Computer evaluation of direct and indirect damage induced by free and DNA-bound iodine-125 in the chromatin fibre.

abstract：PURPOSE:The efficacy of a boron-containing cholesteryl ester compound (BCH) as a boron neutron capture therapy (BNCT) agent for the targeted irradiation of PC-3 human prostate cancer cells was examined. MATERIALS AND METHODS:Liposome-based delivery of BCH was quantified with inductively coupled plasma-mass spectrometr...

journal_title：International journal of radiation biology

authors： Gifford I,Vreeland W,Grdanovska S,Burgett E,Kalinich J,Vergara V,Wang CK,Maimon E,Poster D,Al-Sheikhly M

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:To investigate the effect of gamma radiation-induced alterations in antioxidant defence of radioresistant Sf9 insect cells. MATERIALS AND METHODS:Sf9 cells were irradiated at doses ranging from 0.5-200 Gy. Lipid peroxidation and protein carbonylation levels were observed at 4 h post-exposure along with reduced...

journal_title：International journal of radiation biology

authors： Suman S,Khan Z,Zarin M,Chandna S,Seth RK

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To honour perhaps the most influential man in the radiation sciences, Henry S. Kaplan, by reviewing the field of tumour hypoxia, one of his many interests. RESULTS:It was postulated over 50 years ago by Thomlinson and Gray that human solid tumours would contain hypoxic cells and that they would exert a negativ...

journal_title：International journal of radiation biology

authors： Brown M

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To determine the involvement of c-Jun NH(2)-terminal kinase-1 (JNK1) and possibly of HSP27 in heat-induced apoptosis of human monoblastic leukaemia U937 cells. MATERIALS AND METHODS:Dominant negative JNK1 (APF), in which the phosphorylation sites Thr-Pro-Tyr were changed to Ala-Pro-Phe, was overexpressed in U9...

journal_title：International journal of radiation biology

authors： Enomoto A,Suzuki N,Liu C,Kang Y,Zhu J,Serizawa S,Matsumoto Y,Morita A,Ito M,Hosoi Y

更新日期：2001-08-01 00:00:00

abstract：:Evidence for the roles of proteins and metal ions in the microheterogeneity of DNA damage is reviewed. Decondensation of chromatin in hypotonic buffers markedly sensitizes the DNA to radiation, while treatment of nuclei with hypertonic buffers strips the DNA of histones and other nuclear proteins and enhances the radi...

journal_title：International journal of radiation biology

authors： Oleinick NL,Balasubramaniam U,Xue L,Chiu S

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:To analyze the direct and transgenerational effects of exposure to low-dose 1 GHz (mobile phone/wireless telecommunication range) and 10 GHz (radar/satellite communication range) radiofrequency electromagnetic fields (RF-EMF) on the motility of ciliates Spirostomum ambiguum. MATERIALS AND METHODS:S. ambiguum w...

journal_title：International journal of radiation biology

authors： Sarapultseva EI,Igolkina JV,Tikhonov VN,Dubrova YE

更新日期：2014-03-01 00:00:00

abstract：:Nitrous oxide reacts during irradiation to increase the yield of .OH, a radical many believe to be a major cause of lethality. Logically, one would expect N2O to be a radiation sensitizer. In some instances it is, while in others it is not. In some cases we can explain why N2O fails to sensitize; factors such as dose ...

journal_title：International journal of radiation biology

authors： Ewing D,Walton HL,Guilfoil DS,Ohm MB

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To evaluate and optimize the radioprotective ability of the most potent fraction of an aqueous extract of Coronopus didymus in whole body gamma-irradiated Swiss albino mice and to evaluate the antioxidant status and lipid peroxidation of the livers of the surviving mice. To correlate the free radical scavenging...

journal_title：International journal of radiation biology

authors： Prabhakar KR,Veerapur VP,Parihar KV,Priyadarsini KI,Rao BS,Unnikrishnan MK

更新日期：2006-08-01 00:00:00

abstract：:Cultures of JU-56 cells were irradiated in either G1 or G2 and examined either in their first post-irradiation metaphase (in diploids) or in their second post-irradiation metaphase (in colcemid-induced tetraploids). The timing of fixation, together with tritiated thymidine pulse labelling, allowed selection for scorin...

journal_title：International journal of radiation biology

authors： Moore RC,Bender MA

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:To examine the protective effects of histamine on intestinal damage produced by gamma-radiation. MATERIALS AND METHODS:56 mice were divided into 4 groups. Histamine and Histamine-10 Gy groups received a daily subcutaneous histamine injection (0.1 mg/kg) starting 20 hours before irradiation and continued until ...

journal_title：International journal of radiation biology

authors： Medina VA,Croci M,Mohamad NA,Massari N,Garbarino G,Cricco GP,Núñez MA,Martín GA,Crescenti EJ,Bergoc RM,Rivera ES

更新日期：2007-10-01 00:00:00

abstract：:Purpose: Cancer is one of the most common causes of mortality and morbidity worldwide. Vaccines have been emerged as an attractive approach for their capacity of eliciting long-term immune response targeting cancer cells. Attenuated avirulent Toxoplasma gondii stimulate immunity and activate antitumor cells thereby el...

journal_title：International journal of radiation biology

authors： Hafez EN,Youssef HMG,El-Kabany HA

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:We examined the effects of manganese (III) meso-tetrakis (diethyl-2-5-imidazole) porphyrin, a metalloporphyrin antioxidant (MPA), on neural tissue radiation toxicity in vivo and on tumour cell radiosensitivity in vitro. MATERIALS AND METHODS:MPA was administered directly into the right lateral ventricle of you...

journal_title：International journal of radiation biology

authors： Pearlstein RD,Higuchi Y,Moldovan M,Johnson K,Fukuda S,Gridley DS,Crapo JD,Warner DS,Slater JM

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To examine the relationship between cell killing and residual chromatin breaks after irradiation with qualitatively different types of radiation in six human cell lines. MATERIALS AND METHODS:Six human tumour cell lines and normal human cells were irradiated with 200 kV X-rays and two carbon-ion beams accelera...

journal_title：International journal of radiation biology

authors： Suzuki M,Kase Y,Kanai T,Ando K

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To investigate the mechanism of NFkappaB activation by X-rays in normal primary rat astrocytes. MATERIALS AND METHODS:Primary cultures of type I astrocytes generated from the cortex of neonatal rats were exposed to X-rays with and without various kinase inhibitors and a protease inhibitor. The nuclear or cytop...

journal_title：International journal of radiation biology

authors： Raju U,Gumin GJ,Noel F,Tofilon PJ

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:To investigate whether an adaptive response can be induced in mice which were pre-exposed to 900 MHz radiofrequency fields. MATERIALS AND METHODS:Adult male Kunming mice were exposed to 900 MHz radiofrequency fields (RF) at power intensities of 12, 120 and 1200 μW/cm(2) for 1 h/day for 14 days and then subject...

journal_title：International journal of radiation biology

authors： Cao Y,Xu Q,Jin ZD,Zhou Z,Nie JH,Tong J

更新日期：2011-07-01 00:00:00

abstract：:Because of the role that alveolar macrophages (PAM) play in the pulmonary clearance of inhaled particles via mechanical transport and dissolution, understanding the uptake and dissolution of particles by these cells might provide insight into the mechanisms of particle dissolution in lungs of various species and hence...

journal_title：International journal of radiation biology

authors： Taya A,Carmack DB,Muggenburg BA,Mewhinney JA

更新日期：1992-07-01 00:00:00

abstract：:Human ovarian carcinoma parental and cisplatin-resistant cells were evaluated for their radiation sensitivity to high and low dose-rate irradiation and for the effectiveness of cisplatin in radiosensitization. The cisplatin resistant variant A2780cp showed increased radiation resistance for both low dose-rate (LDRI) a...

journal_title：International journal of radiation biology

authors： Raaphorst GP,Wang G,Stewart D,Ng CE

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:To obtain compounds that will effectively reduce the fixation of uranium in its main target organs: bone and kidney. There is an urgent need for a chelating agent that is suitable and available for human use. MATERIALS AND METHODS:The efficacy of ethane-1-hydroxy-1,1-bisphosphonate (EHBP), already in use as a ...

journal_title：International journal of radiation biology

authors： Henge-Napoli MH,Ansoborlo E,Chazel V,Houpert P,Paquet F,Gourmelon P

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Previous systematic structure-activity studies of the desferrithiocin (DFT) platform have allowed the design and synthesis of analogues and derivatives of DFT that retain the exceptional iron-clearing activity of the parent, while eliminating its adverse effects. We hypothesized that a similar approach could be...

journal_title：International journal of radiation biology

authors： Bergeron RJ,Wiegand J,Singh S

更新日期：2009-04-01 00:00:00

abstract：:This study evaluated the cell-mediated (CMI) and humoral immune responses in four Beagle dogs five to six years after single inhalation exposures to different monodisperse 239PuO2 aerosols (0.72-1.4 microns activity median aerodynamic diameter). These exposures resulted in initial lung burdens ranging from 19 to 35 kB...

journal_title：International journal of radiation biology

authors： Galvin JB,Bice DE,Guilmette RA,Muggenburg BA,Haley PJ

更新日期：1989-02-01 00:00:00

abstract：:Studies of early physical interactions of ionizing radiation in biological medium have evolved from water cylinders or spheres to structured volumes representing nucleosomal DNA, based on spatial co-ordinates for each individual atom. Regarding the physico-chemical and chemical stages, the models of DNA have evolved f...

journal_title：International journal of radiation biology

authors： Terrissol M

更新日期：1994-11-01 00:00:00

abstract：:Rats were chronically exposed to tritiated water (3HHO) and several tritiated organic compounds [( 3H]leucine, [3H]lysine, [3H]glucose, [3H]glucosamine, [3H]thymidine and [3H]uridine) dissolved in their drinking water. An analysis of tritium in wet and dry tissues of rats at the end of 22 days' chronic exposure showed...

journal_title：International journal of radiation biology

authors： Takeda H

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There ...

journal_title：International journal of radiation biology

authors： Ainsbury E,Badie C,Barnard S,Manning G,Moquet J,Abend M,Antunes AC,Barrios L,Bassinet C,Beinke C,Bortolin E,Bossin L,Bricknell C,Brzoska K,Buraczewska I,Castaño CH,Čemusová Z,Christiansson M,Cordero SM,Cosler G,Mo

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Radioresistance is highly correlated with radiotherapy failure in clinical cancer treatment. In the current study, we sought to examine the efficacy of Celecoxib and Afatinib co-treatment as radiosensitizers in the management of non-small cell lung cancer (NSCLC) A549 cells. MATERIALS AND METHODS:Generally, A5...

journal_title：International journal of radiation biology

authors： Zhang P,Song E,Jiang M,Song Y

更新日期：2020-11-12 00:00:00

abstract：:The role of protein kinase C in radiation-induced death of thymocytes was studied. For this purpose murine thymocytes were irradiated and incubated for 6 h at 37 degrees C and afterwards the fraction of fragmented DNA was measured. Results indicate that radiation-induced DNA fragmentation can be prevented by adding th...

journal_title：International journal of radiation biology

authors： Ojeda F,Guarda MI,Maldonado C,Folch H,Diehl H

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:To investigate the induction and persistence of chromosome aberrations in mouse bone marrow cells after X-ray exposure and to detect differential involvement of individual chromosomes in translocations. MATERIALS AND METHODS:Male and female Swiss mice were exposed to 1 and 3 Gy of X-rays. Chromosome aberration...

journal_title：International journal of radiation biology

authors： Xiao Y,Darroudi F,Grigorova M,Natarajan AT

更新日期：1999-09-01 00:00:00

abstract：:Eelpout (Zoarces viviparus), a marine fish, were exposed to gamma-radiation at a dose-rate of 2.0 mGy h-1. They were injected with the antigen trinitrophenyl-keyhole limpet haemocyanin (TNP-KLH) and their specific humoral immune response to the TNP hapten measured. There were no differences in the primary antibody res...

journal_title：International journal of radiation biology

authors： Greenwood LN,Knowles JF

更新日期：1995-01-01 00:00:00

abstract：:CHEF-electrophoresis was used as a technique to detect radiation-induced DNA breakage with special emphasis to biological relevant X-ray doses (0-10 Gy). Fluorescence detection of DNA-fragments using a sensitive image analysis system was directly compared with conventional scintillation counting of 3H-thymidine prelab...

journal_title：International journal of radiation biology

authors： Rosemann M,Kanon B,Konings AW,Kampinga HH

更新日期：1993-08-01 00:00:00

abstract：:The resonant recognition model (RRM) is a model of protein-protein and protein-DNA interaction based on a significant correlation between spectra of numerical presentation of the amino acid or nucleotide sequences and their biological activity. Having compared absorption characteristics of photosensitive proteins with...

journal_title：International journal of radiation biology

authors： Cosic I,Vojisavljevic V,Pavlovic M

更新日期：1989-08-01 00:00:00

abstract：:Resolving the molecular mechanisms of radiation oncogenesis represents an important but daunting challenge in radiation research. This brief review outlines the principal oncogenic mechanisms that need to be considered in the context of radiation effects on the genome, how these might relate to specific gene and chrom...

journal_title：International journal of radiation biology

authors： Cox R

更新日期：1994-01-01 00:00:00