Stereotactic Body Radiation Therapy (SBRT) in Pelvic Lymph Node Oligometastases.

abstract：:Twenty-two patients with disseminated adenocarcinoma of the large bowel received therapy with 5-fluorouracil 800-1000 mg/m2 as a 24 h infusion for 4 consecutive days with 60 mg/m2 intravenous folinic acid administered every 6 hours. Major responses were seen in 3 of 20 (15%) evaluable patients, for a median of 5 month...

journal_title：Cancer investigation

authors： Mortimer JE,Higano C

更新日期：1988-01-01 00:00:00

abstract：:Seven patients developed a lung abscess and bronchopleural fistula after undergoing aggressive treatment of their lung cancer with radiotherapy +/- chemotherapy. These complications were preceded by a prodrome of recurrent bronchitis with increasing refractoriness to antibiotics, weight loss, fever, and generalized de...

journal_title：Cancer investigation

authors： Frytak S,Lee RE,Pairolero PC,Arnold PG,Shaw JN

更新日期：1988-01-01 00:00:00

abstract：:We studied the effects of Shikaron, which is composed of 8 Chinese herb extracts, on carcinogenesis and the cytotoxic activity and cytokine production of lymphocytes in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine (BBN). We found a significantly lower incidence of urinary bladder carcinoma in mice tr...

journal_title：Cancer investigation

authors： Kurashige S,Jin R,Akuzawa Y,Endo F

更新日期：1998-01-01 00:00:00

abstract：:The interleukin-2 (IL2) gene is assigned to human chromosome 4. A synthetic oligonucleotide representing bases 285 to 324 of the IL2 cDNA clone described by Taniguchi et al. [Nature (London) 302:305-310, 1983] was used as hybridization probe in Southern blots. Eco RI digests of DNA derived from 11 somatic mouse-human ...

journal_title：Cancer investigation

authors： Sykora KW,Kolitz J,Szabo P,Grzeschik KH,Moore MA,Mertelsmann R

更新日期：1984-01-01 00:00:00

abstract：:This study compared the antiemetic efficacy and safety of two different intravenous (i.v.) dolasetron dosing regimens in patients receiving their first course of high-dose (> or = 80 mg/m2) cisplatin. Of 30 patients enrolled, 14 received a single i.v. dolasetron dose (0.6 mg/kg) before cisplatin and 16 received a mult...

journal_title：Cancer investigation

authors： Kasimis BS,Tapazoglou E,Schulman P,Stewart WH,Hahne WF,Cramer MB

更新日期：1997-01-01 00:00:00

abstract：:We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle ge...

journal_title：Cancer investigation

authors： Moumtzi SS,Roberts ML,Joyce T,Evangelidou M,Probert L,Frillingos S,Fotsis T,Pintzas A

更新日期：2010-07-01 00:00:00

abstract：:Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34+ progenitor/stem leukemia...

journal_title：Cancer investigation

authors： Lei H,Tu Y,Yang L,Jin J,Luo H,Xu H,Kang J,Zhou L,Wu Y

更新日期：2019-01-01 00:00:00

abstract：:The results of a prospective trial with a specifically devised chemotherapy regimen in elderly patients with unfavorable non-Hodgkin's lymphoma (NHL) are reported. Between April 1983 and April 1986, 37 consecutive patients 70 years old or more (median age 80) received etoposide and prednimustine (E + P) 100 mg/m2 p.o....

journal_title：Cancer investigation

authors： Zagonel V,Tirelli U,Carbone A,Errante D,Morassot S,Sorio R,Monfardini S

更新日期：1990-01-01 00:00:00

abstract：:The role of tyrosine kinase inhibitors (TKIs) in the treatment of advanced malignancies is well established. Imatinib and vatalanib are oral TKIs with different mechanisms of action. This trial sought to establish the safety, tolerability, and maximum tolerated dose (MTD) of the two agents in combination. Secondary ob...

journal_title：Cancer investigation

authors： Spigel D,Jones S,Hainsworth J,Infante J,Greco FA,Thompson D,Doss H,Burris H

更新日期：2011-05-01 00:00:00

abstract：:The structural dimensions of capillary tight junctions and the uptake of 99mTc pertechnetate in human gliomas were studied. Quantitative analysis revealed a correlation between the uptake of radionuclides and the length of endothelial tight junctions. It is suggested that brain scintigraphy might be used for the selec...

journal_title：Cancer investigation

authors： Nir I,Kohn S,Doron Y,Israel O,Front D

更新日期：1986-01-01 00:00:00

abstract：:Interstitial collagenase-1 degrades a variety of extracellular matrix components. A single guanine insertion polymorphism in the promoter has been found that influences on the transcription and expression level of the gene. It is suggested that this polymorphism may enhance susceptibility to some types of cancer. Ther...

journal_title：Cancer investigation

authors： Kouhkan F,Motovali-Bashi M,Hojati Z

更新日期：2008-10-01 00:00:00

abstract：:This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...

journal_title：Cancer investigation

authors： Zhao X,Liu J,Peng M,Liu J,Chen F

更新日期：2013-10-01 00:00:00

abstract：:The complex formed by isopentane, as a model for the isoleucine residue present in the wild-type thymidylate synthase, with 4-mercaptopyridine as a fragment of the thymidylate synthase inhibitor Thymitaq (AG337) is investigated with ab initio quantum chemical calculations at Hartree-Fock and MP2 levels, using the 3-21...

journal_title：Cancer investigation

authors： Sapse DS,Tong Y,Bertino JR,Sapse AM

更新日期：1999-01-01 00:00:00

abstract：:Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal ti...

journal_title：Cancer investigation

authors： Olsen RS,Dimberg J,Geffers R,Wågsäter D

更新日期：2019-01-01 00:00:00

abstract：:The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...

journal_title：Cancer investigation

authors： Yagi S,Oda-Sato E,Uehara I,Asano Y,Nakajima W,Takeshita T,Tanaka N

更新日期：2008-08-01 00:00:00

abstract：:Cells from 11 chronic lymphocytic leukemic (CLL) patients were induced to differentiate with various doses of tetradecanoyl phorbol-13-acetate (TPA) and the degree of induction was followed up to six days by measuring the expression of two surface membrane markers (SmIg and GP-70), Ig secretion, tartrate-resistant aci...

journal_title：Cancer investigation

authors： Gazitt Y,Gurfel D,Leizerowitz R,Feinstein H,Polliack A

更新日期：1987-01-01 00:00:00

abstract：:Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to i...

journal_title：Cancer investigation

authors： Zakaria MA,Rajab NF,Chua EW,Selvarajah GT,Masre SF

更新日期：2020-09-01 00:00:00

abstract：:The immunotherapeutic effects of interleukin-1 alpha (IL-1 alpha) encapsulated within 1-5 microns-diameter poly (D, L-lactide) microspheres and delivered intratumorally into fibrosarcoma-bearing mice were investigated. Such microspheres are avidly taken up by macrophages, and directing IL-1 alpha into these cells may ...

journal_title：Cancer investigation

authors： Mullerad J,Cohen S,Benharroch D,Apte RN

更新日期：2003-01-01 00:00:00

abstract：:Multifractionated dosing (MFD) schedules for chemotherapy administration such as weekly or twice weekly administration are intended to maximize dose intensity while minimizing toxicity, but the cumulative drug effect may result in neutropenia necessitating interruption of dose fractions and thereby compromising dose i...

journal_title：Cancer investigation

authors： Lokich J

更新日期：1999-01-01 00:00:00

abstract：:Patients with metastatic prostate cancer resistant to hormones and docetaxel were treated with vinflunine (320 mg/m(2) every 21 days), a new vinca alkaloid with improved preclinical activity. Only 1 of 36 patients (3%) had partial response; the median progression-free survival (PFS) was 2.1 months. Treatment was well ...

journal_title：Cancer investigation

authors： Hainsworth JD,Meluch AA,Lane CM,Spigel DR,Burris HA 3rd,Gandhi JG,Crane EJ,Stipanov MA,Greco FA

更新日期：2010-03-01 00:00:00

abstract：:Non-invasive pharmacological management of patients with cancer related pain has resulted in pain control in 90-95% of the patients. Thus, 5-10% of patients still experience inadequate pain control despite aggressive combined pharmacological therapy. Moreover, patients may not tolerate an aggressive program of titrati...

journal_title：Cancer investigation

authors： de Leon-Casasola OA

更新日期：2004-01-01 00:00:00

abstract：:Soft tissue sarcomas are generally resistant to most chemotherapeutic agents, and individuals with advanced disease have a poor prognosis. We evaluated amonafide, a new drug that has significant activity against several tumor cell lines, to determine its activity against sarcomas. Amonafide was administered to 18 pati...

journal_title：Cancer investigation

authors： Buys SS,Metch B,Balcerzak SP,Neefe JR,Stuckey WJ

更新日期：1994-01-01 00:00:00

abstract：:Gefitinib (ZD1839, Iressa), a member of the 4-anilinoquinazoline class of compounds, has the chemical name 4-quinazolinamine, N-(3-chloro-4-flurophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]. Gefitinib often is referred to as a "specific" or "selective" inhibitor of epidermal growth factor receptor (EGFR). EGFR expre...

journal_title：Cancer investigation

authors： Freeman BB 3rd,Daw NC,Geyer JR,Furman WL,Stewart CF

更新日期：2006-04-01 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer death with a 5-year survival less than 5 percent despite rigorous interventions. This largely is due to its late presentation, aggressive metastasis, and a lack of effective adjuvant therapies. Cytokines have been studied in many tumor types, where they have been...

journal_title：Cancer investigation

authors： Feurino LW,Fisher WE,Bharadwaj U,Yao Q,Chen C,Li M

更新日期：2006-11-01 00:00:00

abstract：:Previous studies have shown that human PSP94 can inhibit the growth of prostate cancer cells both in vitro and in vivo. To further validate this potential and investigate the protein within a homologous setting, we examined the effects of rat PSP94 on the growth of the rat prostate adenocarcinoma cell line PAIII in vi...

journal_title：Cancer investigation

authors： Cadieux PA,Mikolajczak SA,Reeves J,Strathdee C,Reid G,Panchal CJ,Clarke MW

更新日期：2006-04-01 00:00:00

abstract：:ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZB...

journal_title：Cancer investigation

authors： Qu H,Qu D,Chen F,Zhang Z,Liu B,Liu H

更新日期：2010-07-01 00:00:00

abstract：:A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90(-), CD117(-), and CD123(+). Research in...

journal_title：Cancer investigation

authors： O'Brien JA,Rizzieri DA

更新日期：2013-05-01 00:00:00

abstract：:Triple-negative breast cancer is defined by the lack of expression of estrogen-receptor, progesterone-receptor, and HER-2/neu. It primarily, but not exclusively, carries the basal-like molecular profile on gene expression arrays and is associated with BRCA-1 and p53 mutations. It has an aggressive behavior and predile...

journal_title：Cancer investigation

authors： Maegawa RO,Tang SC

更新日期：2010-10-01 00:00:00

abstract：:Withaferin A (WA) (1) and two analogs [4-epi-withaferin A (2) and 4,27-diacetyl-4-epi-withaferin A (3)] were evaluated for antitumor activity in pancreatic cancer cells. IC(50) for 1, 2, and 3 were 0.87, 0.45, and 0.29 ?M (BxPC-3); 1.28, 1.53, and 0.52 ?M (MIAPaCa-2); and 0.59, 2.25, and 0.56 ?M (PANC-1), respectively...

journal_title：Cancer investigation

authors： Liu X,Qi W,Cooke LS,Kithsiri Wijeratne EM,Xu YM,Marron MT,Leslie Gunatilaka AA,Mahadevan D

更新日期：2011-12-01 00:00:00

abstract：:A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...

journal_title：Cancer investigation

authors： Scherbakov AM,Borunov AM,Buravchenko GI,Andreeva OE,Kudryavtsev IA,Dezhenkova LG,Shchekotikhin AE

更新日期：2018-03-16 00:00:00