Abstract:
:Radioimmunoscintigraphy (RIS) is coming into its own as an imaging modality in clinical oncology. Early experience with indium-111-labeled intact murine monoclonal antibodies (MoAbs) in colorectal cancer suggested that RIS images hepatic metastases poorly. Moreover, an antimurine immune response was frequently provoked, precluding multiple follow-up RIS studies in individual patients due to reticuloendothelial sequestration of the radioimmunoconjugate before tumor targeting could occur. Recent trials of technetium-99m-labeled antibody fragments and human MoAbs have demonstrated significant improvement in imaging efficacy, and repeated or serial imaging is possible because of the absence of associated immunogenicity. RIS is demonstrably more sensitive than conventional diagnostic modalities (CDM) such as computed tomography (CT) for detection of extrahepatic abdominal and pelvic colorectal carcinoma and is complementary to CDM in imaging liver metastases. In a surgical decision-making analysis comparing CT, RIS (IMMU-4 99mTc-Fab'; CEA-Scan), and CT plus RIS in patients with recurrent or metastatic colorectal cancer, CT plus RIS improved correct prediction of resectability by 40% and correct prediction of unresectability by 100% compared with CT alone. At the present time, RIS used in combination with CDM contributes an incremental improvement in diagnostic accuracy in colorectal cancer patients with known or suspected recurrent disease. Basic and clinical research currently in progress promises to yield agents and methods that provide rapid high-resolution imaging, high tumor-to-background ratios in all organs at risk for tumor recurrence or metastasis, negligible immunogenicity and toxicity, and a significant further improvement in the accuracy of clinical decision making in oncology patients.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Moffat FL Jr,Gulec SA,Serafini AN,Sfakianakis GN,Pop R,Robinson DS,Franceschi D,Boggs J,Livingstone ASdoi
10.3109/07357909909032874subject
Has Abstractpub_date
1999-01-01 00:00:00pages
322-34issue
5eissn
0735-7907issn
1532-4192journal_volume
17pub_type
杂志文章,评审abstract::The aim of the current study was to determine the signaling differences between gamma- and proton beam-irradiations. A549 lung adenocarcinoma cells were irradiated with 2 Gy proton beam or gamma-radiation. Proton beam was found to be more cytotoxic than gamma-radiation. Proton beam-irradiated cells showed phosphorylat...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003630991
更新日期:2010-07-01 00:00:00
abstract::Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to i...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2020.1802474
更新日期:2020-09-01 00:00:00
abstract::Prostate-specific antigen (PSA) test is limited in prostate cancer diagnosis due to its inaccuracy. A new approach which integrates the PSA test with miRNA profiling was investigated to improve prostate cancer diagnosis. Six prostate cancer-related miRNAs (miR-16, -21, -34c, -101, -125b, -141) were tested in five cult...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.554477
更新日期:2011-05-01 00:00:00
abstract::To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the patholo...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802527221
更新日期:2009-05-01 00:00:00
abstract::The complex formed by isopentane, as a model for the isoleucine residue present in the wild-type thymidylate synthase, with 4-mercaptopyridine as a fragment of the thymidylate synthase inhibitor Thymitaq (AG337) is investigated with ab initio quantum chemical calculations at Hartree-Fock and MP2 levels, using the 3-21...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909909021431
更新日期:1999-01-01 00:00:00
abstract::The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endotheli...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357908909039849
更新日期:1989-01-01 00:00:00
abstract::erbB-2 protein is believed to be a cell membrane receptor for the recently identified ligand gp30. When overexpressed, erbB-2 is an indicator of poor prognosis in adenocarcinomas of breast, stomach, lung, and endometrium. Even more important, clinical data suggest that erbB-2 overexpression may be an indicator of poor...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909209024819
更新日期:1992-01-01 00:00:00
abstract::The role of stereotactic body radiation therapy (SBRT) in achieving durable local control and palliation of pain in pelvic lymph node oligometastatic disease is not well-studied. We performed a retrospective analysis of 30 patients with 43 pelvic lymph node oligometastases from various primary cancers all but one with...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1801713
更新日期:2020-11-01 00:00:00
abstract::PS-341, now known as bortezomib (Velcade[Millenium Pharmaceuticals, Inc., Cambridge, MA; and Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring house, PA]), is a proteasome inhibitor approved for the treatment of refractory multiple myeloma. Preclinical and early clinical studies showed PS-341 to be ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701506573
更新日期:2007-12-01 00:00:00
abstract::Breast cancer treatment is recognized as the most common cause of secondary lymphedema (LE) in the developed countries of the world. LE occurs as both an acute and chronic health condition in which significant and persistent swelling is associated with an abnormal accumulation of protein-rich fluid. The impact of LE i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120016421
更新日期:2003-04-01 00:00:00
abstract::Psychosocial adjustment in adolescent cancer survivors has been documented to be quite variable. Factors mediating adjustment need to be identified. The current study is an exploration of the impact that cancer diagnosis and treatment has on adolescent's self-perceptions and the role this has in mediating adjustment i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909109018956
更新日期:1991-01-01 00:00:00
abstract::Oncologists deal almost exclusively with patients with serious and life-threatening diseases, many who are terminally ill. While hospice care remains an ideal model of care for cancer patients with life-ending disease, many obstacles are present in the clinical setting that either impede or prevent the otherwise appro...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120027587
更新日期:2004-01-01 00:00:00
abstract::This study combined infusional mitoxantrone with bolus melphalan as a transplant preparative regimen for multiple myeloma. Mitoxantrone was infused over 6 hr on days 6 and 5. Melphalan was given as a 15 min bolus on day 1 followed by autologous transplant on day 0. Thirty-five patients were enrolled; 57% of enrollees ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2010.550663
更新日期:2011-03-01 00:00:00
abstract::A 69-year-old man receiving monotherapy for lung cancer with dichloromethotrexate (DCM), and without exposure to other chemotherapeutic agents or known ototoxic drugs, developed profound cochleovestibular dysfunction. The initial presentation was vestibular. This resolved, but unilateral hearing loss ensued and contin...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909039861
更新日期:1989-01-01 00:00:00
abstract::The purpose of this study was to assess the usefulness of thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) scintimammography to differentiate benign from malignant breast masses in 32 female Taiwanese patients with indeterminate mammographic probability of malignancy because of mammographically...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120025089
更新日期:2003-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide and small cell lung cancer (SCLC) accounts for a significant proportion of all lung cancer cases. Even so, the underlying mechanism governing SCLC development remains poorly understood and SCLC related cancer death stands high despite decades of intensive inve...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2015.1006329
更新日期:2015-04-01 00:00:00
abstract::Renal cell carcinoma is the most common tumor of the kidney. It has an unpredictable behavior and poor response to systemic therapy. Developing newer therapy for this disease is a priority considering the high recurrence rate and the small subset of patients who benefit from the use of cytokines such as interferon-alp...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900600896315
更新日期:2006-10-01 00:00:00
abstract::Data have shown that tamoxifen (TAM) can be used to treat not only breast cancer with positive estrogen receptor (ER), but also negative ER including human glioma. However, the molecular mechanism of this drug against different kinds of cancers remains to be elucidated. In this study, we provided the evidence that PKC...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802672720
更新日期:2009-08-01 00:00:00
abstract::Seven patients developed a lung abscess and bronchopleural fistula after undergoing aggressive treatment of their lung cancer with radiotherapy +/- chemotherapy. These complications were preceded by a prodrome of recurrent bronchitis with increasing refractoriness to antibiotics, weight loss, fever, and generalized de...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077041
更新日期:1988-01-01 00:00:00
abstract::The present study investigates the association between IL12Bpro and +16974A/C in 3' -untranslated region (UTR) polymorphisms of IL12B and IL-12p40 serum level related to development of colorectal cancer (CRC). Our results showed similar distribution of both the investigated polymorphisms among CRC patients and healthy...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.3109/07357900902918486
更新日期:2009-11-01 00:00:00
abstract::A Phase I trial of three carboplatin-based combination chemotherapy regimens was conducted. These included: carboplatin plus vindesine; carboplatin, vindesine, plus bleomycin; and, carboplatin plus vinblastine. Carboplatin was administered every 28 days as an intravenous bolus. The initial dose was 150 mg/m2 and doses...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909009017558
更新日期:1990-01-01 00:00:00
abstract::UFT is the combination of the fluorouracil (5-FU) prodrug tegafur, and the dihydrophyrimidine dehydrogenase inhibitor uracil. UFT and leucovorin have been used in the oral treatment of a variety of malignancies. Given the radiosensitizing properties of UFT, its combination with radiation therapy is a logical step in t...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120022382
更新日期:2003-01-01 00:00:00
abstract::The purpose of this study is to investigate whether hematopoiesis capacity, immunomodulatory effect and ex vivo expansion potential of mesenchymal stem cells (MSCs) are affected by cryopreservation. Chronic myeloid leukemia (CML) patients' bone marrow MSCs cryopreserved for 3 months, 6 months, and 1 year were thawed a...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701788049
更新日期:2008-05-01 00:00:00
abstract::Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357900009031826
更新日期:2000-01-01 00:00:00
abstract::This survey aimed at getting a first insight into diverse side effects and their association with satisfaction with life as well as the use of complementary and alternative medicine (CAM) in cancer patients. A total of 100 patients in a German University Hospital were included. General side effects like fatigue, fever...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1625055
更新日期:2019-01-01 00:00:00
abstract::A case control study of 2,908 breast cancer cases and 3,180 controls, derived from a nationwide screening program, enabled evaluation of the relationship of breast cancer risk to a variety of menstrual factors. Risk was significantly inversely related to age at menarche, with women who first menstruated at age 15 or l...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809080645
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:The decision concerning adjuvant therapy remains difficult in patients with very early stage ovarian carcinomas [Fédération Internationale de Gynécologie et d' Obstétrique (FIGO) Ia/b]. Therefore, we compared the MIB1-determined tumor growth fraction in archival tumor tissue with tumor recurrence and outcome of...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120030206
更新日期:2004-01-01 00:00:00
abstract::Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, an...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1309547
更新日期:2017-07-03 00:00:00
abstract::The interleukin-2 (IL2) gene is assigned to human chromosome 4. A synthetic oligonucleotide representing bases 285 to 324 of the IL2 cDNA clone described by Taniguchi et al. [Nature (London) 302:305-310, 1983] was used as hybridization probe in Southern blots. Eco RI digests of DNA derived from 11 somatic mouse-human ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908409018440
更新日期:1984-01-01 00:00:00