Abstract：
:To study the efficiency of high-dose melphalan in previously untreated patients with advanced myeloma, we performed a Phase I-II trial. Twenty-eight patients were treated at dose level of 60-140 mg/m2. Each patient was first treated with a priming dose of cyclophosphamide (300 mg) followed by high-dose melphalen 1 week later. One course of therapy was given. Patients were then followed without further therapy until relapse. Clinical and laboratory features of the 28 patients in this study included: median age 63, performance status 0-2, hypercalcemia 21%, bone pain 82%, paraprotein types: IgG 76%, Iga 20%, and paraproteinuria 71%. Because none of the patients achieved complete remission (CR) at 60 mg/m2, despite life-threatening toxicity in all patients, the dose level was rapidly increased to 140 mg/m2, a dose previously reported to induce a high percentage of CR. At this dose, CR was achieved in only 1 of 11 patients (9%). This patient had multiple plasmacytomas without generalized bone marrow involvement. One additional patient at 100 mg/m2 achieved CR. Of the whole group, 12 achieved PR. Durations of remissions were generally short: CR 6.3 and 18+ months and PR 2.3-18 month, median 6.9 months. Life-threatening myelosuppression was universal with prolonged pancytopenia. Treatment-related deaths from sepsis were observed in 29% of patients. The median survival of the entire group was 15.6 months. Older patients in this trial did not tolerate high-dose melphalen therapy well; this resulted in a high proportion of toxic deaths and poor overall survival.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Case DC Jr,Coleman M,Gottlieb A,McCarroll Kdoi
10.3109/07357909209032784subject
Has Abstractpub_date
1992-01-01 00:00:00pages
11-7issue
1eissn
0735-7907issn
1532-4192journal_volume
10pub_type
临床试验,杂志文章abstract：:IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infecti...
journal_title：Cancer investigation
pub_type： 杂志文章,评审
doi：10.3109/07357909309011681
更新日期：1993-01-01 00:00:00
abstract：:Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal ti...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357907.2019.1576191
更新日期：2019-01-01 00:00:00
abstract：:Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357908809077025
更新日期：1988-01-01 00:00:00
abstract：INTRODUCTION:A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS:Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by ...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357907.2010.535057
更新日期：2011-01-01 00:00:00
abstract：:Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ER...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357907.2013.845672
更新日期：2013-11-01 00:00:00
abstract：:The purpose of this study is to investigate whether hematopoiesis capacity, immunomodulatory effect and ex vivo expansion potential of mesenchymal stem cells (MSCs) are affected by cryopreservation. Chronic myeloid leukemia (CML) patients' bone marrow MSCs cryopreserved for 3 months, 6 months, and 1 year were thawed a...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357900701788049
更新日期：2008-05-01 00:00:00
abstract：:Because most cancer deaths result from disseminated disease, understanding the regulation of tumor invasion and metastasis is a central theme in tumor cell biology. Interactions between extracellular matrices (ECM) and cellular microenvironment play a crucial role in this process. We have tested selected amino acids a...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357909609018433
更新日期：1996-01-01 00:00:00
abstract：:Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357900600814847
更新日期：2006-08-01 00:00:00
abstract：:Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies...
journal_title：Cancer investigation
pub_type： 杂志文章,评审
doi：10.3109/07357900009031826
更新日期：2000-01-01 00:00:00
abstract：:Adriamycin (ADM, or doxorubicin hydrochloride) is an effective antineoplastic agent whose use is restricted by its well-described, dose-dependent cardiotoxicity. This study measures ADM DNA adduct formation by 32P-radiolabeling DNA, enzymatically digesting radiolabeled DNA, separating the formed adducts on two-dimensi...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1081/cnv-120016404
更新日期：2003-01-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. METHODS:One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. RESULTS:The median normal MnSOD expression...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357900903405918
更新日期：2010-10-01 00:00:00
abstract：:Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal o...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357907.2015.1114123
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. METHODS:Responses from 479 ...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1081/cnv-200026487
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...
journal_title：Cancer investigation
pub_type： 临床试验,杂志文章
doi：10.1081/cnv-120000360
更新日期：2002-01-01 00:00:00
abstract：:Based on cost-effective ratio, there has not yet been imaging methods suitable for breast cancer screening in young women. The aim of this study was to evaluate the sensitivity and specificity of the combination of electrical impedance scanning (EIS) and ultrasound in identifying breast cancer for young women, to calc...
journal_title：Cancer investigation
pub_type： 杂志文章,多中心研究
doi：10.3109/07357900802203658
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:Patients with systemic malignancies have substantial quantities of tumor-specific DNA in their plasma which may serve as a potential biomarker for tumor burden. This approach has not been studied in gliomas. METHODS:Methylation specific polymerase chain reaction (MSP) was used to determine the methylation st...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357900500449546
更新日期：2006-02-01 00:00:00
abstract：:Adjuvant and neoadjuvant chemotherapy is being used increasingly in the treatment of breast cancer patients. However, drug resistance plays an important role in the failure of chemotherapy in breast cancer. The aim of this study was to compare technetium-99m tetrofosmin (Tc-TETRO) mammoscintigraphic findings with the ...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1081/cnv-120001147
更新日期：2002-01-01 00:00:00
abstract：:Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by...
journal_title：Cancer investigation
pub_type： 杂志文章,评审
doi：10.1080/07357907.2019.1662918
更新日期：2019-01-01 00:00:00
abstract：:Reversible epidermal growth factor receptor tyrosine kinase inhibitors are often used for the treatment of non-small cell lung cancer following failure of cytotoxic chemotherapy. While these agents are active in a subset of patients, most develop resistance and progress within the course of 1 year. In nearly half of t...
journal_title：Cancer investigation
pub_type： 杂志文章,评审
doi：10.3109/07357901003631072
更新日期：2010-05-01 00:00:00
abstract：:Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that th...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357907.2012.672607
更新日期：2012-06-01 00:00:00
abstract：:We analyzed the pattern of alpha-fetoprotein (AFP) synthesis in 40 consecutive human hepatocarcinomas (HCC) in relation to hepatitis B viral (HBV) infection. In addition, histopathological characteristics of liver parenchyma and the tumor itself were examined. Elevated AFP (> 20 ng/ml) were found in 90% of HCC patient...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357909209024813
更新日期：1992-01-01 00:00:00
abstract：:Currently, bladder cancer ranks as the second most common genitourinary malignancy which is exacting significant morbidity and mortality worldwide. Although there are abundant epidemiological and basic studies which strongly suggest the role of androgen hormone in bladder cancer, the underlying mechanism is not fully ...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357907.2013.853077
更新日期：2013-12-01 00:00:00
abstract：:In a sample of 633 US adult breast cancer survivors, we examined health-related worry as a function vulnerability as influenced by communication, trust, and planning with their cancer care team during the COVID-19 pandemic. We found significant positive correlations between communication and trust, communication and p...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357907.2020.1841220
更新日期：2021-01-01 00:00:00
abstract：:Between March 1986 and December 1987, two groups of consecutive patients with advanced breast cancer underwent epidoxorubicin (Epidx) monochemotherapy. Twenty-three patients (group A) received Epidx at a dose of 60 mg/m2 and 27 (group B) at a dose of 120 mg/m2 (i.v. every 3 weeks). No patient had undergone anthracycli...
journal_title：Cancer investigation
pub_type： 临床试验,杂志文章
doi：10.3109/07357909309024827
更新日期：1993-01-01 00:00:00
abstract：:We studied the effects of Shikaron, which is composed of 8 Chinese herb extracts, on carcinogenesis and the cytotoxic activity and cytokine production of lymphocytes in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine (BBN). We found a significantly lower incidence of urinary bladder carcinoma in mice tr...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357909809050031
更新日期：1998-01-01 00:00:00
abstract：:Computer visualization techniques (CVTs) are an emerging technology that can organize all cancer specialists. This article describes CVTs' ability to maximize the currently untapped advantages of intensity modulated radiotherapy (IMRT). The visual speed and dynamic strategies inherent in CVTs improves IMRT by distilli...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357900600970490
更新日期：2007-02-01 00:00:00
abstract：:The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endotheli...
journal_title：Cancer investigation
pub_type： 杂志文章,评审
doi：10.3109/07357908909039849
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:A 96-hour infusion schedule of paclitaxel demonstrates tolerability and antitumor activity in lung cancer and breast cancer refractory to short-duration infusion paclitaxel. Given the activity of paclitaxel in esophageal cancer, a phase II trial of 96-hour infusion paclitaxel in esophageal cancer was underta...
journal_title：Cancer investigation
pub_type： 临床试验,杂志文章
doi：10.1081/cnv-120022360
更新日期：2003-01-01 00:00:00
abstract：:Arsenic trioxide is valuable for treatment of promyelocytic leukemia, but less attention has been paid to its therapeutic potential for other cancers. In this study, the effects of arsenic trioxide were tested in human pancreatic (AsPC-1), colonic (HT-29), and breast (MCF-7) cancer cells. In all three cancer cell line...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1081/cnv-200029068
更新日期：2004-01-01 00:00:00
abstract：:Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357900600894773
更新日期：2006-10-01 00:00:00
