Abstract:
:Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, and 30% of controls were positive for APC, DAPK, and GSTP1 hypermethylation respectively. We couldn't find any significant role of DNA hypermethylation in lung cancer. However, long follow-up of methylation positive controls will be required to confirm its role for the prediction of lung cancer.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Ali A,Kumar S,Kakaria VK,Mohan A,Luthra K,Upadhyay AD,Guleria Rdoi
10.1080/07357907.2017.1309547subject
Has Abstractpub_date
2017-07-03 00:00:00pages
423-430issue
6eissn
0735-7907issn
1532-4192journal_volume
35pub_type
杂志文章abstract::To study the efficiency of high-dose melphalan in previously untreated patients with advanced myeloma, we performed a Phase I-II trial. Twenty-eight patients were treated at dose level of 60-140 mg/m2. Each patient was first treated with a priming dose of cyclophosphamide (300 mg) followed by high-dose melphalen 1 wee...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909209032784
更新日期:1992-01-01 00:00:00
abstract::Nerve growth factor receptor (NGF-R) has been shown to have antiproliferative, differentiative, or apoptotic effects on some types of tumor cells, whereas in others it may have mitogenic activity. The immunohistochemical distribution of NGF-R was analyzed in a series of tissue samples from breast cancer patients and i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100106144
更新日期:2001-01-01 00:00:00
abstract::Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909709039724
更新日期:1997-01-01 00:00:00
abstract::We evaluated the clinical impact of a high definition micro-multileaf collimator and a linac-integrated cone-beam computed tomography in 142 patients treated with conformal radiotherapy for localized prostate cancer to a total dose of 76 Gy. Details on treatment toxicity and tumour control were collected. The 3 years ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.970193
更新日期:2014-12-01 00:00:00
abstract::Currently, bladder cancer ranks as the second most common genitourinary malignancy which is exacting significant morbidity and mortality worldwide. Although there are abundant epidemiological and basic studies which strongly suggest the role of androgen hormone in bladder cancer, the underlying mechanism is not fully ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.853077
更新日期:2013-12-01 00:00:00
abstract::Autologous bone marrow transplantation (AuBMT) is an accepted treatment modality for patients with high-risk or relapsed hematological malignancies. Hepatotoxicity, in particular veno-occlusive disease (VOD), is a significant complication of this therapy. The purpose of this study was to determine the clinical relevan...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509031914
更新日期:1995-01-01 00:00:00
abstract::A 69-year-old man receiving monotherapy for lung cancer with dichloromethotrexate (DCM), and without exposure to other chemotherapeutic agents or known ototoxic drugs, developed profound cochleovestibular dysfunction. The initial presentation was vestibular. This resolved, but unilateral hearing loss ensued and contin...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909039861
更新日期:1989-01-01 00:00:00
abstract::erbB-2 protein is believed to be a cell membrane receptor for the recently identified ligand gp30. When overexpressed, erbB-2 is an indicator of poor prognosis in adenocarcinomas of breast, stomach, lung, and endometrium. Even more important, clinical data suggest that erbB-2 overexpression may be an indicator of poor...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909209024819
更新日期:1992-01-01 00:00:00
abstract::A randomized trial was conducted comparing ketoconazole and nystatin in the prevention of oral candidiasis and appearance of invasive fungal infections in 51 neutropenic leukemic patients undergoing induction chemotherapy. Ketoconazole was administered in a 200 mg dose twice daily. Nystatin oral suspension was given i...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-01-01 00:00:00
abstract::Gastrointestinal stromal tumors (GIST) are tumors most frequently found in adults. They are often related to activating mutations in the CD-117 tyrosine kinase receptor, most commonly at exon 11. Gastrointestinal stromal tumors have been reported in children. However, until recently, there had not been reports of acti...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701637824
更新日期:2008-03-01 00:00:00
abstract::The sequential administration of standard chemotherapy regimens to treat metastatic breast cancer may keep patients and oncologists from considering other important, but more psychologically difficult, issues such as the patient's declining health or approaching death. This practice also utilizes health care resources...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909409021402
更新日期:1994-01-01 00:00:00
abstract::While cancer remains an important public health concern, novel and enhanced treatment modalities have increased the length of survival of individuals diagnosed with the disease. The treatment of most cancers requires the use of chemotherapeutic agents to affect cure, maintain control of the disease, or provide palliat...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120018236
更新日期:2003-06-01 00:00:00
abstract::Dysregulation in apoptotic cell death has recently emerged as a factor in tumorigenesis, but its effect in tumor progression is not yet established. In the present study we evaluated the levels of proliferative and apoptotic cell fractions in a T-cell lymphoma tumor progression model. We compared these features and th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012202
更新日期:2000-01-01 00:00:00
abstract::Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120002951
更新日期:2002-01-01 00:00:00
abstract::Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors), cholesterol-lowering agents widely prescribed for cardiovascular health, have been shown to exert several pleiotropic effects. Although some studies reported that statins have no effects on malignancies of any kind, results of several epidemiologic ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900802491444
更新日期:2009-05-01 00:00:00
abstract::We carried out a phase I trial with chlorambucil. Thirty patients with advanced cancer were entered in six dose levels: 36, 48, 60, 84, 108, and 144 mg/m2. The drug was given in six divided oral doses every 6 hours and the regimen was repeated every 3 weeks. The median age was 62 years (31-84), median Karnofsky perfor...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809080064
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120000360
更新日期:2002-01-01 00:00:00
abstract::High-dose acetaminophen (HDAC) produces hepatocellular necrosis and cytotoxic changes in other tissues that express mixed-function-oxidase (MFO) activity. N-acetylcysteine (NAC), administered within 8 hr of HDAC exposure, replenishes reduced glutathione and prevents these effects. Numerous cell culture and animal stud...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909609012140
更新日期:1996-01-01 00:00:00
abstract::There appears to be exceptional and growing public enthusiasm for botanical, or "herbal", medicines, especially amongst cancer patients. This has recently begun to be matched by increasing scientific attention. Whilst it is known that plant extracts are active against cancer, the standard approach has been to isolate,...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120005926
更新日期:2002-01-01 00:00:00
abstract::Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohisto...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.849722
更新日期:2013-11-01 00:00:00
abstract::Psychosocial adjustment in adolescent cancer survivors has been documented to be quite variable. Factors mediating adjustment need to be identified. The current study is an exploration of the impact that cancer diagnosis and treatment has on adolescent's self-perceptions and the role this has in mediating adjustment i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909109018956
更新日期:1991-01-01 00:00:00
abstract::Neurological paraneoplastic syndromes are exceedingly rare, and often difficult to recognize clinically. Paraneoplastic achalasia is a condition characterized by new-onset dysphagia that is unrelated to tumor burden, most often due to the development of auto-immune antibodies targeting esophageal tissue. Due to the ra...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1852412
更新日期:2021-01-06 00:00:00
abstract::Between March 1986 and December 1987, two groups of consecutive patients with advanced breast cancer underwent epidoxorubicin (Epidx) monochemotherapy. Twenty-three patients (group A) received Epidx at a dose of 60 mg/m2 and 27 (group B) at a dose of 120 mg/m2 (i.v. every 3 weeks). No patient had undergone anthracycli...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909309024827
更新日期:1993-01-01 00:00:00
abstract::Despite the dramatic success achieved over the past few years in improving the survival of individuals with cancer, treatment for many patients with advanced malignancies remains far from satisfactory. Unfortunately, centers engaged in clinical cancer research are currently faced with the dilemma of dealing with incre...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357908709011740
更新日期:1987-01-01 00:00:00
abstract::We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice....
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.762781
更新日期:2013-02-01 00:00:00
abstract::Primary squamous cell carcinoma of the breast is a rare clinical entity. We diagnosed a patient who presented with a pure squamous cell cancer of the breast 12 years after local radiation for a primary adenocarcinoma of breast. Previously reported cancers related to radiation of the breast have been squamous cell of s...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012177
更新日期:2000-01-01 00:00:00
abstract::The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, an...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.657817
更新日期:2012-05-01 00:00:00
abstract::A number of studies have demonstrated the presence of mitochondrial DNA (mtDNA) mutations in cancer cells. In this article, we review mitochondrial genomic aberrations reported in solid tumors of the breast, colon, stomach, liver, kidney, bladder, head/neck, and lung. The tantalizing association of tumors with mtDNA m...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120002155
更新日期:2002-01-01 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of cancer death with a 5-year survival less than 5 percent despite rigorous interventions. This largely is due to its late presentation, aggressive metastasis, and a lack of effective adjuvant therapies. Cytokines have been studied in many tumor types, where they have been...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900600981398
更新日期:2006-11-01 00:00:00
abstract::N- and K-ras mutations at codons 12 and 13 were investigated using oligonucleotide hybridization analysis after PCR amplification and subsequent sequence analysis of the amplified DNA from the region of interest in the following prostatic primary and metastatic (met) carcinoma-derived cell lines: 1013L (primary), PC3 ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309020257
更新日期:1993-01-01 00:00:00