Abstract:
:Dysregulation in apoptotic cell death has recently emerged as a factor in tumorigenesis, but its effect in tumor progression is not yet established. In the present study we evaluated the levels of proliferative and apoptotic cell fractions in a T-cell lymphoma tumor progression model. We compared these features and the expression of apoptosis-related genes in primary tumors of several AKR lymphoma malignancy variants. According to DNA flow cytometry, a considerable proportion of cells (35-40%) was in the proliferative (S + G2/M) phase in all variants, but a slight augmentation with increasing malignancy was noted. Apoptotic cell content was, unexpectedly, the lowest in the less malignant variant. This might be due to the higher content in macrophages observed in this variant, which possibly partly eliminated apoptotic bodies. We found an increase in bcl-2 level with increasing malignancy that was probably counterbalanced by the simultaneous increase observed in the Fas receptor.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Donin N,Kay S,Sinai J,Katzenelson D,Siegal A,Michowitz M,Schibi G,Leibovici Jdoi
10.3109/07357900009012202subject
Has Abstractpub_date
2000-01-01 00:00:00pages
702-14issue
8eissn
0735-7907issn
1532-4192journal_volume
18pub_type
杂志文章abstract::A Phase I trial of three carboplatin-based combination chemotherapy regimens was conducted. These included: carboplatin plus vindesine; carboplatin, vindesine, plus bleomycin; and, carboplatin plus vinblastine. Carboplatin was administered every 28 days as an intravenous bolus. The initial dose was 150 mg/m2 and doses...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909009017558
更新日期:1990-01-01 00:00:00
abstract::The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.568566
更新日期:2011-06-01 00:00:00
abstract::A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900902849657
更新日期:2009-10-01 00:00:00
abstract::Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120001180
更新日期:2002-01-01 00:00:00
abstract::The G1 cyclins are clearly important factors that control progression through the eukaryotic cell cycle. The expression and activity of these factors are regulated at many different levels and in response to a large number of signals. Such complicated, multilevel controls on expression and activation of cyclin/cdk com...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909709115767
更新日期:1997-01-01 00:00:00
abstract::Despite increasing evidence of benefit from adjuvant chemotherapy, older women with breast cancer are commonly given less aggressive treatment than younger patients. Conflicting prior data regarding age-related toxicity prompted this prospective study. Forty-four women (aged 35-79 years) with early-stage breast cancer...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012191
更新日期:2000-01-01 00:00:00
abstract::This is a case report of small cell lung cancer (SCLC) that underwent spontaneous regression. This was associated with severe neuropathy, which was unresponsive to therapy, including corticosteroids and plasmapheresis. We present here the case report and a brief review of the literature. ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309024856
更新日期:1993-01-01 00:00:00
abstract::Melanoma is an immunoresponsive malignancy. Interleukin-10 (IL-10) is a potent regulator of immunosuppression. The purpose of this research was to define the relationship of serum IL-10 to survival in patients with metastatic melanoma. Forty-one melanoma patients and 50 normal volunteers were analyzed. The median IL-1...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100102550
更新日期:2001-01-01 00:00:00
abstract::Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2019.1662918
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Patients with systemic malignancies have substantial quantities of tumor-specific DNA in their plasma which may serve as a potential biomarker for tumor burden. This approach has not been studied in gliomas. METHODS:Methylation specific polymerase chain reaction (MSP) was used to determine the methylation st...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900500449546
更新日期:2006-02-01 00:00:00
abstract::Here 145 reported post-splenectomy infections in 115 patients with Hodgkin's disease are reviewed. Such infections can occur at any age (median age 19.8 years) and the interval from splenectomy to the infection is quite variable (median 21.9 months). Most infections are present clinically as pneumonia, septicemia, men...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908309040933
更新日期:1983-01-01 00:00:00
abstract::Cytosolic and nuclear progesterone receptor levels (RPC, RPN) were measured in normal and in pathological human endometria after single-dose progesterone injection 1-3 h before tissue collection (test subjects) and the results compared to those obtained in controls (no progesterone treatment). In test cases of late pr...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809082116
更新日期:1988-01-01 00:00:00
abstract::Combination immune checkpoint inhibitors (ICIs) achieved higher efficacy than monotherapy in many types of cancers. We searched PubMed, Scopus, and Cochrane databases for randomized phase II/III trials in cancer patients receiving combination ICIs vs. Monotherapy. Our search retrieved 934 records. Eight studies were f...
journal_title:Cancer investigation
pub_type: 杂志文章,meta分析
doi:10.1080/07357907.2020.1714053
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:The decision concerning adjuvant therapy remains difficult in patients with very early stage ovarian carcinomas [Fédération Internationale de Gynécologie et d' Obstétrique (FIGO) Ia/b]. Therefore, we compared the MIB1-determined tumor growth fraction in archival tumor tissue with tumor recurrence and outcome of...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120030206
更新日期:2004-01-01 00:00:00
abstract::Twenty-two patients with disseminated adenocarcinoma of the large bowel received therapy with 5-fluorouracil 800-1000 mg/m2 as a 24 h infusion for 4 consecutive days with 60 mg/m2 intravenous folinic acid administered every 6 hours. Major responses were seen in 3 of 20 (15%) evaluable patients, for a median of 5 month...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077039
更新日期:1988-01-01 00:00:00
abstract::Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003630934
更新日期:2010-10-01 00:00:00
abstract::Targeting the nuclear factor kappa B (NFκB) pathway is proposed as therapy for chronic lymphocytic leukemia (CLL). We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFκB activation in lymphocytes of Rai Stage 0-1 CLL patients. The initial dose of 2.4 g n-3/day was gradually increased to 7.2 g...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357907.2012.743553
更新日期:2013-01-01 00:00:00
abstract::The interaction of 5-fluorouracil and cyclophosphamide in the treatment of L1210 and P388 leukemias was studied using response surface methodology. Single dose treatment of each drug was administered simultaneously or with a 24-hr interval between 5-fluorouracil and cyclophosphamide to the advanced tumors or at variou...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908709020311
更新日期:1987-01-01 00:00:00
abstract::Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer and moderate relationship with unmethylated CpG-27 i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.1001892
更新日期:2015-03-01 00:00:00
abstract::This study compared the antiemetic efficacy and safety of two different intravenous (i.v.) dolasetron dosing regimens in patients receiving their first course of high-dose (> or = 80 mg/m2) cisplatin. Of 30 patients enrolled, 14 received a single i.v. dolasetron dose (0.6 mg/kg) before cisplatin and 16 received a mult...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/07357909709039730
更新日期:1997-01-01 00:00:00
abstract::The sponge matrix allograft model made possible the growth of an AKR lymphoma in a certain percentage of BALB/c mice making progressors (tumor-bearing) and regressors (tumor-rejecting) simultaneously available. Mice bearing either an AKR kidney allograft or a sponge alone were used as controls. The cell population inf...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908509040603
更新日期:1985-01-01 00:00:00
abstract::Autologous bone marrow transplantation (AuBMT) is an accepted treatment modality for patients with high-risk or relapsed hematological malignancies. Hepatotoxicity, in particular veno-occlusive disease (VOD), is a significant complication of this therapy. The purpose of this study was to determine the clinical relevan...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509031914
更新日期:1995-01-01 00:00:00
abstract::The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, in situ hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 G...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1793352
更新日期:2020-08-01 00:00:00
abstract::After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900500283101
更新日期:2005-01-01 00:00:00
abstract::Radioimmunoscintigraphy (RIS) is coming into its own as an imaging modality in clinical oncology. Early experience with indium-111-labeled intact murine monoclonal antibodies (MoAbs) in colorectal cancer suggested that RIS images hepatic metastases poorly. Moreover, an antimurine immune response was frequently provoke...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909909032874
更新日期:1999-01-01 00:00:00
abstract::Adjuvant and neoadjuvant chemotherapy is being used increasingly in the treatment of breast cancer patients. However, drug resistance plays an important role in the failure of chemotherapy in breast cancer. The aim of this study was to compare technetium-99m tetrofosmin (Tc-TETRO) mammoscintigraphic findings with the ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120001147
更新日期:2002-01-01 00:00:00
abstract::Cisplatin (CDDP) was administered to a 49-year-old dialysis female patient with advanced uterine cervical cancer. Analysis of the pharmacokinetics of CDDP in the patient with renal failure and at hemodialysis were compared with that of patients without renal impairment. CDDP at 30 mg was administered by drip infusion....
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909109039874
更新日期:1991-01-01 00:00:00
abstract::CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis forma...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802392675
更新日期:2009-03-01 00:00:00
abstract::Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic x...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.697232
更新日期:2012-08-01 00:00:00
abstract::The aim was to determine whether promoter methylation of BRCA1, MGMT, MLH1, RASSF1A, and p16 genes could predict response to platinum-based chemotherapy. Thirty-five subjects with epithelial ovarian cancer (EOC) treated by platinum-based chemotherapy were recruited. Methylation-specific polymerase chain reaction was c...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900902849699
更新日期:2009-10-01 00:00:00