Abstract:
:To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed that rAAV harboring fusion gene NT4-Ant-Shepherdin significantly suppressed A549 cell growth in a time-dependent manner and induced apoptosis. In the infected A549 cells, survivin expression level decreased strongly while Caspase-3/7 activities increased significantly. These results indicated that rAAV harboring fusion gene NT4-Ant-Shepherdin may be a novel strategy in lung cancer peptide therapy.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Xiaojiang T,Jinsong Z,Jiansheng W,Chengen P,Guangxiao Y,Quanying Wdoi
10.3109/07357900903095706subject
Has Abstractpub_date
2010-06-01 00:00:00pages
465-71issue
5eissn
0735-7907issn
1532-4192journal_volume
28pub_type
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journal_title:Cancer investigation
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abstract::Melanoma is an immunoresponsive malignancy. Interleukin-10 (IL-10) is a potent regulator of immunosuppression. The purpose of this research was to define the relationship of serum IL-10 to survival in patients with metastatic melanoma. Forty-one melanoma patients and 50 normal volunteers were analyzed. The median IL-1...
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