Abstract:
:The role of tyrosine kinase inhibitors (TKIs) in the treatment of advanced malignancies is well established. Imatinib and vatalanib are oral TKIs with different mechanisms of action. This trial sought to establish the safety, tolerability, and maximum tolerated dose (MTD) of the two agents in combination. Secondary objectives included determination of potential pharmacologic interactions among vatalanib and imatinib and observation of antitumor activity. Patients with biopsy-proven advanced refractory solid tumors were enrolled in this single-center dose-escalation trial. Patients initially received imatinib and vatalanib once daily following a 14-day run-in period of daily oral vatalanib only, and were observed for a full 28-day treatment cycle prior to dose escalation. An amendment divided the vatalanib dose into two daily doses and gradually escalated the dose over a 2-3 week period. Patients continued combination therapy until disease progression or intolerable toxicity. Forty-five patients were enrolled between September 2004 and November 2007. As of September 2009, a total of 247 cycles of treatment had been administered (range: 1 -44+, median = 2 ). The MTD was determined to be vatalanib 1250 mg daily and imatinib 400 mg daily. Thirty-five patients (78%) were evaluable for response; 2 patients achieved PR, while 14 patients had SD ( 10 had stable disease ≥ 6 cycles). The combination of vatalanib and imatinib was well tolerated. Twice-daily vatalanib dosing improved tolerability and ease of full-dose administration. These results suggest that vatalanib-containing combinations may be active and tolerable, warranting further study.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Spigel D,Jones S,Hainsworth J,Infante J,Greco FA,Thompson D,Doss H,Burris Hdoi
10.3109/07357907.2011.568567subject
Has Abstractpub_date
2011-05-01 00:00:00pages
308-12issue
4eissn
0735-7907issn
1532-4192journal_volume
29pub_type
杂志文章abstract::We have provided an overview of recent studies that have greatly expanded our knowledge of the molecular and cellular mechanisms that determine the sensitivity or resistance to ionizing radiation. Much of this knowledge was obtained by studying tumor and nontumor cell types that under- or overexpress proteins involved...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:
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abstract::Macrophages in malignant pleural effusions (MPEs) demonstrate a promalignant phenotype. They release mediators, which are a source of inflammation within the pleura. We established in vitro model proving that pleural macrophages isolated from effusions affect cancer cells in their pro- or anti-apoptotic activity via h...
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journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
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abstract::Fibronectin (Fn) synergizes with macrophages (M phi) in inducing cytostasis and cytotoxicity of neoplastic cells in culture. Since heparin enhances Fn's opsonic activity in many systems, we investigated its effect on Fn-macrophage synergy in cytostasis. MCG-T14 (a spontaneous mouse mammary adenocarcinoma) cells (4 X 1...
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pub_type: 杂志文章,评审
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journal_title:Cancer investigation
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doi:10.1080/07357907.2016.1242010
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journal_title:Cancer investigation
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journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120000370
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journal_title:Cancer investigation
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doi:10.1080/07357907.2020.1808898
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journal_title:Cancer investigation
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journal_title:Cancer investigation
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doi:10.1080/07357900802239124
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doi:10.1080/07357900701205689
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journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900701208683
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abstract::Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909509024890
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909209024815
更新日期:1992-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
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更新日期:1983-01-01 00:00:00
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journal_title:Cancer investigation
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更新日期:2010-10-01 00:00:00