Abstract:
:CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis formation and angiogenesis in this model, CD147 was stably knocked down in B16 cells. This silencing of CD147 expression resulted in a reduced capability of the tumor cells to metastasize to the draining lymph nodes. Notably, the CD147 knock down caused a decreased VEGF expression in vivo accompanied by reduced blood vessel formation. Thus, in the B16 melanoma model, CD147 promotes metastasis formation by induction of angiogenesis in an MMP independent manner.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Voigt H,Vetter-Kauczok CS,Schrama D,Hofmann UB,Becker JC,Houben Rdoi
10.1080/07357900802392675subject
Has Abstractpub_date
2009-03-01 00:00:00pages
329-33issue
3eissn
0735-7907issn
1532-4192pii
908030261journal_volume
27pub_type
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