Immune signatures predict prognosis in localized cancer.

abstract：:Pancreatic cancer is the fourth leading cause of cancer death with a 5-year survival less than 5 percent despite rigorous interventions. This largely is due to its late presentation, aggressive metastasis, and a lack of effective adjuvant therapies. Cytokines have been studied in many tumor types, where they have been...

journal_title：Cancer investigation

authors： Feurino LW,Fisher WE,Bharadwaj U,Yao Q,Chen C,Li M

更新日期：2006-11-01 00:00:00

abstract：:We analyzed the clinical utility of molecular classification based on anatomical and histological background. The study was conducted on 457 patients treated for gastric cancer with additional information about microsatellite instability status. We divided the patients in three groups of molecular classification based...

journal_title：Cancer investigation

authors： Polom K,Marrelli D,Roviello G,Voglino C,Vindigni C,Generali D,Roviello F

更新日期：2017-05-28 00:00:00

abstract：:The response rate (RR) to single-agent chemotherapy with doxorubicin or ifosfamide in patients with advanced soft-tissue sarcoma (STS) is in the range of 20%. Paclitaxel is clinically useful in treating several solid tumors and has demonstrated activity in a series of human sarcoma cell lines. Twenty-eight patients wi...

journal_title：Cancer investigation

authors： Casper ES,Waltzman RJ,Schwartz GK,Sugarman A,Pfister D,Ilson D,Woodruff J,Leung D,Bertino JR

更新日期：1998-01-01 00:00:00

abstract：:FTIR spectroscopy is a common technique for cancer diagnosis. Applied tissue samples are heterogeneous and may be damaged in preparation procedures. Easier sampling, more available samples and also easier process with assured results would be interesting. Whole blood samples include all of these qualifications and our...

journal_title：Cancer investigation

authors： Khanmohammadi M,Ansari MA,Garmarudi AB,Hassanzadeh G,Garoosi G

更新日期：2007-09-01 00:00:00

abstract：:To identify the relevant CpG sites as molecular markers, for the diagnosis and to distinguish the indolent and aggressive prostate tumors, we have determined the methylation status of 8 genes, including FLNC, EFS, ECRG4, RARB2, PITX2, GSTP1, PDLIM4, and KCNMA1 in 32 nonrecurrent, 32 recurrent primary prostate tumors, ...

journal_title：Cancer investigation

authors： Vanaja DK,Ehrich M,Van den Boom D,Cheville JC,Karnes RJ,Tindall DJ,Cantor CR,Young CY

更新日期：2009-06-01 00:00:00

abstract：:Bone marrow (BM) niche is a specific microenvironment for hematopoietic stem cells (HSCs) as well as non-hematopoietic cells. Evidence shows that chemo/radiotherapy can lead to the disruption of different properties of HSCs such as proliferation, differentiation, localization, self-renewa, and steady-state of cell pop...

journal_title：Cancer investigation

authors： Rafieemehr H,Maleki Behzad M,Azandeh S,Farshchi N,Ghasemi Dehcheshmeh M,Saki N

更新日期：2020-12-10 00:00:00

abstract：:Gastrointestinal stromal tumors (GIST) are tumors most frequently found in adults. They are often related to activating mutations in the CD-117 tyrosine kinase receptor, most commonly at exon 11. Gastrointestinal stromal tumors have been reported in children. However, until recently, there had not been reports of acti...

journal_title：Cancer investigation

authors： Bauer TM,Berlin JD

更新日期：2008-03-01 00:00:00

abstract：UNLABELLED:The effect of castration on the incorporation of [35S]methionine into secreted proteins in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors, was investigated. Biopsy specimens were obtained from 19 tumors, 0, 24, 48, 72, and 96 h after castration. In 14 tumors, castration induced an increase ...

journal_title：Cancer investigation

authors： Geier A,Hemi R,Beery R,Lunenfeld B

更新日期：1992-01-01 00:00:00

abstract：:ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZB...

journal_title：Cancer investigation

authors： Qu H,Qu D,Chen F,Zhang Z,Liu B,Liu H

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...

journal_title：Cancer investigation

authors： Abushullaih S,Saad ED,Munsell M,Hoff PM

更新日期：2002-01-01 00:00:00

abstract：:The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, an...

journal_title：Cancer investigation

authors： Rüschoff JH,Brandenburger T,Strehler EE,Filoteo AG,Heinmöller E,Aumüller G,Wilhelm B

更新日期：2012-05-01 00:00:00

abstract：:This survey aimed at getting a first insight into diverse side effects and their association with satisfaction with life as well as the use of complementary and alternative medicine (CAM) in cancer patients. A total of 100 patients in a German University Hospital were included. General side effects like fatigue, fever...

journal_title：Cancer investigation

authors： Kroker L,Dubois C,Münstedt K,Büntzel J,Keinki C,Hübner J

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this study was to investigate whether the intelligence quotient (IQ) in children treated for leukemia decreases in the years following whole brain irradiation. Twenty-seven leukemic children were assessed following a mean time lapse between radiotherapy and IQ measurement of 9 years. The IQ test used wa...

journal_title：Cancer investigation

authors： Kolotas C,Daniel M,Demetriou L,Martin T,Kurek R,Tonus C,Göbel U,Schnabel T,Zamboglou N

更新日期：2001-01-01 00:00:00

abstract：:A patient with cervical metastases leading to the diagnosis of a primary breast cancer is presented. To better define the frequency, symptoms, and characteristics of breast cancer metastasizing to the uterine cervix, all cases reported in the literature since 1950 are reviewed. This analysis reveals that in 21% of the...

journal_title：Cancer investigation

authors： Hepp HH,Hoos A,Leppien G,Wallwiener D

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. METHODS:One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. RESULTS:The median normal MnSOD expression...

journal_title：Cancer investigation

authors： Martin RC,Li Y,Liu Q,Barker DF,Doll MA,Hein DW

更新日期：2010-10-01 00:00:00

abstract：:Standard chemotherapeutic regimens, such as cisplatin and etoposide, may improve quality of life and prolong survival in patients with incurable non-small cell lung cancer (NSCLC). This trial was designed to evaluate the activity and toxicity of a regimen combining three of the most active agents against advanced-stag...

journal_title：Cancer investigation

authors： Ali MA,Kraut MJ,Valdivieso M,Wozniak AJ,Cummings G,Kalemkerian GP

更新日期：2000-01-01 00:00:00

abstract：:Achieving a cure for metastatic neuroblastoma remains a challenge despite sensitivity to chemotherapy and radiotherapy. Most patients achieve remission, but a failure to eliminate minimal residual disease (MRD) often leads to relapse. Immunotherapy is potentially useful for chemotherapy-resistant disease and may be pa...

journal_title：Cancer investigation

authors： Modak S,Cheung NK

更新日期：2007-02-01 00:00:00

abstract：:SNPs in CYP1A1, CYP2A1, CYP2B6, CYP2C, CYP2D6, CYP3A, GSTM1, GSTT1, GSTP1, SULT1A1, SULT1A2, UGT, and MTHFR are associated with breast cancer susceptibility; however, lack of such associations are also reported in some populations. The contradictory findings are explained on the basis of ethnic variation among populat...

journal_title：Cancer investigation

authors： Singh V,Parmar D,Singh MP

更新日期：2008-10-01 00:00:00

abstract：:A case control study of 2,908 breast cancer cases and 3,180 controls, derived from a nationwide screening program, enabled evaluation of the relationship of breast cancer risk to a variety of menstrual factors. Risk was significantly inversely related to age at menarche, with women who first menstruated at age 15 or l...

journal_title：Cancer investigation

authors： Brinton LA,Schairer C,Hoover RN,Fraumeni JF Jr

更新日期：1988-01-01 00:00:00

abstract：:Until recently physicians have been reluctant to disclose a poor prognosis to patients for fear of harming them with the bad news and/or taking away their will to live. In the last decades we have seen a reversal of practice among Western physicians, and most doctors readily disclose to their patients the full extant ...

journal_title：Cancer investigation

authors： Jotkowitz A,Glick S,Gezundheit B

更新日期：2006-12-01 00:00:00

abstract：:To study the efficiency of high-dose melphalan in previously untreated patients with advanced myeloma, we performed a Phase I-II trial. Twenty-eight patients were treated at dose level of 60-140 mg/m2. Each patient was first treated with a priming dose of cyclophosphamide (300 mg) followed by high-dose melphalen 1 wee...

journal_title：Cancer investigation

authors： Case DC Jr,Coleman M,Gottlieb A,McCarroll K

更新日期：1992-01-01 00:00:00

abstract：:There are many changes in the immune response with age, most of which can be related to the involution of the thymus gland and alteration of the distribution and function of T lymphocytes. These changes indirectly influence B-cell function, which not only amplifies the immune deficits, but leads to the increased produ...

journal_title：Cancer investigation

authors： Ben-Yehuda A,Weksler ME

更新日期：1992-01-01 00:00:00

abstract：:To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...

journal_title：Cancer investigation

authors： Xiaojiang T,Jinsong Z,Jiansheng W,Chengen P,Guangxiao Y,Quanying W

更新日期：2010-06-01 00:00:00

abstract：:Adjuvant and neoadjuvant chemotherapy is being used increasingly in the treatment of breast cancer patients. However, drug resistance plays an important role in the failure of chemotherapy in breast cancer. The aim of this study was to compare technetium-99m tetrofosmin (Tc-TETRO) mammoscintigraphic findings with the ...

journal_title：Cancer investigation

authors： Liu TJ,Tsai SC,Ho YJ,Sun SS,Kao CH

更新日期：2002-01-01 00:00:00

abstract：:Tamoxifen is a first targeted drug that continues to be the gold standard in treatment of estrogen receptor positive breast cancer for almost 50 years. The current review is an update of the paper published in 2012. We provide the new data on the tamoxifen targets that are the key points of signaling cascades activati...

journal_title：Cancer investigation

authors： Bogush TA,Polezhaev BB,Mamichev IA,Bogush EA,Polotsky BE,Tjulandin SA,Ryabov AB

更新日期：2018-04-21 00:00:00

abstract：:Data have shown that tamoxifen (TAM) can be used to treat not only breast cancer with positive estrogen receptor (ER), but also negative ER including human glioma. However, the molecular mechanism of this drug against different kinds of cancers remains to be elucidated. In this study, we provided the evidence that PKC...

journal_title：Cancer investigation

authors： Tian F,Wu H,Li Z,Wang N,Huang J,Li C,Xie F

更新日期：2009-08-01 00:00:00

abstract：:Pyrrolidindithiocarbamate (PDTC), is a metal chelator widely used to study the activation of redox sensitive transcription factors. Recently it has been demonstrated that it manifests pro-oxidant properties. The nuclear factor-Kappa B (NF-kappaB) transcription factor can both promote cell survival and induce apoptosis...

journal_title：Cancer investigation

authors： Malaguarnera L,Pilastro MR,Vicari L,Dimarco R,Manzella L,Palumbo G,Messina A

更新日期：2005-01-01 00:00:00

abstract：:Previous studies have shown that human PSP94 can inhibit the growth of prostate cancer cells both in vitro and in vivo. To further validate this potential and investigate the protein within a homologous setting, we examined the effects of rat PSP94 on the growth of the rat prostate adenocarcinoma cell line PAIII in vi...

journal_title：Cancer investigation

authors： Cadieux PA,Mikolajczak SA,Reeves J,Strathdee C,Reid G,Panchal CJ,Clarke MW

更新日期：2006-04-01 00:00:00

abstract：:U-73,975 (U-73), U-77,779 (U-77), and U-80,244 (U-80) are analogs of the potent antitumor compound CC-1065. This class of drugs act as alkylating agents binding to DNA preferentially. Using the ATP-chemosensitivity assay, this study was designed to compare the potencies of U-73, U-77, and U-80 with cisplatin (DDP) or ...

journal_title：Cancer investigation

authors： Hightower RD,Sevin BU,Perras J,Nguyen H,Angioli R,Untch M,Averette H

更新日期：1993-01-01 00:00:00

abstract：:The standard staging evaluation of prostate cancer includes digital rectal examination, measurement of serum tumor markers, radionuclide bone scan, and abdominal pelvic computed tomography (CT) or nuclear magnetic resonance imaging (MRI). We retrospectively reviewed 300 cases of newly diagnosed, untreated adenocarcino...

journal_title：Cancer investigation

authors： Huncharek M,Muscat J

更新日期：1995-01-01 00:00:00