Abstract:
:The aim was to determine whether promoter methylation of BRCA1, MGMT, MLH1, RASSF1A, and p16 genes could predict response to platinum-based chemotherapy. Thirty-five subjects with epithelial ovarian cancer (EOC) treated by platinum-based chemotherapy were recruited. Methylation-specific polymerase chain reaction was carried out and the methylation index (MI) was also derived. Response to platinum-based chemotherapy was documented clinically, radiologically, and by serial CA125 levels. Methylated BRCA1 (p = .037) and a higher MI (p = .045) were associated with primary chemosensitivity. A better outcome was predicted by a higher MI (p = .032). In EOC, BRCA1 gene promoter methylation is useful in the prediction of response to chemotherapy.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Chaudhry P,Srinivasan R,Patel FDdoi
10.1080/07357900902849699subject
Has Abstractpub_date
2009-10-01 00:00:00pages
877-84issue
8eissn
0735-7907issn
1532-4192pii
912609607journal_volume
27pub_type
杂志文章abstract::In summary, anemia developing in a patient with cancer can be due to several different factors. A relative failure of erythropoiesis, in conjunction with a modestly shortened erythrocyte survival, is the most likely explanation for the anemia and can occur in patients with or without bone marrow invasion. Several theo...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357908509039786
更新日期:1985-01-01 00:00:00
abstract::Multifractionated dosing (MFD) schedules for chemotherapy administration such as weekly or twice weekly administration are intended to maximize dose intensity while minimizing toxicity, but the cumulative drug effect may result in neutropenia necessitating interruption of dose fractions and thereby compromising dose i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909909032865
更新日期:1999-01-01 00:00:00
abstract::Autologous bone marrow transplantation (AuBMT) is an accepted treatment modality for patients with high-risk or relapsed hematological malignancies. Hepatotoxicity, in particular veno-occlusive disease (VOD), is a significant complication of this therapy. The purpose of this study was to determine the clinical relevan...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509031914
更新日期:1995-01-01 00:00:00
abstract::This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.834925
更新日期:2013-10-01 00:00:00
abstract::Standard chemotherapeutic regimens, such as cisplatin and etoposide, may improve quality of life and prolong survival in patients with incurable non-small cell lung cancer (NSCLC). This trial was designed to evaluate the activity and toxicity of a regimen combining three of the most active agents against advanced-stag...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/07357900009023055
更新日期:2000-01-01 00:00:00
abstract::To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903095706
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. METHODS:This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.919305
更新日期:2014-08-01 00:00:00
abstract::Precise quantification of oral complications in cancer patients receiving bone marrow and stem cell transplantation is essential when testing new treatment strategies for mucositis. Using 133 adult transplant patients, the authors evaluated the 20 item oral mucositis index (OMI), adapted from the 34 item OMI, to facil...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120005902
更新日期:2002-01-01 00:00:00
abstract::A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900902849657
更新日期:2009-10-01 00:00:00
abstract::ErbB receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ErbB inhibitors are now used in the clinical setting. A large number of studies have been conducted to examine the expression of ErbB family members in bone and soft tissue sarcomas, includi...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2014.964409
更新日期:2014-12-01 00:00:00
abstract::Seven patients developed a lung abscess and bronchopleural fistula after undergoing aggressive treatment of their lung cancer with radiotherapy +/- chemotherapy. These complications were preceded by a prodrome of recurrent bronchitis with increasing refractoriness to antibiotics, weight loss, fever, and generalized de...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077041
更新日期:1988-01-01 00:00:00
abstract::Triple-negative breast cancer is defined by the lack of expression of estrogen-receptor, progesterone-receptor, and HER-2/neu. It primarily, but not exclusively, carries the basal-like molecular profile on gene expression arrays and is associated with BRCA-1 and p53 mutations. It has an aggressive behavior and predile...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2010.483507
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120000360
更新日期:2002-01-01 00:00:00
abstract::Malignant kidney tumors account for approximately 2% of all new primary cancer cases diagnosed in the United States, with an estimated 30,000 cases occurring annually. Although a variety of agents, chemical and biological, have been implicated as causal agents in the development of renal cell carcinoma (RCC), the etio...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-200055962
更新日期:2005-01-01 00:00:00
abstract::To identify the relevant CpG sites as molecular markers, for the diagnosis and to distinguish the indolent and aggressive prostate tumors, we have determined the methylation status of 8 genes, including FLNC, EFS, ECRG4, RARB2, PITX2, GSTP1, PDLIM4, and KCNMA1 in 32 nonrecurrent, 32 recurrent primary prostate tumors, ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802620794
更新日期:2009-06-01 00:00:00
abstract::Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.721039
更新日期:2012-10-01 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of cancer death with a 5-year survival less than 5 percent despite rigorous interventions. This largely is due to its late presentation, aggressive metastasis, and a lack of effective adjuvant therapies. Cytokines have been studied in many tumor types, where they have been...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900600981398
更新日期:2006-11-01 00:00:00
abstract::This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900902744494
更新日期:2010-03-01 00:00:00
abstract::A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90(-), CD117(-), and CD123(+). Research in...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.700986
更新日期:2013-05-01 00:00:00
abstract::The G1 cyclins are clearly important factors that control progression through the eukaryotic cell cycle. The expression and activity of these factors are regulated at many different levels and in response to a large number of signals. Such complicated, multilevel controls on expression and activation of cyclin/cdk com...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909709115767
更新日期:1997-01-01 00:00:00
abstract::Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (AIPD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908309063292
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVES:To investigate the relative risk factor of food items for colorectal cancer in four time periods through a case-control study in a Chinese rural area. METHODS:Colorectal cancer patients diagnosed at a county cancer center, Hebei Province, China, and non-cancer outpatients with similar age, sex, and place of...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120002145
更新日期:2002-01-01 00:00:00
abstract::The scientific rationale to block angiogenesis as a treatment strategy for human cancer has been developed over the last 30 years, but is only now entering the clinical arena. Preclinical studies have demonstrated the importance of the vascular endothelial growth factor (VEGF) pathways in both physiologic and patholog...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900500360024
更新日期:2005-01-01 00:00:00
abstract::Patients with metastatic prostate cancer resistant to hormones and docetaxel were treated with vinflunine (320 mg/m(2) every 21 days), a new vinca alkaloid with improved preclinical activity. Only 1 of 36 patients (3%) had partial response; the median progression-free survival (PFS) was 2.1 months. Treatment was well ...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.3109/07357900902918460
更新日期:2010-03-01 00:00:00
abstract::Combination immune checkpoint inhibitors (ICIs) achieved higher efficacy than monotherapy in many types of cancers. We searched PubMed, Scopus, and Cochrane databases for randomized phase II/III trials in cancer patients receiving combination ICIs vs. Monotherapy. Our search retrieved 934 records. Eight studies were f...
journal_title:Cancer investigation
pub_type: 杂志文章,meta分析
doi:10.1080/07357907.2020.1714053
更新日期:2020-03-01 00:00:00
abstract::Tamoxifen is a first targeted drug that continues to be the gold standard in treatment of estrogen receptor positive breast cancer for almost 50 years. The current review is an update of the paper published in 2012. We provide the new data on the tamoxifen targets that are the key points of signaling cascades activati...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2018.1453933
更新日期:2018-04-21 00:00:00
abstract::Targeting the nuclear factor kappa B (NFκB) pathway is proposed as therapy for chronic lymphocytic leukemia (CLL). We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFκB activation in lymphocytes of Rai Stage 0-1 CLL patients. The initial dose of 2.4 g n-3/day was gradually increased to 7.2 g...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357907.2012.743553
更新日期:2013-01-01 00:00:00
abstract::This is the first of two papers describing the naturally occurring retroviruses (RNA tumor viruses). Here, the general properties of these viruses and the biology of the fish, reptilian, chicken, and mouse retroviruses are described. In the next issue of Cancer Investigation the biologic properties of the cat, cattle,...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357908309040934
更新日期:1983-01-01 00:00:00
abstract::In this study, we evaluated SEA-H61D, a staphylococcal enterotoxin A mutant without emetic activity, as an antitumor agent in vitro and in vivo. It showed that SEA-H61D could significantly inhibit the growth of many cancer cell lines in vitro at very low concentrations by activating human peripheral blood mononuclear ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903286982
更新日期:2010-10-01 00:00:00
abstract::After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900500283101
更新日期:2005-01-01 00:00:00