Inhibition of vascular endothelial growth factor by octreotide in colorectal cancer patients.

abstract：:A 69-year-old man receiving monotherapy for lung cancer with dichloromethotrexate (DCM), and without exposure to other chemotherapeutic agents or known ototoxic drugs, developed profound cochleovestibular dysfunction. The initial presentation was vestibular. This resolved, but unilateral hearing loss ensued and contin...

journal_title：Cancer investigation

authors： Golden L,Ahlgren JD,Kattah J,Smith JW,Sisk R,Deeb Z

更新日期：1989-01-01 00:00:00

abstract：:Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer and moderate relationship with unmethylated CpG-27 i...

journal_title：Cancer investigation

authors： Tiscornia MM,González HS,Lorenzati MA,Zapata PD

更新日期：2015-03-01 00:00:00

abstract：:Requirements for the induction of anomalous killer (AK) cells to syngeneic MOPC 104E-KI81 plasmacytoma, and their pattern of reaction were investigated. The AK cells are Thy-1.2 positive and were induced by cocultivation of normal BALB/c spleen cells for 5 days in vitro with mitomycin C-treated MOPC 104E-KI81 cells in...

journal_title：Cancer investigation

authors： Hayashida I,Hiramoto RN,Shrestha K,Ghanta VK

更新日期：1989-01-01 00:00:00

abstract：:Targeting the nuclear factor kappa B (NFκB) pathway is proposed as therapy for chronic lymphocytic leukemia (CLL). We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFκB activation in lymphocytes of Rai Stage 0-1 CLL patients. The initial dose of 2.4 g n-3/day was gradually increased to 7.2 g...

journal_title：Cancer investigation

authors： Fahrmann JF,Ballester OF,Ballester G,Witte TR,Salazar AJ,Kordusky B,Cowen KG,Ion G,Primerano DA,Boskovic G,Denvir J,Hardman WE

更新日期：2013-01-01 00:00:00

abstract：:Metastasis is the overwhelming cause of mortality in patients with breast cancer and our understanding of its cellular and molecular determinants is limited. Among cellular determinants, disseminated (DTC) tumor cells undoubtedly are key players in the metastatic cascade. In the past, several models have been construc...

journal_title：Cancer investigation

authors： Braun S,Auer D,Marth C

更新日期：2009-07-01 00:00:00

abstract：:Until recently physicians have been reluctant to disclose a poor prognosis to patients for fear of harming them with the bad news and/or taking away their will to live. In the last decades we have seen a reversal of practice among Western physicians, and most doctors readily disclose to their patients the full extant ...

journal_title：Cancer investigation

authors： Jotkowitz A,Glick S,Gezundheit B

更新日期：2006-12-01 00:00:00

abstract：:A natural tension exists as an IRB attempts of fulfill its mission of providing an independent and unbiased evaluation of a study while also insuring appropriate consideration of all relevant risks, benefits, and alternative strategies. IRB members with often critically relevant knowledge of unique issues involved in ...

journal_title：Cancer investigation

authors： Markman M

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:We conducted a phase I study to determine the maximum tolerated dose of docetaxel in combination with gemcitabine for patients with refractory solid tumors. METHODS:From January 1998 to November 1999, we treated 28 patients on a phase I protocol with gemcitabine given at a constant dose of 800 mg/m2 i.v. ov...

journal_title：Cancer investigation

authors： Poole ME,Bernard SA,Churchel MA,Weissler MC,Calvo B,Cance W,Ollila D,Koruda M,Behrns K,Detterbeck FC

更新日期：2003-06-01 00:00:00

abstract：:The complex formed by isopentane, as a model for the isoleucine residue present in the wild-type thymidylate synthase, with 4-mercaptopyridine as a fragment of the thymidylate synthase inhibitor Thymitaq (AG337) is investigated with ab initio quantum chemical calculations at Hartree-Fock and MP2 levels, using the 3-21...

journal_title：Cancer investigation

authors： Sapse DS,Tong Y,Bertino JR,Sapse AM

更新日期：1999-01-01 00:00:00

abstract：:Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34+ progenitor/stem leukemia...

journal_title：Cancer investigation

authors： Lei H,Tu Y,Yang L,Jin J,Luo H,Xu H,Kang J,Zhou L,Wu Y

更新日期：2019-01-01 00:00:00

abstract：:Cells from 11 chronic lymphocytic leukemic (CLL) patients were induced to differentiate with various doses of tetradecanoyl phorbol-13-acetate (TPA) and the degree of induction was followed up to six days by measuring the expression of two surface membrane markers (SmIg and GP-70), Ig secretion, tartrate-resistant aci...

journal_title：Cancer investigation

authors： Gazitt Y,Gurfel D,Leizerowitz R,Feinstein H,Polliack A

更新日期：1987-01-01 00:00:00

abstract：:To study the efficiency of high-dose melphalan in previously untreated patients with advanced myeloma, we performed a Phase I-II trial. Twenty-eight patients were treated at dose level of 60-140 mg/m2. Each patient was first treated with a priming dose of cyclophosphamide (300 mg) followed by high-dose melphalen 1 wee...

journal_title：Cancer investigation

authors： Case DC Jr,Coleman M,Gottlieb A,McCarroll K

更新日期：1992-01-01 00:00:00

abstract：:We carried out a phase I trial with chlorambucil. Thirty patients with advanced cancer were entered in six dose levels: 36, 48, 60, 84, 108, and 144 mg/m2. The drug was given in six divided oral doses every 6 hours and the regimen was repeated every 3 weeks. The median age was 62 years (31-84), median Karnofsky perfor...

journal_title：Cancer investigation

authors： Blumenreich MS,Woodcock TM,Sherrill EJ,Richman SP,Gentile PS,Epremian BE,Kubota TT,Allegra JC

更新日期：1988-01-01 00:00:00

abstract：:There are many changes in the immune response with age, most of which can be related to the involution of the thymus gland and alteration of the distribution and function of T lymphocytes. These changes indirectly influence B-cell function, which not only amplifies the immune deficits, but leads to the increased produ...

journal_title：Cancer investigation

authors： Ben-Yehuda A,Weksler ME

更新日期：1992-01-01 00:00:00

abstract：:UFT is the combination of the fluorouracil (5-FU) prodrug tegafur, and the dihydrophyrimidine dehydrogenase inhibitor uracil. UFT and leucovorin have been used in the oral treatment of a variety of malignancies. Given the radiosensitizing properties of UFT, its combination with radiation therapy is a logical step in t...

journal_title：Cancer investigation

authors： Saad ED,Hoff PM

更新日期：2003-01-01 00:00:00

abstract：:A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...

journal_title：Cancer investigation

authors： Singh AP,Shah PP,Ruwali M,Mathur N,Pant MC,Parmar D

更新日期：2009-10-01 00:00:00

abstract：:We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes (SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of...

journal_title：Cancer investigation

authors： Vishwakarma S,Agarwal R,Goel SK,Panday RK,Singh R,Sukumaran R,Khare S,Kumar A

更新日期：2017-02-07 00:00:00

abstract：:The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...

journal_title：Cancer investigation

authors： Shang D,Yang P,Liu Y,Song J,Zhang F,Tian Y

更新日期：2011-06-01 00:00:00

abstract：:FTIR spectroscopy is a common technique for cancer diagnosis. Applied tissue samples are heterogeneous and may be damaged in preparation procedures. Easier sampling, more available samples and also easier process with assured results would be interesting. Whole blood samples include all of these qualifications and our...

journal_title：Cancer investigation

authors： Khanmohammadi M,Ansari MA,Garmarudi AB,Hassanzadeh G,Garoosi G

更新日期：2007-09-01 00:00:00

abstract：:Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...

journal_title：Cancer investigation

authors： Brenner PR

更新日期：1997-01-01 00:00:00

abstract：:Temozolomide is an oral cytotoxic agent that has demonstrated its interest in high grade glioma tumors. This drug can be used either concomitantly with radiotherapy or as chemotherapy. The prognosis of relapsing medulloblastoma is poor and treatment is often difficult, especially after radiotherapy. Here, we report th...

journal_title：Cancer investigation

authors： Durando X,Thivat E,Gilliot O,Irthum B,Verrelle P,Vincent C,Bay JO

更新日期：2007-09-01 00:00:00

abstract：:Patients with metastatic prostate cancer resistant to hormones and docetaxel were treated with vinflunine (320 mg/m(2) every 21 days), a new vinca alkaloid with improved preclinical activity. Only 1 of 36 patients (3%) had partial response; the median progression-free survival (PFS) was 2.1 months. Treatment was well ...

journal_title：Cancer investigation

authors： Hainsworth JD,Meluch AA,Lane CM,Spigel DR,Burris HA 3rd,Gandhi JG,Crane EJ,Stipanov MA,Greco FA

更新日期：2010-03-01 00:00:00

abstract：:Esophageal cancer is multifactorial disease involving environmental and genetic risk factors. Tobacco smoke and alcohol are strong environmental risk factors. N-acetyltransferase 2 (NAT2) is known to metabolize heterocyclic amine carcinogens in tobacco smoke. The purpose of this study was to determine whether genetic ...

journal_title：Cancer investigation

authors： Jain M,Kumar S,Lal P,Tiwari A,Ghoshal UC,Mittal B

更新日期：2007-08-01 00:00:00

abstract：:Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal ti...

journal_title：Cancer investigation

authors： Olsen RS,Dimberg J,Geffers R,Wågsäter D

更新日期：2019-01-01 00:00:00

abstract：:The present study investigates the association between IL12Bpro and +16974A/C in 3' -untranslated region (UTR) polymorphisms of IL12B and IL-12p40 serum level related to development of colorectal cancer (CRC). Our results showed similar distribution of both the investigated polymorphisms among CRC patients and healthy...

journal_title：Cancer investigation

authors： Miteva L,Stanilov N,Deliysky T,Mintchev N,Stanilova S

更新日期：2009-11-01 00:00:00

abstract：:Several recent studies have indicated that alterations in expression of major histocompatibility complex (MHC) antigens by tumor cells affects the ability of the host to mount an effective antitumor immune response. To investigate whether newly induced tumors frequently exhibit altered MHC antigen expression, we used ...

journal_title：Cancer investigation

authors： Reagan WJ,Pardi D,Callahan GN

更新日期：1991-01-01 00:00:00

abstract：:We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice....

journal_title：Cancer investigation

authors： Dai J,Wang H,Dong Y,Zhang Y,Wang J

更新日期：2013-02-01 00:00:00

abstract：:Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...

journal_title：Cancer investigation

authors： Zhou Y,Wang S,Yue BG,Gobl A,Oberg K

更新日期：2002-01-01 00:00:00

abstract：:Precise quantification of oral complications in cancer patients receiving bone marrow and stem cell transplantation is essential when testing new treatment strategies for mucositis. Using 133 adult transplant patients, the authors evaluated the 20 item oral mucositis index (OMI), adapted from the 34 item OMI, to facil...

journal_title：Cancer investigation

authors： McGuire DB,Peterson DE,Muller S,Owen DC,Slemmons MF,Schubert MM

更新日期：2002-01-01 00:00:00

abstract：:Expression of epidermal growth factor and its transmembrane receptor (EGFR) stimulates tumor growth. Matuzumab is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth, and provides a clinical benefit for some patients. The plasma half-life (6-10 days) an...

journal_title：Cancer investigation

authors： Schiller JH

更新日期：2008-02-01 00:00:00