On the genetic background of the adaptive response to X-rays in Drosophila melanogaster.

abstract：PURPOSE:Solar energy has a number of short- and long-term detrimental effects on skin that can result in several skin disorders. The aim of this review is to summarise current knowledge on endogenous systems within the skin for protection from solar radiation and present research findings to date, on the exogenous opti...

journal_title：International journal of radiation biology

authors： Svobodová A,Vostálová J

更新日期：2010-12-01 00:00:00

abstract：:DNA neutral (pH 9.6) filter elution was used to measure radiation-induced DNA double-strand break (dsb) frequencies in eight human squamous cell carcinoma cell lines with radiosensitivities (D0) ranging from 1.07 to 2.66 Gy and D values ranging from 1.46 to 4.08 Gy. The elution profiles of unirradiated samples from mo...

journal_title：International journal of radiation biology

authors： Schwartz JL,Mustafi R,Beckett MA,Czyzewski EA,Farhangi E,Grdina DJ,Rotmensch J,Weichselbaum RR

更新日期：1991-06-01 00:00:00

abstract：PURPOSE:The tandemly repeated hexamers (TTAGGG)n present at the telomeric ends protect the human genome from a variety of environmental exposures including ionizing radiation. In order to find out the effect of chronic low dose radiation exposure, we have determined telomere length among newborns from high level natura...

journal_title：International journal of radiation biology

authors： Das B,Saini D,Seshadri M

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:Epidemiological studies have demonstrated a possible correlation between exposure to extremely low-frequency magnetic fields (ELF-MF) and cancer. However, this correlation has yet to be definitively confirmed by epidemiological studies. The principal objective of this study was to assess the effects of 60 Hz ma...

journal_title：International journal of radiation biology

authors： Jin YB,Kang GY,Lee JS,Choi JI,Lee JW,Hong SC,Myung SH,Lee YS

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:To investigate the effect of lupeol, a pentacyclictriterpene, on the radiosensitivity of a human hepatocellular carcinoma (HCC) in vitro and in vivo xenografts. METHODS:SMMC-7721 cells were exposed to γ-radiation with or without lupeol and assayed for proliferation, clonogenic survival, apoptosis and cell cycl...

journal_title：International journal of radiation biology

authors： Jin Y,Lyu Y,Tang X,Zhang Y,Chen J,Zheng D,Liang Y

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:This study evaluates early changes in human mesenchymal stem cells (MSC) isolated from dental pulp and periodontal ligament after γ-irradiation and the effect of ataxia-telangiectasia mutated (ATM) inhibition. METHODS:MSC were irradiated with 2 and 20 Gy by (60)Co. For ATM inhibition, specific inhibitor KU5593...

journal_title：International journal of radiation biology

authors： Cmielova J,Havelek R,Kohlerova R,Soukup T,Bruckova L,Suchanek J,Vavrova J,Mokry J,Rezacova M

更新日期：2013-07-01 00:00:00

abstract：:Radiation-induced DNA double-strand breaks (dsbs) were measured in CHO-K1 cells by means of an experimental approach involving constant-field gel electrophoresis and densitometric scanning of ethidium bromide stained gels. For X-irradiation, an induction efficiency of 36 +/- 5 dsbs (Gy x cell)-1 was determined. With t...

journal_title：International journal of radiation biology

authors： Heilmann J,Taucher-Scholz G,Kraft G

更新日期：1995-08-01 00:00:00

abstract：PURPOSE:To study cell damage and possible apoptosis in K562 human erythroleukemic cells exposed for 2 h to an extremely low frequency (ELF) 50 Hz sinusoidal magnetic field with a magnetic induction of either 1 or 5 mT using high resolution proton nuclear magnetic resonance (1H-NMR) spectroscopy. MATERIALS AND METHODS:...

journal_title：International journal of radiation biology

authors： Santini MT,Ferrante A,Romano R,Rainaldi G,Motta A,Donelli G,Vecchia P,Indovina PL

更新日期：2005-02-01 00:00:00

abstract：:The repair activity of verbascoside (VER), isolated from Pedicularis spicata, towards the oxidizing hydroxyl radical adduct of dGMP and its reaction mechanism were studied using pulse radiolysis. Upon pulse radiolysis of nitrous oxide saturated aqueous solution of 2'-deoxyguanosine-5'-monophosphate (dGMP) and VER, it ...

journal_title：International journal of radiation biology

authors： Li W,Zheng R,Su B,Jia Z,Li H,Jiang Y,Yao S,Lin N

更新日期：1996-04-01 00:00:00

abstract：PURPOSE:Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrimental effects of radiation, in part due to the compromised repair of c...

journal_title：International journal of radiation biology

authors： Cunniffe S,Walker A,Stabler R,O'Neill P,Lomax ME

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:To present details of the recent version of the 'Local Effect Model' (LEM), that has been developed and implemented in treatment planning for the ion beam therapy pilot project performed at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. MATERIALS AND METHODS:The new version of the model i...

journal_title：International journal of radiation biology

authors： Friedrich T,Scholz U,Elsässer T,Durante M,Scholz M

更新日期：2012-01-01 00:00:00

abstract：:One of the important temporal stages of radiation action in cellular systems is the chemical phase, where oxygen fixation reactions compete with chemical repair reactions involving reducing agents such as GSH. Using the gas explosion technique it is possible to follow the kinetics of these fast (greater than 1 ms) rea...

journal_title：International journal of radiation biology

authors： Prise KM,Davies S,Michael BD

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:Terrorist attacks, with their intent to maximize psychological and economic damage as well as inflicting sickness and death on given targeted populations, are an ever-growing worldwide concern in government and public sectors as they become more frequent, violent, and sensational. If given the chance, it is lik...

journal_title：International journal of radiation biology

authors： Singh VK,Hanlon BK,Santiago PT,Seed TM

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Hypoxic cells in tumours are resistant to 5-fluorouracil (5-FU). This in vivo study investigated the ability of hypoxia to regulate the gene expression of thymidylate synthase (TS), the target enzyme of 5-FU. MATERIALS AND METHODS:C3H mammary carcinomas, grown in the feet of female CDF1 mice, were used for all...

journal_title：International journal of radiation biology

authors： Ehrnrooth E,von der Maase H,Sørensen BS,Poulsen JH,Horsman MR

更新日期：1999-07-01 00:00:00

abstract：:Intraoperative irradiation (IORT) is used to enhance local tumour control by using large, single doses while removing critical structures from the treatment field. Peripheral nerve remains a dose-limiting normal tissue that often cannot be removed from the field. To assess ultrastructural changes in canine sciatic ner...

journal_title：International journal of radiation biology

authors： Vujaskovic Z,Gillette SM,Powers BE,Thurmond DN,Gillette EL,Colacchio TA

更新日期：1995-07-01 00:00:00

abstract：:High doses of rHIL-1 protected C3H/HeN mice against lethal radiation damage. The optimum time of radioprotection was found when this cytokine was administered at 4 h and at 20 h before irradiation. The dose reduction factors when the IL-1 was administered at those times were about 1.30. The radioprotection at the opti...

journal_title：International journal of radiation biology

authors： Wu SG,Tuboi A,Miyamoto T

更新日期：1989-10-01 00:00:00

abstract：:Radiologic accidents or terrorist acts involving radioactive material, as well as radiation exposure in medical or industrial procedures are potential sources of risk for human health. All these risks share a common element, exposure to ionizing radiation. The extent of ionizing radiation injury will depend on a numbe...

journal_title：International journal of radiation biology

authors： Soriano JL,Calpena AC,Souto EB,Clares B

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Ifosfamide as a chemotherapeutic drug is used for the treatment of different cancer types. The purpose of this study is the preparation of 99mTc-ifosfamide complex to be evaluated as a potential candidate for tumor imaging. MATERIALS AND METHODS:The radiolabeling of ifosfamide with technetium-99m was carried o...

journal_title：International journal of radiation biology

authors： Motaleb MA,El-Safoury DM,Abd-Alla WH,Awad GAS,Sakr TM

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:DNA damage is one of the main consequences of exposure to ionizing irradiation (IR). Recent studies indicate that IR can modulate the expression of immune system-related genes. However, the effects of IR on the expression of genes and pathways of the B7-CD28 superfamily remain poorly defined. The aim of this st...

journal_title：International journal of radiation biology

authors： Silveira DA,Ribeiro FM,Simão ÉM,Mattos VLD,Góes EG

更新日期：2020-12-17 00:00:00

abstract：:The studies of the late effects of atomic-bomb (A-bomb) radiation on the immune system were started about 20 years after the bombings in 1945. The most remarkable late effects of radiation are the functional and quantitative abnormalities of T and B cells in survivors exposed to high doses (> or = 1.0 Gy). Abnormaliti...

journal_title：International journal of radiation biology

authors： Akiyama M

更新日期：1995-11-01 00:00:00

abstract：:Purpose: To examine the effects of low-dose exposure to uranium with a systems biology approach, a multiscale high-throughput multi-omics analysis was applied with a protocol for chronic exposure to the rat kidney. Methods: Male and female rats were contaminated for nine months through their drinking water with a nont...

journal_title：International journal of radiation biology

authors： Grison S,Kereselidze D,Cohen D,Gloaguen C,Elie C,Lestaevel P,Legendre A,Manens L,Habchi B,Benadjaoud MA,Tarlet G,Milliat F,Martin JC,Lobaccaro JM,Souidi M

更新日期：2019-06-01 00:00:00

abstract：:The aim was to investigate further the relationship between radiation-induced mitotic delay and the expression of chromosome damage in V79 cells. Recently published data on the time-course of chromosome aberrations in V79 first-cycle metaphases after exposure to 10.4 MeV u(-1) Ar ions (LET = 1226 keV microm(-1)) were ...

journal_title：International journal of radiation biology

authors： Gudowska-Nowak E,Kleczkowski A,Nasonova E,Scholz M,Ritter S

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To compare experimental yields of single strand breaks (SSB) and double strand breaks (DSB) induced in plasmid DNA in aqueous solution by alpha-particles and Al(K) ultrasoft X-rays (USX) with the corresponding yields, generated via computer simulations, for a range of mean diffusion distances of the hydroxyl ra...

journal_title：International journal of radiation biology

authors： Fulford J,Nikjoo H,Goodhead DT,O'Neill P

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:In case of a large-scale radiation accident when hundreds of people may be exposed, it is important to distinguish the severely exposed individuals (> or =1 gray), who require early medical treatment, from those less exposed. The aim of our study was to develop a quick population triage method based on automate...

journal_title：International journal of radiation biology

authors： Willems P,August L,Slabbert J,Romm H,Oestreicher U,Thierens H,Vral A

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Ionizing radiation has been recognized to increase the risk of cardiovascular diseases (CVD). However, there is no consensus concerning the dose-risk relationship for low radiation doses and a mechanistic understanding of low dose effects is needed. MATERIAL AND METHODS:Previously, human umbilical vein endothe...

journal_title：International journal of radiation biology

authors： Rombouts C,Aerts A,Quintens R,Baselet B,El-Saghire H,Harms-Ringdahl M,Haghdoost S,Janssen A,Michaux A,Yentrapalli R,Benotmane MA,Van Oostveldt P,Baatout S

更新日期：2014-07-01 00:00:00

abstract：:The role of protein kinase C in radiation-induced death of thymocytes was studied. For this purpose murine thymocytes were irradiated and incubated for 6 h at 37 degrees C and afterwards the fraction of fragmented DNA was measured. Results indicate that radiation-induced DNA fragmentation can be prevented by adding th...

journal_title：International journal of radiation biology

authors： Ojeda F,Guarda MI,Maldonado C,Folch H,Diehl H

更新日期：1992-05-01 00:00:00

abstract：:Swiss albino mice (7-8 weeks old) were irradiated with different doses (0-25 Gy) of gamma-radiation at a dose-rate of 0.05 Gy/s. The specific activities of glyoxalase I (GI) and glyoxalase II (GII) were determined in the spleen and liver immediately and on the 3rd and 6th day postirradiation. The results indicate that...

journal_title：International journal of radiation biology

authors： Sharma R,Kale RK

更新日期：1993-02-01 00:00:00

abstract：PURPOSE:To investigate the induction and persistence of chromosome aberrations in mouse bone marrow cells after X-ray exposure and to detect differential involvement of individual chromosomes in translocations. MATERIALS AND METHODS:Male and female Swiss mice were exposed to 1 and 3 Gy of X-rays. Chromosome aberration...

journal_title：International journal of radiation biology

authors： Xiao Y,Darroudi F,Grigorova M,Natarajan AT

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:To evaluate the radioprotective activity of C3, a regioisomer of water-soluble carboxyfullerene and a potent free radical scavenger, on both normal and tumour cells. MATERIALS AND METHODS:The murine committed bone-marrow stem cells for both granulocytes and monocytes (GM-CFC) were used to represent normal cell...

journal_title：International journal of radiation biology

authors： Lin HS,Lin TS,Lai RS,D'Rosario T,Luh TY

更新日期：2001-02-01 00:00:00

abstract：:Mutations in the p53 tumour suppressor gene are found at high frequency in bladder cancer. There is strong evidence that p53 plays an important role in controlling the cell cycle after DNA damage by ionizing radiation. However, the effect of loss of p53 function on radiosensitivity is not yet clear. Radiotherapy combi...

journal_title：International journal of radiation biology

authors： Ribeiro JC,Barnetson AR,Fisher RJ,Mameghan H,Russell PJ

更新日期：1997-07-01 00:00:00