Bile acids affect the growth of human cholangiocarcinoma via NF-kB pathway.

abstract：:Gefitinib (ZD1839, Iressa), a member of the 4-anilinoquinazoline class of compounds, has the chemical name 4-quinazolinamine, N-(3-chloro-4-flurophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]. Gefitinib often is referred to as a "specific" or "selective" inhibitor of epidermal growth factor receptor (EGFR). EGFR expre...

journal_title：Cancer investigation

authors： Freeman BB 3rd,Daw NC,Geyer JR,Furman WL,Stewart CF

更新日期：2006-04-01 00:00:00

abstract：:CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis forma...

journal_title：Cancer investigation

authors： Voigt H,Vetter-Kauczok CS,Schrama D,Hofmann UB,Becker JC,Houben R

更新日期：2009-03-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) play an important role in the development of human cancers. In the present study, we observed that hMSCs promoted human prostate cancer (PCa) cell PC-3 growth in vivo and in vitro. The conditional medium of hMSCs promoted the proliferation, migration, and invasion of PC-3 cells. Th...

journal_title：Cancer investigation

authors： Ye H,Cheng J,Tang Y,Liu Z,Xu C,Liu Y,Sun Y

更新日期：2012-08-01 00:00:00

abstract：:High expression of vascular endothelial growth factor (VEGF) in patients with hepatocellular carcinoma (HCC) is associated with poor prognosis. Here, we investigated the antitumor activity of lenvatinib, a multiple receptor tyrosine kinase inhibitor, in VEGF-overexpressing HCC models. In human umbilical vein endotheli...

journal_title：Cancer investigation

authors： Adachi Y,Matsuki M,Watanabe H,Takase K,Kodama K,Matsui J,Funahashi Y,Nomoto K

更新日期：2019-01-01 00:00:00

abstract：:A case control study of 2,908 breast cancer cases and 3,180 controls, derived from a nationwide screening program, enabled evaluation of the relationship of breast cancer risk to a variety of menstrual factors. Risk was significantly inversely related to age at menarche, with women who first menstruated at age 15 or l...

journal_title：Cancer investigation

authors： Brinton LA,Schairer C,Hoover RN,Fraumeni JF Jr

更新日期：1988-01-01 00:00:00

abstract：:We carried out a phase I trial with chlorambucil. Thirty patients with advanced cancer were entered in six dose levels: 36, 48, 60, 84, 108, and 144 mg/m2. The drug was given in six divided oral doses every 6 hours and the regimen was repeated every 3 weeks. The median age was 62 years (31-84), median Karnofsky perfor...

journal_title：Cancer investigation

authors： Blumenreich MS,Woodcock TM,Sherrill EJ,Richman SP,Gentile PS,Epremian BE,Kubota TT,Allegra JC

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...

journal_title：Cancer investigation

authors： Abushullaih S,Saad ED,Munsell M,Hoff PM

更新日期：2002-01-01 00:00:00

abstract：:Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...

journal_title：Cancer investigation

authors： Allison RR,Vongtama V,Vaughan J,Shin KH

更新日期：1995-01-01 00:00:00

abstract：:Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by...

journal_title：Cancer investigation

authors： Jain S,Sengupta M,Jain P

更新日期：2019-01-01 00:00:00

abstract：:Combination immune checkpoint inhibitors (ICIs) achieved higher efficacy than monotherapy in many types of cancers. We searched PubMed, Scopus, and Cochrane databases for randomized phase II/III trials in cancer patients receiving combination ICIs vs. Monotherapy. Our search retrieved 934 records. Eight studies were f...

journal_title：Cancer investigation

authors： Abdelhafeez AAM,Shohdy KS,Ibrahim W

更新日期：2020-03-01 00:00:00

abstract：:In the present study, we searched selective cytotoxicity and mitochondria mediated apoptosis of novel COX-2 inhibitor 2-(4-(Methylsulfonyl)phenyl)imidazo[1,2-a] pyridine-8-carboxylic acid on B-lymphocytes and their mitochondria isolated from normal subjects and acute lymphoblastic leukemia (ALL) patients' blood. Our r...

journal_title：Cancer investigation

authors： Salimi A,Aghvami M,Azami Movahed M,Zarei MH,Eshghi P,Zarghi A,Pourahmad J

更新日期：2020-09-01 00:00:00

abstract：:This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...

journal_title：Cancer investigation

authors： Zhao X,Liu J,Peng M,Liu J,Chen F

更新日期：2013-10-01 00:00:00

abstract：:Transarterial radioembolization (TARE) is one of the therapeutic options for hepatocellular carcinoma (HCC). This study aimed to investigate the predictors and prognostic values of achieving curative treatments after TARE. Overall, 143 patients with intrahepatic HCC treated with TARE between 2011 and 2017 were recruit...

journal_title：Cancer investigation

authors： Kim Y,Lee HA,Lee JS,Jeon MY,Kim BK,Park JY,Kim DY,Ahn SH,Um SH,Seo YS,Kim SU

更新日期：2021-01-11 00:00:00

abstract：:Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, an...

journal_title：Cancer investigation

authors： Ali A,Kumar S,Kakaria VK,Mohan A,Luthra K,Upadhyay AD,Guleria R

更新日期：2017-07-03 00:00:00

abstract：:The immunotherapeutic effects of interleukin-1 alpha (IL-1 alpha) encapsulated within 1-5 microns-diameter poly (D, L-lactide) microspheres and delivered intratumorally into fibrosarcoma-bearing mice were investigated. Such microspheres are avidly taken up by macrophages, and directing IL-1 alpha into these cells may ...

journal_title：Cancer investigation

authors： Mullerad J,Cohen S,Benharroch D,Apte RN

更新日期：2003-01-01 00:00:00

abstract：:The structural dimensions of capillary tight junctions and the uptake of 99mTc pertechnetate in human gliomas were studied. Quantitative analysis revealed a correlation between the uptake of radionuclides and the length of endothelial tight junctions. It is suggested that brain scintigraphy might be used for the selec...

journal_title：Cancer investigation

authors： Nir I,Kohn S,Doron Y,Israel O,Front D

更新日期：1986-01-01 00:00:00

abstract：:We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle ge...

journal_title：Cancer investigation

authors： Moumtzi SS,Roberts ML,Joyce T,Evangelidou M,Probert L,Frillingos S,Fotsis T,Pintzas A

更新日期：2010-07-01 00:00:00

abstract：:Venous thromboembolic disease is a major cause of morbidity in cancer patients. The Perspective database was used to identify patients with solid tumors and a diagnosis of VTE from 2006 to 2012. We examined use of IVC filters, thrombolysis, and thrombectomy. Among 32,545 patients, 23.1% received an IVC filter, 1.9% th...

journal_title：Cancer investigation

authors： Yoon L,Clarke Hillyer G,Chen L,Hu JC,Neugut AI,Hershman DL,Wright JD

更新日期：2016-09-13 00:00:00

abstract：:The role of stereotactic body radiation therapy (SBRT) in achieving durable local control and palliation of pain in pelvic lymph node oligometastatic disease is not well-studied. We performed a retrospective analysis of 30 patients with 43 pelvic lymph node oligometastases from various primary cancers all but one with...

journal_title：Cancer investigation

authors： Reshko LB,Richardson MK,Spencer K,Kersh CR

更新日期：2020-11-01 00:00:00

abstract：:A dosimetric comparison was made of Helical Tomotherapy (HT) and Rapid'Arc(®) (RA) in 115 patients with head and neck carcinoma included in a prospective and multicentric study. HT and RA provided highly conformal plans that easily complied with dose volume constraints for organs at risk. HT reduced high doses to the ...

journal_title：Cancer investigation

authors： Vernat SS,Ali D,Messina C,Pommier P,Dussart S,Puyraveau M,Viard R,Lacornerie T,Lisbona A,Fenoglietto P,Mazurier J,Garcia R,Hangard G,Zefkili S,Makovicka L,Giraud P

更新日期：2014-06-01 00:00:00

abstract：:We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes (SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of...

journal_title：Cancer investigation

authors： Vishwakarma S,Agarwal R,Goel SK,Panday RK,Singh R,Sukumaran R,Khare S,Kumar A

更新日期：2017-02-07 00:00:00

abstract：PURPOSE:The decision concerning adjuvant therapy remains difficult in patients with very early stage ovarian carcinomas [Fédération Internationale de Gynécologie et d' Obstétrique (FIGO) Ia/b]. Therefore, we compared the MIB1-determined tumor growth fraction in archival tumor tissue with tumor recurrence and outcome of...

journal_title：Cancer investigation

authors： Münstedt K,von Georgi R,Franke FE

更新日期：2004-01-01 00:00:00

abstract：:Psychosocial adjustment in adolescent cancer survivors has been documented to be quite variable. Factors mediating adjustment need to be identified. The current study is an exploration of the impact that cancer diagnosis and treatment has on adolescent's self-perceptions and the role this has in mediating adjustment i...

journal_title：Cancer investigation

authors： Smith K,Ostroff J,Tan C,Lesko L

更新日期：1991-01-01 00:00:00

abstract：:We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baselin...

journal_title：Cancer investigation

authors： Chasseing NA,Barañao RI,Fernández O,Bordenave H,Rumi LS

更新日期：1993-01-01 00:00:00

abstract：:Objectives: We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at dia...

journal_title：Cancer investigation

authors： Akhtar-Danesh N,Akhtar-Danseh GG,Seow HY,Shakeel S,Finley C

更新日期：2019-01-01 00:00:00

abstract：:Breast cancer treatment is recognized as the most common cause of secondary lymphedema (LE) in the developed countries of the world. LE occurs as both an acute and chronic health condition in which significant and persistent swelling is associated with an abnormal accumulation of protein-rich fluid. The impact of LE i...

journal_title：Cancer investigation

authors： Armer JM

更新日期：2005-01-01 00:00:00

abstract：:We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to b...

journal_title：Cancer investigation

authors： Gunduz E,Gunduz M,Ali MA,Beder L,Tamamura R,Katase N,Tominaga S,Yamanaka N,Shimizu K,Nagatsuka H

更新日期：2009-07-01 00:00:00

abstract：:Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b i...

journal_title：Cancer investigation

authors： Liu W,Dong Z,Liang J,Guo X,Guo Y,Shen S,Kuang G,Guo W

更新日期：2016-11-25 00:00:00

abstract：:Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition ...

journal_title：Cancer investigation

authors： Guo W,Dong Z,Lin X,Zhang M,Kuang G,Zhu T

更新日期：2012-12-01 00:00:00

abstract：:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

journal_title：Cancer investigation

authors： Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

更新日期：2010-03-01 00:00:00