Interferon-α induces G1 cell-cycle arrest in renal cell carcinoma cells via activation of Jak-Stat signaling.

abstract：:The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endotheli...

journal_title：Cancer investigation

authors： Baker DG,Krochak RJ

更新日期：1989-01-01 00:00:00

abstract：:An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...

journal_title：Cancer investigation

authors： Herbert PN,Friedland ML

更新日期：1986-01-01 00:00:00

abstract：:Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis...

journal_title：Cancer investigation

authors： Rico MJ,Perroud HA,Mainetti LE,Rozados VR,Scharovsky OG

更新日期：2014-03-01 00:00:00

abstract：:Hepatitis B virus X protein (HBx) promotes hepatocellular carcinoma (HCC) invasion and metastasis by a poorly understood mechanism. This study investigated the role of NF-kappa B in HBx-mediated upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). In a stably expressing HBx c...

journal_title：Cancer investigation

authors： Liu LP,Liang HF,Chen XP,Zhang WG,Yang SL,Xu T,Ren L

更新日期：2010-06-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by specific t(15;17), distinct morphologic picture, and clinical coagulopathy that contribute to the morbidity and mortality of the disease. This study aims to investigate the effects of antitelomerase compound BIBR1532 on APL cells (NB4). BIBR 1532 exerts a direct s...

journal_title：Cancer investigation

authors： Bashash D,Ghaffari SH,Zaker F,Hezave K,Kazerani M,Ghavamzadeh A,Alimoghaddam K,Mosavi SA,Gharehbaghian A,Vossough P

更新日期：2012-01-01 00:00:00

abstract：:Nerve growth factor receptor (NGF-R) has been shown to have antiproliferative, differentiative, or apoptotic effects on some types of tumor cells, whereas in others it may have mitogenic activity. The immunohistochemical distribution of NGF-R was analyzed in a series of tissue samples from breast cancer patients and i...

journal_title：Cancer investigation

authors： Aragona M,Panetta S,Silipigni AM,Romeo DL,Pastura G,Mesiti M,Cascinu S,La Torre F

更新日期：2001-01-01 00:00:00

abstract：:A phase II trial of 5-fluorouracil (5-FU) [250-450 mg/m2/day x 5 days as an intravenous (IV) bolus] combined with calcium leucovorin (500 mg/m2/day x 5 1/2 days by continuous IV infusion) administered on a 28-day schedule was performed in 15 patients with advanced hepatocellular carcinoma. The median age was 58 years;...

journal_title：Cancer investigation

authors： Tetef M,Doroshow J,Akman S,Coluzzi P,Leong L,Margolin K,Morgan RJ Jr,Raschko J,Shibata S,Somlo G

更新日期：1995-01-01 00:00:00

abstract：:In a sample of 633 US adult breast cancer survivors, we examined health-related worry as a function vulnerability as influenced by communication, trust, and planning with their cancer care team during the COVID-19 pandemic. We found significant positive correlations between communication and trust, communication and p...

journal_title：Cancer investigation

authors： Papautsky EL,Hamlish T

更新日期：2021-01-01 00:00:00

abstract：:The purpose of this study was to assess the usefulness of thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) scintimammography to differentiate benign from malignant breast masses in 32 female Taiwanese patients with indeterminate mammographic probability of malignancy because of mammographically...

journal_title：Cancer investigation

authors： Chiou JF,Lin MC,Chen DR,Jim YF,Kao CH

更新日期：2003-01-01 00:00:00

abstract：:Tumor-infiltrating leukocytes and other immunohistochemical parameters were evaluated in pretherapeutic biopsies and resection specimens in 73 patients undergoing neoadjuvant chemotherapy with doxorubicin and paclitaxel. Ten patients with pathological complete response had significantly higher p53 expression, CD3(+) l...

journal_title：Cancer investigation

authors： Hornychova H,Melichar B,Tomsova M,Mergancova J,Urminska H,Ryska A

更新日期：2008-12-01 00:00:00

abstract：:Placement of carmustine-impregnated wafers has become a common practice after surgical resection of malignant gliomas. Bevacizumab is used as a second-line agent for the treatment of malignant gliomas and is sometimes used in patients who have had recent wafer implantation. We describe two cases of fatal cerebrospinal...

journal_title：Cancer investigation

authors： Nagaiah G,Almubarak M,Khan M,Altaha R

更新日期：2010-12-01 00:00:00

abstract：:Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...

journal_title：Cancer investigation

authors： Leonard JP,Siegel JA,Goldsmith SJ

更新日期：2003-04-01 00:00:00

abstract：:Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...

journal_title：Cancer investigation

authors： Brenner PR

更新日期：1997-01-01 00:00:00

abstract：:Peroxiredoxins are thiol-specific antioxidant proteins that protect cells from ROS-induced cell death and are elevated in several cancers. We found that five of the six mammalian peroxiredoxins are overexpressed in MCF-7 breast cancer cells at the mRNA and protein levels, compared to noncancerous MCF-10A cells. Inhibi...

journal_title：Cancer investigation

authors： Tehan L,Taparra K,Phelan S

更新日期：2013-07-01 00:00:00

abstract：:Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied abou...

journal_title：Cancer investigation

authors： Luwor R,Morokoff AP,Amiridis S,D'Abaco G,Paradiso L,Stylli SS,Nguyen HPT,Tarleton M,Young KA,O'Brien TJ,Robinson PJ,Chircop M,McCluskey A,Jones NC

更新日期：2019-01-01 00:00:00

abstract：:Serum C-reactive protein (CRP), a sensitive marker of systemic inflammation, has been reported to be associated with the risk of a number of cancers including breast cancer. However, the results are inconsistent. To investigate the association between serum CRP levels and early breast cancer, we conducted a hospital-b...

journal_title：Cancer investigation

authors： Hong T,Liu A,Cai D,Zhang Y,Hua D,Hang X,Wu X

更新日期：2013-05-01 00:00:00

abstract：:Based on cost-effective ratio, there has not yet been imaging methods suitable for breast cancer screening in young women. The aim of this study was to evaluate the sensitivity and specificity of the combination of electrical impedance scanning (EIS) and ultrasound in identifying breast cancer for young women, to calc...

journal_title：Cancer investigation

authors： Wang T,Wang K,Yao Q,Chen JH,Ling R,Zhang JL,Dong XZ,Fu F,Dou KF,Wang L

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:We conducted a phase I study to determine the maximum tolerated dose of docetaxel in combination with gemcitabine for patients with refractory solid tumors. METHODS:From January 1998 to November 1999, we treated 28 patients on a phase I protocol with gemcitabine given at a constant dose of 800 mg/m2 i.v. ov...

journal_title：Cancer investigation

authors： Poole ME,Bernard SA,Churchel MA,Weissler MC,Calvo B,Cance W,Ollila D,Koruda M,Behrns K,Detterbeck FC

更新日期：2003-06-01 00:00:00

abstract：:Oncologists deal almost exclusively with patients with serious and life-threatening diseases, many who are terminally ill. While hospice care remains an ideal model of care for cancer patients with life-ending disease, many obstacles are present in the clinical setting that either impede or prevent the otherwise appro...

journal_title：Cancer investigation

authors： Daugherty CK

更新日期：2004-01-01 00:00:00

abstract：:For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...

journal_title：Cancer investigation

authors： Tang SC

更新日期：2008-06-01 00:00:00

abstract：:A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...

journal_title：Cancer investigation

authors： Singh AP,Shah PP,Ruwali M,Mathur N,Pant MC,Parmar D

更新日期：2009-10-01 00:00:00

abstract：:Adriamycin (ADM, or doxorubicin hydrochloride) is an effective antineoplastic agent whose use is restricted by its well-described, dose-dependent cardiotoxicity. This study measures ADM DNA adduct formation by 32P-radiolabeling DNA, enzymatically digesting radiolabeled DNA, separating the formed adducts on two-dimensi...

journal_title：Cancer investigation

authors： Hahm S,Dresner HS,Podwall D,Golden M,Winiarsky R,Moosikasuwan M,Cajigas A,Steinberg JJ

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the efficacy and toxicity of the combination of vinorelbine and interleukin (IL)-2 in patients with metastatic melanoma as second-line chemotherapy. PATIENTS AND METHODS:Twenty-two patients with histologically confirmed stage IV melanoma previously treated with temozolomide-based chemotherapy--o...

journal_title：Cancer investigation

authors： Gogas H,Bafaloukos D,Aravantinos G,Fountzilas G,Tsoutsos D,Panagiotou P,Frangia K,Kalofonos HP,Briasoulis E,Castana O,Polyzos A,Pectasides D,Ioannovich J,Hellenic Cooperative Oncology Group.

更新日期：2004-01-01 00:00:00

abstract：:Fulvestrant (Faslodex) is a new type of estrogen receptor (ER) antagonist that binds, blocks, and degrades the ER, leading to reduced expression of the progesterone receptor (PgR). Unlike the selective ER modulator tamoxifen, fulvestrant is devoid of any known agonist activity. Fulvestrant has a steroidal structure th...

journal_title：Cancer investigation

authors： Bundred N

更新日期：2005-01-01 00:00:00

abstract：:A number of studies have demonstrated the presence of mitochondrial DNA (mtDNA) mutations in cancer cells. In this article, we review mitochondrial genomic aberrations reported in solid tumors of the breast, colon, stomach, liver, kidney, bladder, head/neck, and lung. The tantalizing association of tumors with mtDNA m...

journal_title：Cancer investigation

authors： Copeland WC,Wachsman JT,Johnson FM,Penta JS

更新日期：2002-01-01 00:00:00

abstract：:Despite increasing evidence of benefit from adjuvant chemotherapy, older women with breast cancer are commonly given less aggressive treatment than younger patients. Conflicting prior data regarding age-related toxicity prompted this prospective study. Forty-four women (aged 35-79 years) with early-stage breast cancer...

journal_title：Cancer investigation

authors： Dees EC,O'Reilly S,Goodman SN,Sartorius S,Levine MA,Jones RJ,Grochow LB,Donehower RC,Fetting JH

更新日期：2000-01-01 00:00:00

abstract：:Between March 1986 and December 1987, two groups of consecutive patients with advanced breast cancer underwent epidoxorubicin (Epidx) monochemotherapy. Twenty-three patients (group A) received Epidx at a dose of 60 mg/m2 and 27 (group B) at a dose of 120 mg/m2 (i.v. every 3 weeks). No patient had undergone anthracycli...

journal_title：Cancer investigation

authors： Neri B,Pacini P,Algeri R,Lottini G,Rinaldini M,Tucci E,Pusterla R

更新日期：1993-01-01 00:00:00

abstract：:The aim was to determine whether promoter methylation of BRCA1, MGMT, MLH1, RASSF1A, and p16 genes could predict response to platinum-based chemotherapy. Thirty-five subjects with epithelial ovarian cancer (EOC) treated by platinum-based chemotherapy were recruited. Methylation-specific polymerase chain reaction was c...

journal_title：Cancer investigation

authors： Chaudhry P,Srinivasan R,Patel FD

更新日期：2009-10-01 00:00:00

abstract：:The transforming growth factor beta 1 (TGF-beta1) is a multifunctional cytokine with several regulatory activities in tumor cells affecting growth, differentiation, and function. Alterations in gene expression, secretion, and regulation of TGF-beta1 may lead to a favorable environment for tumor development by angiogen...

journal_title：Cancer investigation

authors： Faria PC,Saba K,Neves AF,Cordeiro ER,Marangoni K,Freitas DG,Goulart LR

更新日期：2007-12-01 00:00:00

abstract：:This study compared the antiemetic efficacy and safety of two different intravenous (i.v.) dolasetron dosing regimens in patients receiving their first course of high-dose (> or = 80 mg/m2) cisplatin. Of 30 patients enrolled, 14 received a single i.v. dolasetron dose (0.6 mg/kg) before cisplatin and 16 received a mult...

journal_title：Cancer investigation

authors： Kasimis BS,Tapazoglou E,Schulman P,Stewart WH,Hahne WF,Cramer MB

更新日期：1997-01-01 00:00:00