Genetic testing for inherited breast cancer risk in African Americans.

abstract：:Lung cancer is the leading cause of cancer death worldwide and small cell lung cancer (SCLC) accounts for a significant proportion of all lung cancer cases. Even so, the underlying mechanism governing SCLC development remains poorly understood and SCLC related cancer death stands high despite decades of intensive inve...

journal_title：Cancer investigation

authors： Yang H,Luo J,Liu Z,Zhou R,Luo H

更新日期：2015-04-01 00:00:00

abstract：:Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that th...

journal_title：Cancer investigation

authors： Kimura T,Wang L,Tabu K,Nishihara H,Mashita Y,Kikuchi N,Tanino M,Hiraga H,Tanaka S

更新日期：2012-06-01 00:00:00

abstract：:Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...

journal_title：Cancer investigation

authors： Leonard JP,Siegel JA,Goldsmith SJ

更新日期：2003-04-01 00:00:00

abstract：:IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infecti...

journal_title：Cancer investigation

authors： Mahanty S,Nutman TB

更新日期：1993-01-01 00:00:00

abstract：:Nerve growth factor receptor (NGF-R) has been shown to have antiproliferative, differentiative, or apoptotic effects on some types of tumor cells, whereas in others it may have mitogenic activity. The immunohistochemical distribution of NGF-R was analyzed in a series of tissue samples from breast cancer patients and i...

journal_title：Cancer investigation

authors： Aragona M,Panetta S,Silipigni AM,Romeo DL,Pastura G,Mesiti M,Cascinu S,La Torre F

更新日期：2001-01-01 00:00:00

abstract：:Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to i...

journal_title：Cancer investigation

authors： Zakaria MA,Rajab NF,Chua EW,Selvarajah GT,Masre SF

更新日期：2020-09-01 00:00:00

abstract：:Interstitial collagenase-1 degrades a variety of extracellular matrix components. A single guanine insertion polymorphism in the promoter has been found that influences on the transcription and expression level of the gene. It is suggested that this polymorphism may enhance susceptibility to some types of cancer. Ther...

journal_title：Cancer investigation

authors： Kouhkan F,Motovali-Bashi M,Hojati Z

更新日期：2008-10-01 00:00:00

abstract：:Peroxiredoxins are thiol-specific antioxidant proteins that protect cells from ROS-induced cell death and are elevated in several cancers. We found that five of the six mammalian peroxiredoxins are overexpressed in MCF-7 breast cancer cells at the mRNA and protein levels, compared to noncancerous MCF-10A cells. Inhibi...

journal_title：Cancer investigation

authors： Tehan L,Taparra K,Phelan S

更新日期：2013-07-01 00:00:00

abstract：:Venous thromboembolic disease is a major cause of morbidity in cancer patients. The Perspective database was used to identify patients with solid tumors and a diagnosis of VTE from 2006 to 2012. We examined use of IVC filters, thrombolysis, and thrombectomy. Among 32,545 patients, 23.1% received an IVC filter, 1.9% th...

journal_title：Cancer investigation

authors： Yoon L,Clarke Hillyer G,Chen L,Hu JC,Neugut AI,Hershman DL,Wright JD

更新日期：2016-09-13 00:00:00

abstract：:To study the efficiency of high-dose melphalan in previously untreated patients with advanced myeloma, we performed a Phase I-II trial. Twenty-eight patients were treated at dose level of 60-140 mg/m2. Each patient was first treated with a priming dose of cyclophosphamide (300 mg) followed by high-dose melphalen 1 wee...

journal_title：Cancer investigation

authors： Case DC Jr,Coleman M,Gottlieb A,McCarroll K

更新日期：1992-01-01 00:00:00

abstract：:Dysregulation in apoptotic cell death has recently emerged as a factor in tumorigenesis, but its effect in tumor progression is not yet established. In the present study we evaluated the levels of proliferative and apoptotic cell fractions in a T-cell lymphoma tumor progression model. We compared these features and th...

journal_title：Cancer investigation

authors： Donin N,Kay S,Sinai J,Katzenelson D,Siegal A,Michowitz M,Schibi G,Leibovici J

更新日期：2000-01-01 00:00:00

abstract：:In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor ti...

journal_title：Cancer investigation

authors： Singh N,Das P,Datta Gupta S,Sahni P,Pandey RM,Gupta S,Chauhan SS,Saraya A

更新日期：2013-08-01 00:00:00

abstract：:Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic x...

journal_title：Cancer investigation

authors： Tan GW,Lan FL,Gao JG,Jiang CM,Zhang Y,Huang XH,Ma YH,Shao HD,He XY,Chen JL,Long JW,Xiao HS,Guo ZT,Diao Y

更新日期：2012-08-01 00:00:00

abstract：:The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy subsequent to tumor debulking, citing drug resistance and host toxicity as the primary reasons for ...

journal_title：Cancer investigation

authors： Retsky MW,Swartzendruber DE,Bame PD,Wardwell RH

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the efficacy and toxicity of the combination of vinorelbine and interleukin (IL)-2 in patients with metastatic melanoma as second-line chemotherapy. PATIENTS AND METHODS:Twenty-two patients with histologically confirmed stage IV melanoma previously treated with temozolomide-based chemotherapy--o...

journal_title：Cancer investigation

authors： Gogas H,Bafaloukos D,Aravantinos G,Fountzilas G,Tsoutsos D,Panagiotou P,Frangia K,Kalofonos HP,Briasoulis E,Castana O,Polyzos A,Pectasides D,Ioannovich J,Hellenic Cooperative Oncology Group.

更新日期：2004-01-01 00:00:00

abstract：:Reversible epidermal growth factor receptor tyrosine kinase inhibitors are often used for the treatment of non-small cell lung cancer following failure of cytotoxic chemotherapy. While these agents are active in a subset of patients, most develop resistance and progress within the course of 1 year. In nearly half of t...

journal_title：Cancer investigation

authors： Belani CP

更新日期：2010-05-01 00:00:00

abstract：:This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...

journal_title：Cancer investigation

authors： Zhao X,Liu J,Peng M,Liu J,Chen F

更新日期：2013-10-01 00:00:00

abstract：:This review summarizes the literature on QoL in early stage lung cancer patients who underwent surgery. PubMed and PsycINFO were searched. Twelve articles from 10 distinct studies were identified for a total of 992 patients. Five QoL measures were used. One study reported only on pre-surgical QoL, six only on post-sur...

journal_title：Cancer investigation

authors： Yip R,Taioli E,Schwartz R,Li K,Becker BJ,Tam K,Htwe YM,Yankelevitz DF,Henschke CI

更新日期：2018-01-01 00:00:00

abstract：:To identify the relevant CpG sites as molecular markers, for the diagnosis and to distinguish the indolent and aggressive prostate tumors, we have determined the methylation status of 8 genes, including FLNC, EFS, ECRG4, RARB2, PITX2, GSTP1, PDLIM4, and KCNMA1 in 32 nonrecurrent, 32 recurrent primary prostate tumors, ...

journal_title：Cancer investigation

authors： Vanaja DK,Ehrich M,Van den Boom D,Cheville JC,Karnes RJ,Tindall DJ,Cantor CR,Young CY

更新日期：2009-06-01 00:00:00

abstract：:Non-invasive pharmacological management of patients with cancer related pain has resulted in pain control in 90-95% of the patients. Thus, 5-10% of patients still experience inadequate pain control despite aggressive combined pharmacological therapy. Moreover, patients may not tolerate an aggressive program of titrati...

journal_title：Cancer investigation

authors： de Leon-Casasola OA

更新日期：2004-01-01 00:00:00

abstract：:The response rate (RR) to single-agent chemotherapy with doxorubicin or ifosfamide in patients with advanced soft-tissue sarcoma (STS) is in the range of 20%. Paclitaxel is clinically useful in treating several solid tumors and has demonstrated activity in a series of human sarcoma cell lines. Twenty-eight patients wi...

journal_title：Cancer investigation

authors： Casper ES,Waltzman RJ,Schwartz GK,Sugarman A,Pfister D,Ilson D,Woodruff J,Leung D,Bertino JR

更新日期：1998-01-01 00:00:00

abstract：:Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies...

journal_title：Cancer investigation

authors： Shklar G,Oh SK

更新日期：2000-01-01 00:00:00

abstract：:Computer visualization techniques (CVTs) are an emerging technology that can organize all cancer specialists. This article describes CVTs' ability to maximize the currently untapped advantages of intensity modulated radiotherapy (IMRT). The visual speed and dynamic strategies inherent in CVTs improves IMRT by distilli...

journal_title：Cancer investigation

authors： Butler EB,Shukla V,Paulino AC,Lu HH,Butler R,Smiedala M,Kurk J,Grant WH 3rd,McGary JE,Teh BS

更新日期：2007-02-01 00:00:00

abstract：:The aim of our study was to investigate the role of nerve growth factor (NGF) on the expression of the p73 protein in human ependymoblastoma (EP) and medulloblastoma (MB) cells. It was found that NGF exposure on MB cells blocks proliferation, as well as on EP cells and induces overexpression of p73. NGF reduces the nu...

journal_title：Cancer investigation

authors： Antonelli A,Lenzi L,Nakagawara A,Osaki T,Chiaretti A,Aloe L

更新日期：2007-03-01 00:00:00

abstract：:Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydroge...

journal_title：Cancer investigation

authors： Agah S,Akbari A,Talebi A,Masoudi M,Sarveazad A,Mirzaei A,Nazmi F

更新日期：2017-11-26 00:00:00

abstract：:Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ER...

journal_title：Cancer investigation

authors： Karimi P,Hematti S,Safari F,Tavassoli M

更新日期：2013-11-01 00:00:00

abstract：:Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal o...

journal_title：Cancer investigation

authors： Xi J,Zeng ST,Guo L,Feng J

更新日期：2016-01-01 00:00:00

abstract：:The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC...

journal_title：Cancer investigation

authors： Szondy K,Rusai K,Szabó AJ,Nagy A,Gal K,Fekete A,Kovats Z,Losonczy G,Lukacsovits J,Müller V

更新日期：2012-05-01 00:00:00

abstract：:Tumor-infiltrating leukocytes and other immunohistochemical parameters were evaluated in pretherapeutic biopsies and resection specimens in 73 patients undergoing neoadjuvant chemotherapy with doxorubicin and paclitaxel. Ten patients with pathological complete response had significantly higher p53 expression, CD3(+) l...

journal_title：Cancer investigation

authors： Hornychova H,Melichar B,Tomsova M,Mergancova J,Urminska H,Ryska A

更新日期：2008-12-01 00:00:00

abstract：:Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34+ progenitor/stem leukemia...

journal_title：Cancer investigation

authors： Lei H,Tu Y,Yang L,Jin J,Luo H,Xu H,Kang J,Zhou L,Wu Y

更新日期：2019-01-01 00:00:00