Infusional mitoxantrone plus bolus melphalan as a stem cell transplant conditioning regimen for multiple myeloma.

abstract：:Despite increasing evidence of benefit from adjuvant chemotherapy, older women with breast cancer are commonly given less aggressive treatment than younger patients. Conflicting prior data regarding age-related toxicity prompted this prospective study. Forty-four women (aged 35-79 years) with early-stage breast cancer...

journal_title：Cancer investigation

authors： Dees EC,O'Reilly S,Goodman SN,Sartorius S,Levine MA,Jones RJ,Grochow LB,Donehower RC,Fetting JH

更新日期：2000-01-01 00:00:00

abstract：:Arsenic trioxide is valuable for treatment of promyelocytic leukemia, but less attention has been paid to its therapeutic potential for other cancers. In this study, the effects of arsenic trioxide were tested in human pancreatic (AsPC-1), colonic (HT-29), and breast (MCF-7) cancer cells. In all three cancer cell line...

journal_title：Cancer investigation

authors： Li X,Ding X,Adrian TE

更新日期：2004-01-01 00:00:00

abstract：:Serum C-reactive protein (CRP), a sensitive marker of systemic inflammation, has been reported to be associated with the risk of a number of cancers including breast cancer. However, the results are inconsistent. To investigate the association between serum CRP levels and early breast cancer, we conducted a hospital-b...

journal_title：Cancer investigation

authors： Hong T,Liu A,Cai D,Zhang Y,Hua D,Hang X,Wu X

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. METHODS:This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from ...

journal_title：Cancer investigation

authors： Wirth MD,Burch JB,Hébert JR,Kowtal P,Mehrotra-Kapoor A,Steck SE,Hurley TG,Gupta PC,Pednekar MS,Youngstedt SD,Zhang H,Sarin R

更新日期：2014-08-01 00:00:00

abstract：:Peroxiredoxins are thiol-specific antioxidant proteins that protect cells from ROS-induced cell death and are elevated in several cancers. We found that five of the six mammalian peroxiredoxins are overexpressed in MCF-7 breast cancer cells at the mRNA and protein levels, compared to noncancerous MCF-10A cells. Inhibi...

journal_title：Cancer investigation

authors： Tehan L,Taparra K,Phelan S

更新日期：2013-07-01 00:00:00

abstract：:Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...

journal_title：Cancer investigation

authors： Zhou Y,Wang S,Yue BG,Gobl A,Oberg K

更新日期：2002-01-01 00:00:00

abstract：:The purpose of this study was to investigate whether the intelligence quotient (IQ) in children treated for leukemia decreases in the years following whole brain irradiation. Twenty-seven leukemic children were assessed following a mean time lapse between radiotherapy and IQ measurement of 9 years. The IQ test used wa...

journal_title：Cancer investigation

authors： Kolotas C,Daniel M,Demetriou L,Martin T,Kurek R,Tonus C,Göbel U,Schnabel T,Zamboglou N

更新日期：2001-01-01 00:00:00

abstract：:Despite the dramatic success achieved over the past few years in improving the survival of individuals with cancer, treatment for many patients with advanced malignancies remains far from satisfactory. Unfortunately, centers engaged in clinical cancer research are currently faced with the dilemma of dealing with incre...

journal_title：Cancer investigation

authors： Markman M

更新日期：1987-01-01 00:00:00

abstract：:Objectives: We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at dia...

journal_title：Cancer investigation

authors： Akhtar-Danesh N,Akhtar-Danseh GG,Seow HY,Shakeel S,Finley C

更新日期：2019-01-01 00:00:00

abstract：:PS-341, now known as bortezomib (Velcade[Millenium Pharmaceuticals, Inc., Cambridge, MA; and Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring house, PA]), is a proteasome inhibitor approved for the treatment of refractory multiple myeloma. Preclinical and early clinical studies showed PS-341 to be ...

journal_title：Cancer investigation

authors： Engel RH,Brown JA,Von Roenn JH,O'Regan RM,Bergan R,Badve S,Rademaker A,Gradishar WJ

更新日期：2007-12-01 00:00:00

abstract：:Venous thromboembolic disease is a major cause of morbidity in cancer patients. The Perspective database was used to identify patients with solid tumors and a diagnosis of VTE from 2006 to 2012. We examined use of IVC filters, thrombolysis, and thrombectomy. Among 32,545 patients, 23.1% received an IVC filter, 1.9% th...

journal_title：Cancer investigation

authors： Yoon L,Clarke Hillyer G,Chen L,Hu JC,Neugut AI,Hershman DL,Wright JD

更新日期：2016-09-13 00:00:00

abstract：:Prostate-specific antigen (PSA) test is limited in prostate cancer diagnosis due to its inaccuracy. A new approach which integrates the PSA test with miRNA profiling was investigated to improve prostate cancer diagnosis. Six prostate cancer-related miRNAs (miR-16, -21, -34c, -101, -125b, -141) were tested in five cult...

journal_title：Cancer investigation

authors： Hao Y,Zhao Y,Zhao X,He C,Pang X,Wu TC,Califano JA,Gu X

更新日期：2011-05-01 00:00:00

abstract：:The sponge matrix allograft model made possible the growth of an AKR lymphoma in a certain percentage of BALB/c mice making progressors (tumor-bearing) and regressors (tumor-rejecting) simultaneously available. Mice bearing either an AKR kidney allograft or a sponge alone were used as controls. The cell population inf...

journal_title：Cancer investigation

authors： Barrera CN,Mazzolli AB,Bustuoabad OD,Andreetta AM,Pasqualini CD

更新日期：1985-01-01 00:00:00

abstract：:Until recently physicians have been reluctant to disclose a poor prognosis to patients for fear of harming them with the bad news and/or taking away their will to live. In the last decades we have seen a reversal of practice among Western physicians, and most doctors readily disclose to their patients the full extant ...

journal_title：Cancer investigation

authors： Jotkowitz A,Glick S,Gezundheit B

更新日期：2006-12-01 00:00:00

abstract：:Adriamycin (ADM, or doxorubicin hydrochloride) is an effective antineoplastic agent whose use is restricted by its well-described, dose-dependent cardiotoxicity. This study measures ADM DNA adduct formation by 32P-radiolabeling DNA, enzymatically digesting radiolabeled DNA, separating the formed adducts on two-dimensi...

journal_title：Cancer investigation

authors： Hahm S,Dresner HS,Podwall D,Golden M,Winiarsky R,Moosikasuwan M,Cajigas A,Steinberg JJ

更新日期：2003-01-01 00:00:00

abstract：:The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...

journal_title：Cancer investigation

authors： Yagi S,Oda-Sato E,Uehara I,Asano Y,Nakajima W,Takeshita T,Tanaka N

更新日期：2008-08-01 00:00:00

abstract：:Malignant kidney tumors account for approximately 2% of all new primary cancer cases diagnosed in the United States, with an estimated 30,000 cases occurring annually. Although a variety of agents, chemical and biological, have been implicated as causal agents in the development of renal cell carcinoma (RCC), the etio...

journal_title：Cancer investigation

authors： Moore LE,Wilson RT,Campleman SL

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed. PATIENTS AND METHODS:Premenopausal women with ESBC and planned chemotherapy (>/= 25% risk of amenorrhea) were evaluated. Foll...

journal_title：Cancer investigation

authors： Anders C,Marcom PK,Peterson B,Gu L,Unruhe S,Welch R,Lyons P,Behera M,Copland S,Kimmick G,Shaw H,Snyder S,Antenos M,Woodruff T,Blackwell K

更新日期：2008-04-01 00:00:00

abstract：:Breast cancer treatment is recognized as the most common cause of secondary lymphedema (LE) in the developed countries of the world. LE occurs as both an acute and chronic health condition in which significant and persistent swelling is associated with an abnormal accumulation of protein-rich fluid. The impact of LE i...

journal_title：Cancer investigation

authors： Armer JM

更新日期：2005-01-01 00:00:00

abstract：:We analyzed the clinical utility of molecular classification based on anatomical and histological background. The study was conducted on 457 patients treated for gastric cancer with additional information about microsatellite instability status. We divided the patients in three groups of molecular classification based...

journal_title：Cancer investigation

authors： Polom K,Marrelli D,Roviello G,Voglino C,Vindigni C,Generali D,Roviello F

更新日期：2017-05-28 00:00:00

abstract：:Increasing evidence indicates that disruption of circadian rhythms may be directly linked to cancer. Here we report that the expression levels of the core clock genes Per1 and Per3 measured by droplet digital polymerase chain reaction are significantly decreased in tumour tissue from 16 patients undergoing colorectal ...

journal_title：Cancer investigation

authors： Orhan T,Nielsen PB,Hviid TVF,Rosen AW,Gögenür I

更新日期：2019-01-01 00:00:00

abstract：:Because most cancer deaths result from disseminated disease, understanding the regulation of tumor invasion and metastasis is a central theme in tumor cell biology. Interactions between extracellular matrices (ECM) and cellular microenvironment play a crucial role in this process. We have tested selected amino acids a...

journal_title：Cancer investigation

authors： Singh RK,Rinehart CA,Kim JP,Tolleson-Rinehart S,Lawing LF,Kaufman DG,Siegal GP

更新日期：1996-01-01 00:00:00

abstract：:ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZB...

journal_title：Cancer investigation

authors： Qu H,Qu D,Chen F,Zhang Z,Liu B,Liu H

更新日期：2010-07-01 00:00:00

abstract：:Withaferin A (WA) (1) and two analogs [4-epi-withaferin A (2) and 4,27-diacetyl-4-epi-withaferin A (3)] were evaluated for antitumor activity in pancreatic cancer cells. IC(50) for 1, 2, and 3 were 0.87, 0.45, and 0.29 ?M (BxPC-3); 1.28, 1.53, and 0.52 ?M (MIAPaCa-2); and 0.59, 2.25, and 0.56 ?M (PANC-1), respectively...

journal_title：Cancer investigation

authors： Liu X,Qi W,Cooke LS,Kithsiri Wijeratne EM,Xu YM,Marron MT,Leslie Gunatilaka AA,Mahadevan D

更新日期：2011-12-01 00:00:00

abstract：:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

journal_title：Cancer investigation

authors： Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

更新日期：2010-03-01 00:00:00

abstract：:Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...

journal_title：Cancer investigation

authors： Erfani N,Razmkhah M,Ghaderi A

更新日期：2010-10-01 00:00:00

abstract：:A patient with cervical metastases leading to the diagnosis of a primary breast cancer is presented. To better define the frequency, symptoms, and characteristics of breast cancer metastasizing to the uterine cervix, all cases reported in the literature since 1950 are reviewed. This analysis reveals that in 21% of the...

journal_title：Cancer investigation

authors： Hepp HH,Hoos A,Leppien G,Wallwiener D

更新日期：1999-01-01 00:00:00

abstract：:Radioimmunoscintigraphy (RIS) is coming into its own as an imaging modality in clinical oncology. Early experience with indium-111-labeled intact murine monoclonal antibodies (MoAbs) in colorectal cancer suggested that RIS images hepatic metastases poorly. Moreover, an antimurine immune response was frequently provoke...

journal_title：Cancer investigation

authors： Moffat FL Jr,Gulec SA,Serafini AN,Sfakianakis GN,Pop R,Robinson DS,Franceschi D,Boggs J,Livingstone AS

更新日期：1999-01-01 00:00:00

abstract：:The present study investigates the association between IL12Bpro and +16974A/C in 3' -untranslated region (UTR) polymorphisms of IL12B and IL-12p40 serum level related to development of colorectal cancer (CRC). Our results showed similar distribution of both the investigated polymorphisms among CRC patients and healthy...

journal_title：Cancer investigation

authors： Miteva L,Stanilov N,Deliysky T,Mintchev N,Stanilova S

更新日期：2009-11-01 00:00:00

abstract：:The overexpression of HER-2/neu and p53 has been associated with poor outcome in many neoplasms. Their role in patients with osteosarcoma is unclear. We studied the expression of HER-2/neu and p53 in 22 osteosarcoma samples (from 20 patients--2 had locally recurrent disease) biopsied at the University of Medicine and ...

journal_title：Cancer investigation

authors： Tsai JY,Aviv H,Benevenia J,Chang VT,Patterson F,Aisner S,Hameed M

更新日期：2004-01-01 00:00:00