A phase I trial of combination chemotherapy employing carboplatin, vinca alkaloids, with or without bleomycin in patients with advanced malignant tumors.

abstract：:The purpose of this study is to investigate whether hematopoiesis capacity, immunomodulatory effect and ex vivo expansion potential of mesenchymal stem cells (MSCs) are affected by cryopreservation. Chronic myeloid leukemia (CML) patients' bone marrow MSCs cryopreserved for 3 months, 6 months, and 1 year were thawed a...

journal_title：Cancer investigation

authors： Zhao ZG,Li WM,Chen ZC,You Y,Zou P

更新日期：2008-05-01 00:00:00

abstract：:Autologous bone marrow transplantation (AuBMT) is an accepted treatment modality for patients with high-risk or relapsed hematological malignancies. Hepatotoxicity, in particular veno-occlusive disease (VOD), is a significant complication of this therapy. The purpose of this study was to determine the clinical relevan...

journal_title：Cancer investigation

authors： Wasserheit C,Acaba L,Gulati S

更新日期：1995-01-01 00:00:00

abstract：:The G1 cyclins are clearly important factors that control progression through the eukaryotic cell cycle. The expression and activity of these factors are regulated at many different levels and in response to a large number of signals. Such complicated, multilevel controls on expression and activation of cyclin/cdk com...

journal_title：Cancer investigation

authors： Hamel PA,Hanley-Hyde J

更新日期：1997-01-01 00:00:00

abstract：:Two groups of patients with disseminated breast carcinomas who had failed radiotherapy, chemotherapy, and hormonotherapy were treated with natural interferon alpha (nIFN-alpha) alone or in combination with nIFN-gamma delivered in cycles of 10-12 intralesional (i.l.) injections to recurrent and metastatic lesions. In g...

journal_title：Cancer investigation

authors： Habif DV,Ozzello L,De Rosa CM,Cantell K,Lattes R

更新日期：1995-01-01 00:00:00

abstract：:Until recently physicians have been reluctant to disclose a poor prognosis to patients for fear of harming them with the bad news and/or taking away their will to live. In the last decades we have seen a reversal of practice among Western physicians, and most doctors readily disclose to their patients the full extant ...

journal_title：Cancer investigation

authors： Jotkowitz A,Glick S,Gezundheit B

更新日期：2006-12-01 00:00:00

abstract：:Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that th...

journal_title：Cancer investigation

authors： Kimura T,Wang L,Tabu K,Nishihara H,Mashita Y,Kikuchi N,Tanino M,Hiraga H,Tanaka S

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...

journal_title：Cancer investigation

authors： Abushullaih S,Saad ED,Munsell M,Hoff PM

更新日期：2002-01-01 00:00:00

abstract：:Esophageal cancer is multifactorial disease involving environmental and genetic risk factors. Tobacco smoke and alcohol are strong environmental risk factors. N-acetyltransferase 2 (NAT2) is known to metabolize heterocyclic amine carcinogens in tobacco smoke. The purpose of this study was to determine whether genetic ...

journal_title：Cancer investigation

authors： Jain M,Kumar S,Lal P,Tiwari A,Ghoshal UC,Mittal B

更新日期：2007-08-01 00:00:00

abstract：:Type-I insulin-like growth factor receptor (IGF1R) and its signaling play an important role in osteosarcomagenesis, tumor progression, and chemoresistance. The purpose of this study was to investigate both the effect and mechanisms of IGF1R inhibition by tyrphostin AG1024 in the presence or absence of doxorubicin in a...

journal_title：Cancer investigation

authors： Luk F,Yu Y,Walsh WR,Yang JL

更新日期：2011-10-01 00:00:00

abstract：:Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (AIPD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an ...

journal_title：Cancer investigation

authors： Lopez-Berestein G,Cabanillas F,Osborne BM,Libshitz HI,Bodey GP

更新日期：1983-01-01 00:00:00

abstract：:This review summarizes the literature on QoL in early stage lung cancer patients who underwent surgery. PubMed and PsycINFO were searched. Twelve articles from 10 distinct studies were identified for a total of 992 patients. Five QoL measures were used. One study reported only on pre-surgical QoL, six only on post-sur...

journal_title：Cancer investigation

authors： Yip R,Taioli E,Schwartz R,Li K,Becker BJ,Tam K,Htwe YM,Yankelevitz DF,Henschke CI

更新日期：2018-01-01 00:00:00

abstract：:Radioimmunoscintigraphy (RIS) is coming into its own as an imaging modality in clinical oncology. Early experience with indium-111-labeled intact murine monoclonal antibodies (MoAbs) in colorectal cancer suggested that RIS images hepatic metastases poorly. Moreover, an antimurine immune response was frequently provoke...

journal_title：Cancer investigation

authors： Moffat FL Jr,Gulec SA,Serafini AN,Sfakianakis GN,Pop R,Robinson DS,Franceschi D,Boggs J,Livingstone AS

更新日期：1999-01-01 00:00:00

abstract：:Triple-negative breast cancer is defined by the lack of expression of estrogen-receptor, progesterone-receptor, and HER-2/neu. It primarily, but not exclusively, carries the basal-like molecular profile on gene expression arrays and is associated with BRCA-1 and p53 mutations. It has an aggressive behavior and predile...

journal_title：Cancer investigation

authors： Maegawa RO,Tang SC

更新日期：2010-10-01 00:00:00

abstract：:Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis...

journal_title：Cancer investigation

authors： Rico MJ,Perroud HA,Mainetti LE,Rozados VR,Scharovsky OG

更新日期：2014-03-01 00:00:00

abstract：:Enhanced proteolysis and altered tight junction (TJ) proteins associate with carcinoma invasion. We hypothesized that trypsin-2, a tumor-associated serine proteinase, induces tongue carcinoma invasion by activating pro-membrane type-1 matrix metalloproteinase (MT1-MMP) and disturbing the TJs. The effects of invasion w...

journal_title：Cancer investigation

authors： Vilen ST,Suojanen J,Salas F,Risteli J,Ylipalosaari M,Itkonen O,Koistinen H,Baumann M,Stenman UH,Sorsa T,Salo T,Nyberg P

更新日期：2012-10-01 00:00:00

abstract：:Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...

journal_title：Cancer investigation

authors： Ejaz S,Chekarova I,Ashraf M,Lim CW

更新日期：2006-10-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. METHODS:One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. RESULTS:The median normal MnSOD expression...

journal_title：Cancer investigation

authors： Martin RC,Li Y,Liu Q,Barker DF,Doll MA,Hein DW

更新日期：2010-10-01 00:00:00

abstract：:Thirty patients with a diagnosis of metastatic adenocarcinoma of the lung were entered on a trial to evaluate the antitumor efficacy of 5-fluorouracil 370 mg/m2 daily for 5 days every four weeks in combination with folinic acid 200 mg/m2, 60 min prior to 5FU. All patients had a good performance status, bidimensionally...

journal_title：Cancer investigation

authors： Evans WK,Wierzbicki R,Shepherd FA,Rusthoven J,Stewart DJ,Aitken SE,Maroun JA,Ezzat A

更新日期：1990-01-01 00:00:00

abstract：:Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydroge...

journal_title：Cancer investigation

authors： Agah S,Akbari A,Talebi A,Masoudi M,Sarveazad A,Mirzaei A,Nazmi F

更新日期：2017-11-26 00:00:00

abstract：:In conclusion, the prognosis for women with stage I borderline tumors is excellent. Surgery alone is the recommended treatment. For young patients, fertility-sparing surgery is optimal, with a small percentage eventually developing tumor in the contralateral ovary. For patients with advanced stage borderline tumors, 1...

journal_title：Cancer investigation

authors： Gershenson DM

更新日期：1999-01-01 00:00:00

abstract：:Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...

journal_title：Cancer investigation

authors： Erfani N,Razmkhah M,Ghaderi A

更新日期：2010-10-01 00:00:00

abstract：:For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...

journal_title：Cancer investigation

authors： Tang SC

更新日期：2008-06-01 00:00:00

abstract：:This study combined infusional mitoxantrone with bolus melphalan as a transplant preparative regimen for multiple myeloma. Mitoxantrone was infused over 6 hr on days 6 and 5. Melphalan was given as a 15 min bolus on day 1 followed by autologous transplant on day 0. Thirty-five patients were enrolled; 57% of enrollees ...

journal_title：Cancer investigation

authors： Beaven AW,Moore DT,Sharf A,Serody JS,Shea TC,Gabriel DA

更新日期：2011-03-01 00:00:00

abstract：:Melanoma is an immunoresponsive malignancy. Interleukin-10 (IL-10) is a potent regulator of immunosuppression. The purpose of this research was to define the relationship of serum IL-10 to survival in patients with metastatic melanoma. Forty-one melanoma patients and 50 normal volunteers were analyzed. The median IL-1...

journal_title：Cancer investigation

authors： Nemunaitis J,Fong T,Shabe P,Martineau D,Ando D

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:A 96-hour infusion schedule of paclitaxel demonstrates tolerability and antitumor activity in lung cancer and breast cancer refractory to short-duration infusion paclitaxel. Given the activity of paclitaxel in esophageal cancer, a phase II trial of 96-hour infusion paclitaxel in esophageal cancer was underta...

journal_title：Cancer investigation

authors： Anderson SE,O'Reilly EM,Kelsen DP,Ilson DH

更新日期：2003-01-01 00:00:00

abstract：:Expression of epidermal growth factor and its transmembrane receptor (EGFR) stimulates tumor growth. Matuzumab is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth, and provides a clinical benefit for some patients. The plasma half-life (6-10 days) an...

journal_title：Cancer investigation

authors： Schiller JH

更新日期：2008-02-01 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer death with a 5-year survival less than 5 percent despite rigorous interventions. This largely is due to its late presentation, aggressive metastasis, and a lack of effective adjuvant therapies. Cytokines have been studied in many tumor types, where they have been...

journal_title：Cancer investigation

authors： Feurino LW,Fisher WE,Bharadwaj U,Yao Q,Chen C,Li M

更新日期：2006-11-01 00:00:00

abstract：:As genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations is increasingly integrated into the clinical management of high-risk women, it will be important to understand barriers and motivations for genetic counseling among women from underserved minority groups to ensure equitable access to these services. Therefore,...

journal_title：Cancer investigation

authors： Halbert CH,Kessler LJ,Mitchell E

更新日期：2005-01-01 00:00:00

abstract：:Enthusiasms into the application of PI3K-δ inhibitor CAL-101 has been muted due to the over-activation of compensatory molecules. Our results delineated that c-Myc suppression using 10058-F4 enhanced CAL-101 cytotoxicity in less sensitive cells through different mechanisms based on p53 status; while CAL-101-plus-10058...

journal_title：Cancer investigation

authors： Riyahi N,Safaroghli-Azar A,Sheikh-Zeineddini N,Sayyadi M,Bashash D

更新日期：2019-01-01 00:00:00

abstract：:The results of a prospective trial with a specifically devised chemotherapy regimen in elderly patients with unfavorable non-Hodgkin's lymphoma (NHL) are reported. Between April 1983 and April 1986, 37 consecutive patients 70 years old or more (median age 80) received etoposide and prednimustine (E + P) 100 mg/m2 p.o....

journal_title：Cancer investigation

authors： Zagonel V,Tirelli U,Carbone A,Errante D,Morassot S,Sorio R,Monfardini S

更新日期：1990-01-01 00:00:00