Abstract:
:Fulvestrant (Faslodex) is a new type of estrogen receptor (ER) antagonist that binds, blocks, and degrades the ER, leading to reduced expression of the progesterone receptor (PgR). Unlike the selective ER modulator tamoxifen, fulvestrant is devoid of any known agonist activity. Fulvestrant has a steroidal structure that competitively binds to the ER with an affinity much greater than that of tamoxifen. After binding to fulvestrant, degradation of the ER is accelerated, ultimately resulting in a reduction in cellular ER. Immunohistochemical studies have demonstrated that a single intramuscular injection of fulvestrant results in a dose-dependent decrease in ER and PgR indices and in Ki-67 expression. At the approved 250 mg dose, the decrease in receptor positivity with fulvestrant treatment was greater than that with tamoxifen. Phase III clinical trials have demonstrated the clinical benefit of fulvestrant in the endocrine treatment of breast cancer. Among patients who progressed during adjuvant or first-line endocrine therapy, fulvestrant was at least as effective as anastrozole as second-line treatment for the primary endpoints of objective response and time to progression, and was well tolerated. After a median follow-up of 24.5 months, a combined survival analysis from two Phase III studies has shown that fulvestrant may be considered similar to anastrozole for time to death (27.4 months versus 27.7 months, respectively). For the first-line therapy of advanced breast cancer in postmenopausal women, fulvestrant was shown to be active and well tolerated in a trial that compared fulvestrant 250 mg once monthly and tamoxifen 20 mg once daily. Treatment with fulvestrant has also demonstrated clinical efficacy among patients who progressed following treatment with tamoxifen followed by nonsteroidal aromatase inhibitors. The efficacy of fulvestrant in sequential endocrine therapy and in combination with other agents appears promising and active investigations are ongoing to explore the clinical potential of this novel antiestrogen.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Bundred Ndoi
10.1081/cnv-50480subject
Has Abstractpub_date
2005-01-01 00:00:00pages
173-81issue
2eissn
0735-7907issn
1532-4192journal_volume
23pub_type
杂志文章,评审abstract::CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis forma...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802392675
更新日期:2009-03-01 00:00:00
abstract::Standard chemotherapeutic regimens, such as cisplatin and etoposide, may improve quality of life and prolong survival in patients with incurable non-small cell lung cancer (NSCLC). This trial was designed to evaluate the activity and toxicity of a regimen combining three of the most active agents against advanced-stag...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/07357900009023055
更新日期:2000-01-01 00:00:00
abstract::Renal cell carcinoma is the most common tumor of the kidney. It has an unpredictable behavior and poor response to systemic therapy. Developing newer therapy for this disease is a priority considering the high recurrence rate and the small subset of patients who benefit from the use of cytokines such as interferon-alp...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900600896315
更新日期:2006-10-01 00:00:00
abstract::For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900701781812
更新日期:2008-06-01 00:00:00
abstract::Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.672607
更新日期:2012-06-01 00:00:00
abstract::In conclusion, the prognosis for women with stage I borderline tumors is excellent. Surgery alone is the recommended treatment. For young patients, fertility-sparing surgery is optimal, with a small percentage eventually developing tumor in the contralateral ovary. For patients with advanced stage borderline tumors, 1...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909909021423
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS:Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2010.535057
更新日期:2011-01-01 00:00:00
abstract::The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, an...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.657817
更新日期:2012-05-01 00:00:00
abstract::To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the patholo...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802527221
更新日期:2009-05-01 00:00:00
abstract::The transforming growth factor beta 1 (TGF-beta1) is a multifunctional cytokine with several regulatory activities in tumor cells affecting growth, differentiation, and function. Alterations in gene expression, secretion, and regulation of TGF-beta1 may lead to a favorable environment for tumor development by angiogen...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701600921
更新日期:2007-12-01 00:00:00
abstract::Computer visualization techniques (CVTs) are an emerging technology that can organize all cancer specialists. This article describes CVTs' ability to maximize the currently untapped advantages of intensity modulated radiotherapy (IMRT). The visual speed and dynamic strategies inherent in CVTs improves IMRT by distilli...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600970490
更新日期:2007-02-01 00:00:00
abstract::To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903095706
更新日期:2010-06-01 00:00:00
abstract::As genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations is increasingly integrated into the clinical management of high-risk women, it will be important to understand barriers and motivations for genetic counseling among women from underserved minority groups to ensure equitable access to these services. Therefore,...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-58819
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:We conducted a phase I study to determine the maximum tolerated dose of docetaxel in combination with gemcitabine for patients with refractory solid tumors. METHODS:From January 1998 to November 1999, we treated 28 patients on a phase I protocol with gemcitabine given at a constant dose of 800 mg/m2 i.v. ov...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120018225
更新日期:2003-06-01 00:00:00
abstract::In vivo and in vitro observations of cellular immune response in 70 patients with squamous cell cancer of the oral cavity and in 40 age-matched normal controls, were made using delayed hypersensitivity responses to DNCB, PPD, and Candida albicans extract (Dermatophytin 'O'), absolute lymphocyte counts, absolute T-cell...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908609018450
更新日期:1986-01-01 00:00:00
abstract::FTIR spectroscopy is a common technique for cancer diagnosis. Applied tissue samples are heterogeneous and may be damaged in preparation procedures. Easier sampling, more available samples and also easier process with assured results would be interesting. Whole blood samples include all of these qualifications and our...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/02770900701512555
更新日期:2007-09-01 00:00:00
abstract::Venous thromboembolic disease is a major cause of morbidity in cancer patients. The Perspective database was used to identify patients with solid tumors and a diagnosis of VTE from 2006 to 2012. We examined use of IVC filters, thrombolysis, and thrombectomy. Among 32,545 patients, 23.1% received an IVC filter, 1.9% th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2016.1221078
更新日期:2016-09-13 00:00:00
abstract::ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZB...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003631007
更新日期:2010-07-01 00:00:00
abstract::The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, in situ hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 G...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1793352
更新日期:2020-08-01 00:00:00
abstract::Two groups of patients with disseminated breast carcinomas who had failed radiotherapy, chemotherapy, and hormonotherapy were treated with natural interferon alpha (nIFN-alpha) alone or in combination with nIFN-gamma delivered in cycles of 10-12 intralesional (i.l.) injections to recurrent and metastatic lesions. In g...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509011686
更新日期:1995-01-01 00:00:00
abstract::Mice bearing LP07 lung adenocarcinoma present some characteristics similar to those shown in patients with several malignant diseases. LP07 tumor bearers develop paraneoplastic syndromes such as cachexia, leukocytosis, and hypercalcemia, partly due to a systemic inflammatory response. We analyzed some of the mechanism...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900500524322
更新日期:2006-03-01 00:00:00
abstract::A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900902849657
更新日期:2009-10-01 00:00:00
abstract::Autologous bone marrow transplantation (AuBMT) is an accepted treatment modality for patients with high-risk or relapsed hematological malignancies. Hepatotoxicity, in particular veno-occlusive disease (VOD), is a significant complication of this therapy. The purpose of this study was to determine the clinical relevan...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509031914
更新日期:1995-01-01 00:00:00
abstract::We hypothesized that co-targeting the epidermal growth factor receptor (EGFR) and Src with the EGFR inhibitor gefitinib and the Src inhibitor AZD0530 would increase growth inhibition and impede migration. Cells overexpressing EGFR were more sensitive to gefitinib than cells expressing mutated EGFR or normal levels of ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802570759
更新日期:2009-02-01 00:00:00
abstract::This study is to evaluate the association between IL-8 -251A/T polymorphism and lung cancer risk in diverse populations. We performed a meta-analysis of six case-control studies that included 3,265 lung-cancer cases and 3,607 case-free controls. Overall, results showed that the IL-8 -251A/T polymorphism was not associ...
journal_title:Cancer investigation
pub_type: 杂志文章,meta分析
doi:10.3109/07357907.2014.964410
更新日期:2014-12-01 00:00:00
abstract::The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.568566
更新日期:2011-06-01 00:00:00
abstract::We evaluated the clinical impact of a high definition micro-multileaf collimator and a linac-integrated cone-beam computed tomography in 142 patients treated with conformal radiotherapy for localized prostate cancer to a total dose of 76 Gy. Details on treatment toxicity and tumour control were collected. The 3 years ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.970193
更新日期:2014-12-01 00:00:00
abstract::Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34+ progenitor/stem leukemia...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1630633
更新日期:2019-01-01 00:00:00
abstract::The purpose of this study was to assess the usefulness of thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) scintimammography to differentiate benign from malignant breast masses in 32 female Taiwanese patients with indeterminate mammographic probability of malignancy because of mammographically...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120025089
更新日期:2003-01-01 00:00:00
abstract::The role of stereotactic body radiation therapy (SBRT) in achieving durable local control and palliation of pain in pelvic lymph node oligometastatic disease is not well-studied. We performed a retrospective analysis of 30 patients with 43 pelvic lymph node oligometastases from various primary cancers all but one with...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1801713
更新日期:2020-11-01 00:00:00