Abstract:
:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confidence intervals (95%CIs). Familial breast cancer risk due to CYP1A1 wt/m1 and m1/m1 genotypes was 2.3 (1.51-3.61)-fold and 7.1 (3.69-13.7)-fold, respectively. In addition to the main effects, certain first-order interactions were also significantly associated with familial breast cancer. Our results favor a possible risk modification by estrogen metabolizing gene polymorphisms in familial breast cancer susceptibility.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil Rdoi
10.3109/07357900902744494subject
Has Abstractpub_date
2010-03-01 00:00:00pages
304-11issue
3eissn
0735-7907issn
1532-4192pii
10.3109/07357900902744494journal_volume
28pub_type
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