Abstract:
:Radiation-resistant L5178Y-R (LY-R) and radiation-sensitive L5178Y-S (LY-S) murine lymphoma cells were X-irradiated and their free Ca2+ concentration was examined with Fura-2 in Ca2(+)-free salt solution. The release of free Ca2+ from intracellular stores was linear between 10 and 60 min after irradiation (1-5 Gy X-rays) and was higher in LY-S than in LY-R cells. Pre-treatment with 2 mM benzamide (Bz) further increased the concentration of free Ca2+ in LY-S cells but not in LY-R cells. In contrast with LY-R cells, LY-S cells had previously been found to be radiosensitized by continuous 2 mM Bz treatment (Szumiel et al. 1984b). Thus, there was a parallel effect of Bz on survival and on the increase in free Ca2+ concentration in LY cells. Moreover, the rates of Ca2+ release after irradiation with 1-5 Gy of X-rays with or without Bz treatment were inversely related to the respective surviving fractions of LY cells.
journal_name
Int J Radiat Bioljournal_title
International journal of radiation biologyauthors
Szumiel I,Sochanowicz B,Buraczewska Idoi
10.1080/09553009014551481subject
Has Abstractpub_date
1990-07-01 00:00:00pages
125-31issue
1eissn
0955-3002issn
1362-3095pii
JLXWG2JPNV1FVT53journal_volume
58pub_type
杂志文章abstract:PURPOSE:In a previous study, we found that exposure to a 50 Hz magnetic field (MF) could activate stress-activated protein kinase (SAPK) and P38 mitogen-activated protein (MAP) kinase (P38 MAPK) in Chinese hamster lung (CHL) fibroblast cells, and simultaneous exposure to a 'noise' MF of the same intensity inhibited the...
journal_title:International journal of radiation biology
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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更新日期:1991-03-01 00:00:00
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journal_title:International journal of radiation biology
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更新日期:1992-12-01 00:00:00
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journal_title:International journal of radiation biology
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abstract::The repair activity of verbascoside (VER), isolated from Pedicularis spicata, towards the oxidizing hydroxyl radical adduct of dGMP and its reaction mechanism were studied using pulse radiolysis. Upon pulse radiolysis of nitrous oxide saturated aqueous solution of 2'-deoxyguanosine-5'-monophosphate (dGMP) and VER, it ...
journal_title:International journal of radiation biology
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更新日期:1996-04-01 00:00:00
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更新日期:1999-07-01 00:00:00
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更新日期:2002-12-01 00:00:00
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doi:10.1080/09553009314551971
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journal_title:International journal of radiation biology
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更新日期:1997-11-01 00:00:00
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更新日期:2020-11-16 00:00:00
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更新日期:1989-02-01 00:00:00
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journal_title:International journal of radiation biology
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doi:10.1080/09553009514550941
更新日期:1995-07-01 00:00:00
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journal_title:International journal of radiation biology
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doi:
更新日期:1994-12-01 00:00:00
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更新日期:1998-09-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:2000-09-01 00:00:00
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更新日期:2002-05-01 00:00:00
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journal_title:International journal of radiation biology
pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
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更新日期:2014-07-01 00:00:00
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更新日期:2010-02-01 00:00:00
abstract:PURPOSE:This study evaluates early changes in human mesenchymal stem cells (MSC) isolated from dental pulp and periodontal ligament after γ-irradiation and the effect of ataxia-telangiectasia mutated (ATM) inhibition. METHODS:MSC were irradiated with 2 and 20 Gy by (60)Co. For ATM inhibition, specific inhibitor KU5593...
journal_title:International journal of radiation biology
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更新日期:2003-06-01 00:00:00