Incidence and severity of hand-foot syndrome in colorectal cancer patients treated with capecitabine: a single-institution experience.

abstract：:We have provided an overview of recent studies that have greatly expanded our knowledge of the molecular and cellular mechanisms that determine the sensitivity or resistance to ionizing radiation. Much of this knowledge was obtained by studying tumor and nontumor cell types that under- or overexpress proteins involved...

journal_title：Cancer investigation

authors： Rosen EM,Fan S,Rockwell S,Goldberg ID

更新日期：1999-01-01 00:00:00

abstract：:To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the patholo...

journal_title：Cancer investigation

authors： Augoff K,Grabowski K,Rabczynski J,Kolondra A,Tabola R,Sikorski AF

更新日期：2009-05-01 00:00:00

abstract：:Autologous bone marrow transplantation (AuBMT) is an accepted treatment modality for patients with high-risk or relapsed hematological malignancies. Hepatotoxicity, in particular veno-occlusive disease (VOD), is a significant complication of this therapy. The purpose of this study was to determine the clinical relevan...

journal_title：Cancer investigation

authors： Wasserheit C,Acaba L,Gulati S

更新日期：1995-01-01 00:00:00

abstract：:Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b i...

journal_title：Cancer investigation

authors： Liu W,Dong Z,Liang J,Guo X,Guo Y,Shen S,Kuang G,Guo W

更新日期：2016-11-25 00:00:00

abstract：:8-Chloro-cyclic-adenosine-3',5'-monophosphate (8-Cl-cAMP), a site-selective synthetic cyclic adenosine 3',5'-monophosphate (cAMP) analog exhibits growth inhibition in a broad spectrum of human cancer lines. However, detailed studies on the effects exerted by cAMP analogs on cell-cycle kinetics have been lacking. We ha...

journal_title：Cancer investigation

authors： Grbovic O,Jovic V,Ruzdijic S,Pejanovic V,Rakic L,Kanazir S

更新日期：2002-01-01 00:00:00

abstract：:A patient with cervical metastases leading to the diagnosis of a primary breast cancer is presented. To better define the frequency, symptoms, and characteristics of breast cancer metastasizing to the uterine cervix, all cases reported in the literature since 1950 are reviewed. This analysis reveals that in 21% of the...

journal_title：Cancer investigation

authors： Hepp HH,Hoos A,Leppien G,Wallwiener D

更新日期：1999-01-01 00:00:00

abstract：:We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to b...

journal_title：Cancer investigation

authors： Gunduz E,Gunduz M,Ali MA,Beder L,Tamamura R,Katase N,Tominaga S,Yamanaka N,Shimizu K,Nagatsuka H

更新日期：2009-07-01 00:00:00

abstract：:Withaferin A (WA) (1) and two analogs [4-epi-withaferin A (2) and 4,27-diacetyl-4-epi-withaferin A (3)] were evaluated for antitumor activity in pancreatic cancer cells. IC(50) for 1, 2, and 3 were 0.87, 0.45, and 0.29 ?M (BxPC-3); 1.28, 1.53, and 0.52 ?M (MIAPaCa-2); and 0.59, 2.25, and 0.56 ?M (PANC-1), respectively...

journal_title：Cancer investigation

authors： Liu X,Qi W,Cooke LS,Kithsiri Wijeratne EM,Xu YM,Marron MT,Leslie Gunatilaka AA,Mahadevan D

更新日期：2011-12-01 00:00:00

abstract：:This study is to evaluate the association between IL-8 -251A/T polymorphism and lung cancer risk in diverse populations. We performed a meta-analysis of six case-control studies that included 3,265 lung-cancer cases and 3,607 case-free controls. Overall, results showed that the IL-8 -251A/T polymorphism was not associ...

journal_title：Cancer investigation

authors： Gao P,Zhao H,You J,Jing F,Hu Y

更新日期：2014-12-01 00:00:00

abstract：:Type-I insulin-like growth factor receptor (IGF1R) and its signaling play an important role in osteosarcomagenesis, tumor progression, and chemoresistance. The purpose of this study was to investigate both the effect and mechanisms of IGF1R inhibition by tyrphostin AG1024 in the presence or absence of doxorubicin in a...

journal_title：Cancer investigation

authors： Luk F,Yu Y,Walsh WR,Yang JL

更新日期：2011-10-01 00:00:00

abstract：:We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baselin...

journal_title：Cancer investigation

authors： Chasseing NA,Barañao RI,Fernández O,Bordenave H,Rumi LS

更新日期：1993-01-01 00:00:00

abstract：:There appears to be exceptional and growing public enthusiasm for botanical, or "herbal", medicines, especially amongst cancer patients. This has recently begun to be matched by increasing scientific attention. Whilst it is known that plant extracts are active against cancer, the standard approach has been to isolate,...

journal_title：Cancer investigation

authors： Vickers A

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. METHODS:One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. RESULTS:The median normal MnSOD expression...

journal_title：Cancer investigation

authors： Martin RC,Li Y,Liu Q,Barker DF,Doll MA,Hein DW

更新日期：2010-10-01 00:00:00

abstract：:The results of a prospective trial with a specifically devised chemotherapy regimen in elderly patients with unfavorable non-Hodgkin's lymphoma (NHL) are reported. Between April 1983 and April 1986, 37 consecutive patients 70 years old or more (median age 80) received etoposide and prednimustine (E + P) 100 mg/m2 p.o....

journal_title：Cancer investigation

authors： Zagonel V,Tirelli U,Carbone A,Errante D,Morassot S,Sorio R,Monfardini S

更新日期：1990-01-01 00:00:00

abstract：:The vinca alkaloids represent one of the oldest classes of antineoplastic agents used in humans with a wide spectrum of activity against both animal and human tumors. These agents are known to inhibit microtubule polymerization. Vinorelbine is a semisynthetic analog that reached clinical trial on the basis of less pre...

journal_title：Cancer investigation

authors： Budman DR

更新日期：1997-01-01 00:00:00

abstract：:High expression of vascular endothelial growth factor (VEGF) in patients with hepatocellular carcinoma (HCC) is associated with poor prognosis. Here, we investigated the antitumor activity of lenvatinib, a multiple receptor tyrosine kinase inhibitor, in VEGF-overexpressing HCC models. In human umbilical vein endotheli...

journal_title：Cancer investigation

authors： Adachi Y,Matsuki M,Watanabe H,Takase K,Kodama K,Matsui J,Funahashi Y,Nomoto K

更新日期：2019-01-01 00:00:00

abstract：:Mice bearing LP07 lung adenocarcinoma present some characteristics similar to those shown in patients with several malignant diseases. LP07 tumor bearers develop paraneoplastic syndromes such as cachexia, leukocytosis, and hypercalcemia, partly due to a systemic inflammatory response. We analyzed some of the mechanism...

journal_title：Cancer investigation

authors： Diament MJ,Peluffo GD,Stillitani I,Cerchietti LC,Navigante A,Ranuncolo SM,Klein SM

更新日期：2006-03-01 00:00:00

abstract：:We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle ge...

journal_title：Cancer investigation

authors： Moumtzi SS,Roberts ML,Joyce T,Evangelidou M,Probert L,Frillingos S,Fotsis T,Pintzas A

更新日期：2010-07-01 00:00:00

abstract：:Patients with metastatic prostate cancer resistant to hormones and docetaxel were treated with vinflunine (320 mg/m(2) every 21 days), a new vinca alkaloid with improved preclinical activity. Only 1 of 36 patients (3%) had partial response; the median progression-free survival (PFS) was 2.1 months. Treatment was well ...

journal_title：Cancer investigation

authors： Hainsworth JD,Meluch AA,Lane CM,Spigel DR,Burris HA 3rd,Gandhi JG,Crane EJ,Stipanov MA,Greco FA

更新日期：2010-03-01 00:00:00

abstract：:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

journal_title：Cancer investigation

authors： Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

更新日期：2010-03-01 00:00:00

abstract：:Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34+ progenitor/stem leukemia...

journal_title：Cancer investigation

authors： Lei H,Tu Y,Yang L,Jin J,Luo H,Xu H,Kang J,Zhou L,Wu Y

更新日期：2019-01-01 00:00:00

abstract：:In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor ti...

journal_title：Cancer investigation

authors： Singh N,Das P,Datta Gupta S,Sahni P,Pandey RM,Gupta S,Chauhan SS,Saraya A

更新日期：2013-08-01 00:00:00

abstract：:Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated wi...

journal_title：Cancer investigation

authors： Yang Z,Ma J,Qi G,Zhang X

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:We conducted a phase I study to determine the maximum tolerated dose of docetaxel in combination with gemcitabine for patients with refractory solid tumors. METHODS:From January 1998 to November 1999, we treated 28 patients on a phase I protocol with gemcitabine given at a constant dose of 800 mg/m2 i.v. ov...

journal_title：Cancer investigation

authors： Poole ME,Bernard SA,Churchel MA,Weissler MC,Calvo B,Cance W,Ollila D,Koruda M,Behrns K,Detterbeck FC

更新日期：2003-06-01 00:00:00

abstract：:Increasing evidence indicates that disruption of circadian rhythms may be directly linked to cancer. Here we report that the expression levels of the core clock genes Per1 and Per3 measured by droplet digital polymerase chain reaction are significantly decreased in tumour tissue from 16 patients undergoing colorectal ...

journal_title：Cancer investigation

authors： Orhan T,Nielsen PB,Hviid TVF,Rosen AW,Gögenür I

更新日期：2019-01-01 00:00:00

abstract：:Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...

journal_title：Cancer investigation

authors： Erfani N,Razmkhah M,Ghaderi A

更新日期：2010-10-01 00:00:00

abstract：:Psychosocial adjustment in adolescent cancer survivors has been documented to be quite variable. Factors mediating adjustment need to be identified. The current study is an exploration of the impact that cancer diagnosis and treatment has on adolescent's self-perceptions and the role this has in mediating adjustment i...

journal_title：Cancer investigation

authors： Smith K,Ostroff J,Tan C,Lesko L

更新日期：1991-01-01 00:00:00

abstract：:In vivo and in vitro observations of cellular immune response in 70 patients with squamous cell cancer of the oral cavity and in 40 age-matched normal controls, were made using delayed hypersensitivity responses to DNCB, PPD, and Candida albicans extract (Dermatophytin 'O'), absolute lymphocyte counts, absolute T-cell...

journal_title：Cancer investigation

authors： Das SN,Khanna NN,Khanna S

更新日期：1986-01-01 00:00:00

abstract：:A 69-year-old man receiving monotherapy for lung cancer with dichloromethotrexate (DCM), and without exposure to other chemotherapeutic agents or known ototoxic drugs, developed profound cochleovestibular dysfunction. The initial presentation was vestibular. This resolved, but unilateral hearing loss ensued and contin...

journal_title：Cancer investigation

authors： Golden L,Ahlgren JD,Kattah J,Smith JW,Sisk R,Deeb Z

更新日期：1989-01-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by specific t(15;17), distinct morphologic picture, and clinical coagulopathy that contribute to the morbidity and mortality of the disease. This study aims to investigate the effects of antitelomerase compound BIBR1532 on APL cells (NB4). BIBR 1532 exerts a direct s...

journal_title：Cancer investigation

authors： Bashash D,Ghaffari SH,Zaker F,Hezave K,Kazerani M,Ghavamzadeh A,Alimoghaddam K,Mosavi SA,Gharehbaghian A,Vossough P

更新日期：2012-01-01 00:00:00