Endothelin converting enzyme-1 expression in endometrial adenocarcinomas.

abstract：:We analyzed the clinical utility of molecular classification based on anatomical and histological background. The study was conducted on 457 patients treated for gastric cancer with additional information about microsatellite instability status. We divided the patients in three groups of molecular classification based...

journal_title：Cancer investigation

authors： Polom K,Marrelli D,Roviello G,Voglino C,Vindigni C,Generali D,Roviello F

更新日期：2017-05-28 00:00:00

abstract：:Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Hi...

journal_title：Cancer investigation

authors： Germanová A,Germanová A,Tesarová P,Jáchymová M,Zvára K,Zima T,Kalousová M

更新日期：2009-07-01 00:00:00

abstract：:Nature has provided many effective anticancer agents in current use, such as the microbially derived drugs; dactinomycin; bleomycin and doxorubicin; and the plant-derived drugs, vinblastine, irinotecan, topotecan, etoposide, and paclitaxel. The search for novel antitumor agents from natural sources continues through c...

journal_title：Cancer investigation

authors： Cragg GM,Newman DJ

更新日期：1999-01-01 00:00:00

abstract：:Non-invasive pharmacological management of patients with cancer related pain has resulted in pain control in 90-95% of the patients. Thus, 5-10% of patients still experience inadequate pain control despite aggressive combined pharmacological therapy. Moreover, patients may not tolerate an aggressive program of titrati...

journal_title：Cancer investigation

authors： de Leon-Casasola OA

更新日期：2004-01-01 00:00:00

abstract：:This is the first of two papers describing the naturally occurring retroviruses (RNA tumor viruses). Here, the general properties of these viruses and the biology of the fish, reptilian, chicken, and mouse retroviruses are described. In the next issue of Cancer Investigation the biologic properties of the cat, cattle,...

journal_title：Cancer investigation

authors： Hardy WD Jr

更新日期：1983-01-01 00:00:00

abstract：:Adriamycin (ADM, or doxorubicin hydrochloride) is an effective antineoplastic agent whose use is restricted by its well-described, dose-dependent cardiotoxicity. This study measures ADM DNA adduct formation by 32P-radiolabeling DNA, enzymatically digesting radiolabeled DNA, separating the formed adducts on two-dimensi...

journal_title：Cancer investigation

authors： Hahm S,Dresner HS,Podwall D,Golden M,Winiarsky R,Moosikasuwan M,Cajigas A,Steinberg JJ

更新日期：2003-01-01 00:00:00

abstract：:Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...

journal_title：Cancer investigation

authors： Ejaz S,Chekarova I,Ashraf M,Lim CW

更新日期：2006-10-01 00:00:00

abstract：:The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, in situ hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 G...

journal_title：Cancer investigation

authors： Limam S,Missaoui N,Hmissa S,Yacoubi MT,Krifa H,Mokni M,Selmi B

更新日期：2020-08-01 00:00:00

abstract：:Expression of epidermal growth factor and its transmembrane receptor (EGFR) stimulates tumor growth. Matuzumab is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth, and provides a clinical benefit for some patients. The plasma half-life (6-10 days) an...

journal_title：Cancer investigation

authors： Schiller JH

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...

journal_title：Cancer investigation

authors： Abushullaih S,Saad ED,Munsell M,Hoff PM

更新日期：2002-01-01 00:00:00

abstract：:Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...

journal_title：Cancer investigation

authors： Erfani N,Razmkhah M,Ghaderi A

更新日期：2010-10-01 00:00:00

abstract：:We carried out a phase I trial with chlorambucil. Thirty patients with advanced cancer were entered in six dose levels: 36, 48, 60, 84, 108, and 144 mg/m2. The drug was given in six divided oral doses every 6 hours and the regimen was repeated every 3 weeks. The median age was 62 years (31-84), median Karnofsky perfor...

journal_title：Cancer investigation

authors： Blumenreich MS,Woodcock TM,Sherrill EJ,Richman SP,Gentile PS,Epremian BE,Kubota TT,Allegra JC

更新日期：1988-01-01 00:00:00

abstract：:Withaferin A (WA) (1) and two analogs [4-epi-withaferin A (2) and 4,27-diacetyl-4-epi-withaferin A (3)] were evaluated for antitumor activity in pancreatic cancer cells. IC(50) for 1, 2, and 3 were 0.87, 0.45, and 0.29 ?M (BxPC-3); 1.28, 1.53, and 0.52 ?M (MIAPaCa-2); and 0.59, 2.25, and 0.56 ?M (PANC-1), respectively...

journal_title：Cancer investigation

authors： Liu X,Qi W,Cooke LS,Kithsiri Wijeratne EM,Xu YM,Marron MT,Leslie Gunatilaka AA,Mahadevan D

更新日期：2011-12-01 00:00:00

abstract：:Tumor-infiltrating leukocytes and other immunohistochemical parameters were evaluated in pretherapeutic biopsies and resection specimens in 73 patients undergoing neoadjuvant chemotherapy with doxorubicin and paclitaxel. Ten patients with pathological complete response had significantly higher p53 expression, CD3(+) l...

journal_title：Cancer investigation

authors： Hornychova H,Melichar B,Tomsova M,Mergancova J,Urminska H,Ryska A

更新日期：2008-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...

journal_title：Cancer investigation

authors： Cascinu S,Del Ferro E,Ligi M,Staccioli MP,Giordani P,Catalano V,Agostinelli R,Muretto P,Catalano G

更新日期：2001-01-01 00:00:00

abstract：:Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...

journal_title：Cancer investigation

authors： Zhou Y,Wang S,Yue BG,Gobl A,Oberg K

更新日期：2002-01-01 00:00:00

abstract：:PS-341, now known as bortezomib (Velcade[Millenium Pharmaceuticals, Inc., Cambridge, MA; and Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring house, PA]), is a proteasome inhibitor approved for the treatment of refractory multiple myeloma. Preclinical and early clinical studies showed PS-341 to be ...

journal_title：Cancer investigation

authors： Engel RH,Brown JA,Von Roenn JH,O'Regan RM,Bergan R,Badve S,Rademaker A,Gradishar WJ

更新日期：2007-12-01 00:00:00

abstract：:The purpose of this study was to assess the usefulness of thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) scintimammography to differentiate benign from malignant breast masses in 32 female Taiwanese patients with indeterminate mammographic probability of malignancy because of mammographically...

journal_title：Cancer investigation

authors： Chiou JF,Lin MC,Chen DR,Jim YF,Kao CH

更新日期：2003-01-01 00:00:00

abstract：:The host immune response can impact cancer growth, prognosis, and response to therapy. In colorectal cancer, the presence of cells involved with T-cell-mediated adaptive immunity predicts survival better than the current staging method. We used the expression of genes recently associated with host immune responses (T(...

journal_title：Cancer investigation

authors： Hsu DS,Kim MK,Balakumaran BS,Acharya CR,Anders CK,Clay T,Lyerly HK,Drake CG,Morse MA,Febbo PG

更新日期：2010-08-01 00:00:00

abstract：:We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes (SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of...

journal_title：Cancer investigation

authors： Vishwakarma S,Agarwal R,Goel SK,Panday RK,Singh R,Sukumaran R,Khare S,Kumar A

更新日期：2017-02-07 00:00:00

abstract：:Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...

journal_title：Cancer investigation

authors： Razis E,Karina M,Karanastassi S,Fountzilas G

更新日期：2006-08-01 00:00:00

abstract：:To identify the relevant CpG sites as molecular markers, for the diagnosis and to distinguish the indolent and aggressive prostate tumors, we have determined the methylation status of 8 genes, including FLNC, EFS, ECRG4, RARB2, PITX2, GSTP1, PDLIM4, and KCNMA1 in 32 nonrecurrent, 32 recurrent primary prostate tumors, ...

journal_title：Cancer investigation

authors： Vanaja DK,Ehrich M,Van den Boom D,Cheville JC,Karnes RJ,Tindall DJ,Cantor CR,Young CY

更新日期：2009-06-01 00:00:00

abstract：:We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baselin...

journal_title：Cancer investigation

authors： Chasseing NA,Barañao RI,Fernández O,Bordenave H,Rumi LS

更新日期：1993-01-01 00:00:00

abstract：:There appears to be exceptional and growing public enthusiasm for botanical, or "herbal", medicines, especially amongst cancer patients. This has recently begun to be matched by increasing scientific attention. Whilst it is known that plant extracts are active against cancer, the standard approach has been to isolate,...

journal_title：Cancer investigation

authors： Vickers A

更新日期：2002-01-01 00:00:00

abstract：:In summary, anemia developing in a patient with cancer can be due to several different factors. A relative failure of erythropoiesis, in conjunction with a modestly shortened erythrocyte survival, is the most likely explanation for the anemia and can occur in patients with or without bone marrow invasion. Several theo...

journal_title：Cancer investigation

authors： Zucker S

更新日期：1985-01-01 00:00:00

abstract：:Between March 1986 and December 1987, two groups of consecutive patients with advanced breast cancer underwent epidoxorubicin (Epidx) monochemotherapy. Twenty-three patients (group A) received Epidx at a dose of 60 mg/m2 and 27 (group B) at a dose of 120 mg/m2 (i.v. every 3 weeks). No patient had undergone anthracycli...

journal_title：Cancer investigation

authors： Neri B,Pacini P,Algeri R,Lottini G,Rinaldini M,Tucci E,Pusterla R

更新日期：1993-01-01 00:00:00

abstract：:After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...

journal_title：Cancer investigation

authors： Crane E,List A

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS:Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by ...

journal_title：Cancer investigation

authors： Kohli M,Williams K,Yao JL,Dennis RA,Huang J,Reeder J,Ricke WA

更新日期：2011-01-01 00:00:00

abstract：:IFN regulatory factor 4 binding protein (IBP) has been shown to play an important role in the progression of malignant tumors such as breast cancer cells, but its function in oral squamous cell carcinoma (OSCC) remains unclear. We found that IBP ectopically expressed in some OSCC specimens but not in normal oral mucos...

journal_title：Cancer investigation

authors： Jian CX,Yang MZ,Li P,Xiong J,Zhang ZJ,Li CJ,Chen A,Hu CM,Zhou JX,Li SH

更新日期：2012-12-01 00:00:00

abstract：:We studied the effects of Shikaron, which is composed of 8 Chinese herb extracts, on carcinogenesis and the cytotoxic activity and cytokine production of lymphocytes in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine (BBN). We found a significantly lower incidence of urinary bladder carcinoma in mice tr...

journal_title：Cancer investigation

authors： Kurashige S,Jin R,Akuzawa Y,Endo F

更新日期：1998-01-01 00:00:00