Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients.

abstract：:Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...

journal_title：Cancer investigation

authors： Bierman HR,Faith MR,Stewart ME

更新日期：1988-01-01 00:00:00

abstract：:Hepatitis B virus X protein (HBx) promotes hepatocellular carcinoma (HCC) invasion and metastasis by a poorly understood mechanism. This study investigated the role of NF-kappa B in HBx-mediated upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). In a stably expressing HBx c...

journal_title：Cancer investigation

authors： Liu LP,Liang HF,Chen XP,Zhang WG,Yang SL,Xu T,Ren L

更新日期：2010-06-01 00:00:00

abstract：:After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...

journal_title：Cancer investigation

authors： Crane E,List A

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. METHODS:One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. RESULTS:The median normal MnSOD expression...

journal_title：Cancer investigation

authors： Martin RC,Li Y,Liu Q,Barker DF,Doll MA,Hein DW

更新日期：2010-10-01 00:00:00

abstract：:The present study examines the effect of tobacco smoking on the expression of cyclooxygenase (COX)-2 gene, COX enzymatic activity and prostaglandin (PG) synthesis in urothelial mucosal tissues from patients with bladder cancer and from normal individuals. The detection frequency of COX-2 mRNA was 2-fold higher in blad...

journal_title：Cancer investigation

authors： Badawi AF,Habib SL,Mohammed MA,Abadi AA,Michael MS

更新日期：2002-01-01 00:00:00

abstract：:Prostate-specific antigen (PSA) test is limited in prostate cancer diagnosis due to its inaccuracy. A new approach which integrates the PSA test with miRNA profiling was investigated to improve prostate cancer diagnosis. Six prostate cancer-related miRNAs (miR-16, -21, -34c, -101, -125b, -141) were tested in five cult...

journal_title：Cancer investigation

authors： Hao Y,Zhao Y,Zhao X,He C,Pang X,Wu TC,Califano JA,Gu X

更新日期：2011-05-01 00:00:00

abstract：:Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied abou...

journal_title：Cancer investigation

authors： Luwor R,Morokoff AP,Amiridis S,D'Abaco G,Paradiso L,Stylli SS,Nguyen HPT,Tarleton M,Young KA,O'Brien TJ,Robinson PJ,Chircop M,McCluskey A,Jones NC

更新日期：2019-01-01 00:00:00

abstract：:Computer visualization techniques (CVTs) are an emerging technology that can organize all cancer specialists. This article describes CVTs' ability to maximize the currently untapped advantages of intensity modulated radiotherapy (IMRT). The visual speed and dynamic strategies inherent in CVTs improves IMRT by distilli...

journal_title：Cancer investigation

authors： Butler EB,Shukla V,Paulino AC,Lu HH,Butler R,Smiedala M,Kurk J,Grant WH 3rd,McGary JE,Teh BS

更新日期：2007-02-01 00:00:00

abstract：:Interstitial collagenase-1 degrades a variety of extracellular matrix components. A single guanine insertion polymorphism in the promoter has been found that influences on the transcription and expression level of the gene. It is suggested that this polymorphism may enhance susceptibility to some types of cancer. Ther...

journal_title：Cancer investigation

authors： Kouhkan F,Motovali-Bashi M,Hojati Z

更新日期：2008-10-01 00:00:00

abstract：:Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (AIPD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an ...

journal_title：Cancer investigation

authors： Lopez-Berestein G,Cabanillas F,Osborne BM,Libshitz HI,Bodey GP

更新日期：1983-01-01 00:00:00

abstract：:The addition of corticosteroids in the early 1950s to the treatment armamentarium provided cure of some diseases and control of many. They have become an integral part of many cancer treatment regimens. Early reports of severe affective disorders appear less frequent today in patients receiving steroids, though contro...

journal_title：Cancer investigation

authors： Stiefel FC,Breitbart WS,Holland JC

更新日期：1989-01-01 00:00:00

abstract：:An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...

journal_title：Cancer investigation

authors： Herbert PN,Friedland ML

更新日期：1986-01-01 00:00:00

abstract：:The G1 cyclins are clearly important factors that control progression through the eukaryotic cell cycle. The expression and activity of these factors are regulated at many different levels and in response to a large number of signals. Such complicated, multilevel controls on expression and activation of cyclin/cdk com...

journal_title：Cancer investigation

authors： Hamel PA,Hanley-Hyde J

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVES:To investigate the relative risk factor of food items for colorectal cancer in four time periods through a case-control study in a Chinese rural area. METHODS:Colorectal cancer patients diagnosed at a county cancer center, Hebei Province, China, and non-cancer outpatients with similar age, sex, and place of...

journal_title：Cancer investigation

authors： Zhang B,Li X,Nakama H,Zhang X,Wei N,Zhang X,Zhang L

更新日期：2002-01-01 00:00:00

abstract：:A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...

journal_title：Cancer investigation

authors： Scherbakov AM,Borunov AM,Buravchenko GI,Andreeva OE,Kudryavtsev IA,Dezhenkova LG,Shchekotikhin AE

更新日期：2018-03-16 00:00:00

abstract：:SNPs in CYP1A1, CYP2A1, CYP2B6, CYP2C, CYP2D6, CYP3A, GSTM1, GSTT1, GSTP1, SULT1A1, SULT1A2, UGT, and MTHFR are associated with breast cancer susceptibility; however, lack of such associations are also reported in some populations. The contradictory findings are explained on the basis of ethnic variation among populat...

journal_title：Cancer investigation

authors： Singh V,Parmar D,Singh MP

更新日期：2008-10-01 00:00:00

abstract：:The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, in situ hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 G...

journal_title：Cancer investigation

authors： Limam S,Missaoui N,Hmissa S,Yacoubi MT,Krifa H,Mokni M,Selmi B

更新日期：2020-08-01 00:00:00

abstract：:High expression of vascular endothelial growth factor (VEGF) in patients with hepatocellular carcinoma (HCC) is associated with poor prognosis. Here, we investigated the antitumor activity of lenvatinib, a multiple receptor tyrosine kinase inhibitor, in VEGF-overexpressing HCC models. In human umbilical vein endotheli...

journal_title：Cancer investigation

authors： Adachi Y,Matsuki M,Watanabe H,Takase K,Kodama K,Matsui J,Funahashi Y,Nomoto K

更新日期：2019-01-01 00:00:00

abstract：:The sequential administration of standard chemotherapy regimens to treat metastatic breast cancer may keep patients and oncologists from considering other important, but more psychologically difficult, issues such as the patient's declining health or approaching death. This practice also utilizes health care resources...

journal_title：Cancer investigation

authors： Benner SE,Fetting JH,Brenner MH

更新日期：1994-01-01 00:00:00

abstract：:We have provided an overview of recent studies that have greatly expanded our knowledge of the molecular and cellular mechanisms that determine the sensitivity or resistance to ionizing radiation. Much of this knowledge was obtained by studying tumor and nontumor cell types that under- or overexpress proteins involved...

journal_title：Cancer investigation

authors： Rosen EM,Fan S,Rockwell S,Goldberg ID

更新日期：1999-01-01 00:00:00

abstract：:The purpose of this study was to investigate whether the intelligence quotient (IQ) in children treated for leukemia decreases in the years following whole brain irradiation. Twenty-seven leukemic children were assessed following a mean time lapse between radiotherapy and IQ measurement of 9 years. The IQ test used wa...

journal_title：Cancer investigation

authors： Kolotas C,Daniel M,Demetriou L,Martin T,Kurek R,Tonus C,Göbel U,Schnabel T,Zamboglou N

更新日期：2001-01-01 00:00:00

abstract：:ErbB receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ErbB inhibitors are now used in the clinical setting. A large number of studies have been conducted to examine the expression of ErbB family members in bone and soft tissue sarcomas, includi...

journal_title：Cancer investigation

authors： Wang H,Yang Q,Fu Z,Zuo D,Hua Y,Cai Z

更新日期：2014-12-01 00:00:00

abstract：:Malignant kidney tumors account for approximately 2% of all new primary cancer cases diagnosed in the United States, with an estimated 30,000 cases occurring annually. Although a variety of agents, chemical and biological, have been implicated as causal agents in the development of renal cell carcinoma (RCC), the etio...

journal_title：Cancer investigation

authors： Moore LE,Wilson RT,Campleman SL

更新日期：2005-01-01 00:00:00

abstract：:Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohisto...

journal_title：Cancer investigation

authors： Cho H,Lee YS,Kim J,Chung JY,Kim JH

更新日期：2013-11-01 00:00:00

abstract：:Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition ...

journal_title：Cancer investigation

authors： Guo W,Dong Z,Lin X,Zhang M,Kuang G,Zhu T

更新日期：2012-12-01 00:00:00

abstract：:Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...

journal_title：Cancer investigation

authors： Allison RR,Vongtama V,Vaughan J,Shin KH

更新日期：1995-01-01 00:00:00

abstract：:Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal o...

journal_title：Cancer investigation

authors： Xi J,Zeng ST,Guo L,Feng J

更新日期：2016-01-01 00:00:00

abstract：:We hypothesized that co-targeting the epidermal growth factor receptor (EGFR) and Src with the EGFR inhibitor gefitinib and the Src inhibitor AZD0530 would increase growth inhibition and impede migration. Cells overexpressing EGFR were more sensitive to gefitinib than cells expressing mutated EGFR or normal levels of ...

journal_title：Cancer investigation

authors： Andersen P,Villingshøj M,Poulsen HS,Stockhausen MT

更新日期：2009-02-01 00:00:00

abstract：:Multifractionated dosing (MFD) schedules for chemotherapy administration such as weekly or twice weekly administration are intended to maximize dose intensity while minimizing toxicity, but the cumulative drug effect may result in neutropenia necessitating interruption of dose fractions and thereby compromising dose i...

journal_title：Cancer investigation

authors： Lokich J

更新日期：1999-01-01 00:00:00

abstract：:IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infecti...

journal_title：Cancer investigation

authors： Mahanty S,Nutman TB

更新日期：1993-01-01 00:00:00