Putative determinants of the cellular response to hyperthermia.

abstract：PURPOSE:Biomarkers of ionising radiation exposure are useful in a variety of scenarios, such as medical diagnostic imaging, occupational exposures, and spaceflight. This study investigates to what extent microRNA (miRNA) expression signatures in mouse peripheral blood can be used as biomarkers for exposures to radiatio...

journal_title：International journal of radiation biology

authors： Templin T,Amundson SA,Brenner DJ,Smilenov LB

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To clarify the experimental conditions that might influence the release of cytokines in the culture medium and give some basic input for building a model for cytokine (e.g., Interleukin-6, IL-6) regulation in the case of 'sham irradiation' and after ionising radiation exposure. MATERIALS AND METHODS:The influe...

journal_title：International journal of radiation biology

authors： Facoetti A,Mariotti L,Ballarini F,Bertolotti A,Nano R,Pasi F,Ranza E,Ottolenghi A

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To develop a procedure, using the inverse polymerase chain reaction, to detect and sequence ionizing radiation-induced DNA rearrangements without prior phenotypic selection of mutant cells. METHOD:Normal human fibroblast cells (IMR-90) were given 30Gy of gamma-irradiation and then incubated at 37 degrees C for...

journal_title：International journal of radiation biology

authors： Forrester HB,Radford IR

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:To study the formation and subsequent reactions of the 5-methyl-2'-deoxycytidine cation radical (5-Me-2'-dC•(+)) in nucleosides and DNA-oligomers and compare to one-electron oxidized thymidine. MATERIALS AND METHODS:Employing electron spin resonance (ESR), cation radical formation and its reactions were invest...

journal_title：International journal of radiation biology

authors： Adhikary A,Kumar A,Palmer BJ,Todd AD,Heizer AN,Sevilla MD

更新日期：2014-06-01 00:00:00

abstract：:Cultures of JU-56 cells were irradiated in either G1 or G2 and examined either in their first post-irradiation metaphase (in diploids) or in their second post-irradiation metaphase (in colcemid-induced tetraploids). The timing of fixation, together with tritiated thymidine pulse labelling, allowed selection for scorin...

journal_title：International journal of radiation biology

authors： Moore RC,Bender MA

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:To calculate the depth distribution of radioactive decays in bone by fitting a calculated alpha-particle energy spectrum to a measured spectrum. The dose to bone surface cells is then calculated from the depth distribution. MATERIALS AND METHODS:The spectra are calculated using Monte Carlo methods and a numeri...

journal_title：International journal of radiation biology

authors： Charlton DE,Salmon PL,Utteridge TD

更新日期：1998-01-01 00:00:00

abstract：:Electron transfer to 5-bromouracil (5-BrU) from nucleobase (N) electron adducts (and their protonated forms) has been studied by product analysis and pulse radiolysis. When an electron is transferred to 5-BrU, the ensuing 5-BrU radical anion rapidly loses a bromide ion; the uracilyl radical thus formed reacts with add...

journal_title：International journal of radiation biology

authors： Nese C,Yuan Z,Schuchmann MN,Von Sonntag C

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:The main aim of the present study is to gain mechanistic insights into the modulating effect of molecular hydrogen on the γ-radiation-induced alteration pathways of DNA nucleobases. MATERIALS AND METHODS:Aerated aqueous solutions of calf thymus DNA were exposed to a (60)Co source at doses ranging from 0 to 55 ...

journal_title：International journal of radiation biology

authors： Abou-Hamdan M,Gardette B,Cadet J,Gharib B,De Reggi M,Douki T,Triantaphylides C

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Radiation-induced bystander effects have important implications in radiotherapy. Their persistence in normal cells may contribute to risk of health hazards, including cancer. This study investigates the role of radiation quality and gap junction intercellular communication (GJIC) in the propagation of harmful e...

journal_title：International journal of radiation biology

authors： Autsavapromporn N,Plante I,Liu C,Konishi T,Usami N,Funayama T,Azzam EI,Murakami T,Suzuki M

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To investigate the influence of chromatin organization and scavenging capacity in relation to irradiation temperature on the induction of double-strand breaks (DSB) in structures derived from human diploid fibroblasts. MATERIALS AND METHODS:Agarose plugs with different chromatin structures (intact cells+/-wort...

journal_title：International journal of radiation biology

authors： Elmroth K,Nygren J,Stenerlöw B,Hultborn R

更新日期：2003-10-01 00:00:00

abstract：:Despite the extensive utilization of radiotherapy in cancer treatments, clinicians often face challenges in achieving desired outcomes. This is because of the existence of secondary radiation effects like bystander phenomenon that influence radiation nontargeted cells and tissues. The concept of bystander effects of r...

journal_title：International journal of radiation biology

authors： Mukherjee S,Chakraborty A

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Multicellular tumour spheroids are being used with increasing frequency in various aspects of tumour biology, including studies dealing with radiation biology. This review attempts to outline recent studies using these three-dimensional systems in radiation biology with particular reference made to papers testi...

journal_title：International journal of radiation biology

authors： Santini MT,Rainaldi G,Indovina PL

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Previous systematic structure-activity studies of the desferrithiocin (DFT) platform have allowed the design and synthesis of analogues and derivatives of DFT that retain the exceptional iron-clearing activity of the parent, while eliminating its adverse effects. We hypothesized that a similar approach could be...

journal_title：International journal of radiation biology

authors： Bergeron RJ,Wiegand J,Singh S

更新日期：2009-04-01 00:00:00

abstract：:Terminally differentiated cells usually do not divide and are, thus, reproductively dead. To elucidate the significance of radiation-enhanced differentiation to reproductive cell death, murine erythroid progenitor cells were gamma-irradiated in plasma clot cultures and the development of haemoglobinized clones was stu...

journal_title：International journal of radiation biology

authors： Schwenke K,Peterson HP,von Wangenheim KH,Feinendegen LE

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:This study evaluates early changes in human mesenchymal stem cells (MSC) isolated from dental pulp and periodontal ligament after γ-irradiation and the effect of ataxia-telangiectasia mutated (ATM) inhibition. METHODS:MSC were irradiated with 2 and 20 Gy by (60)Co. For ATM inhibition, specific inhibitor KU5593...

journal_title：International journal of radiation biology

authors： Cmielova J,Havelek R,Kohlerova R,Soukup T,Bruckova L,Suchanek J,Vavrova J,Mokry J,Rezacova M

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:Effects of radiation on the differentiation of C2C12 myoblasts were studied using cell cultures in which the cells differentiated into either muscle cells or osteoblasts. MATERIALS AND METHODS:A mouse skeletal myoblast cell line, C2C12, was cultured and irradiated at confluence. Muscle differentiation was esti...

journal_title：International journal of radiation biology

authors： Ikeda S,Hachisu R,Yamaguchi A,Gao YH,Okano T

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:To find detectable cytogenetic biomarkers that can offer information about the radiation quality of in vivo exposure retrospectively. MATERIALS AND METHODS:Chromosome-type aberrations of peripheral lymphocytes of uterine cancer patients that received internal gamma- and external X-ray therapy or carbon beam th...

journal_title：International journal of radiation biology

authors： Kanda R,Minamihisamatsu M,Tsuji S,Ohmachi Y,Hiraoka T,Shimada Y,Ogiu T,Ohno T,Hayata I

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To evaluate the impact of oral administration of purslane (Portulaca oleracea) extract or fish oil and their co-treatments in the modulation of radiation-induced damage. MATERIAL AND METHODS:Purslane (P) (400 mg/kg body weight) or fish oil (Fo) (60 mg/kg body weight) was administrated to male albino rats via g...

journal_title：International journal of radiation biology

authors： Abd El-Azime AS,Hussein EM,Ashry OM

更新日期：2014-12-01 00:00:00

abstract：:Purpose: To summarize existing knowledge and to understand individual response to radiation exposure, the MELODI Association together with CONCERT European Joint Programme has organized a workshop in March 2018 on radiation sensitivity and susceptibility.Methods: The workshop reviewed the current evidence on this matt...

journal_title：International journal of radiation biology

authors： Seibold P,Auvinen A,Averbeck D,Bourguignon M,Hartikainen JM,Hoeschen C,Laurent O,Noël G,Sabatier L,Salomaa S,Blettner M

更新日期：2020-03-01 00:00:00

abstract：:Murine bone marrow contains osteogenic precursor cells that undergo differentiation during in vitro cultivation. In vitro these cells are potential target cells for alpha-irradiation-induced bone tumour formation. Under defined tissue culture conditions these differentiating cells were directly exposed to alpha-partic...

journal_title：International journal of radiation biology

authors： Schoeters GE,Vander Plaetse F,van den Heuvel RL

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:To compare experimental yields of single strand breaks (SSB) and double strand breaks (DSB) induced in plasmid DNA in aqueous solution by alpha-particles and Al(K) ultrasoft X-rays (USX) with the corresponding yields, generated via computer simulations, for a range of mean diffusion distances of the hydroxyl ra...

journal_title：International journal of radiation biology

authors： Fulford J,Nikjoo H,Goodhead DT,O'Neill P

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Neutron irradiations at the McMaster Tandetron Accelerator were performed to study direct and bystander effects of neutrons in a live organism. METHODS:The neutrons were produced through (7)Li(p,n)(7)Be reaction. Although the gamma contamination of the neutron beam cannot be completely eliminated, it was desig...

journal_title：International journal of radiation biology

authors： Wang C,Smith RW,Duhig J,Prestwich WV,Byun SH,McNeill FE,Seymour CB,Mothersill CE

更新日期：2011-09-01 00:00:00

abstract：:Four of the most radiosensitive xrs variants of CHO-K1 cells, obtained after mutagenizing treatment with EMS, have been studied in detail over three to five decades of cell survival. Although these lines were initially reported to have very steep exponential survival curves, and to vary in sensitivity between themselv...

journal_title：International journal of radiation biology

authors： Denekamp J,Whitmore GF,Jeggo P

更新日期：1989-04-01 00:00:00

abstract：PURPOSE:In a previous study, we found that exposure to a 50 Hz magnetic field (MF) could activate stress-activated protein kinase (SAPK) and P38 mitogen-activated protein (MAP) kinase (P38 MAPK) in Chinese hamster lung (CHL) fibroblast cells, and simultaneous exposure to a 'noise' MF of the same intensity inhibited the...

journal_title：International journal of radiation biology

authors： Ke XQ,Sun WJ,Lu DQ,Fu YT,Chiang H

更新日期：2008-05-01 00:00:00

abstract：:Genetic analysis was performed on 72 Italian A-T families ascertained through 91 probands. The frequency of the A-T gene was estimated through Dahlberg's formula, which uses the frequencies of first cousin marriages among the patients' parents and in the general population were obtained from the collection of Catholic...

journal_title：International journal of radiation biology

authors： Chessa L,Lisa A,Fiorani O,Zei G

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:To investigate whether an adaptive response can be induced in mice which were pre-exposed to 900 MHz radiofrequency fields. MATERIALS AND METHODS:Adult male Kunming mice were exposed to 900 MHz radiofrequency fields (RF) at power intensities of 12, 120 and 1200 μW/cm(2) for 1 h/day for 14 days and then subject...

journal_title：International journal of radiation biology

authors： Cao Y,Xu Q,Jin ZD,Zhou Z,Nie JH,Tong J

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases. Emphasis was placed on the estimation of the respective contribution of direct ionization and indirect effects, mostly by comparison with low linear energy transfer (LET) g...

journal_title：International journal of radiation biology

authors： Douki T,Ravanat JL,Pouget JP,Testard I,Cadet J

更新日期：2006-02-01 00:00:00

abstract：:One of the important temporal stages of radiation action in cellular systems is the chemical phase, where oxygen fixation reactions compete with chemical repair reactions involving reducing agents such as GSH. Using the gas explosion technique it is possible to follow the kinetics of these fast (greater than 1 ms) rea...

journal_title：International journal of radiation biology

authors： Prise KM,Davies S,Michael BD

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:To illustrate the progress in normal tissue radiation biology over the last five decades and its impact on radiotherapy. MATERIALS AND METHODS:Major milestones over the last 50 years and their consequences for radiation oncology are described: The identification of clonogenic cell survival and the (target) ste...

journal_title：International journal of radiation biology

authors： Stewart FA,Dörr W

更新日期：2009-07-01 00:00:00

abstract：:The behaviour of polyamines (putrescine, spermidine and spermine) in the small intestine was studied in rats exposed to a single whole-body dose of 3 Gy administered at four different times of the day. Polyamine content decreased a few hours after irradiation but quickly returned to normal values. Putrescine levels re...

journal_title：International journal of radiation biology

authors： Becciolini A,Porciani S,Lanini A,Attanasio M

更新日期：1989-07-01 00:00:00