve with the curve obtained following gamma (60)Co-irradiation indicates an RBE of 2.2 for absorptive colonic function in rat calculated at 4 days after exposure.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Dublineau I,Ksas B,Joubert C,Aigueperse J,Gourmelon P,Griffiths NMdoi
10.1080/0955300021000019221subject
Has Abstractpub_date
2002-12-01 00:00:00pages
1127-38issue
12eissn
0955-3002issn
1362-3095pii
LYEHY2VN7G91KTY6journal_volume
78pub_type
杂志文章abstract::A/J and C57BL/6J mice, strains which differ in susceptibility to chemical-induced lung tumours, were examined for differential sensitivity to radon-induced lung cancer. Sixty weeks after exposure to 952 WLM radon (3.34 J h1 m-3), no lung tumours were found in the control, sham- (one dust-) exposed, or radon-exposed C5...
journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/095530097144184
更新日期:1997-03-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of radiation biology
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doi:10.1080/095530098142419
更新日期:1998-03-01 00:00:00
abstract:PURPOSE:The impact of the damage distribution to cellular survival and chromosomal aberrations following high Linear Energy Transfer (LET) radiation was investigated. MATERIALS AND METHODS:High LET iron-ions (500 MeV/n, LET 200 keV/μm) were delivered to G1-phase synchronized Chinese Hamster Ovary (CHO) cells located a...
journal_title:International journal of radiation biology
pub_type: 杂志文章
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abstract::I calculate the probability that a single high-energy ionizing particle or photon makes two widely spaced double-strand breaks in the same DNA molecule. Deletions (or inversions) between two breaks formed by the same incident particle are linear in radiation dose and occur even at extremely low dose-rates; deletions b...
journal_title:International journal of radiation biology
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journal_title:International journal of radiation biology
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pub_type: 杂志文章,评审
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doi:10.3109/09553002.2012.698366
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journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553002.2016.1206235
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journal_title:International journal of radiation biology
pub_type: 杂志文章
doi:10.1080/09553009214550601
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journal_title:International journal of radiation biology
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更新日期:2008-08-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:1997-12-01 00:00:00
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