Human bone marrow-derived mesenchymal stem cells produced TGFbeta contributes to progression and metastasis of prostate cancer.

abstract：:Requirements for the induction of anomalous killer (AK) cells to syngeneic MOPC 104E-KI81 plasmacytoma, and their pattern of reaction were investigated. The AK cells are Thy-1.2 positive and were induced by cocultivation of normal BALB/c spleen cells for 5 days in vitro with mitomycin C-treated MOPC 104E-KI81 cells in...

journal_title：Cancer investigation

authors： Hayashida I,Hiramoto RN,Shrestha K,Ghanta VK

更新日期：1989-01-01 00:00:00

abstract：:There appears to be exceptional and growing public enthusiasm for botanical, or "herbal", medicines, especially amongst cancer patients. This has recently begun to be matched by increasing scientific attention. Whilst it is known that plant extracts are active against cancer, the standard approach has been to isolate,...

journal_title：Cancer investigation

authors： Vickers A

更新日期：2002-01-01 00:00:00

abstract：:Previous studies have shown that human PSP94 can inhibit the growth of prostate cancer cells both in vitro and in vivo. To further validate this potential and investigate the protein within a homologous setting, we examined the effects of rat PSP94 on the growth of the rat prostate adenocarcinoma cell line PAIII in vi...

journal_title：Cancer investigation

authors： Cadieux PA,Mikolajczak SA,Reeves J,Strathdee C,Reid G,Panchal CJ,Clarke MW

更新日期：2006-04-01 00:00:00

abstract：:The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endotheli...

journal_title：Cancer investigation

authors： Baker DG,Krochak RJ

更新日期：1989-01-01 00:00:00

abstract：:We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice....

journal_title：Cancer investigation

authors： Dai J,Wang H,Dong Y,Zhang Y,Wang J

更新日期：2013-02-01 00:00:00

abstract：:Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...

journal_title：Cancer investigation

authors： Brenner PR

更新日期：1997-01-01 00:00:00

abstract：:The aim of our study was to investigate the role of nerve growth factor (NGF) on the expression of the p73 protein in human ependymoblastoma (EP) and medulloblastoma (MB) cells. It was found that NGF exposure on MB cells blocks proliferation, as well as on EP cells and induces overexpression of p73. NGF reduces the nu...

journal_title：Cancer investigation

authors： Antonelli A,Lenzi L,Nakagawara A,Osaki T,Chiaretti A,Aloe L

更新日期：2007-03-01 00:00:00

abstract：:Type-I insulin-like growth factor receptor (IGF1R) and its signaling play an important role in osteosarcomagenesis, tumor progression, and chemoresistance. The purpose of this study was to investigate both the effect and mechanisms of IGF1R inhibition by tyrphostin AG1024 in the presence or absence of doxorubicin in a...

journal_title：Cancer investigation

authors： Luk F,Yu Y,Walsh WR,Yang JL

更新日期：2011-10-01 00:00:00

abstract：:We performed the analysis of database on 409 patients with LD-SCLC to evaluate as to what extent the clinical outcome of large prospective trials was reproduced in routine practice. The analysis has shown that the hazard rate of death in the absence of prophylactic cranial irradiation (PCI) adjusted for the effects of...

journal_title：Cancer investigation

authors： Wzietek I,Suwinski R,Nowara E,Bialas M,Bentzen S,Tukiendorf A

更新日期：2014-01-01 00:00:00

abstract：:We have provided an overview of recent studies that have greatly expanded our knowledge of the molecular and cellular mechanisms that determine the sensitivity or resistance to ionizing radiation. Much of this knowledge was obtained by studying tumor and nontumor cell types that under- or overexpress proteins involved...

journal_title：Cancer investigation

authors： Rosen EM,Fan S,Rockwell S,Goldberg ID

更新日期：1999-01-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by specific t(15;17), distinct morphologic picture, and clinical coagulopathy that contribute to the morbidity and mortality of the disease. This study aims to investigate the effects of antitelomerase compound BIBR1532 on APL cells (NB4). BIBR 1532 exerts a direct s...

journal_title：Cancer investigation

authors： Bashash D,Ghaffari SH,Zaker F,Hezave K,Kazerani M,Ghavamzadeh A,Alimoghaddam K,Mosavi SA,Gharehbaghian A,Vossough P

更新日期：2012-01-01 00:00:00

abstract：:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

journal_title：Cancer investigation

authors： Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

更新日期：2010-03-01 00:00:00

abstract：:We analyzed the clinical utility of molecular classification based on anatomical and histological background. The study was conducted on 457 patients treated for gastric cancer with additional information about microsatellite instability status. We divided the patients in three groups of molecular classification based...

journal_title：Cancer investigation

authors： Polom K,Marrelli D,Roviello G,Voglino C,Vindigni C,Generali D,Roviello F

更新日期：2017-05-28 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...

journal_title：Cancer investigation

authors： Cascinu S,Del Ferro E,Ligi M,Staccioli MP,Giordani P,Catalano V,Agostinelli R,Muretto P,Catalano G

更新日期：2001-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent mitogen in various precursor tumor cells, including endometrial adenocarcinoma. It is proposed that ET-1 produced by endometrial adenocarcinoma may participate in the angiogenesis of this carcinoma in vivo. Endothelin converting enzyme-1 (ECE-1) is the key enzyme that synthesizes ET-1. ...

journal_title：Cancer investigation

authors： Arun B,Kilic G,Ashfaq R,Saboorian HM,Gokaslan T

更新日期：2001-01-01 00:00:00

abstract：:There are many changes in the immune response with age, most of which can be related to the involution of the thymus gland and alteration of the distribution and function of T lymphocytes. These changes indirectly influence B-cell function, which not only amplifies the immune deficits, but leads to the increased produ...

journal_title：Cancer investigation

authors： Ben-Yehuda A,Weksler ME

更新日期：1992-01-01 00:00:00

abstract：:Tumor-infiltrating leukocytes and other immunohistochemical parameters were evaluated in pretherapeutic biopsies and resection specimens in 73 patients undergoing neoadjuvant chemotherapy with doxorubicin and paclitaxel. Ten patients with pathological complete response had significantly higher p53 expression, CD3(+) l...

journal_title：Cancer investigation

authors： Hornychova H,Melichar B,Tomsova M,Mergancova J,Urminska H,Ryska A

更新日期：2008-12-01 00:00:00

abstract：:Prostate-specific antigen (PSA) test is limited in prostate cancer diagnosis due to its inaccuracy. A new approach which integrates the PSA test with miRNA profiling was investigated to improve prostate cancer diagnosis. Six prostate cancer-related miRNAs (miR-16, -21, -34c, -101, -125b, -141) were tested in five cult...

journal_title：Cancer investigation

authors： Hao Y,Zhao Y,Zhao X,He C,Pang X,Wu TC,Califano JA,Gu X

更新日期：2011-05-01 00:00:00

abstract：:Thirty patients with a diagnosis of metastatic adenocarcinoma of the lung were entered on a trial to evaluate the antitumor efficacy of 5-fluorouracil 370 mg/m2 daily for 5 days every four weeks in combination with folinic acid 200 mg/m2, 60 min prior to 5FU. All patients had a good performance status, bidimensionally...

journal_title：Cancer investigation

authors： Evans WK,Wierzbicki R,Shepherd FA,Rusthoven J,Stewart DJ,Aitken SE,Maroun JA,Ezzat A

更新日期：1990-01-01 00:00:00

abstract：:Macrophages in malignant pleural effusions (MPEs) demonstrate a promalignant phenotype. They release mediators, which are a source of inflammation within the pleura. We established in vitro model proving that pleural macrophages isolated from effusions affect cancer cells in their pro- or anti-apoptotic activity via h...

journal_title：Cancer investigation

authors： Kaczmarek M,Rubis B,Frydrychowicz M,Nowicka A,Brajer-Luftmann B,Kozlowska M,Lagiedo M,Batura-Gabryel H,Sikora J

更新日期：2018-01-01 00:00:00

abstract：:Two groups of patients with disseminated breast carcinomas who had failed radiotherapy, chemotherapy, and hormonotherapy were treated with natural interferon alpha (nIFN-alpha) alone or in combination with nIFN-gamma delivered in cycles of 10-12 intralesional (i.l.) injections to recurrent and metastatic lesions. In g...

journal_title：Cancer investigation

authors： Habif DV,Ozzello L,De Rosa CM,Cantell K,Lattes R

更新日期：1995-01-01 00:00:00

abstract：:The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...

journal_title：Cancer investigation

authors： Yagi S,Oda-Sato E,Uehara I,Asano Y,Nakajima W,Takeshita T,Tanaka N

更新日期：2008-08-01 00:00:00

abstract：:Precise quantification of oral complications in cancer patients receiving bone marrow and stem cell transplantation is essential when testing new treatment strategies for mucositis. Using 133 adult transplant patients, the authors evaluated the 20 item oral mucositis index (OMI), adapted from the 34 item OMI, to facil...

journal_title：Cancer investigation

authors： McGuire DB,Peterson DE,Muller S,Owen DC,Slemmons MF,Schubert MM

更新日期：2002-01-01 00:00:00

abstract：:Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...

journal_title：Cancer investigation

authors： Zhou Y,Wang S,Yue BG,Gobl A,Oberg K

更新日期：2002-01-01 00:00:00

abstract：:To study the efficiency of high-dose melphalan in previously untreated patients with advanced myeloma, we performed a Phase I-II trial. Twenty-eight patients were treated at dose level of 60-140 mg/m2. Each patient was first treated with a priming dose of cyclophosphamide (300 mg) followed by high-dose melphalen 1 wee...

journal_title：Cancer investigation

authors： Case DC Jr,Coleman M,Gottlieb A,McCarroll K

更新日期：1992-01-01 00:00:00

abstract：:Despite the dramatic success achieved over the past few years in improving the survival of individuals with cancer, treatment for many patients with advanced malignancies remains far from satisfactory. Unfortunately, centers engaged in clinical cancer research are currently faced with the dilemma of dealing with incre...

journal_title：Cancer investigation

authors： Markman M

更新日期：1987-01-01 00:00:00

abstract：:Mice bearing LP07 lung adenocarcinoma present some characteristics similar to those shown in patients with several malignant diseases. LP07 tumor bearers develop paraneoplastic syndromes such as cachexia, leukocytosis, and hypercalcemia, partly due to a systemic inflammatory response. We analyzed some of the mechanism...

journal_title：Cancer investigation

authors： Diament MJ,Peluffo GD,Stillitani I,Cerchietti LC,Navigante A,Ranuncolo SM,Klein SM

更新日期：2006-03-01 00:00:00

abstract：:UFT is the combination of the fluorouracil (5-FU) prodrug tegafur, and the dihydrophyrimidine dehydrogenase inhibitor uracil. UFT and leucovorin have been used in the oral treatment of a variety of malignancies. Given the radiosensitizing properties of UFT, its combination with radiation therapy is a logical step in t...

journal_title：Cancer investigation

authors： Saad ED,Hoff PM

更新日期：2003-01-01 00:00:00

abstract：:This is the first of two papers describing the naturally occurring retroviruses (RNA tumor viruses). Here, the general properties of these viruses and the biology of the fish, reptilian, chicken, and mouse retroviruses are described. In the next issue of Cancer Investigation the biologic properties of the cat, cattle,...

journal_title：Cancer investigation

authors： Hardy WD Jr

更新日期：1983-01-01 00:00:00

abstract：:Although it is not proven by causative association, several studies indicate that patients with acquired immune deficiency syndrome (AIDS) have a high risk for developing cutaneous malignancies, especially lymphoma and Kaposi's sarcoma. Other malignant cutaneous lesions seen in this patient population include basal-ce...

journal_title：Cancer investigation

authors： Aboulafia DM

更新日期：1998-01-01 00:00:00