Repair of potentially lethal damage by introduction of T4 DNA ligase in eucaryotic cells.

abstract：PURPOSE:The present work summarises the history and current status of research into the importance of cancer stem cells for radiobiological research and for clinical radiation oncology. An effort is made to differentiate clonogenicity from stemness of cancer cells. CONCLUSION:In radiooncology, cancer stem cells have b...

journal_title：International journal of radiation biology

authors： Baumann M,Krause M,Thames H,Trott K,Zips D

更新日期：2009-05-01 00:00:00

abstract：:The recently released data on cancer incidence in the Japanese atomic bomb survivors are analysed using a variety of relative risk models which take account of errors in estimates of dose to assess the dose-response at low doses. For all solid cancers analysed together there is a significant positive dose-response (at...

journal_title：International journal of radiation biology

authors： Little MP,Muirhead CR

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:To test the importance of serotonin as a signaling molecule involved in the production and response of radiation-induced bystander effects. MATERIALS AND METHODS:HPV-G human keratinocyte cultures were spiked with various concentrations of Granisetron or Ketanserin and subject to either 0 Gy or 0.5 Gy X-irradia...

journal_title：International journal of radiation biology

authors： Fazzari J,Mersov A,Smith R,Seymour C,Mothersill C

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Effects of radiation on the differentiation of C2C12 myoblasts were studied using cell cultures in which the cells differentiated into either muscle cells or osteoblasts. MATERIALS AND METHODS:A mouse skeletal myoblast cell line, C2C12, was cultured and irradiated at confluence. Muscle differentiation was esti...

journal_title：International journal of radiation biology

authors： Ikeda S,Hachisu R,Yamaguchi A,Gao YH,Okano T

更新日期：2000-03-01 00:00:00

abstract：:Free radical formation in aqueous solutions of ubiquinone (coenzyme Qo) induced by ultrasound was studied by EPR and spin trapping with 3,5-dibromo-4-nitrosobenzene sulphonate. When aqueous solutions of ubiquinone were sonicated with 50-kHz ultrasound in the presence of argon or nitrogen, radicals formed by addition o...

journal_title：International journal of radiation biology

authors： Kondo T,Riesz P

更新日期：1996-01-01 00:00:00

abstract：:Pulsed-field electrophoresis is being used extensively in the gene mapping studies and in the analysis of DNA strand breakage by ionizing radiation. We have evaluated the relationship between the fraction of S phase DNA in a cell population and its ability to modify the migration of DNA in pulsed-field gel electrophor...

journal_title：International journal of radiation biology

authors： Mateos S,Gordon AT,Steel GG,McMillan TJ

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:The effects of radiation +/- hypogravity on immunologic function were investigated using the Partial Weight Suspension (PWS) model ( Wagner et al. 2010 ). MATERIALS AND METHODS:Mice were exposed to 0.5, 1, or 2 Gray (Gy) dose of gamma radiation and then placed in the PWS system for 4, 24, 48 hours, or 4 days. ...

journal_title：International journal of radiation biology

authors： Sanzari JK,Wilson JM,Wagner EB,Kennedy AR

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:DNA damage is one of the main consequences of exposure to ionizing irradiation (IR). Recent studies indicate that IR can modulate the expression of immune system-related genes. However, the effects of IR on the expression of genes and pathways of the B7-CD28 superfamily remain poorly defined. The aim of this st...

journal_title：International journal of radiation biology

authors： Silveira DA,Ribeiro FM,Simão ÉM,Mattos VLD,Góes EG

更新日期：2020-12-17 00:00:00

abstract：:The past recommendations of the ICRP about dose limits to the skin are reviewed. Recently, an ICRP Task Group has been revisiting the old arguments and setting them against new data. With the exception of the function of cells in the skin associated with immunocompetence, non-stochastic effects have been well characte...

journal_title：International journal of radiation biology

authors： Fry RJ

更新日期：1990-04-01 00:00:00

abstract：:Photoirradiation of aqueous solutions of DNA in the presence of Al- or Zn-tetrasulphonated phthalocyanines (AIPcS4 and ZnPcS4) causes formation of strand breaks and liberation of nucleobases. The effect of added D2O, which enhances singlet oxygen (1O2) lifetime, radical scavengers including alcohols and the spin-trap ...

journal_title：International journal of radiation biology

authors： Gantchev TG,Gowans BJ,Hunting DJ,Wagner JR,van Lier JE

更新日期：1994-12-01 00:00:00

abstract：:We characterized in vitro the effects of gamma-radiation (12.5-100 cGy) on pulmonary microvascular endothelial cell (PMEC) morphology and F-actin organization. Cellular retraction was documented by phase-contrast microscopy and the organization of actin microfilaments was determined by immunofluorescence. Characteriza...

journal_title：International journal of radiation biology

authors： Kantak SS,Diglio CA,Onoda JM

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:Although the significance of cell cycle checkpoints in overcoming low-dose hyper-radiosensitivity (HRS) has been proposed, the underlying mechanism of HRS in human hepatocellular cells remains unclear. Therefore, the aim of this study was to characterize HRS inhuman hepatocellular HepG2 cells and to explore the...

journal_title：International journal of radiation biology

authors： Xue J,Zong Y,Li PD,Wang LX,Li YQ,Niu YF

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Ionizing radiation causes various types of DNA damage e.g. single strand breaks (SSB) and double strand breaks (DSB), whereby the SSB/DSB ratio is shifted toward the DSB with increasing LET. For the DNA-incorporated Auger electron emitter Iodine-125 a SSB/DSB ratio of 5.4:1 is calculated based on computer simul...

journal_title：International journal of radiation biology

authors： Unverricht-Yeboah M,Holtmann K,Kriehuber R

更新日期：2020-12-03 00:00:00

abstract：:Radiation-induced myocardial degeneration in the rat is preceded by changes in capillary structure and function, which may be a major factor in the pathogenesis of radiation-induced heart disease. In order to investigate the mechanism of capillary damage we studied endothelial cell proliferation in untreated control r...

journal_title：International journal of radiation biology

authors： Lauk S,Trott KR

更新日期：1990-05-01 00:00:00

abstract：:Purpose: This review discusses recent developments in our understanding of biological and physiological mechanisms underlying radiation cataractogenesis. The areas discussed include effects of low-dose exposures to the lens including potential relevance of non-targeted effects, the development of new personal-protecti...

journal_title：International journal of radiation biology

authors： Laskowski L,Williams D,Seymour C,Mothersill C

更新日期：2020-05-26 00:00:00

abstract：:The studies of the late effects of atomic-bomb (A-bomb) radiation on the immune system were started about 20 years after the bombings in 1945. The most remarkable late effects of radiation are the functional and quantitative abnormalities of T and B cells in survivors exposed to high doses (> or = 1.0 Gy). Abnormaliti...

journal_title：International journal of radiation biology

authors： Akiyama M

更新日期：1995-11-01 00:00:00

abstract：:The rate of recovery from radiation damage, as a function of dose per fraction, was investigated in mouse skin. Two different experimental designs were used, both incorporating the neutron top-up technique which enables the X-ray dose per fraction to be kept constant whilst changing the interfraction interval. Either ...

journal_title：International journal of radiation biology

authors： Rojas A,Joiner MC,Johns H

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:The main aim of the present study is to gain mechanistic insights into the modulating effect of molecular hydrogen on the γ-radiation-induced alteration pathways of DNA nucleobases. MATERIALS AND METHODS:Aerated aqueous solutions of calf thymus DNA were exposed to a (60)Co source at doses ranging from 0 to 55 ...

journal_title：International journal of radiation biology

authors： Abou-Hamdan M,Gardette B,Cadet J,Gharib B,De Reggi M,Douki T,Triantaphylides C

更新日期：2016-09-01 00:00:00

abstract：:The aim was to investigate further the relationship between radiation-induced mitotic delay and the expression of chromosome damage in V79 cells. Recently published data on the time-course of chromosome aberrations in V79 first-cycle metaphases after exposure to 10.4 MeV u(-1) Ar ions (LET = 1226 keV microm(-1)) were ...

journal_title：International journal of radiation biology

authors： Gudowska-Nowak E,Kleczkowski A,Nasonova E,Scholz M,Ritter S

更新日期：2005-01-01 00:00:00

abstract：:A novel 2-nitroimidazole with a theophylline side-chain, 7-(4'-(2-nitroimidazol-1-yl)-butyl)-theophylline, (NITP) was as efficient a hypoxic-cell radiosensitizer as misonidazole. However, if cells were irradiated with NITP under hypoxic conditions and then exposed to the drug under aerobic conditions, a much larger ra...

journal_title：International journal of radiation biology

authors： Hodgkiss RJ,Kelleher E,Parrick J

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:To study the influence of TGF-beta1 and TGF-beta-neutralizing antibodies on the clonogenic activity and terminal differentiation of rat lung fibroblasts following radiation exposure. MATERIAL AND METHODS:Early passage rat lung fibroblasts were used in this study. Colony formation assays were applied to determi...

journal_title：International journal of radiation biology

authors： Hakenjos L,Bamberg M,Rodemann HP

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:To investigate whether an adaptive response can be induced in mice which were pre-exposed to 900 MHz radiofrequency fields. MATERIALS AND METHODS:Adult male Kunming mice were exposed to 900 MHz radiofrequency fields (RF) at power intensities of 12, 120 and 1200 μW/cm(2) for 1 h/day for 14 days and then subject...

journal_title：International journal of radiation biology

authors： Cao Y,Xu Q,Jin ZD,Zhou Z,Nie JH,Tong J

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:The hemorrhagic syndrome is a major cause of morbidity and mortality associated with the acute radiation syndrome (ARS). We previously characterized the dose-response relationship for total body irradiation (TBI)-induced ARS in the New Zealand White (NZW) rabbit. Thrombocytopenia, hemorrhage, and anemia were st...

journal_title：International journal of radiation biology

authors： Jackson IL,Gurung G,Ayompe E,Fown ER,Triesler S,Mali B,Casildo A,Gibbs A,Poirier Y,Cohen EP,Newman D,Vujaskovic Z

更新日期：2020-10-16 00:00:00

abstract：:Cell killing and the production of DNA double-strand breaks (dsbs) were measured in parallel for V79 cells and a human tumour cell line (Caski) following exposure to radiations of differing linear energy transfer (LET) including accelerated heavy ions. Dsb induction was assessed by neutral filter elution (pH 7.4) and ...

journal_title：International journal of radiation biology

authors： Weber KJ,Flentje M

更新日期：1993-08-01 00:00:00

abstract：PURPOSE:Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the two copies of the BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although the precise function of the proteins is still not known. Some studies on a small num...

journal_title：International journal of radiation biology

authors： Nieuwenhuis B,Van Assen-Bolt AJ,Van Waarde-Verhagen MA,Sijmons RH,Van der Hout AH,Bauch T,Streffer C,Kampinga HH

更新日期：2002-04-01 00:00:00

abstract：:Terminally differentiated cells usually do not divide and are, thus, reproductively dead. To elucidate the significance of radiation-enhanced differentiation to reproductive cell death, murine erythroid progenitor cells were gamma-irradiated in plasma clot cultures and the development of haemoglobinized clones was stu...

journal_title：International journal of radiation biology

authors： Schwenke K,Peterson HP,von Wangenheim KH,Feinendegen LE

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:Human diseases associated with acute radiation responses are rare genetic disorders with common clinical and biological features including radiosensitivity, genomic instability, chromosomal aberrations, and frequently immunodeficiency. To determine what molecular assays are predictive of cellular radiosensitivi...

journal_title：International journal of radiation biology

authors： Joubert A,Zimmerman KM,Bencokova Z,Gastaldo J,Chavaudra N,Favaudon V,Arlett CF,Foray N

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:We already reported that levels of interferon (IFN)-γ have been shown to be markedly reduced in mice seven weeks after irradiation, resulting in a T helper (Th) 1/Th2 imbalance. To investigate whether the single or fractionated γ-irradiation induced an immune imbalance, we analysed the Th1-related immune respon...

journal_title：International journal of radiation biology

authors： Park HR,Jo SK,Eom HS

更新日期：2011-05-01 00:00:00

abstract：:This paper presents a summary of our understanding to date of the formation of DNA strand breaks induced by highly energetic particle beams (high-LET radiation). We have compared our own recent data on the formation of strand breaks induced in DNA in an aqueous solution with our previous data and those of others avail...

journal_title：International journal of radiation biology

authors： Roots R,Holley W,Chatterjee A,Irizarry M,Kraft G

更新日期：1990-07-01 00:00:00

abstract：:I calculate the probability that a single high-energy ionizing particle or photon makes two widely spaced double-strand breaks in the same DNA molecule. Deletions (or inversions) between two breaks formed by the same incident particle are linear in radiation dose and occur even at extremely low dose-rates; deletions b...

journal_title：International journal of radiation biology

authors： Hutchinson F

更新日期：1996-11-01 00:00:00