Abstract:
INTRODUCTION:The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. METHODS:One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. RESULTS:The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%. CONCLUSION:MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Martin RC,Li Y,Liu Q,Barker DF,Doll MA,Hein DWdoi
10.3109/07357900903405918subject
Has Abstractpub_date
2010-10-01 00:00:00pages
813-9issue
8eissn
0735-7907issn
1532-4192journal_volume
28pub_type
杂志文章abstract::We analyzed the pattern of alpha-fetoprotein (AFP) synthesis in 40 consecutive human hepatocarcinomas (HCC) in relation to hepatitis B viral (HBV) infection. In addition, histopathological characteristics of liver parenchyma and the tumor itself were examined. Elevated AFP (> 20 ng/ml) were found in 90% of HCC patient...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909209024813
更新日期:1992-01-01 00:00:00
abstract::Increasing evidence indicates that disruption of circadian rhythms may be directly linked to cancer. Here we report that the expression levels of the core clock genes Per1 and Per3 measured by droplet digital polymerase chain reaction are significantly decreased in tumour tissue from 16 patients undergoing colorectal ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1571079
更新日期:2019-01-01 00:00:00
abstract::In this study, we investigated ALDH1A3, Mcl1, and miR-125a/b expression in HT29 cells and the effect of miR-125a/b on ALDH1A3 and Mcl1 expression. Our results showed that low expression of miR-125a/b and high expression of ALDH1A3 and Mel1 were observed in both ALDH1-positive HT29 and HT29-taxol cells. Overexpression ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.743557
更新日期:2013-01-01 00:00:00
abstract::The present study investigates the association between IL12Bpro and +16974A/C in 3' -untranslated region (UTR) polymorphisms of IL12B and IL-12p40 serum level related to development of colorectal cancer (CRC). Our results showed similar distribution of both the investigated polymorphisms among CRC patients and healthy...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.3109/07357900902918486
更新日期:2009-11-01 00:00:00
abstract::Two groups of patients with disseminated breast carcinomas who had failed radiotherapy, chemotherapy, and hormonotherapy were treated with natural interferon alpha (nIFN-alpha) alone or in combination with nIFN-gamma delivered in cycles of 10-12 intralesional (i.l.) injections to recurrent and metastatic lesions. In g...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509011686
更新日期:1995-01-01 00:00:00
abstract::Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydroge...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1408814
更新日期:2017-11-26 00:00:00
abstract::This survey aimed at getting a first insight into diverse side effects and their association with satisfaction with life as well as the use of complementary and alternative medicine (CAM) in cancer patients. A total of 100 patients in a German University Hospital were included. General side effects like fatigue, fever...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1625055
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed. PATIENTS AND METHODS:Premenopausal women with ESBC and planned chemotherapy (>/= 25% risk of amenorrhea) were evaluated. Foll...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701829777
更新日期:2008-04-01 00:00:00
abstract::We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes (SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2016.1272695
更新日期:2017-02-07 00:00:00
abstract::The aim was to determine whether promoter methylation of BRCA1, MGMT, MLH1, RASSF1A, and p16 genes could predict response to platinum-based chemotherapy. Thirty-five subjects with epithelial ovarian cancer (EOC) treated by platinum-based chemotherapy were recruited. Methylation-specific polymerase chain reaction was c...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900902849699
更新日期:2009-10-01 00:00:00
abstract::A number of studies have demonstrated the presence of mitochondrial DNA (mtDNA) mutations in cancer cells. In this article, we review mitochondrial genomic aberrations reported in solid tumors of the breast, colon, stomach, liver, kidney, bladder, head/neck, and lung. The tantalizing association of tumors with mtDNA m...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120002155
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:A 96-hour infusion schedule of paclitaxel demonstrates tolerability and antitumor activity in lung cancer and breast cancer refractory to short-duration infusion paclitaxel. Given the activity of paclitaxel in esophageal cancer, a phase II trial of 96-hour infusion paclitaxel in esophageal cancer was underta...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120022360
更新日期:2003-01-01 00:00:00
abstract::Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120016421
更新日期:2003-04-01 00:00:00
abstract::Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (AIPD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908309063292
更新日期:1983-01-01 00:00:00
abstract::The aim of the current study was to determine the signaling differences between gamma- and proton beam-irradiations. A549 lung adenocarcinoma cells were irradiated with 2 Gy proton beam or gamma-radiation. Proton beam was found to be more cytotoxic than gamma-radiation. Proton beam-irradiated cells showed phosphorylat...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003630991
更新日期:2010-07-01 00:00:00
abstract::Triple-negative breast cancer is defined by the lack of expression of estrogen-receptor, progesterone-receptor, and HER-2/neu. It primarily, but not exclusively, carries the basal-like molecular profile on gene expression arrays and is associated with BRCA-1 and p53 mutations. It has an aggressive behavior and predile...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2010.483507
更新日期:2010-10-01 00:00:00
abstract::Data have shown that tamoxifen (TAM) can be used to treat not only breast cancer with positive estrogen receptor (ER), but also negative ER including human glioma. However, the molecular mechanism of this drug against different kinds of cancers remains to be elucidated. In this study, we provided the evidence that PKC...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802672720
更新日期:2009-08-01 00:00:00
abstract::PS-341, now known as bortezomib (Velcade[Millenium Pharmaceuticals, Inc., Cambridge, MA; and Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring house, PA]), is a proteasome inhibitor approved for the treatment of refractory multiple myeloma. Preclinical and early clinical studies showed PS-341 to be ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701506573
更新日期:2007-12-01 00:00:00
abstract::The scientific rationale to block angiogenesis as a treatment strategy for human cancer has been developed over the last 30 years, but is only now entering the clinical arena. Preclinical studies have demonstrated the importance of the vascular endothelial growth factor (VEGF) pathways in both physiologic and patholog...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900500360024
更新日期:2005-01-01 00:00:00
abstract::Bone marrow (BM) niche is a specific microenvironment for hematopoietic stem cells (HSCs) as well as non-hematopoietic cells. Evidence shows that chemo/radiotherapy can lead to the disruption of different properties of HSCs such as proliferation, differentiation, localization, self-renewa, and steady-state of cell pop...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1855353
更新日期:2020-12-10 00:00:00
abstract:BACKGROUND:This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. METHODS:This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.919305
更新日期:2014-08-01 00:00:00
abstract::Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic x...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.697232
更新日期:2012-08-01 00:00:00
abstract::Several recent studies have indicated that alterations in expression of major histocompatibility complex (MHC) antigens by tumor cells affects the ability of the host to mount an effective antitumor immune response. To investigate whether newly induced tumors frequently exhibit altered MHC antigen expression, we used ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909109021324
更新日期:1991-01-01 00:00:00
abstract::A case control study of 2,908 breast cancer cases and 3,180 controls, derived from a nationwide screening program, enabled evaluation of the relationship of breast cancer risk to a variety of menstrual factors. Risk was significantly inversely related to age at menarche, with women who first menstruated at age 15 or l...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809080645
更新日期:1988-01-01 00:00:00
abstract::We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle ge...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903095623
更新日期:2010-07-01 00:00:00
abstract::The overexpression of HER-2/neu and p53 has been associated with poor outcome in many neoplasms. Their role in patients with osteosarcoma is unclear. We studied the expression of HER-2/neu and p53 in 22 osteosarcoma samples (from 20 patients--2 had locally recurrent disease) biopsied at the University of Medicine and ...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120027577
更新日期:2004-01-01 00:00:00
abstract::Gastrointestinal stromal tumors (GIST) are tumors most frequently found in adults. They are often related to activating mutations in the CD-117 tyrosine kinase receptor, most commonly at exon 11. Gastrointestinal stromal tumors have been reported in children. However, until recently, there had not been reports of acti...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701637824
更新日期:2008-03-01 00:00:00
abstract::A randomized trial was conducted comparing ketoconazole and nystatin in the prevention of oral candidiasis and appearance of invasive fungal infections in 51 neutropenic leukemic patients undergoing induction chemotherapy. Ketoconazole was administered in a 200 mg dose twice daily. Nystatin oral suspension was given i...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-01-01 00:00:00
abstract::Ammonium sulfate (AS) precipitation by consecutive steps at 10% to 50% saturation has been utilized for fractionation of cytoplasmic estrogen receptor (ER) and progesterone receptor (PgR). The highest percentage of both receptor activities are confined mainly in two fractions at AS saturation from 20% to 30% and 30% t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909039842
更新日期:1989-01-01 00:00:00
abstract::This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900902744494
更新日期:2010-03-01 00:00:00