Abstract:
:Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigated. Results revealed significant concentration of sCTLA4 in patients with breast cancer (23.5 ± 14.96 versus 7.69 ± 4.04 ng/ml, p < .001). Patients' sCTLA4 concentration observed to be affected by the SNPs at positions +49 and +1822 and haplotype combination TACACA/TACGTG. These findings suggest that increased sCTLA4 may contribute in CTLA4-induced suppression of tumor immunity and provide explanations for the widely reported association of CTLA4 gene with cancer.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Erfani N,Razmkhah M,Ghaderi Adoi
10.3109/07357901003630934subject
Has Abstractpub_date
2010-10-01 00:00:00pages
828-32issue
8eissn
0735-7907issn
1532-4192journal_volume
28pub_type
杂志文章abstract::Fulvestrant (Faslodex) is a new type of estrogen receptor (ER) antagonist that binds, blocks, and degrades the ER, leading to reduced expression of the progesterone receptor (PgR). Unlike the selective ER modulator tamoxifen, fulvestrant is devoid of any known agonist activity. Fulvestrant has a steroidal structure th...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-50480
更新日期:2005-01-01 00:00:00
abstract::Bone marrow (BM) niche is a specific microenvironment for hematopoietic stem cells (HSCs) as well as non-hematopoietic cells. Evidence shows that chemo/radiotherapy can lead to the disruption of different properties of HSCs such as proliferation, differentiation, localization, self-renewa, and steady-state of cell pop...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1855353
更新日期:2020-12-10 00:00:00
abstract::To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the patholo...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802527221
更新日期:2009-05-01 00:00:00
abstract::A dosimetric comparison was made of Helical Tomotherapy (HT) and Rapid'Arc(®) (RA) in 115 patients with head and neck carcinoma included in a prospective and multicentric study. HT and RA provided highly conformal plans that easily complied with dose volume constraints for organs at risk. HT reduced high doses to the ...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.3109/07357907.2014.889705
更新日期:2014-06-01 00:00:00
abstract::Several recent studies have indicated that alterations in expression of major histocompatibility complex (MHC) antigens by tumor cells affects the ability of the host to mount an effective antitumor immune response. To investigate whether newly induced tumors frequently exhibit altered MHC antigen expression, we used ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909109021324
更新日期:1991-01-01 00:00:00
abstract::One hundred twenty-two early-stage anal canal cancer patients (median age: 69 years) were treated with curative radiotherapy with (70 patients) or without (52 patients) concomitant chemotherapy. Median follow-up was 65 months (range: 4-238). At multivariate analysis, concomitant chemotherapy significantly improved loc...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.1001898
更新日期:2015-04-01 00:00:00
abstract::Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077025
更新日期:1988-01-01 00:00:00
abstract::Neurological paraneoplastic syndromes are exceedingly rare, and often difficult to recognize clinically. Paraneoplastic achalasia is a condition characterized by new-onset dysphagia that is unrelated to tumor burden, most often due to the development of auto-immune antibodies targeting esophageal tissue. Due to the ra...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1852412
更新日期:2021-01-06 00:00:00
abstract::Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120002951
更新日期:2002-01-01 00:00:00
abstract::A number of studies have demonstrated the presence of mitochondrial DNA (mtDNA) mutations in cancer cells. In this article, we review mitochondrial genomic aberrations reported in solid tumors of the breast, colon, stomach, liver, kidney, bladder, head/neck, and lung. The tantalizing association of tumors with mtDNA m...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120002155
更新日期:2002-01-01 00:00:00
abstract::An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908609017510
更新日期:1986-01-01 00:00:00
abstract::We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle ge...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903095623
更新日期:2010-07-01 00:00:00
abstract::The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701840212
更新日期:2008-08-01 00:00:00
abstract::This study combined infusional mitoxantrone with bolus melphalan as a transplant preparative regimen for multiple myeloma. Mitoxantrone was infused over 6 hr on days 6 and 5. Melphalan was given as a 15 min bolus on day 1 followed by autologous transplant on day 0. Thirty-five patients were enrolled; 57% of enrollees ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2010.550663
更新日期:2011-03-01 00:00:00
abstract::Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, an...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1309547
更新日期:2017-07-03 00:00:00
abstract::Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.672607
更新日期:2012-06-01 00:00:00
abstract::This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900902744494
更新日期:2010-03-01 00:00:00
abstract::We performed the analysis of database on 409 patients with LD-SCLC to evaluate as to what extent the clinical outcome of large prospective trials was reproduced in routine practice. The analysis has shown that the hazard rate of death in the absence of prophylactic cranial irradiation (PCI) adjusted for the effects of...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.861470
更新日期:2014-01-01 00:00:00
abstract::Previous studies have shown that human PSP94 can inhibit the growth of prostate cancer cells both in vitro and in vivo. To further validate this potential and investigate the protein within a homologous setting, we examined the effects of rat PSP94 on the growth of the rat prostate adenocarcinoma cell line PAIII in vi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600629575
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:This Phase II study was undertaken to define the efficacy and toxicity of the combination of docetaxel and irinotecan for the second-line treatment of non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Forty-six patients with measurable NSCLC who had relapsed after an initial response to chemotherapy or ...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.1080/07357900600705318
更新日期:2006-06-01 00:00:00
abstract::We studied the effects of Shikaron, which is composed of 8 Chinese herb extracts, on carcinogenesis and the cytotoxic activity and cytokine production of lymphocytes in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine (BBN). We found a significantly lower incidence of urinary bladder carcinoma in mice tr...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909809050031
更新日期:1998-01-01 00:00:00
abstract::Soft tissue sarcomas are generally resistant to most chemotherapeutic agents, and individuals with advanced disease have a poor prognosis. We evaluated amonafide, a new drug that has significant activity against several tumor cell lines, to determine its activity against sarcomas. Amonafide was administered to 18 pati...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/07357909409038230
更新日期:1994-01-01 00:00:00
abstract::Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909509024890
更新日期:1995-01-01 00:00:00
abstract::Cisplatin (CDDP) was administered to a 49-year-old dialysis female patient with advanced uterine cervical cancer. Analysis of the pharmacokinetics of CDDP in the patient with renal failure and at hemodialysis were compared with that of patients without renal impairment. CDDP at 30 mg was administered by drip infusion....
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909109039874
更新日期:1991-01-01 00:00:00
abstract::Data have shown that tamoxifen (TAM) can be used to treat not only breast cancer with positive estrogen receptor (ER), but also negative ER including human glioma. However, the molecular mechanism of this drug against different kinds of cancers remains to be elucidated. In this study, we provided the evidence that PKC...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802672720
更新日期:2009-08-01 00:00:00
abstract::We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baselin...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309011669
更新日期:1993-01-01 00:00:00
abstract::One of the hallmarks of cancer is limitless proliferative capacity, which is tightly associated with the ability to maintain telomeres. Over the last decade, the telomere biology of pediatric cancers has begun to be elucidated. Most pediatric leukemias and embryonal solid tumors activate the enzyme telomerase, a speci...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900701208683
更新日期:2007-04-01 00:00:00
abstract::Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied abou...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1582060
更新日期:2019-01-01 00:00:00
abstract::SNPs in CYP1A1, CYP2A1, CYP2B6, CYP2C, CYP2D6, CYP3A, GSTM1, GSTT1, GSTP1, SULT1A1, SULT1A2, UGT, and MTHFR are associated with breast cancer susceptibility; however, lack of such associations are also reported in some populations. The contradictory findings are explained on the basis of ethnic variation among populat...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900801953196
更新日期:2008-10-01 00:00:00
abstract::Gefitinib (ZD1839, Iressa), a member of the 4-anilinoquinazoline class of compounds, has the chemical name 4-quinazolinamine, N-(3-chloro-4-flurophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]. Gefitinib often is referred to as a "specific" or "selective" inhibitor of epidermal growth factor receptor (EGFR). EGFR expre...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900600632058
更新日期:2006-04-01 00:00:00