Abstract:
:The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy subsequent to tumor debulking, citing drug resistance and host toxicity as the primary reasons for treatment failure. To better understand treatment failure, we have studied breast cancer from the perspective of computer modeling. Our results demonstrate breast cancers grow in an irregular fashion; this differs from the Gompertzian mode of animal models and thus challenges the validity of the current paradigm. Clinical and laboratory data support the concept of irregular growth rather than the common claim that human tumors grow in a Gompertzian fashion. Treatment failure mechanisms for breast cancer appear to differ from those for animal models, and thus treatments optimize on animal models may not be optimal for breast cancer. A failure mechanism consistent with our results involves temporarily dormant tumor cells in anatomical or pharmacological sanctuary, which eventually result in aggressive metastatic disease.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Retsky MW,Swartzendruber DE,Bame PD,Wardwell RHdoi
10.3109/07357909409023040subject
Has Abstractpub_date
1994-01-01 00:00:00pages
559-67issue
6eissn
0735-7907issn
1532-4192journal_volume
12pub_type
杂志文章abstract::Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies...
journal_title:Cancer investigation
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journal_title:Cancer investigation
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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