Effects of interferon alpha on the expression of p21cip1/waf1 and cell cycle distribution in carcinoid tumors.

abstract：OBJECTIVES:To evaluate the efficacy and toxicity of the combination of vinorelbine and interleukin (IL)-2 in patients with metastatic melanoma as second-line chemotherapy. PATIENTS AND METHODS:Twenty-two patients with histologically confirmed stage IV melanoma previously treated with temozolomide-based chemotherapy--o...

journal_title：Cancer investigation

authors： Gogas H,Bafaloukos D,Aravantinos G,Fountzilas G,Tsoutsos D,Panagiotou P,Frangia K,Kalofonos HP,Briasoulis E,Castana O,Polyzos A,Pectasides D,Ioannovich J,Hellenic Cooperative Oncology Group.

更新日期：2004-01-01 00:00:00

abstract：:We performed the analysis of database on 409 patients with LD-SCLC to evaluate as to what extent the clinical outcome of large prospective trials was reproduced in routine practice. The analysis has shown that the hazard rate of death in the absence of prophylactic cranial irradiation (PCI) adjusted for the effects of...

journal_title：Cancer investigation

authors： Wzietek I,Suwinski R,Nowara E,Bialas M,Bentzen S,Tukiendorf A

更新日期：2014-01-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) play an important role in the development of human cancers. In the present study, we observed that hMSCs promoted human prostate cancer (PCa) cell PC-3 growth in vivo and in vitro. The conditional medium of hMSCs promoted the proliferation, migration, and invasion of PC-3 cells. Th...

journal_title：Cancer investigation

authors： Ye H,Cheng J,Tang Y,Liu Z,Xu C,Liu Y,Sun Y

更新日期：2012-08-01 00:00:00

abstract：:Pyrrolidindithiocarbamate (PDTC), is a metal chelator widely used to study the activation of redox sensitive transcription factors. Recently it has been demonstrated that it manifests pro-oxidant properties. The nuclear factor-Kappa B (NF-kappaB) transcription factor can both promote cell survival and induce apoptosis...

journal_title：Cancer investigation

authors： Malaguarnera L,Pilastro MR,Vicari L,Dimarco R,Manzella L,Palumbo G,Messina A

更新日期：2005-01-01 00:00:00

abstract：:Combination immune checkpoint inhibitors (ICIs) achieved higher efficacy than monotherapy in many types of cancers. We searched PubMed, Scopus, and Cochrane databases for randomized phase II/III trials in cancer patients receiving combination ICIs vs. Monotherapy. Our search retrieved 934 records. Eight studies were f...

journal_title：Cancer investigation

authors： Abdelhafeez AAM,Shohdy KS,Ibrahim W

更新日期：2020-03-01 00:00:00

abstract：:Nerve growth factor receptor (NGF-R) has been shown to have antiproliferative, differentiative, or apoptotic effects on some types of tumor cells, whereas in others it may have mitogenic activity. The immunohistochemical distribution of NGF-R was analyzed in a series of tissue samples from breast cancer patients and i...

journal_title：Cancer investigation

authors： Aragona M,Panetta S,Silipigni AM,Romeo DL,Pastura G,Mesiti M,Cascinu S,La Torre F

更新日期：2001-01-01 00:00:00

abstract：:Because most cancer deaths result from disseminated disease, understanding the regulation of tumor invasion and metastasis is a central theme in tumor cell biology. Interactions between extracellular matrices (ECM) and cellular microenvironment play a crucial role in this process. We have tested selected amino acids a...

journal_title：Cancer investigation

authors： Singh RK,Rinehart CA,Kim JP,Tolleson-Rinehart S,Lawing LF,Kaufman DG,Siegal GP

更新日期：1996-01-01 00:00:00

abstract：:The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC...

journal_title：Cancer investigation

authors： Szondy K,Rusai K,Szabó AJ,Nagy A,Gal K,Fekete A,Kovats Z,Losonczy G,Lukacsovits J,Müller V

更新日期：2012-05-01 00:00:00

abstract：:Arsenic trioxide is valuable for treatment of promyelocytic leukemia, but less attention has been paid to its therapeutic potential for other cancers. In this study, the effects of arsenic trioxide were tested in human pancreatic (AsPC-1), colonic (HT-29), and breast (MCF-7) cancer cells. In all three cancer cell line...

journal_title：Cancer investigation

authors： Li X,Ding X,Adrian TE

更新日期：2004-01-01 00:00:00

abstract：:Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal c...

journal_title：Cancer investigation

authors： Jasin M

更新日期：2000-01-01 00:00:00

abstract：:Achieving a cure for metastatic neuroblastoma remains a challenge despite sensitivity to chemotherapy and radiotherapy. Most patients achieve remission, but a failure to eliminate minimal residual disease (MRD) often leads to relapse. Immunotherapy is potentially useful for chemotherapy-resistant disease and may be pa...

journal_title：Cancer investigation

authors： Modak S,Cheung NK

更新日期：2007-02-01 00:00:00

abstract：:The structural dimensions of capillary tight junctions and the uptake of 99mTc pertechnetate in human gliomas were studied. Quantitative analysis revealed a correlation between the uptake of radionuclides and the length of endothelial tight junctions. It is suggested that brain scintigraphy might be used for the selec...

journal_title：Cancer investigation

authors： Nir I,Kohn S,Doron Y,Israel O,Front D

更新日期：1986-01-01 00:00:00

abstract：:There appears to be exceptional and growing public enthusiasm for botanical, or "herbal", medicines, especially amongst cancer patients. This has recently begun to be matched by increasing scientific attention. Whilst it is known that plant extracts are active against cancer, the standard approach has been to isolate,...

journal_title：Cancer investigation

authors： Vickers A

更新日期：2002-01-01 00:00:00

abstract：:There is no known effective salvage chemotherapy for patients with refractory or relapsed urothelial tumors after methotrexate/cisplatin-based regimen. We report the results of a phase II trial with the FIFO regimen that includes from day 1 to 5: fluorouracil 350 mg/m2, folinic acid 20 mg/m2, and ifosfamide 1000 mg/m2...

journal_title：Cancer investigation

authors： Kattan J,Culine S,Theodore C,Droz JP

更新日期：1995-01-01 00:00:00

abstract：:An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...

journal_title：Cancer investigation

authors： Herbert PN,Friedland ML

更新日期：1986-01-01 00:00:00

abstract：:We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle ge...

journal_title：Cancer investigation

authors： Moumtzi SS,Roberts ML,Joyce T,Evangelidou M,Probert L,Frillingos S,Fotsis T,Pintzas A

更新日期：2010-07-01 00:00:00

abstract：:Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that th...

journal_title：Cancer investigation

authors： Kimura T,Wang L,Tabu K,Nishihara H,Mashita Y,Kikuchi N,Tanino M,Hiraga H,Tanaka S

更新日期：2012-06-01 00:00:00

abstract：:The anticancer effects of synthetic, non-natural analogs of ceramide were tested using human TSU-Pr1 prostate cancer cells in-vitro as well as in-vivo, following their effects on tumors development in mice. When incubated with the cultured cancer cells, the analogs elevated cellular ceramide and induced a cytotoxicity...

journal_title：Cancer investigation

authors： Qin JD,Weiss L,Slavin S,Gatt S,Dagan A

更新日期：2010-06-01 00:00:00

abstract：:Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...

journal_title：Cancer investigation

authors： Erfani N,Razmkhah M,Ghaderi A

更新日期：2010-10-01 00:00:00

abstract：:Breast cancer treatment is recognized as the most common cause of secondary lymphedema (LE) in the developed countries of the world. LE occurs as both an acute and chronic health condition in which significant and persistent swelling is associated with an abnormal accumulation of protein-rich fluid. The impact of LE i...

journal_title：Cancer investigation

authors： Armer JM

更新日期：2005-01-01 00:00:00

abstract：:We have provided an overview of recent studies that have greatly expanded our knowledge of the molecular and cellular mechanisms that determine the sensitivity or resistance to ionizing radiation. Much of this knowledge was obtained by studying tumor and nontumor cell types that under- or overexpress proteins involved...

journal_title：Cancer investigation

authors： Rosen EM,Fan S,Rockwell S,Goldberg ID

更新日期：1999-01-01 00:00:00

abstract：:Following is a review of altered fractionation in radiation therapy for head and neck cancer. The goals of altered fractionation are to increase local-regional control and/or reduce the risk of late complications. Altered fractionation schedules can be broadly classified as accelerated fractionation and hyperfractiona...

journal_title：Cancer investigation

authors： Mendenhall WM,Parsons JT

更新日期：1998-01-01 00:00:00

abstract：:Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...

journal_title：Cancer investigation

authors： Ejaz S,Chekarova I,Ashraf M,Lim CW

更新日期：2006-10-01 00:00:00

abstract：:The vinca alkaloids represent one of the oldest classes of antineoplastic agents used in humans with a wide spectrum of activity against both animal and human tumors. These agents are known to inhibit microtubule polymerization. Vinorelbine is a semisynthetic analog that reached clinical trial on the basis of less pre...

journal_title：Cancer investigation

authors： Budman DR

更新日期：1997-01-01 00:00:00

abstract：:Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic x...

journal_title：Cancer investigation

authors： Tan GW,Lan FL,Gao JG,Jiang CM,Zhang Y,Huang XH,Ma YH,Shao HD,He XY,Chen JL,Long JW,Xiao HS,Guo ZT,Diao Y

更新日期：2012-08-01 00:00:00

abstract：:There are many changes in the immune response with age, most of which can be related to the involution of the thymus gland and alteration of the distribution and function of T lymphocytes. These changes indirectly influence B-cell function, which not only amplifies the immune deficits, but leads to the increased produ...

journal_title：Cancer investigation

authors： Ben-Yehuda A,Weksler ME

更新日期：1992-01-01 00:00:00

abstract：:Esophageal cancer is multifactorial disease involving environmental and genetic risk factors. Tobacco smoke and alcohol are strong environmental risk factors. N-acetyltransferase 2 (NAT2) is known to metabolize heterocyclic amine carcinogens in tobacco smoke. The purpose of this study was to determine whether genetic ...

journal_title：Cancer investigation

authors： Jain M,Kumar S,Lal P,Tiwari A,Ghoshal UC,Mittal B

更新日期：2007-08-01 00:00:00

abstract：:Precise quantification of oral complications in cancer patients receiving bone marrow and stem cell transplantation is essential when testing new treatment strategies for mucositis. Using 133 adult transplant patients, the authors evaluated the 20 item oral mucositis index (OMI), adapted from the 34 item OMI, to facil...

journal_title：Cancer investigation

authors： McGuire DB,Peterson DE,Muller S,Owen DC,Slemmons MF,Schubert MM

更新日期：2002-01-01 00:00:00

abstract：:The generation of genetically modified immunological effector cells is of potential therapeutic value in the treatment of malignancies. Cytokine-induced killer cells (CIKs) have been described as highly efficient cytotoxic effector cells capable of recognizing and lysing tumor cell targets in a non-major histocompatib...

journal_title：Cancer investigation

authors： Wang J,He M,Shi W,Sha H,Feng J,Wang S,Wang Y

更新日期：2009-03-01 00:00:00

abstract：:Nature has provided many effective anticancer agents in current use, such as the microbially derived drugs; dactinomycin; bleomycin and doxorubicin; and the plant-derived drugs, vinblastine, irinotecan, topotecan, etoposide, and paclitaxel. The search for novel antitumor agents from natural sources continues through c...

journal_title：Cancer investigation

authors： Cragg GM,Newman DJ

更新日期：1999-01-01 00:00:00