TGF-beta1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype.

abstract：PURPOSE:5-Formyluracil (5-foU) is a major derivative of thymine produced in DNA by ionizing radiation and various chemical oxidants. It has been previously shown that 5-foU in template DNA directs misincorporation of nucleotides by DNA polymerases during in vitro DNA synthesis. The present experiments were designed to ...

journal_title：International journal of radiation biology

authors： Miyabe I,Zhang QM,Sugiyama H,Kino K,Yonei S

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To study the relationship between cell reproductive death and exchange frequency in SW-1573 human lung tumour cells with and without incorporated iodo-deoxyuridine (IdUrd) following irradiation of plateau-phase cultures with y-rays. METHOD:Linear-quadratic (LQ) analysis was performed for the data on clonogenic...

journal_title：International journal of radiation biology

authors： Franken NA,Ruurs P,Ludwików G,van Bree C,Kipp JB,Darroudi F,Barendsen GW

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:The space environment contains two major biologically significant influences; space radiations and microgravity. The 53 kDa tumour suppressor protein (p53) plays a role as a guardian of the genome through the activity of p53-centered signal transduction pathways. The aim of this study was to clarify the biologi...

journal_title：International journal of radiation biology

authors： Takahashi A,Suzuki H,Omori K,Seki M,Hashizume T,Shimazu T,Ishioka N,Ohnishi T

更新日期：2010-08-01 00:00:00

abstract：:Single crystals of cytosine hydrochloride with thiocytosine as an impurity were found suitable for the study of a possible new mechanism of long-range migration of energy deposited by ionizing radiation. In a crystal containing thiocytosine, two kinds of chlorine-containing paramagnetic centres are present that are co...

journal_title：International journal of radiation biology

authors： Herak JN,Sankovic K,Hütterman J

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:The radiation-induced bystander effect (RIBE) has important implications for the efficiency of radiotherapy but the underlying role of cellular metabolism is widely unknown. The roles of synthesis of cytochrome c oxidase 2 (SCO2), a key effector for respiratory chain, and related signaling factors in α-particle...

journal_title：International journal of radiation biology

authors： Li J,He M,Shen B,Yuan D,Shao C

更新日期：2013-12-01 00:00:00

abstract：:The effect of heat (43-45 degrees C) on the induction and the repair of DNA double-strand breaks (dsb) was studied in CHO cells after 60 Gy of X-rays using constant-field gel electrophoresis. Heat given prior to irradiation was found not to alter the number of dsb when measured immediately after irradiation. In non-he...

journal_title：International journal of radiation biology

authors： Dahm-Daphi J,Brammer I,Dikomey E

更新日期：1997-08-01 00:00:00

abstract：:A study has been made of the intrinsic radiosensitivity of peripheral blood lymphocytes from normal individuals. Cell survival following in vitro high (1.55 Gy min-1) and low (0.0098 Gy min-1) dose-rate irradiation was obtained for single lymphocyte samples from three individuals in six experiments. Despite wide inter...

journal_title：International journal of radiation biology

authors： Elyan SA,West CM,Roberts SA,Hunter RD

更新日期：1993-10-01 00:00:00

abstract：:The kinetic scheme of the reaction of desferrioxamine (DFO) with O2-. was studied using pulse and gamma-radiolysis. The rate constant k(O2-. + DFO) is equal to 1.3 +/- 0.1 x 10(6) dm3 mol-1s-1 at pH 7.4. Studying the competition between DFO and ferricytochrome-c for O2-. generated by gamma-radiolysis, we observed that...

journal_title：International journal of radiation biology

authors： Sabourault D,Ribiere C,Nordmann R,Houee-Levin C,Ferradini C

更新日期：1989-12-01 00:00:00

abstract：PURPOSE:To find detectable cytogenetic biomarkers that can offer information about the radiation quality of in vivo exposure retrospectively. MATERIALS AND METHODS:Chromosome-type aberrations of peripheral lymphocytes of uterine cancer patients that received internal gamma- and external X-ray therapy or carbon beam th...

journal_title：International journal of radiation biology

authors： Kanda R,Minamihisamatsu M,Tsuji S,Ohmachi Y,Hiraoka T,Shimada Y,Ogiu T,Ohno T,Hayata I

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:MRL-lpr/lpr mice, a model for various autoimmune diseases, were repeatedly irradiated with 0.5 Gy of gamma-rays, and changes in their autoimmune manifestations were investigated. MATERIALS AND METHODS:MRL-lpr/lpr mice at 13 weeks of age were maintained in plastic cages and exposed whole-body to 0.5 Gy gamma-ra...

journal_title：International journal of radiation biology

authors： Tanaka T,Tago F,Fang SP,Shimura N,Kojima S

更新日期：2005-10-01 00:00:00

abstract：:Radiation-resistant L5178Y-R (LY-R) and radiation-sensitive L5178Y-S (LY-S) murine lymphoma cells were X-irradiated and their free Ca2+ concentration was examined with Fura-2 in Ca2(+)-free salt solution. The release of free Ca2+ from intracellular stores was linear between 10 and 60 min after irradiation (1-5 Gy X-ra...

journal_title：International journal of radiation biology

authors： Szumiel I,Sochanowicz B,Buraczewska I

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases. Emphasis was placed on the estimation of the respective contribution of direct ionization and indirect effects, mostly by comparison with low linear energy transfer (LET) g...

journal_title：International journal of radiation biology

authors： Douki T,Ravanat JL,Pouget JP,Testard I,Cadet J

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To examine how folate status influences chromosomal damage following X-ray irradiation. MATERIAL AND METHODS:In an animal study, mice were fed either a low, basal, or high folic acid diet (0, 2, or 40 mg/kg diet, respectively) for 4 weeks, and then given total body irradiation (TBI) at 0.5 Gy. In a human study...

journal_title：International journal of radiation biology

authors： Endoh K,Murakami M,Araki R,Maruyama C,Umegaki K

更新日期：2006-04-01 00:00:00

abstract：:We have previously described a cell-free assay that can be employed to study rejoining of radiation-induced DNA double-stranded breaks (dsb) in 'naked' DNA prepared from agarose-embedded cells using an extract of HeLa cells as a source of enzymes. Rejoining of dsb in this assay is absolutely dependent on cell extract ...

journal_title：International journal of radiation biology

authors： Cheong N,Iliakis G

更新日期：1997-04-01 00:00:00

abstract：:Purpose: Ionizing radiation is a risk factor to the whole organism, including the heart. Cardiac damage is considered to be a late effect of radiation exposure. While the acute cardiotoxicity of high doses is well characterized, the knowledge about nature and magnitude of the cardiac risk following lower doses exposur...

journal_title：International journal of radiation biology

authors： Gramatyka M,Sokół M

更新日期：2020-03-01 00:00:00

abstract：:Determinations of cell sensitivity in terms of survival fraction after doses employed in clinical radiation therapy, say 1-3 Gy, are of increasing interest to clinicians as they provide direct experimental data which can be employed without reference to models of cell inactivation. SF2 values are expected ultimately t...

journal_title：International journal of radiation biology

authors： Suit HD,Baumann M,Skates S,Convery K

更新日期：1989-11-01 00:00:00

abstract：:The aim was to identify the decorporation and anti-oxidation efficacy of prompt and delayed consecutive administration of the catecholicpolyaminopolycarboxylate ligands 9501 and 7601 for radiothorium in vivo. The chelating agents 9501 or 7601 were administered intramuscularly to ICR mice 3 min or 3 days after intraper...

journal_title：International journal of radiation biology

authors： Chen H,Luo M,Sun M,Hu Y,Wang Y,Jin M,Cheng W

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:A minority of patients exhibits severe late normal tissue toxicity after radiotherapy (RT), possibly related to their inherent individual radiation sensitivity. This study aimed to evaluate four different candidate in vitro cellular radiosensitivity assays for prediction of late normal tissue reactions, in a re...

journal_title：International journal of radiation biology

authors： Vandevoorde C,Depuydt J,Veldeman L,De Neve W,Sebastià N,Wieme G,Baert A,De Langhe S,Philippé J,Thierens H,Vral A

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Radiation-induced bystander effects have important implications in radiotherapy. Their persistence in normal cells may contribute to risk of health hazards, including cancer. This study investigates the role of radiation quality and gap junction intercellular communication (GJIC) in the propagation of harmful e...

journal_title：International journal of radiation biology

authors： Autsavapromporn N,Plante I,Liu C,Konishi T,Usami N,Funayama T,Azzam EI,Murakami T,Suzuki M

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The actinides are chemical poisons and radiological hazards. One challenge to better appraise their toxicity and develop countermeasures in case of exposure of living organisms is to better assess pathways of contamination. Because of the high chemical affinity of those actinide elements for phosphate groups an...

journal_title：International journal of radiation biology

authors： Mostapha S,Fontaine-Vive F,Berthon L,Boubals N,Zorz N,Solari PL,Charbonnel MC,Den Auwer C

更新日期：2014-11-01 00:00:00

abstract：:We have measured clonal survival following gamma-irradiation of unstimulated (G0) T-lymphocytes from 35 donors, of 11 T-lymphocyte cell lines, of six lymphoblastoid cell lines, and of nine primary fibroblast strains for which we have G0 T-lymphocyte material from the same donor. Amongst the G0 lymphocytes we have resu...

journal_title：International journal of radiation biology

authors： Cole J,Arlett CF,Green MH,Harcourt SA,Priestley A,Henderson L,Cole H,James SE,Richmond F

更新日期：1988-12-01 00:00:00

abstract：:SR 2508 (etanidazole) (1 mM) or buthionine sulphoximine (BSO, 50 microM) or both drugs together did not radiosensitize oxic V79 Chinese hamster cells irradiated at either an acute dose rate (2.35 Gy/min) or at a low dose rate (0.117 Gy/min). BSO pretreatment (15 h at 37 degrees C) depleted cellular glutathione (GSH) t...

journal_title：International journal of radiation biology

authors： Wong RS,Basas RA,Ling CC

更新日期：1991-01-01 00:00:00

abstract：:The radiation survival response of asynchronously-dividing populations of the cell line V79-WNRE indicates substructure in the low dose region that can be better characterized by separately fitting the data within the low and high dose regions to the linear-quadratic (LQ) equation. Flow cytometry and cell sorting tech...

journal_title：International journal of radiation biology

authors： Skwarchuk MW,Wouters BG,Skarsgard LD

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:High dose ionizing radiation exposure is associated with myelo-depression leading to pancytopenia and the expected clinical manifestations of acute radiation syndrome (ARS). Herein, we evaluated the efficacy of sargramostim (Leukine®, yeast-derived rhu GM-CSF), with regimens delivered at 48, 72, 96, or 120 h...

journal_title：International journal of radiation biology

authors： Zhong Y,Pouliot M,Downey AM,Mockbee C,Roychowdhury D,Wierzbicki W,Authier S

更新日期：2020-09-22 00:00:00

abstract：:Samples of human rib were collected at autopsy and 20 were selected for marrow fat cell measurement, representing an age range of 16-96 years. The mean diameter of fat cells in red bone marrow of human rib was found to increase from around 48 microns at ages 16-29 years to around 65 microns at ages 82-96 years. There ...

journal_title：International journal of radiation biology

authors： Allen JE,Henshaw DL,Keitch PA,Fews AP,Eatough JP

更新日期：1995-12-01 00:00:00

abstract：PURPOSE:To reduce retention and toxicity of the alpha particle emitter polonium-210 in rats by newly developed chelating agents. MATERIALS AND METHODS:Repeated subcutaneous chelation was conducted after intravenous injection of 210Po nitrate. For reduction of 210Po retention the treatment with vicinal dithiols meso-an...

journal_title：International journal of radiation biology

authors： Rencová J,Volf V,Jones MM,Singh PK

更新日期：2000-10-01 00:00:00

abstract：:A new approach is reported that combines synchrotron radiolysis and mass spectrometry to probe the structure of proteins. Hydroxyl radicals produced upon the radiolysis of protein solutions using synchrotron light modify amino acid side-chains on millisecond timescales. This results in the formation of stable oxidatio...

journal_title：International journal of radiation biology

authors： Kiselar JG,Maleknia SD,Sullivan M,Downard KM,Chance MR

更新日期：2002-02-01 00:00:00

abstract：:PACE (programmable, autonomously controlled electrodes) pulsed field gel electrophoresis technology was used to develop a DNA double-strand break assay that simultaneously combined (1) resolution across a broad range of DNA sizes, (2) high sensitivity (in terms of detecting dsb at low doses) and (3) speed. A 48 h PACE...

journal_title：International journal of radiation biology

authors： Elia MC,Nichols WW

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To investigate the induction and persistence of chromosome aberrations in mouse bone marrow cells after X-ray exposure and to detect differential involvement of individual chromosomes in translocations. MATERIALS AND METHODS:Male and female Swiss mice were exposed to 1 and 3 Gy of X-rays. Chromosome aberration...

journal_title：International journal of radiation biology

authors： Xiao Y,Darroudi F,Grigorova M,Natarajan AT

更新日期：1999-09-01 00:00:00

abstract：:Cells use substrates such as glucose and glutamine to provide energy for repair of radiation damage. Glutaminolysis and glycolysis were inhibited by aminooxyacetic acid (AOAA) and 2-deoxyglucose (2DG), respectively, to inhibit metabolism of these substrates in order to determine the effect on radiation response of CHO...

journal_title：International journal of radiation biology

authors： Hunter AJ,Blekkenhorst GH

更新日期：1998-03-01 00:00:00